Q6PJT7 (ZC3HE_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger CCCH domain-containing protein 14

Alternative name(s):
Mammalian suppressor of tau pathology-2
Short name=MSUT-2
Renal carcinoma antigen NY-REN-37

Gene names

Name:

ZC3H14

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	736 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds the polyadenosine RNA oligonucleotides. Ref.11
Subunit structure	Interacts with HOOK2. Ref.17
Subcellular location	Nucleus speckle Ref.11 Ref.16. Isoform 1: Nucleus speckle Ref.11 Ref.16. Isoform 3: Nucleus speckle Ref.11 Ref.16. Isoform 6: Cytoplasm Ref.11 Ref.16.
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.10 Ref.12 Ref.13 Ref.14
Sequence similarities	Belongs to the ZC3H14 family. Contains 5 C3H1-type zinc fingers.
Sequence caution	The sequence AAL83289.1 differs from that shown. Reason: Several sequencing errors. The sequence AAS90302.1 differs from that shown. Reason: Frameshift at several positions. The sequence AAS90302.1 differs from that shown. Reason: Aberrant splicing. The sequence AK021868 differs from that shown. Reason: Frameshift at position 199. The sequence CAE45933.1 differs from that shown. Reason: Aberrant splicing.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat Zinc-finger
Ligand	Metal-binding RNA-binding Zinc
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nuclear speck Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction Ref.17. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6PJT7-1)

Also known as: Isoform 1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6PJT7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     669-669: Missing.

Isoform 3 (identifier: Q6PJT7-3)

Also known as: Isoform 2;

The sequence of this isoform differs from the canonical sequence as follows:
     427-582: Missing.
     669-669: Missing.

Isoform 4 (identifier: Q6PJT7-4)

Also known as: Isoform 3 short;

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.
     452-582: Missing.

Isoform 5 (identifier: Q6PJT7-5)

The sequence of this isoform differs from the canonical sequence as follows:
     427-451: Missing.

Isoform 6 (identifier: Q6PJT7-6)

Also known as: Isoform 4;

The sequence of this isoform differs from the canonical sequence as follows:
     1-298: Missing.
     299-426: VSSVVKVKKF...TKGDSVEKNQ → MRMSSKFPSP...IIGFLRNVEK
     452-582: Missing.
     669-669: Missing.

Isoform 8 (identifier: Q6PJT7-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1-454: Missing.
     455-582: DMESMVHADT...LEDPNGSFSN → MRMSSKFPSP...IIGFLRNVEK

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 736	736	Zinc finger CCCH domain-containing protein 14		PRO_0000331311
Regions
	Zinc finger	595 – 620	26	C3H1-type 1
	Zinc finger	621 – 640	20	C3H1-type 2
	Zinc finger	641 – 656	16	C3H1-type 3
	Zinc finger	682 – 699	18	C3H1-type 4
	Zinc finger	701 – 719	19	C3H1-type 5
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine Ref.15
	Modified residue	357	1	N6-acetyllysine Ref.18
	Modified residue	409	1	Phosphoserine Ref.10
	Modified residue	450	1	Phosphoserine Ref.12
	Modified residue	515	1	Phosphoserine Ref.10 Ref.13 Ref.14
	Modified residue	620	1	Phosphoserine Ref.10
Natural variations
	Alternative sequence	1 – 454	454	Missing in isoform 8.		VSP_033162
	Alternative sequence	1 – 298	298	Missing in isoform 6.		VSP_033163
	Alternative sequence	1 – 34	34	Missing in isoform 4.		VSP_033164
	Alternative sequence	299 – 426	128	VSSVV…VEKNQ → MRMSSKFPSPPLPIFLPPEP VDLGSITSSSCSLNELDNIS HLLRKISADINEIKGMKAAI LTVEANLFDLNVRVSKNEAK ISSLEVKMNEYSTTYECNRQ FEDQEEDTESQSRTTDVKII GFLRNVEK in isoform 6.		VSP_033165
	Alternative sequence	427 – 582	156	Missing in isoform 3.		VSP_033166
	Alternative sequence	427 – 451	25	Missing in isoform 5.		VSP_033167
	Alternative sequence	452 – 582	131	Missing in isoform 4 and isoform 6.		VSP_033168
	Alternative sequence	455 – 582	128	DMESM…GSFSN → MRMSSKFPSPPLPIFLPPEP VDLGSITSSSCSLNELDNIS HLLRKISADINEIKGMKAAI LTVEANLFDLNVRVSKNEAK ISSLEVKMNEYSTTYECNRQ FEDQEEDTESQSRTTDVKII GFLRNVEK in isoform 8.		VSP_033169
	Alternative sequence	669	1	Missing in isoform 2, isoform 3 and isoform 6.		VSP_033171
Experimental info
	Sequence conflict	674	1	A → V in AAH23641. Ref.7
	Sequence conflict	712	1	C → F in AAS90302. Ref.2
	Sequence conflict	712	1	C → F in CAE45933. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Isoform 1) [UniParc]. Last modified July 5, 2004. Version 1. Checksum: BCF3E36CBA66170A	FASTA	736	82,876
	10 20 30 40 50 60 MEIGTEISRK IRSAIKGKLQ ELGAYVDEEL PDYIMVMVAN KKSQDQMTED LSLFLGNNTI 70 80 90 100 110 120 RFTVWLHGVL DKLRSVTTEP SSLKSSDTNI FDSNVPSNKS NFSRGDERRH EAAVPPLAIP 130 140 150 160 170 180 SARPEKRDSR VSTSSQESKT TNVRQTYDDG AATRLMSTVK PLREPAPSED VIDIKPEPDD 190 200 210 220 230 240 LIDEDLNFVQ ENPLSQKKPT VTLTYGSSRP SIEIYRPPAS RNADSGVHLN RLQFQQQQNS 250 260 270 280 290 300 IHAAKQLDMQ SSWVYETGRL CEPEVLNSLE ETYSPFFRNN SEKMSMEDEN FRKRKLPVVS 310 320 330 340 350 360 SVVKVKKFNH DGEEEEEDDD YGSRTGSISS SVSVPAKPER RPSLPPSKQA NKNLILKAIS 370 380 390 400 410 420 EAQESVTKTT NYSTVPQKQT LPVAPRTRTS QEELLAEVVQ GQSRTPRISP PIKEEETKGD 430 440 450 460 470 480 SVEKNQGTQQ RQLLSRLQID PVMAETLQMS QDYYDMESMV HADTRSFILK KPKLSEEVVV 490 500 510 520 530 540 APNQESGMKT ADSLRVLSGH LMQTRDLVQP DKPASPKFIV TLDGVPSPPG YMSDQEEDMC 550 560 570 580 590 600 FEGMKPVNQT AASNKGLRGL LHPQQLHLLS RQLEDPNGSF SNAEMSELSV AQKPEKLLER 610 620 630 640 650 660 CKYWPACKNG DECAYHHPIS PCKAFPNCKF AEKCLFVHPN CKYDAKCTKP DCPFTHVSRR 670 680 690 700 710 720 IPVLSPKPAV APPAPPSSSQ LCRYFPACKK MECPFYHPKH CRFNTQCTRP DCTFYHPTIN 730 VPPRHALKWI RPQTSE
	Isoform 2 [UniParc]. Checksum: 23DE4F1ECFAB49DE	FASTA	735	82,805
	10 20 30 40 50 60 MEIGTEISRK IRSAIKGKLQ ELGAYVDEEL PDYIMVMVAN KKSQDQMTED LSLFLGNNTI 70 80 90 100 110 120 RFTVWLHGVL DKLRSVTTEP SSLKSSDTNI FDSNVPSNKS NFSRGDERRH EAAVPPLAIP 130 140 150 160 170 180 SARPEKRDSR VSTSSQESKT TNVRQTYDDG AATRLMSTVK PLREPAPSED VIDIKPEPDD 190 200 210 220 230 240 LIDEDLNFVQ ENPLSQKKPT VTLTYGSSRP SIEIYRPPAS RNADSGVHLN RLQFQQQQNS 250 260 270 280 290 300 IHAAKQLDMQ SSWVYETGRL CEPEVLNSLE ETYSPFFRNN SEKMSMEDEN FRKRKLPVVS 310 320 330 340 350 360 SVVKVKKFNH DGEEEEEDDD YGSRTGSISS SVSVPAKPER RPSLPPSKQA NKNLILKAIS 370 380 390 400 410 420 EAQESVTKTT NYSTVPQKQT LPVAPRTRTS QEELLAEVVQ GQSRTPRISP PIKEEETKGD 430 440 450 460 470 480 SVEKNQGTQQ RQLLSRLQID PVMAETLQMS QDYYDMESMV HADTRSFILK KPKLSEEVVV 490 500 510 520 530 540 APNQESGMKT ADSLRVLSGH LMQTRDLVQP DKPASPKFIV TLDGVPSPPG YMSDQEEDMC 550 560 570 580 590 600 FEGMKPVNQT AASNKGLRGL LHPQQLHLLS RQLEDPNGSF SNAEMSELSV AQKPEKLLER 610 620 630 640 650 660 CKYWPACKNG DECAYHHPIS PCKAFPNCKF AEKCLFVHPN CKYDAKCTKP DCPFTHVSRR 670 680 690 700 710 720 IPVLSPKPVA PPAPPSSSQL CRYFPACKKM ECPFYHPKHC RFNTQCTRPD CTFYHPTINV 730 PPRHALKWIR PQTSE
	Isoform 3 (Isoform 2) [UniParc]. Checksum: 9F97392E74A1F612	FASTA	579	65,425
	10 20 30 40 50 60 MEIGTEISRK IRSAIKGKLQ ELGAYVDEEL PDYIMVMVAN KKSQDQMTED LSLFLGNNTI 70 80 90 100 110 120 RFTVWLHGVL DKLRSVTTEP SSLKSSDTNI FDSNVPSNKS NFSRGDERRH EAAVPPLAIP 130 140 150 160 170 180 SARPEKRDSR VSTSSQESKT TNVRQTYDDG AATRLMSTVK PLREPAPSED VIDIKPEPDD 190 200 210 220 230 240 LIDEDLNFVQ ENPLSQKKPT VTLTYGSSRP SIEIYRPPAS RNADSGVHLN RLQFQQQQNS 250 260 270 280 290 300 IHAAKQLDMQ SSWVYETGRL CEPEVLNSLE ETYSPFFRNN SEKMSMEDEN FRKRKLPVVS 310 320 330 340 350 360 SVVKVKKFNH DGEEEEEDDD YGSRTGSISS SVSVPAKPER RPSLPPSKQA NKNLILKAIS 370 380 390 400 410 420 EAQESVTKTT NYSTVPQKQT LPVAPRTRTS QEELLAEVVQ GQSRTPRISP PIKEEETKGD 430 440 450 460 470 480 SVEKNQAEMS ELSVAQKPEK LLERCKYWPA CKNGDECAYH HPISPCKAFP NCKFAEKCLF 490 500 510 520 530 540 VHPNCKYDAK CTKPDCPFTH VSRRIPVLSP KPVAPPAPPS SSQLCRYFPA CKKMECPFYH 550 560 570 PKHCRFNTQC TRPDCTFYHP TINVPPRHAL KWIRPQTSE
	Isoform 4 (Isoform 3 short) [UniParc]. Checksum: 95D7DEA373BCA94B	FASTA	571	64,502
	10 20 30 40 50 60 MVMVANKKSQ DQMTEDLSLF LGNNTIRFTV WLHGVLDKLR SVTTEPSSLK SSDTNIFDSN 70 80 90 100 110 120 VPSNKSNFSR GDERRHEAAV PPLAIPSARP EKRDSRVSTS SQESKTTNVR QTYDDGAATR 130 140 150 160 170 180 LMSTVKPLRE PAPSEDVIDI KPEPDDLIDE DLNFVQENPL SQKKPTVTLT YGSSRPSIEI 190 200 210 220 230 240 YRPPASRNAD SGVHLNRLQF QQQQNSIHAA KQLDMQSSWV YETGRLCEPE VLNSLEETYS 250 260 270 280 290 300 PFFRNNSEKM SMEDENFRKR KLPVVSSVVK VKKFNHDGEE EEEDDDYGSR TGSISSSVSV 310 320 330 340 350 360 PAKPERRPSL PPSKQANKNL ILKAISEAQE SVTKTTNYST VPQKQTLPVA PRTRTSQEEL 370 380 390 400 410 420 LAEVVQGQSR TPRISPPIKE EETKGDSVEK NQGTQQRQLL SRLQIDPVMA ETLQMSQAEM 430 440 450 460 470 480 SELSVAQKPE KLLERCKYWP ACKNGDECAY HHPISPCKAF PNCKFAEKCL FVHPNCKYDA 490 500 510 520 530 540 KCTKPDCPFT HVSRRIPVLS PKPAVAPPAP PSSSQLCRYF PACKKMECPF YHPKHCRFNT 550 560 570 QCTRPDCTFY HPTINVPPRH ALKWIRPQTS E
	Isoform 5 [UniParc]. Checksum: 9D8B3AF17DC0FB13	FASTA	711	80,021
	10 20 30 40 50 60 MEIGTEISRK IRSAIKGKLQ ELGAYVDEEL PDYIMVMVAN KKSQDQMTED LSLFLGNNTI 70 80 90 100 110 120 RFTVWLHGVL DKLRSVTTEP SSLKSSDTNI FDSNVPSNKS NFSRGDERRH EAAVPPLAIP 130 140 150 160 170 180 SARPEKRDSR VSTSSQESKT TNVRQTYDDG AATRLMSTVK PLREPAPSED VIDIKPEPDD 190 200 210 220 230 240 LIDEDLNFVQ ENPLSQKKPT VTLTYGSSRP SIEIYRPPAS RNADSGVHLN RLQFQQQQNS 250 260 270 280 290 300 IHAAKQLDMQ SSWVYETGRL CEPEVLNSLE ETYSPFFRNN SEKMSMEDEN FRKRKLPVVS 310 320 330 340 350 360 SVVKVKKFNH DGEEEEEDDD YGSRTGSISS SVSVPAKPER RPSLPPSKQA NKNLILKAIS 370 380 390 400 410 420 EAQESVTKTT NYSTVPQKQT LPVAPRTRTS QEELLAEVVQ GQSRTPRISP PIKEEETKGD 430 440 450 460 470 480 SVEKNQDYYD MESMVHADTR SFILKKPKLS EEVVVAPNQE SGMKTADSLR VLSGHLMQTR 490 500 510 520 530 540 DLVQPDKPAS PKFIVTLDGV PSPPGYMSDQ EEDMCFEGMK PVNQTAASNK GLRGLLHPQQ 550 560 570 580 590 600 LHLLSRQLED PNGSFSNAEM SELSVAQKPE KLLERCKYWP ACKNGDECAY HHPISPCKAF 610 620 630 640 650 660 PNCKFAEKCL FVHPNCKYDA KCTKPDCPFT HVSRRIPVLS PKPAVAPPAP PSSSQLCRYF 670 680 690 700 710 PACKKMECPF YHPKHCRFNT QCTRPDCTFY HPTINVPPRH ALKWIRPQTS E
	Isoform 6 (Isoform 4) [UniParc]. Checksum: 6122BC10CFCE1D25	FASTA	306	34,867
	10 20 30 40 50 60 MRMSSKFPSP PLPIFLPPEP VDLGSITSSS CSLNELDNIS HLLRKISADI NEIKGMKAAI 70 80 90 100 110 120 LTVEANLFDL NVRVSKNEAK ISSLEVKMNE YSTTYECNRQ FEDQEEDTES QSRTTDVKII 130 140 150 160 170 180 GFLRNVEKGT QQRQLLSRLQ IDPVMAETLQ MSQAEMSELS VAQKPEKLLE RCKYWPACKN 190 200 210 220 230 240 GDECAYHHPI SPCKAFPNCK FAEKCLFVHP NCKYDAKCTK PDCPFTHVSR RIPVLSPKPV 250 260 270 280 290 300 APPAPPSSSQ LCRYFPACKK MECPFYHPKH CRFNTQCTRP DCTFYHPTIN VPPRHALKWI RPQTSE
	Isoform 8 [UniParc]. Checksum: D32BB78C85628238	FASTA	282	32,084
	10 20 30 40 50 60 MRMSSKFPSP PLPIFLPPEP VDLGSITSSS CSLNELDNIS HLLRKISADI NEIKGMKAAI 70 80 90 100 110 120 LTVEANLFDL NVRVSKNEAK ISSLEVKMNE YSTTYECNRQ FEDQEEDTES QSRTTDVKII 130 140 150 160 170 180 GFLRNVEKAE MSELSVAQKP EKLLERCKYW PACKNGDECA YHHPISPCKA FPNCKFAEKC 190 200 210 220 230 240 LFVHPNCKYD AKCTKPDCPF THVSRRIPVL SPKPAVAPPA PPSSSQLCRY FPACKKMECP 250 260 270 280 FYHPKHCRFN TQCTRPDCTF YHPTINVPPR HALKWIRPQT SE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Guo J.H. Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 8).
[2]	"Homo sapiens putative NY-REN-37 antigen alternatively spliced isoforms." Zhou G., Wang X., Yu L. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3 AND 4).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Embryo.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4). Tissue: Oesophageal carcinoma and Testis.
[5]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed: 12508121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 91-736 (ISOFORM 2). Tissue: Muscle, Skin and Testis.
[8]	"Full-length cDNA libraries and normalization." Li W.B., Gruber C., Jessee J., Polayes D. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 86-736 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 368-736 (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 630-736 (ISOFORM 1). Tissue: Neuroblastoma and Placenta.
[9]	"Antigens recognized by autologous antibody in patients with renal-cell carcinoma." Scanlan M.J., Gordan J.D., Williamson B., Stockert E., Bander N.H., Jongeneel C.V., Gure A.O., Jaeger D., Jaeger E., Knuth A., Chen Y.-T., Old L.J. Int. J. Cancer 83:456-464(1999) [PubMed: 10508479] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 563-736 (ISOFORM 2), IDENTIFICATION AS A RENAL CANCER ANTIGEN. Tissue: Renal cell carcinoma.
[10]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409; SER-515 AND SER-620, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Recognition of polyadenosine RNA by zinc finger proteins." Kelly S.M., Pabit S.A., Kitchen C.M., Guo P., Marfatia K.A., Murphy T.J., Corbett A.H., Berland K.M. Proc. Natl. Acad. Sci. U.S.A. 104:12306-12311(2007) [PubMed: 17630287] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[12]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-450, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[13]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-515, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-515, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[15]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[16]	"Splice variants of the human ZC3H14 gene generate multiple isoforms of a zinc finger polyadenosine RNA binding protein." Leung S.W., Apponi L.H., Cornejo O.E., Kitchen C.M., Valentini S.R., Pavlath G.K., Dunham C.M., Corbett A.H. Gene 439:71-78(2009) [PubMed: 19303045] [Abstract] Cited for: ALTERNATIVE SPLICING, SUBCELLULAR LOCATION.
[17]	"SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans." Guthrie C.R., Schellenberg G.D., Kraemer B.C. Hum. Mol. Genet. 18:1825-1838(2009) [PubMed: 19273536] [Abstract] Cited for: INTERACTION WITH HOOK2.
[18]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-357, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF474376 mRNA. Translation: AAL83289.1. Sequence problems. AY578060 mRNA. Translation: AAS90299.1. AY578061 mRNA. Translation: AAS90300.1. AY578062 mRNA. Translation: AAS90301.1. AY578063 mRNA. Translation: AAS90302.1. Sequence problems. AK021868 mRNA. No translation available. AL834215 mRNA. Translation: CAD38897.1. BX640716 mRNA. Translation: CAE45835.1. BX640876 mRNA. Translation: CAE45933.1. Sequence problems. AL162171 Genomic DNA. No translation available. CH471061 Genomic DNA. Translation: EAW81385.1. CH471061 Genomic DNA. Translation: EAW81388.1. CH471061 Genomic DNA. Translation: EAW81389.1. CH471061 Genomic DNA. Translation: EAW81390.1. BC011793 mRNA. Translation: AAH11793.1. BC023641 mRNA. Translation: AAH23641.1. BC027607 mRNA. Translation: AAH27607.1. BX248265 mRNA. Translation: CAD62593.1. BX248281 mRNA. Translation: CAD62609.1. BX248769 mRNA. Translation: CAD66576.1. AF155107 mRNA. Translation: AAD42873.1.
IPI	IPI00168449. IPI00168501. IPI00291357. IPI00397376. IPI00451437. IPI00890689. IPI00890821.
RefSeq	NP_001153575.1. NM_001160103.1. NP_001153576.1. NM_001160104.1. NP_079100.2. NM_024824.4. NP_997543.1. NM_207660.3. NP_997544.1. NM_207661.2. NP_997545.2. NM_207662.3.
UniGene	Hs.725164.
3D structure databases
ProteinModelPortal	Q6PJT7.
SMR	Q6PJT7. Positions 9-75, 592-639, 679-717.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6PJT7. 3 interactions.
MINT	MINT-1455250.
STRING	Q6PJT7.
PTM databases
PhosphoSite	Q6PJT7.
Polymorphism databases
DMDM	74737935.
Proteomic databases
PRIDE	Q6PJT7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000251038; ENSP00000251038; ENSG00000100722.
GeneID	79882.
KEGG	hsa:79882.
NMPDR	fig|9606.3.peg.9985.
UCSC	uc001xww.1. human. uc001xwx.1. human. uc001xwy.1. human. uc001xwz.1. human. uc001xxb.1. human. uc001xxc.1. human.
Organism-specific databases
CTD	79882.
GeneCards	GC14P089029.
H-InvDB	HIX0011871.
HGNC	HGNC:20509. ZC3H14.
MIM	613279. gene.
neXtProt	NX_Q6PJT7.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG19174.
GeneTree	ENSGT00440000038430.
HOVERGEN	HBG108760.
InParanoid	Q6PJT7.
PhylomeDB	Q6PJT7.
Gene expression databases
ArrayExpress	Q6PJT7.
Bgee	Q6PJT7.
CleanEx	HS_ZC3H14.
Genevestigator	Q6PJT7.
Family and domain databases
InterPro	IPR000571. Znf_CCCH. [Graphical view]
SMART	SM00356. ZnF_C3H1. 3 hits. [Graphical view]
PROSITE	PS50103. ZF_C3H1. 3 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	69673.
SOURCE	Search...

Entry information

Entry name

ZC3HE_HUMAN

Accession

Primary (citable) accession number: Q6PJT7
Secondary accession number(s): A8MY46 , Q6MZU4, Q6PJ32, Q6PUI6, Q6PUI8, Q86TQ5, Q86TW0, Q86TW1, Q8NCT6, Q8NCZ3, Q8TDE2, Q9HAC9, Q9Y5A0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.