ID   FOXR2_HUMAN             Reviewed;         311 AA.
AC   Q6PJQ5;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   24-JAN-2024, entry version 158.
DE   RecName: Full=Forkhead box protein R2;
DE   AltName: Full=Forkhead box protein N6;
GN   Name=FOXR2; Synonyms=FOXN6;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   TISSUE SPECIFICITY.
RX   PubMed=15202009;
RA   Katoh M., Katoh M.;
RT   "Identification and characterization of human FOXN6, mouse Foxn6, and rat
RT   Foxn6 genes in silico.";
RL   Int. J. Oncol. 25:219-223(2004).
CC   -!- INTERACTION:
CC       Q6PJQ5; P24863: CCNC; NbExp=3; IntAct=EBI-8468543, EBI-395261;
CC       Q6PJQ5; Q01546: KRT76; NbExp=3; IntAct=EBI-8468543, EBI-2952745;
CC       Q6PJQ5; Q9UBV8: PEF1; NbExp=7; IntAct=EBI-8468543, EBI-724639;
CC       Q6PJQ5; O15160: POLR1C; NbExp=3; IntAct=EBI-8468543, EBI-1055079;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
CC   -!- TISSUE SPECIFICITY: Expressed in breast cancer cell lines and primary
CC       cancer. {ECO:0000269|PubMed:15202009}.
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DR   EMBL; BC012934; AAH12934.1; -; mRNA.
DR   CCDS; CCDS35308.1; -.
DR   RefSeq; NP_940853.1; NM_198451.3.
DR   AlphaFoldDB; Q6PJQ5; -.
DR   SMR; Q6PJQ5; -.
DR   BioGRID; 126579; 43.
DR   IntAct; Q6PJQ5; 36.
DR   MINT; Q6PJQ5; -.
DR   STRING; 9606.ENSP00000427329; -.
DR   PhosphoSitePlus; Q6PJQ5; -.
DR   BioMuta; FOXR2; -.
DR   DMDM; 74737923; -.
DR   MassIVE; Q6PJQ5; -.
DR   PaxDb; 9606-ENSP00000427329; -.
DR   PeptideAtlas; Q6PJQ5; -.
DR   ProteomicsDB; 67215; -.
DR   TopDownProteomics; Q6PJQ5; -.
DR   Antibodypedia; 12993; 149 antibodies from 25 providers.
DR   DNASU; 139628; -.
DR   Ensembl; ENST00000339140.5; ENSP00000427329.2; ENSG00000189299.7.
DR   GeneID; 139628; -.
DR   KEGG; hsa:139628; -.
DR   MANE-Select; ENST00000339140.5; ENSP00000427329.2; NM_198451.4; NP_940853.1.
DR   UCSC; uc004duo.4; human.
DR   AGR; HGNC:30469; -.
DR   CTD; 139628; -.
DR   DisGeNET; 139628; -.
DR   GeneCards; FOXR2; -.
DR   HGNC; HGNC:30469; FOXR2.
DR   HPA; ENSG00000189299; Tissue enriched (testis).
DR   MIM; 300949; gene.
DR   neXtProt; NX_Q6PJQ5; -.
DR   OpenTargets; ENSG00000189299; -.
DR   PharmGKB; PA134950741; -.
DR   VEuPathDB; HostDB:ENSG00000189299; -.
DR   eggNOG; KOG2294; Eukaryota.
DR   GeneTree; ENSGT00940000162993; -.
DR   HOGENOM; CLU_077699_3_1_1; -.
DR   InParanoid; Q6PJQ5; -.
DR   OMA; FFWTAPD; -.
DR   OrthoDB; 5385885at2759; -.
DR   PhylomeDB; Q6PJQ5; -.
DR   TreeFam; TF329867; -.
DR   PathwayCommons; Q6PJQ5; -.
DR   SignaLink; Q6PJQ5; -.
DR   BioGRID-ORCS; 139628; 7 hits in 794 CRISPR screens.
DR   ChiTaRS; FOXR2; human.
DR   GenomeRNAi; 139628; -.
DR   Pharos; Q6PJQ5; Tbio.
DR   PRO; PR:Q6PJQ5; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; Q6PJQ5; Protein.
DR   Bgee; ENSG00000189299; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 4 other cell types or tissues.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR   CDD; cd20036; FH_FOXR; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR46789; FORKHEAD BOX PROTEIN R1; 1.
DR   PANTHER; PTHR46789:SF2; FORKHEAD BOX PROTEIN R2; 1.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
DR   Genevisible; Q6PJQ5; HS.
PE   1: Evidence at protein level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..311
FT                   /note="Forkhead box protein R2"
FT                   /id="PRO_0000253780"
FT   DNA_BIND        192..294
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          56..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          90..171
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        126..149
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         286
FT                   /note="V -> A (in dbSNP:rs2375465)"
FT                   /id="VAR_028731"
SQ   SEQUENCE   311 AA;  35924 MW;  CB837CDB0F5EB4FE CRC64;
     MDLKLKDCEF WYSLHGQVPG LLDWDMRNEL FLPCTTDQCS LAEQILAKYR VGVMKPPEMP
     QKRRPSPDGD GPPCEPNLWM WVDPNILCPL GSQEAPKPSG KEDLTNISPF PQPPQKDEGS
     NCSEDKVVES LPSSSSEQSP LQKQGIHSPS DFELTEEEAE EPDDNSLQSP EMKCYQSQKL
     WQINNQEKSW QRPPLNCSHL IALALRNNPH CGLSVQEIYN FTRQHFPFFW TAPDGWKSTI
     HYNLCFLDSF EKVPDSLKDE DNARPRSCLW KLTKEGHRRF WEETRVLAFA QRERIQECMS
     QPELLTSLFD L
//