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Q6PJQ5

- FOXR2_HUMAN

UniProt

Q6PJQ5 - FOXR2_HUMAN

Protein

Forkhead box protein R2

Gene

FOXR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi192 – 294103Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein R2
    Alternative name(s):
    Forkhead box protein N6
    Gene namesi
    Name:FOXR2
    Synonyms:FOXN6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:30469. FOXR2.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134950741.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311Forkhead box protein R2PRO_0000253780Add
    BLAST

    Proteomic databases

    PRIDEiQ6PJQ5.

    Expressioni

    Tissue specificityi

    Expressed in breast cancer cell lines and primary cancer.1 Publication

    Gene expression databases

    BgeeiQ6PJQ5.
    CleanExiHS_FOXR2.
    GenevestigatoriQ6PJQ5.

    Organism-specific databases

    HPAiHPA034487.

    Interactioni

    Protein-protein interaction databases

    BioGridi126579. 1 interaction.
    IntActiQ6PJQ5. 1 interaction.
    MINTiMINT-8417667.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PJQ5.
    SMRiQ6PJQ5. Positions 192-280.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOGENOMiHOG000004846.
    HOVERGENiHBG080262.
    InParanoidiQ6PJQ5.
    OMAiLPCTTDQ.
    OrthoDBiEOG7J9VQ2.
    PhylomeDBiQ6PJQ5.
    TreeFamiTF329867.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    [Graphical view]
    PROSITEiPS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6PJQ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLKLKDCEF WYSLHGQVPG LLDWDMRNEL FLPCTTDQCS LAEQILAKYR    50
    VGVMKPPEMP QKRRPSPDGD GPPCEPNLWM WVDPNILCPL GSQEAPKPSG 100
    KEDLTNISPF PQPPQKDEGS NCSEDKVVES LPSSSSEQSP LQKQGIHSPS 150
    DFELTEEEAE EPDDNSLQSP EMKCYQSQKL WQINNQEKSW QRPPLNCSHL 200
    IALALRNNPH CGLSVQEIYN FTRQHFPFFW TAPDGWKSTI HYNLCFLDSF 250
    EKVPDSLKDE DNARPRSCLW KLTKEGHRRF WEETRVLAFA QRERIQECMS 300
    QPELLTSLFD L 311
    Length:311
    Mass (Da):35,924
    Last modified:July 5, 2004 - v1
    Checksum:iCB837CDB0F5EB4FE
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti286 – 2861V → A.
    Corresponds to variant rs2375465 [ dbSNP | Ensembl ].
    VAR_028731

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC012934 mRNA. Translation: AAH12934.1.
    CCDSiCCDS35308.1.
    RefSeqiNP_940853.1. NM_198451.3.
    UniGeneiHs.364260.

    Genome annotation databases

    EnsembliENST00000339140; ENSP00000427329; ENSG00000189299.
    GeneIDi139628.
    KEGGihsa:139628.
    UCSCiuc004duo.3. human.

    Polymorphism databases

    DMDMi74737923.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC012934 mRNA. Translation: AAH12934.1 .
    CCDSi CCDS35308.1.
    RefSeqi NP_940853.1. NM_198451.3.
    UniGenei Hs.364260.

    3D structure databases

    ProteinModelPortali Q6PJQ5.
    SMRi Q6PJQ5. Positions 192-280.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126579. 1 interaction.
    IntActi Q6PJQ5. 1 interaction.
    MINTi MINT-8417667.

    Polymorphism databases

    DMDMi 74737923.

    Proteomic databases

    PRIDEi Q6PJQ5.

    Protocols and materials databases

    DNASUi 139628.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000339140 ; ENSP00000427329 ; ENSG00000189299 .
    GeneIDi 139628.
    KEGGi hsa:139628.
    UCSCi uc004duo.3. human.

    Organism-specific databases

    CTDi 139628.
    GeneCardsi GC0XP055666.
    HGNCi HGNC:30469. FOXR2.
    HPAi HPA034487.
    neXtProti NX_Q6PJQ5.
    PharmGKBi PA134950741.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000004846.
    HOVERGENi HBG080262.
    InParanoidi Q6PJQ5.
    OMAi LPCTTDQ.
    OrthoDBi EOG7J9VQ2.
    PhylomeDBi Q6PJQ5.
    TreeFami TF329867.

    Miscellaneous databases

    GenomeRNAii 139628.
    NextBioi 84008.
    PROi Q6PJQ5.

    Gene expression databases

    Bgeei Q6PJQ5.
    CleanExi HS_FOXR2.
    Genevestigatori Q6PJQ5.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    [Graphical view ]
    PROSITEi PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.
    2. "Identification and characterization of human FOXN6, mouse Foxn6, and rat Foxn6 genes in silico."
      Katoh M., Katoh M.
      Int. J. Oncol. 25:219-223(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiFOXR2_HUMAN
    AccessioniPrimary (citable) accession number: Q6PJQ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3