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Q6PJQ5

- FOXR2_HUMAN

UniProt

Q6PJQ5 - FOXR2_HUMAN

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Protein

Forkhead box protein R2

Gene
FOXR2, FOXN6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi192 – 294103Fork-headAdd
BLAST

GO - Molecular functioni

  1. DNA binding, bending Source: RefGenome
  2. double-stranded DNA binding Source: RefGenome
  3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: RefGenome
  4. sequence-specific DNA binding Source: InterPro
  5. transcription factor binding Source: RefGenome

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: RefGenome
  2. organ development Source: RefGenome
  3. pattern specification process Source: RefGenome
  4. regulation of sequence-specific DNA binding transcription factor activity Source: RefGenome
  5. tissue development Source: RefGenome
  6. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein R2
Alternative name(s):
Forkhead box protein N6
Gene namesi
Name:FOXR2
Synonyms:FOXN6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:30469. FOXR2.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. transcription factor complex Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134950741.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Forkhead box protein R2PRO_0000253780Add
BLAST

Proteomic databases

PRIDEiQ6PJQ5.

Expressioni

Tissue specificityi

Expressed in breast cancer cell lines and primary cancer.1 Publication

Gene expression databases

BgeeiQ6PJQ5.
CleanExiHS_FOXR2.
GenevestigatoriQ6PJQ5.

Organism-specific databases

HPAiHPA034487.

Interactioni

Protein-protein interaction databases

BioGridi126579. 1 interaction.
IntActiQ6PJQ5. 1 interaction.
MINTiMINT-8417667.

Structurei

3D structure databases

ProteinModelPortaliQ6PJQ5.
SMRiQ6PJQ5. Positions 192-280.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000004846.
HOVERGENiHBG080262.
InParanoidiQ6PJQ5.
OMAiLPCTTDQ.
OrthoDBiEOG7J9VQ2.
PhylomeDBiQ6PJQ5.
TreeFamiTF329867.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PJQ5-1 [UniParc]FASTAAdd to Basket

« Hide

MDLKLKDCEF WYSLHGQVPG LLDWDMRNEL FLPCTTDQCS LAEQILAKYR    50
VGVMKPPEMP QKRRPSPDGD GPPCEPNLWM WVDPNILCPL GSQEAPKPSG 100
KEDLTNISPF PQPPQKDEGS NCSEDKVVES LPSSSSEQSP LQKQGIHSPS 150
DFELTEEEAE EPDDNSLQSP EMKCYQSQKL WQINNQEKSW QRPPLNCSHL 200
IALALRNNPH CGLSVQEIYN FTRQHFPFFW TAPDGWKSTI HYNLCFLDSF 250
EKVPDSLKDE DNARPRSCLW KLTKEGHRRF WEETRVLAFA QRERIQECMS 300
QPELLTSLFD L 311
Length:311
Mass (Da):35,924
Last modified:July 5, 2004 - v1
Checksum:iCB837CDB0F5EB4FE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti286 – 2861V → A.
Corresponds to variant rs2375465 [ dbSNP | Ensembl ].
VAR_028731

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC012934 mRNA. Translation: AAH12934.1.
CCDSiCCDS35308.1.
RefSeqiNP_940853.1. NM_198451.3.
UniGeneiHs.364260.

Genome annotation databases

EnsembliENST00000339140; ENSP00000427329; ENSG00000189299.
GeneIDi139628.
KEGGihsa:139628.
UCSCiuc004duo.3. human.

Polymorphism databases

DMDMi74737923.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC012934 mRNA. Translation: AAH12934.1 .
CCDSi CCDS35308.1.
RefSeqi NP_940853.1. NM_198451.3.
UniGenei Hs.364260.

3D structure databases

ProteinModelPortali Q6PJQ5.
SMRi Q6PJQ5. Positions 192-280.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126579. 1 interaction.
IntActi Q6PJQ5. 1 interaction.
MINTi MINT-8417667.

Polymorphism databases

DMDMi 74737923.

Proteomic databases

PRIDEi Q6PJQ5.

Protocols and materials databases

DNASUi 139628.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000339140 ; ENSP00000427329 ; ENSG00000189299 .
GeneIDi 139628.
KEGGi hsa:139628.
UCSCi uc004duo.3. human.

Organism-specific databases

CTDi 139628.
GeneCardsi GC0XP055666.
HGNCi HGNC:30469. FOXR2.
HPAi HPA034487.
neXtProti NX_Q6PJQ5.
PharmGKBi PA134950741.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000004846.
HOVERGENi HBG080262.
InParanoidi Q6PJQ5.
OMAi LPCTTDQ.
OrthoDBi EOG7J9VQ2.
PhylomeDBi Q6PJQ5.
TreeFami TF329867.

Miscellaneous databases

GenomeRNAii 139628.
NextBioi 84008.
PROi Q6PJQ5.

Gene expression databases

Bgeei Q6PJQ5.
CleanExi HS_FOXR2.
Genevestigatori Q6PJQ5.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  2. "Identification and characterization of human FOXN6, mouse Foxn6, and rat Foxn6 genes in silico."
    Katoh M., Katoh M.
    Int. J. Oncol. 25:219-223(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiFOXR2_HUMAN
AccessioniPrimary (citable) accession number: Q6PJQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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