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Protein

Forkhead box protein R2

Gene

FOXR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi192 – 294Fork-headPROSITE-ProRule annotationAdd BLAST103

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein R2
Alternative name(s):
Forkhead box protein N6
Gene namesi
Name:FOXR2
Synonyms:FOXN6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000189299.6
HGNCiHGNC:30469 FOXR2
MIMi300949 gene
neXtProtiNX_Q6PJQ5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi139628
OpenTargetsiENSG00000189299
PharmGKBiPA134950741

Polymorphism and mutation databases

BioMutaiFOXR2
DMDMi74737923

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002537801 – 311Forkhead box protein R2Add BLAST311

Proteomic databases

PaxDbiQ6PJQ5
PeptideAtlasiQ6PJQ5
PRIDEiQ6PJQ5
TopDownProteomicsiQ6PJQ5

PTM databases

PhosphoSitePlusiQ6PJQ5

Expressioni

Tissue specificityi

Expressed in breast cancer cell lines and primary cancer.1 Publication

Gene expression databases

BgeeiENSG00000189299
CleanExiHS_FOXR2
GenevisibleiQ6PJQ5 HS

Organism-specific databases

HPAiHPA034487
HPA057358

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PEF1Q9UBV85EBI-8468543,EBI-724639

Protein-protein interaction databases

BioGridi126579, 37 interactors
IntActiQ6PJQ5, 13 interactors
MINTiQ6PJQ5
STRINGi9606.ENSP00000427329

Structurei

3D structure databases

ProteinModelPortaliQ6PJQ5
SMRiQ6PJQ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00910000144055
HOGENOMiHOG000004846
HOVERGENiHBG080262
InParanoidiQ6PJQ5
OMAiPFFWTAP
OrthoDBiEOG091G0G6D
PhylomeDBiQ6PJQ5
TreeFamiTF329867

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50039 FORK_HEAD_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q6PJQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLKLKDCEF WYSLHGQVPG LLDWDMRNEL FLPCTTDQCS LAEQILAKYR
60 70 80 90 100
VGVMKPPEMP QKRRPSPDGD GPPCEPNLWM WVDPNILCPL GSQEAPKPSG
110 120 130 140 150
KEDLTNISPF PQPPQKDEGS NCSEDKVVES LPSSSSEQSP LQKQGIHSPS
160 170 180 190 200
DFELTEEEAE EPDDNSLQSP EMKCYQSQKL WQINNQEKSW QRPPLNCSHL
210 220 230 240 250
IALALRNNPH CGLSVQEIYN FTRQHFPFFW TAPDGWKSTI HYNLCFLDSF
260 270 280 290 300
EKVPDSLKDE DNARPRSCLW KLTKEGHRRF WEETRVLAFA QRERIQECMS
310
QPELLTSLFD L
Length:311
Mass (Da):35,924
Last modified:July 5, 2004 - v1
Checksum:iCB837CDB0F5EB4FE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028731286V → A. Corresponds to variant dbSNP:rs2375465Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC012934 mRNA Translation: AAH12934.1
CCDSiCCDS35308.1
RefSeqiNP_940853.1, NM_198451.3
UniGeneiHs.364260

Genome annotation databases

EnsembliENST00000339140; ENSP00000427329; ENSG00000189299
GeneIDi139628
KEGGihsa:139628
UCSCiuc004duo.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFOXR2_HUMAN
AccessioniPrimary (citable) accession number: Q6PJQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health