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Q6PJQ5 (FOXR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Forkhead box protein R2
Alternative name(s):
Forkhead box protein N6
Gene names
Name:FOXR2
Synonyms:FOXN6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus Potential.

Tissue specificity

Expressed in breast cancer cell lines and primary cancer. Ref.2

Sequence similarities

Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnegative regulation of transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: RefGenome

organ development

Inferred from Biological aspect of Ancestor. Source: RefGenome

pattern specification process

Inferred from Biological aspect of Ancestor. Source: RefGenome

regulation of sequence-specific DNA binding transcription factor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

tissue development

Inferred from Biological aspect of Ancestor. Source: RefGenome

transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: GOC

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

transcription factor complex

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionDNA binding, bending

Inferred from Biological aspect of Ancestor. Source: RefGenome

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

double-stranded DNA binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

transcription factor binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Forkhead box protein R2
PRO_0000253780

Regions

DNA binding192 – 294103Fork-head

Natural variations

Natural variant2861V → A.
Corresponds to variant rs2375465 [ dbSNP | Ensembl ].
VAR_028731

Sequences

Sequence LengthMass (Da)Tools
Q6PJQ5 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: CB837CDB0F5EB4FE

FASTA31135,924
        10         20         30         40         50         60 
MDLKLKDCEF WYSLHGQVPG LLDWDMRNEL FLPCTTDQCS LAEQILAKYR VGVMKPPEMP 

        70         80         90        100        110        120 
QKRRPSPDGD GPPCEPNLWM WVDPNILCPL GSQEAPKPSG KEDLTNISPF PQPPQKDEGS 

       130        140        150        160        170        180 
NCSEDKVVES LPSSSSEQSP LQKQGIHSPS DFELTEEEAE EPDDNSLQSP EMKCYQSQKL 

       190        200        210        220        230        240 
WQINNQEKSW QRPPLNCSHL IALALRNNPH CGLSVQEIYN FTRQHFPFFW TAPDGWKSTI 

       250        260        270        280        290        300 
HYNLCFLDSF EKVPDSLKDE DNARPRSCLW KLTKEGHRRF WEETRVLAFA QRERIQECMS 

       310 
QPELLTSLFD L 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary gland.
[2]"Identification and characterization of human FOXN6, mouse Foxn6, and rat Foxn6 genes in silico."
Katoh M., Katoh M.
Int. J. Oncol. 25:219-223(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC012934 mRNA. Translation: AAH12934.1.
CCDSCCDS35308.1.
RefSeqNP_940853.1. NM_198451.3.
UniGeneHs.364260.

3D structure databases

ProteinModelPortalQ6PJQ5.
SMRQ6PJQ5. Positions 192-280.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126579. 1 interaction.
IntActQ6PJQ5. 1 interaction.
MINTMINT-8417667.

Polymorphism databases

DMDM74737923.

Proteomic databases

PRIDEQ6PJQ5.

Protocols and materials databases

DNASU139628.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000339140; ENSP00000427329; ENSG00000189299.
GeneID139628.
KEGGhsa:139628.
UCSCuc004duo.3. human.

Organism-specific databases

CTD139628.
GeneCardsGC0XP055666.
HGNCHGNC:30469. FOXR2.
HPAHPA034487.
neXtProtNX_Q6PJQ5.
PharmGKBPA134950741.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000004846.
HOVERGENHBG080262.
InParanoidQ6PJQ5.
OMALPCTTDQ.
OrthoDBEOG7J9VQ2.
PhylomeDBQ6PJQ5.
TreeFamTF329867.

Gene expression databases

BgeeQ6PJQ5.
CleanExHS_FOXR2.
GenevestigatorQ6PJQ5.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR001766. TF_fork_head.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSPR00053. FORKHEAD.
SMARTSM00339. FH. 1 hit.
[Graphical view]
PROSITEPS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi139628.
NextBio84008.
PROQ6PJQ5.

Entry information

Entry nameFOXR2_HUMAN
AccessionPrimary (citable) accession number: Q6PJQ5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM