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Protein

DNA cross-link repair 1A protein

Gene

DCLRE1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons.1 Publication

GO - Molecular functioni

  • 5'-3' exodeoxyribonuclease activity Source: CACAO
  • damaged DNA binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA repair, Mitosis

Enzyme and pathway databases

BioCyciZFISH:G66-31340-MONOMER.
ReactomeiR-HSA-6783310. Fanconi Anemia Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA cross-link repair 1A protein
Alternative name(s):
SNM1 homolog A
Short name:
hSNM1
Short name:
hSNM1A
Gene namesi
Name:DCLRE1A
Synonyms:KIAA0086, SNM1, SNM1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:17660. DCLRE1A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi838D → N: Impaired nuclear focus formation, reduced interaction with PIAS and increased sensitivity to cisplatin. 1 Publication1
Mutagenesisi994H → A: Impaired nuclear focus formation, reduced interaction with PIAS and increased sensitivity to cisplatin. 1 Publication1

Organism-specific databases

DisGeNETi9937.
OpenTargetsiENSG00000198924.
PharmGKBiPA27174.

Polymorphism and mutation databases

DMDMi311033461.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002091161 – 1040DNA cross-link repair 1A proteinAdd BLAST1040

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki488Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei590PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ6PJP8.
MaxQBiQ6PJP8.
PaxDbiQ6PJP8.
PeptideAtlasiQ6PJP8.
PRIDEiQ6PJP8.

PTM databases

iPTMnetiQ6PJP8.
PhosphoSitePlusiQ6PJP8.

Expressioni

Tissue specificityi

Expressed in brain, heart, kidney, liver, pancreas, placenta and skeletal muscle.1 Publication

Inductioni

During mitosis. The mRNA encoding this protein contains an internal ribosome entry site (IRES) in its 5'-UTR. This 5'-UTR generally suppresses translation while specifically promoting expression during mitosis, when cap-dependent translation may be impaired.1 Publication

Gene expression databases

BgeeiENSG00000198924.
CleanExiHS_DCLRE1A.
GenevisibleiQ6PJP8. HS.

Organism-specific databases

HPAiHPA036907.

Interactioni

Subunit structurei

Binds constitutively to TP53BP1. Binds CDC27, which is itself a component of the anaphase promoting complex (APC). Binds PIAS1.

Protein-protein interaction databases

BioGridi115263. 6 interactors.
IntActiQ6PJP8. 1 interactor.
STRINGi9606.ENSP00000355185.

Structurei

Secondary structure

11040
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi703 – 705Combined sources3
Beta strandi710 – 715Combined sources6
Beta strandi718 – 721Combined sources4
Beta strandi727 – 729Combined sources3
Helixi735 – 738Combined sources4
Beta strandi749 – 751Combined sources3
Helixi753 – 762Combined sources10
Helixi767 – 769Combined sources3
Beta strandi770 – 772Combined sources3
Beta strandi779 – 781Combined sources3
Beta strandi784 – 790Combined sources7
Beta strandi792 – 794Combined sources3
Beta strandi798 – 803Combined sources6
Beta strandi809 – 812Combined sources4
Helixi820 – 824Combined sources5
Helixi826 – 828Combined sources3
Beta strandi834 – 837Combined sources4
Helixi851 – 868Combined sources18
Beta strandi872 – 881Combined sources10
Helixi884 – 893Combined sources10
Helixi902 – 909Combined sources8
Helixi916 – 919Combined sources4
Beta strandi920 – 922Combined sources3
Helixi924 – 926Combined sources3
Beta strandi928 – 933Combined sources6
Helixi934 – 936Combined sources3
Helixi939 – 947Combined sources9
Helixi949 – 951Combined sources3
Beta strandi955 – 961Combined sources7
Beta strandi979 – 981Combined sources3
Beta strandi984 – 989Combined sources6
Helixi997 – 1007Combined sources11
Beta strandi1010 – 1014Combined sources5
Helixi1021 – 1038Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4B87X-ray2.16A676-1040[»]
5AHRX-ray2.19A700-1040[»]
ProteinModelPortaliQ6PJP8.
SMRiQ6PJP8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 190Nuclear localization regionAdd BLAST190
Regioni396 – 614Nuclear focus formationAdd BLAST219

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1361. Eukaryota.
COG1236. LUCA.
GeneTreeiENSGT00530000063183.
HOGENOMiHOG000168450.
HOVERGENiHBG081418.
InParanoidiQ6PJP8.
KOiK15340.
OMAiPDGLLCT.
OrthoDBiEOG091G0DBZ.
PhylomeDBiQ6PJP8.
TreeFamiTF314510.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR011084. DRMBL.
IPR001279. Metallo-B-lactamas.
[Graphical view]
PfamiPF07522. DRMBL. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6PJP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEDISEEDI WEYKSKRKPK RVDPNNGSKN ILKSVEKATD GKYQSKRSRN
60 70 80 90 100
RKRAAEAKEV KDHEVPLGNA GCQTSVASSQ NSSCGDGIQQ TQDKETTPGK
110 120 130 140 150
LCRTQKSQHV SPKIRPVYDG YCPNCQMPFS SLIGQTPRWH VFECLDSPPR
160 170 180 190 200
SETECPDGLL CTSTIPFHYK RYTHFLLAQS RAGDHPFSSP SPASGGSFSE
210 220 230 240 250
TKSGVLCSLE ERWSSYQNQT DNSVSNDPLL MTQYFKKSPS LTEASEKIST
260 270 280 290 300
HIQTSQQALQ FTDFVENDKL VGVALRLANN SEHINLPLPE NDFSDCEISY
310 320 330 340 350
SPLQSDEDTH DIDEKPDDSQ EQLFFTESSK DGSLEEDDDS CGFFKKRHGP
360 370 380 390 400
LLKDQDESCP KVNSFLTRDK YDEGLYRFNS LNDLSQPISQ NNESTLPYDL
410 420 430 440 450
ACTGGDFVLF PPALAGKLAA SVHQATKAKP DEPEFHSAQS NKQKQVIEES
460 470 480 490 500
SVYNQVSLPL VKSLMLKPFE SQVEGYLSSQ PTQNTIRKLS SENLNAKNNT
510 520 530 540 550
NSACFCRKAL EGVPVGKATI LNTENLSSTP APKYLKILPS GLKYNARHPS
560 570 580 590 600
TKVMKQMDIG VYFGLPPKRK EEKLLGESAL EGINLNPVPS PNQKRSSQCK
610 620 630 640 650
RKAEKSLSDL EFDASTLHES QLSVELSSER SQRQKKRCRK SNSLQEGACQ
660 670 680 690 700
KRSDHLINTE SEAVNLSKVK VFTKSAHGGL QRGNKKIPES SNVGGSRKKT
710 720 730 740 750
CPFYKKIPGT GFTVDAFQYG VVEGCTAYFL THFHSDHYAG LSKHFTFPVY
760 770 780 790 800
CSEITGNLLK NKLHVQEQYI HPLPLDTECI VNGVKVVLLD ANHCPGAVMI
810 820 830 840 850
LFYLPNGTVI LHTGDFRADP SMERSLLADQ KVHMLYLDTT YCSPEYTFPS
860 870 880 890 900
QQEVIRFAIN TAFEAVTLNP HALVVCGTYS IGKEKVFLAI ADVLGSKVGM
910 920 930 940 950
SQEKYKTLQC LNIPEINSLI TTDMCSSLVH LLPMMQINFK GLQSHLKKCG
960 970 980 990 1000
GKYNQILAFR PTGWTHSNKF TRIADVIPQT KGNISIYGIP YSEHSSYLEM
1010 1020 1030 1040
KRFVQWLKPQ KIIPTVNVGT WKSRSTMEKY FREWKLEAGY
Length:1,040
Mass (Da):116,400
Last modified:November 2, 2010 - v3
Checksum:i708FFA1F75451803
GO

Sequence cautioni

The sequence BAA07646 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02328658K → E.1 PublicationCorresponds to variant rs17235066dbSNPEnsembl.1
Natural variantiVAR_02328759E → D.1 PublicationCorresponds to variant rs17228665dbSNPEnsembl.1
Natural variantiVAR_02328871G → D.1 PublicationCorresponds to variant rs17228672dbSNPEnsembl.1
Natural variantiVAR_023289287P → L.1 PublicationCorresponds to variant rs17235094dbSNPEnsembl.1
Natural variantiVAR_023290317D → H.3 PublicationsCorresponds to variant rs3750898dbSNPEnsembl.1
Natural variantiVAR_030574582G → W.1 PublicationCorresponds to variant rs17855759dbSNPEnsembl.1
Natural variantiVAR_023291859I → F.1 PublicationCorresponds to variant rs11196530dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42045 mRNA. Translation: BAA07646.2. Different initiation.
AY607842 Genomic DNA. Translation: AAT09762.1.
AL592546 Genomic DNA. Translation: CAI12637.1.
CH471066 Genomic DNA. Translation: EAW49489.1.
CH471066 Genomic DNA. Translation: EAW49490.1.
BC013124 mRNA. Translation: AAH13124.1.
BC062582 mRNA. Translation: AAH62582.1.
CCDSiCCDS7584.1.
RefSeqiNP_001258745.1. NM_001271816.1.
NP_055696.3. NM_014881.4.
XP_006718153.1. XM_006718090.1.
XP_011538731.1. XM_011540429.1.
UniGeneiHs.1560.
Hs.703616.

Genome annotation databases

EnsembliENST00000361384; ENSP00000355185; ENSG00000198924.
ENST00000369305; ENSP00000358311; ENSG00000198924.
GeneIDi9937.
KEGGihsa:9937.
UCSCiuc001law.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42045 mRNA. Translation: BAA07646.2. Different initiation.
AY607842 Genomic DNA. Translation: AAT09762.1.
AL592546 Genomic DNA. Translation: CAI12637.1.
CH471066 Genomic DNA. Translation: EAW49489.1.
CH471066 Genomic DNA. Translation: EAW49490.1.
BC013124 mRNA. Translation: AAH13124.1.
BC062582 mRNA. Translation: AAH62582.1.
CCDSiCCDS7584.1.
RefSeqiNP_001258745.1. NM_001271816.1.
NP_055696.3. NM_014881.4.
XP_006718153.1. XM_006718090.1.
XP_011538731.1. XM_011540429.1.
UniGeneiHs.1560.
Hs.703616.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4B87X-ray2.16A676-1040[»]
5AHRX-ray2.19A700-1040[»]
ProteinModelPortaliQ6PJP8.
SMRiQ6PJP8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115263. 6 interactors.
IntActiQ6PJP8. 1 interactor.
STRINGi9606.ENSP00000355185.

PTM databases

iPTMnetiQ6PJP8.
PhosphoSitePlusiQ6PJP8.

Polymorphism and mutation databases

DMDMi311033461.

Proteomic databases

EPDiQ6PJP8.
MaxQBiQ6PJP8.
PaxDbiQ6PJP8.
PeptideAtlasiQ6PJP8.
PRIDEiQ6PJP8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361384; ENSP00000355185; ENSG00000198924.
ENST00000369305; ENSP00000358311; ENSG00000198924.
GeneIDi9937.
KEGGihsa:9937.
UCSCiuc001law.4. human.

Organism-specific databases

CTDi9937.
DisGeNETi9937.
GeneCardsiDCLRE1A.
HGNCiHGNC:17660. DCLRE1A.
HPAiHPA036907.
MIMi609682. gene.
neXtProtiNX_Q6PJP8.
OpenTargetsiENSG00000198924.
PharmGKBiPA27174.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1361. Eukaryota.
COG1236. LUCA.
GeneTreeiENSGT00530000063183.
HOGENOMiHOG000168450.
HOVERGENiHBG081418.
InParanoidiQ6PJP8.
KOiK15340.
OMAiPDGLLCT.
OrthoDBiEOG091G0DBZ.
PhylomeDBiQ6PJP8.
TreeFamiTF314510.

Enzyme and pathway databases

BioCyciZFISH:G66-31340-MONOMER.
ReactomeiR-HSA-6783310. Fanconi Anemia Pathway.

Miscellaneous databases

ChiTaRSiDCLRE1A. human.
GeneWikiiDCLRE1A.
GenomeRNAii9937.
PROiQ6PJP8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198924.
CleanExiHS_DCLRE1A.
GenevisibleiQ6PJP8. HS.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR011084. DRMBL.
IPR001279. Metallo-B-lactamas.
[Graphical view]
PfamiPF07522. DRMBL. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDCR1A_HUMAN
AccessioniPrimary (citable) accession number: Q6PJP8
Secondary accession number(s): D3DRC1
, Q14701, Q6P5Y3, Q6PKL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: November 2, 2010
Last modified: November 2, 2016
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.