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Protein

WD repeat-containing protein 59

Gene

WDR59

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and GATSL3 (PubMed:25457612, PubMed:27487210).3 Publications

GO - Biological processi

  • cellular response to amino acid starvation Source: UniProtKB
  • positive regulation of TOR signaling Source: SGD
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ6PJI9.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 59
Gene namesi
Name:WDR59
Synonyms:KIAA1923
ORF Names:FP977
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:25706. WDR59.

Subcellular locationi

GO - Cellular componenti

  • GATOR2 complex Source: SGD
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi79726.
OpenTargetsiENSG00000103091.
PharmGKBiPA142670593.

Polymorphism and mutation databases

BioMutaiWDR59.
DMDMi134035358.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002807211 – 974WD repeat-containing protein 59Add BLAST974

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei564PhosphoserineCombined sources1
Modified residuei821PhosphoserineCombined sources1
Modified residuei822PhosphoserineCombined sources1
Modified residuei830PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PJI9.
MaxQBiQ6PJI9.
PaxDbiQ6PJI9.
PeptideAtlasiQ6PJI9.
PRIDEiQ6PJI9.

PTM databases

iPTMnetiQ6PJI9.
PhosphoSitePlusiQ6PJI9.

Expressioni

Gene expression databases

BgeeiENSG00000103091.
CleanExiHS_WDR59.
ExpressionAtlasiQ6PJI9. baseline and differential.
GenevisibleiQ6PJI9. HS.

Organism-specific databases

HPAiHPA041084.

Interactioni

Subunit structurei

Interacts with DDB1-CUL4A/B E3 ligase complexes (By similarity). Within the GATOR complex, component of the GATOR2 subcomplex, made of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR complex strongly interacts with RRAGA/RRAGC and RRAGB/RRAGC heterodimers. The GATOR2 complex interacts with GATSL2 and GATSL3; the interaction is negatively regulated by arginine (PubMed:26972053). The GATOR2 complex interacts with SESN1, SESN2 and SESN3; the interaction is negatively regulated by amino acids (PubMed:25263562, PubMed:25457612).By similarity4 Publications

Protein-protein interaction databases

BioGridi122841. 31 interactors.
IntActiQ6PJI9. 9 interactors.
STRINGi9606.ENSP00000262144.

Structurei

3D structure databases

ProteinModelPortaliQ6PJI9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati57 – 98WD 1Add BLAST42
Repeati103 – 143WD 2Add BLAST41
Repeati146 – 185WD 3Add BLAST40
Repeati189 – 229WD 4Add BLAST41
Repeati232 – 276WD 5Add BLAST45
Repeati278 – 318WD 6Add BLAST41
Repeati319 – 362WD 7Add BLAST44
Domaini393 – 494RWDPROSITE-ProRule annotationAdd BLAST102
Repeati668 – 706WD 8Add BLAST39

Sequence similaritiesi

Belongs to the WD repeat WDR59 family.Curated
Contains 1 RWD domain.PROSITE-ProRule annotation
Contains 8 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0264. Eukaryota.
KOG0309. Eukaryota.
COG2319. LUCA.
GeneTreeiENSGT00850000132398.
HOGENOMiHOG000004834.
HOVERGENiHBG092820.
InParanoidiQ6PJI9.
KOiK20409.
OMAiCQKNAAS.
OrthoDBiEOG091G0S7I.
PhylomeDBiQ6PJI9.
TreeFamiTF314695.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
3.10.110.10. 1 hit.
InterProiIPR006575. RWD-domain.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00591. RWD. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF54495. SSF54495. 1 hit.
PROSITEiPS50908. RWD. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PJI9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAARWSSENV VVEFRDSQAT AMSVDCLGQH AVLSGRRFLY IVNLDAPFEG
60 70 80 90 100
HRKISRQSKW DIGAVQWNPH DSFAHYFAAS SNQRVDLYKW KDGSGEVGTT
110 120 130 140 150
LQGHTRVISD LDWAVFEPDL LVTSSVDTYI YIWDIKDTRK PTVALSAVAG
160 170 180 190 200
ASQVKWNKKN ANCLATSHDG DVRIWDKRKP STAVEYLAAH LSKIHGLDWH
210 220 230 240 250
PDSEHILATS SQDNSVKFWD YRQPRKYLNI LPCQVPVWKA RYTPFSNGLV
260 270 280 290 300
TVMVPQLRRE NSLLLWNVFD LNTPVHTFVG HDDVVLEFQW RKQKEGSKDY
310 320 330 340 350
QLVTWSRDQT LRMWRVDSQM QRLCANDILD GVDEFIESIS LLPEPEKTLH
360 370 380 390 400
TEDTDHQHTA SHGEEEALKE DPPRNLLEER KSDQLGLPQT LQQEFSLINV
410 420 430 440 450
QIRNVNVEMD AADRSCTVSV HCSNHRVKML VKFPAQYPNN AAPSFQFINP
460 470 480 490 500
TTITSTMKAK LLKILKDTAL QKVKRGQSCL EPCLRQLVSC LESFVNQEDS
510 520 530 540 550
ASSNPFALPN SVTPPLPTFA RVTTAYGSYQ DANIPFPRTS GARFCGAGYL
560 570 580 590 600
VYFTRPMTMH RAVSPTEPTP RSLSALSAYH TGLIAPMKIR TEAPGNLRLY
610 620 630 640 650
SGSPTRSEKE QVSISSFYYK ERKSRRWKSK REGSDSGNRQ IKAAGKVIIQ
660 670 680 690 700
DIACLLPVHK SLGELYILNV NDIQETCQKN AASALLVGRK DLVQVWSLAT
710 720 730 740 750
VATDLCLGPK SDPDLETPWA RHPFGRQLLE SLLAHYCRLR DVQTLAMLCS
760 770 780 790 800
VFEAQSRPQG LPNPFGPFPN RSSNLVVSHS RYPSFTSSGS CSSMSDPGLN
810 820 830 840 850
TGGWNIAGRE AEHLSSPWGE SSPEELRFGS LTYSDPRERE RDQHDKNKRL
860 870 880 890 900
LDPANTQQFD DFKKCYGEIL YRWGLREKRA EVLKFVSCPP DPHKGIEFGV
910 920 930 940 950
YCSHCRSEVR GTQCAICKGF TFQCAICHVA VRGSSNFCLT CGHGGHTSHM
960 970
MEWFRTQEVC PTGCGCHCLL ESTF
Length:974
Mass (Da):109,793
Last modified:March 20, 2007 - v2
Checksum:i72F651A38EA51CBA
GO
Isoform 2 (identifier: Q6PJI9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     572-974: Missing.

Note: No experimental confirmation available.
Show »
Length:571
Mass (Da):64,848
Checksum:i9F0F69BD39E3FB60
GO
Isoform 3 (identifier: Q6PJI9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-408: Missing.

Show »
Length:566
Mass (Da):62,908
Checksum:i9FF9AC7DFEFB28FE
GO
Isoform 4 (identifier: Q6PJI9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-556: Missing.
     557-571: MTMHRAVSPTEPTPR → MTGLQPVWIIIIFNYR

Note: No experimental confirmation available.
Show »
Length:419
Mass (Da):46,909
Checksum:iD9E96013D5098D33
GO

Sequence cautioni

The sequence BAB67816 differs from that shown. Reason: Frameshift at position 157.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti441A → S in BAB67816 (PubMed:11572484).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053436201P → T.Corresponds to variant rs11557260dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0238811 – 556Missing in isoform 4. 1 PublicationAdd BLAST556
Alternative sequenceiVSP_0238821 – 408Missing in isoform 3. 2 PublicationsAdd BLAST408
Alternative sequenceiVSP_023883557 – 571MTMHR…EPTPR → MTGLQPVWIIIIFNYR in isoform 4. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_023884572 – 974Missing in isoform 2. 1 PublicationAdd BLAST403

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022332 mRNA. Translation: BAB14015.1.
AK091316 mRNA. Translation: BAG52335.1.
AF370390 mRNA. Translation: AAQ15226.1.
BC004519 mRNA. Translation: AAH04519.1.
BC014887 mRNA. Translation: AAH14887.2.
AB067510 mRNA. Translation: BAB67816.1. Frameshift.
CCDSiCCDS32488.1. [Q6PJI9-1]
CCDS82011.1. [Q6PJI9-2]
RefSeqiNP_001311100.1. NM_001324171.1. [Q6PJI9-2]
NP_085058.3. NM_030581.3. [Q6PJI9-1]
UniGeneiHs.280951.

Genome annotation databases

EnsembliENST00000262144; ENSP00000262144; ENSG00000103091. [Q6PJI9-1]
ENST00000616369; ENSP00000482446; ENSG00000103091. [Q6PJI9-2]
GeneIDi79726.
KEGGihsa:79726.
UCSCiuc002fdh.2. human. [Q6PJI9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022332 mRNA. Translation: BAB14015.1.
AK091316 mRNA. Translation: BAG52335.1.
AF370390 mRNA. Translation: AAQ15226.1.
BC004519 mRNA. Translation: AAH04519.1.
BC014887 mRNA. Translation: AAH14887.2.
AB067510 mRNA. Translation: BAB67816.1. Frameshift.
CCDSiCCDS32488.1. [Q6PJI9-1]
CCDS82011.1. [Q6PJI9-2]
RefSeqiNP_001311100.1. NM_001324171.1. [Q6PJI9-2]
NP_085058.3. NM_030581.3. [Q6PJI9-1]
UniGeneiHs.280951.

3D structure databases

ProteinModelPortaliQ6PJI9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122841. 31 interactors.
IntActiQ6PJI9. 9 interactors.
STRINGi9606.ENSP00000262144.

PTM databases

iPTMnetiQ6PJI9.
PhosphoSitePlusiQ6PJI9.

Polymorphism and mutation databases

BioMutaiWDR59.
DMDMi134035358.

Proteomic databases

EPDiQ6PJI9.
MaxQBiQ6PJI9.
PaxDbiQ6PJI9.
PeptideAtlasiQ6PJI9.
PRIDEiQ6PJI9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262144; ENSP00000262144; ENSG00000103091. [Q6PJI9-1]
ENST00000616369; ENSP00000482446; ENSG00000103091. [Q6PJI9-2]
GeneIDi79726.
KEGGihsa:79726.
UCSCiuc002fdh.2. human. [Q6PJI9-1]

Organism-specific databases

CTDi79726.
DisGeNETi79726.
GeneCardsiWDR59.
H-InvDBHIX0013239.
HGNCiHGNC:25706. WDR59.
HPAiHPA041084.
neXtProtiNX_Q6PJI9.
OpenTargetsiENSG00000103091.
PharmGKBiPA142670593.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0264. Eukaryota.
KOG0309. Eukaryota.
COG2319. LUCA.
GeneTreeiENSGT00850000132398.
HOGENOMiHOG000004834.
HOVERGENiHBG092820.
InParanoidiQ6PJI9.
KOiK20409.
OMAiCQKNAAS.
OrthoDBiEOG091G0S7I.
PhylomeDBiQ6PJI9.
TreeFamiTF314695.

Enzyme and pathway databases

SignaLinkiQ6PJI9.

Miscellaneous databases

ChiTaRSiWDR59. human.
GenomeRNAii79726.
PROiQ6PJI9.

Gene expression databases

BgeeiENSG00000103091.
CleanExiHS_WDR59.
ExpressionAtlasiQ6PJI9. baseline and differential.
GenevisibleiQ6PJI9. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
3.10.110.10. 1 hit.
InterProiIPR006575. RWD-domain.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00591. RWD. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF54495. SSF54495. 1 hit.
PROSITEiPS50908. RWD. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWDR59_HUMAN
AccessioniPrimary (citable) accession number: Q6PJI9
Secondary accession number(s): B3KRC3
, Q71RE7, Q96PW5, Q9BSW6, Q9HA43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: November 30, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.