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Q6PJI9

- WDR59_HUMAN

UniProt

Q6PJI9 - WDR59_HUMAN

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Protein
WD repeat-containing protein 59
Gene
WDR59, KIAA1923, FP977
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway.

Enzyme and pathway databases

SignaLinkiQ6PJI9.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 59
Gene namesi
Name:WDR59
Synonyms:KIAA1923
ORF Names:FP977
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:25706. WDR59.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670593.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 974974WD repeat-containing protein 59
PRO_0000280721Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei821 – 8211Phosphoserine1 Publication
Modified residuei822 – 8221Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6PJI9.
PaxDbiQ6PJI9.
PRIDEiQ6PJI9.

PTM databases

PhosphoSiteiQ6PJI9.

Expressioni

Gene expression databases

ArrayExpressiQ6PJI9.
BgeeiQ6PJI9.
CleanExiHS_WDR59.
GenevestigatoriQ6PJI9.

Organism-specific databases

HPAiHPA041084.

Interactioni

Subunit structurei

Interacts with DDB1-CUL4A/B E3 ligase complexes By similarity. Within the GATOR complex, component of the GATOR2 subcomplex, made of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR complex strongly interacts with RRAGA/RRAGC and RRAGB/RRAGC heterodimers.1 Publication

Protein-protein interaction databases

BioGridi122841. 4 interactions.
IntActiQ6PJI9. 6 interactions.
STRINGi9606.ENSP00000262144.

Structurei

3D structure databases

ProteinModelPortaliQ6PJI9.
SMRiQ6PJI9. Positions 43-320.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati57 – 9842WD 1
Add
BLAST
Repeati103 – 14341WD 2
Add
BLAST
Repeati146 – 18540WD 3
Add
BLAST
Repeati189 – 22941WD 4
Add
BLAST
Repeati232 – 27645WD 5
Add
BLAST
Repeati278 – 31841WD 6
Add
BLAST
Repeati319 – 36244WD 7
Add
BLAST
Domaini393 – 494102RWD
Add
BLAST
Repeati668 – 70639WD 8
Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat WDR59 family.
Contains 1 RWD domain.
Contains 8 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
HOGENOMiHOG000004834.
HOVERGENiHBG092820.
InParanoidiQ6PJI9.
OMAiSCLLPVH.
OrthoDBiEOG70S74N.
PhylomeDBiQ6PJI9.
TreeFamiTF314695.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
3.10.110.10. 1 hit.
InterProiIPR006575. RWD-domain.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00591. RWD. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF54495. SSF54495. 1 hit.
PROSITEiPS50908. RWD. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6PJI9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAARWSSENV VVEFRDSQAT AMSVDCLGQH AVLSGRRFLY IVNLDAPFEG    50
HRKISRQSKW DIGAVQWNPH DSFAHYFAAS SNQRVDLYKW KDGSGEVGTT 100
LQGHTRVISD LDWAVFEPDL LVTSSVDTYI YIWDIKDTRK PTVALSAVAG 150
ASQVKWNKKN ANCLATSHDG DVRIWDKRKP STAVEYLAAH LSKIHGLDWH 200
PDSEHILATS SQDNSVKFWD YRQPRKYLNI LPCQVPVWKA RYTPFSNGLV 250
TVMVPQLRRE NSLLLWNVFD LNTPVHTFVG HDDVVLEFQW RKQKEGSKDY 300
QLVTWSRDQT LRMWRVDSQM QRLCANDILD GVDEFIESIS LLPEPEKTLH 350
TEDTDHQHTA SHGEEEALKE DPPRNLLEER KSDQLGLPQT LQQEFSLINV 400
QIRNVNVEMD AADRSCTVSV HCSNHRVKML VKFPAQYPNN AAPSFQFINP 450
TTITSTMKAK LLKILKDTAL QKVKRGQSCL EPCLRQLVSC LESFVNQEDS 500
ASSNPFALPN SVTPPLPTFA RVTTAYGSYQ DANIPFPRTS GARFCGAGYL 550
VYFTRPMTMH RAVSPTEPTP RSLSALSAYH TGLIAPMKIR TEAPGNLRLY 600
SGSPTRSEKE QVSISSFYYK ERKSRRWKSK REGSDSGNRQ IKAAGKVIIQ 650
DIACLLPVHK SLGELYILNV NDIQETCQKN AASALLVGRK DLVQVWSLAT 700
VATDLCLGPK SDPDLETPWA RHPFGRQLLE SLLAHYCRLR DVQTLAMLCS 750
VFEAQSRPQG LPNPFGPFPN RSSNLVVSHS RYPSFTSSGS CSSMSDPGLN 800
TGGWNIAGRE AEHLSSPWGE SSPEELRFGS LTYSDPRERE RDQHDKNKRL 850
LDPANTQQFD DFKKCYGEIL YRWGLREKRA EVLKFVSCPP DPHKGIEFGV 900
YCSHCRSEVR GTQCAICKGF TFQCAICHVA VRGSSNFCLT CGHGGHTSHM 950
MEWFRTQEVC PTGCGCHCLL ESTF 974
Length:974
Mass (Da):109,793
Last modified:March 20, 2007 - v2
Checksum:i72F651A38EA51CBA
GO
Isoform 2 (identifier: Q6PJI9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     572-974: Missing.

Note: No experimental confirmation available.

Show »
Length:571
Mass (Da):64,848
Checksum:i9F0F69BD39E3FB60
GO
Isoform 3 (identifier: Q6PJI9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-408: Missing.

Show »
Length:566
Mass (Da):62,908
Checksum:i9FF9AC7DFEFB28FE
GO
Isoform 4 (identifier: Q6PJI9-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-556: Missing.
     557-571: MTMHRAVSPTEPTPR → MTGLQPVWIIIIFNYR

Note: No experimental confirmation available.

Show »
Length:419
Mass (Da):46,909
Checksum:iD9E96013D5098D33
GO

Sequence cautioni

The sequence BAB67816.1 differs from that shown. Reason: Frameshift at position 157.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti201 – 2011P → T.
Corresponds to variant rs11557260 [ dbSNP | Ensembl ].
VAR_053436

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 556556Missing in isoform 4.
VSP_023881Add
BLAST
Alternative sequencei1 – 408408Missing in isoform 3.
VSP_023882Add
BLAST
Alternative sequencei557 – 57115MTMHR…EPTPR → MTGLQPVWIIIIFNYR in isoform 4.
VSP_023883Add
BLAST
Alternative sequencei572 – 974403Missing in isoform 2.
VSP_023884Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti441 – 4411A → S in BAB67816. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK022332 mRNA. Translation: BAB14015.1.
AK091316 mRNA. Translation: BAG52335.1.
AF370390 mRNA. Translation: AAQ15226.1.
BC004519 mRNA. Translation: AAH04519.1.
BC014887 mRNA. Translation: AAH14887.2.
AB067510 mRNA. Translation: BAB67816.1. Frameshift.
CCDSiCCDS32488.1. [Q6PJI9-1]
RefSeqiNP_085058.3. NM_030581.3. [Q6PJI9-1]
UniGeneiHs.280951.

Genome annotation databases

EnsembliENST00000262144; ENSP00000262144; ENSG00000103091. [Q6PJI9-1]
GeneIDi79726.
KEGGihsa:79726.
UCSCiuc002fdf.1. human. [Q6PJI9-4]
uc002fdg.1. human. [Q6PJI9-1]

Polymorphism databases

DMDMi134035358.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK022332 mRNA. Translation: BAB14015.1 .
AK091316 mRNA. Translation: BAG52335.1 .
AF370390 mRNA. Translation: AAQ15226.1 .
BC004519 mRNA. Translation: AAH04519.1 .
BC014887 mRNA. Translation: AAH14887.2 .
AB067510 mRNA. Translation: BAB67816.1 . Frameshift.
CCDSi CCDS32488.1. [Q6PJI9-1 ]
RefSeqi NP_085058.3. NM_030581.3. [Q6PJI9-1 ]
UniGenei Hs.280951.

3D structure databases

ProteinModelPortali Q6PJI9.
SMRi Q6PJI9. Positions 43-320.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122841. 4 interactions.
IntActi Q6PJI9. 6 interactions.
STRINGi 9606.ENSP00000262144.

PTM databases

PhosphoSitei Q6PJI9.

Polymorphism databases

DMDMi 134035358.

Proteomic databases

MaxQBi Q6PJI9.
PaxDbi Q6PJI9.
PRIDEi Q6PJI9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262144 ; ENSP00000262144 ; ENSG00000103091 . [Q6PJI9-1 ]
GeneIDi 79726.
KEGGi hsa:79726.
UCSCi uc002fdf.1. human. [Q6PJI9-4 ]
uc002fdg.1. human. [Q6PJI9-1 ]

Organism-specific databases

CTDi 79726.
GeneCardsi GC16M074908.
H-InvDB HIX0013239.
HGNCi HGNC:25706. WDR59.
HPAi HPA041084.
neXtProti NX_Q6PJI9.
PharmGKBi PA142670593.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2319.
HOGENOMi HOG000004834.
HOVERGENi HBG092820.
InParanoidi Q6PJI9.
OMAi SCLLPVH.
OrthoDBi EOG70S74N.
PhylomeDBi Q6PJI9.
TreeFami TF314695.

Enzyme and pathway databases

SignaLinki Q6PJI9.

Miscellaneous databases

GenomeRNAii 79726.
NextBioi 69094.
PROi Q6PJI9.

Gene expression databases

ArrayExpressi Q6PJI9.
Bgeei Q6PJI9.
CleanExi HS_WDR59.
Genevestigatori Q6PJI9.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
3.10.110.10. 1 hit.
InterProi IPR006575. RWD-domain.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 3 hits.
[Graphical view ]
SMARTi SM00591. RWD. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
SSF54495. SSF54495. 1 hit.
PROSITEi PS50908. RWD. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
    Tissue: Mammary gland.
  2. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 170-974 (ISOFORM 1).
    Tissue: Lung and Uterus.
  4. "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 143-974 (ISOFORM 1).
    Tissue: Brain.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-821 AND SER-822, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1."
    Bar-Peled L., Chantranupong L., Cherniack A.D., Chen W.W., Ottina K.A., Grabiner B.C., Spear E.D., Carter S.L., Meyerson M., Sabatini D.M.
    Science 340:1100-1106(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN GATOR COMPLEX, SUBUNIT.

Entry informationi

Entry nameiWDR59_HUMAN
AccessioniPrimary (citable) accession number: Q6PJI9
Secondary accession number(s): B3KRC3
, Q71RE7, Q96PW5, Q9BSW6, Q9HA43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: July 9, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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