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Q6PJI9

- WDR59_HUMAN

UniProt

Q6PJI9 - WDR59_HUMAN

Protein

WD repeat-containing protein 59

Gene

WDR59

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway.

    Enzyme and pathway databases

    SignaLinkiQ6PJI9.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    WD repeat-containing protein 59
    Gene namesi
    Name:WDR59
    Synonyms:KIAA1923
    ORF Names:FP977
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:25706. WDR59.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670593.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 974974WD repeat-containing protein 59PRO_0000280721Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei821 – 8211Phosphoserine1 Publication
    Modified residuei822 – 8221Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ6PJI9.
    PaxDbiQ6PJI9.
    PRIDEiQ6PJI9.

    PTM databases

    PhosphoSiteiQ6PJI9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6PJI9.
    BgeeiQ6PJI9.
    CleanExiHS_WDR59.
    GenevestigatoriQ6PJI9.

    Organism-specific databases

    HPAiHPA041084.

    Interactioni

    Subunit structurei

    Interacts with DDB1-CUL4A/B E3 ligase complexes By similarity. Within the GATOR complex, component of the GATOR2 subcomplex, made of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR complex strongly interacts with RRAGA/RRAGC and RRAGB/RRAGC heterodimers.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi122841. 4 interactions.
    IntActiQ6PJI9. 6 interactions.
    STRINGi9606.ENSP00000262144.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PJI9.
    SMRiQ6PJI9. Positions 43-320.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati57 – 9842WD 1Add
    BLAST
    Repeati103 – 14341WD 2Add
    BLAST
    Repeati146 – 18540WD 3Add
    BLAST
    Repeati189 – 22941WD 4Add
    BLAST
    Repeati232 – 27645WD 5Add
    BLAST
    Repeati278 – 31841WD 6Add
    BLAST
    Repeati319 – 36244WD 7Add
    BLAST
    Domaini393 – 494102RWDPROSITE-ProRule annotationAdd
    BLAST
    Repeati668 – 70639WD 8Add
    BLAST

    Sequence similaritiesi

    Belongs to the WD repeat WDR59 family.Curated
    Contains 1 RWD domain.PROSITE-ProRule annotation
    Contains 8 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    HOGENOMiHOG000004834.
    HOVERGENiHBG092820.
    InParanoidiQ6PJI9.
    OMAiSCLLPVH.
    OrthoDBiEOG70S74N.
    PhylomeDBiQ6PJI9.
    TreeFamiTF314695.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    3.10.110.10. 1 hit.
    InterProiIPR006575. RWD-domain.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 3 hits.
    [Graphical view]
    SMARTiSM00591. RWD. 1 hit.
    SM00320. WD40. 5 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    SSF54495. SSF54495. 1 hit.
    PROSITEiPS50908. RWD. 1 hit.
    PS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 2 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6PJI9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAARWSSENV VVEFRDSQAT AMSVDCLGQH AVLSGRRFLY IVNLDAPFEG    50
    HRKISRQSKW DIGAVQWNPH DSFAHYFAAS SNQRVDLYKW KDGSGEVGTT 100
    LQGHTRVISD LDWAVFEPDL LVTSSVDTYI YIWDIKDTRK PTVALSAVAG 150
    ASQVKWNKKN ANCLATSHDG DVRIWDKRKP STAVEYLAAH LSKIHGLDWH 200
    PDSEHILATS SQDNSVKFWD YRQPRKYLNI LPCQVPVWKA RYTPFSNGLV 250
    TVMVPQLRRE NSLLLWNVFD LNTPVHTFVG HDDVVLEFQW RKQKEGSKDY 300
    QLVTWSRDQT LRMWRVDSQM QRLCANDILD GVDEFIESIS LLPEPEKTLH 350
    TEDTDHQHTA SHGEEEALKE DPPRNLLEER KSDQLGLPQT LQQEFSLINV 400
    QIRNVNVEMD AADRSCTVSV HCSNHRVKML VKFPAQYPNN AAPSFQFINP 450
    TTITSTMKAK LLKILKDTAL QKVKRGQSCL EPCLRQLVSC LESFVNQEDS 500
    ASSNPFALPN SVTPPLPTFA RVTTAYGSYQ DANIPFPRTS GARFCGAGYL 550
    VYFTRPMTMH RAVSPTEPTP RSLSALSAYH TGLIAPMKIR TEAPGNLRLY 600
    SGSPTRSEKE QVSISSFYYK ERKSRRWKSK REGSDSGNRQ IKAAGKVIIQ 650
    DIACLLPVHK SLGELYILNV NDIQETCQKN AASALLVGRK DLVQVWSLAT 700
    VATDLCLGPK SDPDLETPWA RHPFGRQLLE SLLAHYCRLR DVQTLAMLCS 750
    VFEAQSRPQG LPNPFGPFPN RSSNLVVSHS RYPSFTSSGS CSSMSDPGLN 800
    TGGWNIAGRE AEHLSSPWGE SSPEELRFGS LTYSDPRERE RDQHDKNKRL 850
    LDPANTQQFD DFKKCYGEIL YRWGLREKRA EVLKFVSCPP DPHKGIEFGV 900
    YCSHCRSEVR GTQCAICKGF TFQCAICHVA VRGSSNFCLT CGHGGHTSHM 950
    MEWFRTQEVC PTGCGCHCLL ESTF 974
    Length:974
    Mass (Da):109,793
    Last modified:March 20, 2007 - v2
    Checksum:i72F651A38EA51CBA
    GO
    Isoform 2 (identifier: Q6PJI9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         572-974: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:571
    Mass (Da):64,848
    Checksum:i9F0F69BD39E3FB60
    GO
    Isoform 3 (identifier: Q6PJI9-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-408: Missing.

    Show »
    Length:566
    Mass (Da):62,908
    Checksum:i9FF9AC7DFEFB28FE
    GO
    Isoform 4 (identifier: Q6PJI9-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-556: Missing.
         557-571: MTMHRAVSPTEPTPR → MTGLQPVWIIIIFNYR

    Note: No experimental confirmation available.

    Show »
    Length:419
    Mass (Da):46,909
    Checksum:iD9E96013D5098D33
    GO

    Sequence cautioni

    The sequence BAB67816.1 differs from that shown. Reason: Frameshift at position 157.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti441 – 4411A → S in BAB67816. (PubMed:11572484)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti201 – 2011P → T.
    Corresponds to variant rs11557260 [ dbSNP | Ensembl ].
    VAR_053436

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 556556Missing in isoform 4. 1 PublicationVSP_023881Add
    BLAST
    Alternative sequencei1 – 408408Missing in isoform 3. 2 PublicationsVSP_023882Add
    BLAST
    Alternative sequencei557 – 57115MTMHR…EPTPR → MTGLQPVWIIIIFNYR in isoform 4. 1 PublicationVSP_023883Add
    BLAST
    Alternative sequencei572 – 974403Missing in isoform 2. 1 PublicationVSP_023884Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022332 mRNA. Translation: BAB14015.1.
    AK091316 mRNA. Translation: BAG52335.1.
    AF370390 mRNA. Translation: AAQ15226.1.
    BC004519 mRNA. Translation: AAH04519.1.
    BC014887 mRNA. Translation: AAH14887.2.
    AB067510 mRNA. Translation: BAB67816.1. Frameshift.
    CCDSiCCDS32488.1. [Q6PJI9-1]
    RefSeqiNP_085058.3. NM_030581.3. [Q6PJI9-1]
    UniGeneiHs.280951.

    Genome annotation databases

    EnsembliENST00000262144; ENSP00000262144; ENSG00000103091. [Q6PJI9-1]
    GeneIDi79726.
    KEGGihsa:79726.
    UCSCiuc002fdf.1. human. [Q6PJI9-4]
    uc002fdg.1. human. [Q6PJI9-1]

    Polymorphism databases

    DMDMi134035358.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022332 mRNA. Translation: BAB14015.1 .
    AK091316 mRNA. Translation: BAG52335.1 .
    AF370390 mRNA. Translation: AAQ15226.1 .
    BC004519 mRNA. Translation: AAH04519.1 .
    BC014887 mRNA. Translation: AAH14887.2 .
    AB067510 mRNA. Translation: BAB67816.1 . Frameshift.
    CCDSi CCDS32488.1. [Q6PJI9-1 ]
    RefSeqi NP_085058.3. NM_030581.3. [Q6PJI9-1 ]
    UniGenei Hs.280951.

    3D structure databases

    ProteinModelPortali Q6PJI9.
    SMRi Q6PJI9. Positions 43-320.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122841. 4 interactions.
    IntActi Q6PJI9. 6 interactions.
    STRINGi 9606.ENSP00000262144.

    PTM databases

    PhosphoSitei Q6PJI9.

    Polymorphism databases

    DMDMi 134035358.

    Proteomic databases

    MaxQBi Q6PJI9.
    PaxDbi Q6PJI9.
    PRIDEi Q6PJI9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262144 ; ENSP00000262144 ; ENSG00000103091 . [Q6PJI9-1 ]
    GeneIDi 79726.
    KEGGi hsa:79726.
    UCSCi uc002fdf.1. human. [Q6PJI9-4 ]
    uc002fdg.1. human. [Q6PJI9-1 ]

    Organism-specific databases

    CTDi 79726.
    GeneCardsi GC16M074908.
    H-InvDB HIX0013239.
    HGNCi HGNC:25706. WDR59.
    HPAi HPA041084.
    neXtProti NX_Q6PJI9.
    PharmGKBi PA142670593.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2319.
    HOGENOMi HOG000004834.
    HOVERGENi HBG092820.
    InParanoidi Q6PJI9.
    OMAi SCLLPVH.
    OrthoDBi EOG70S74N.
    PhylomeDBi Q6PJI9.
    TreeFami TF314695.

    Enzyme and pathway databases

    SignaLinki Q6PJI9.

    Miscellaneous databases

    GenomeRNAii 79726.
    NextBioi 69094.
    PROi Q6PJI9.

    Gene expression databases

    ArrayExpressi Q6PJI9.
    Bgeei Q6PJI9.
    CleanExi HS_WDR59.
    Genevestigatori Q6PJI9.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    3.10.110.10. 1 hit.
    InterProi IPR006575. RWD-domain.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 3 hits.
    [Graphical view ]
    SMARTi SM00591. RWD. 1 hit.
    SM00320. WD40. 5 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    SSF54495. SSF54495. 1 hit.
    PROSITEi PS50908. RWD. 1 hit.
    PS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 2 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
      Tissue: Mammary gland.
    2. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 170-974 (ISOFORM 1).
      Tissue: Lung and Uterus.
    4. "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
      Nagase T., Kikuno R., Ohara O.
      DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 143-974 (ISOFORM 1).
      Tissue: Brain.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-821 AND SER-822, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1."
      Bar-Peled L., Chantranupong L., Cherniack A.D., Chen W.W., Ottina K.A., Grabiner B.C., Spear E.D., Carter S.L., Meyerson M., Sabatini D.M.
      Science 340:1100-1106(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN GATOR COMPLEX, SUBUNIT.

    Entry informationi

    Entry nameiWDR59_HUMAN
    AccessioniPrimary (citable) accession number: Q6PJI9
    Secondary accession number(s): B3KRC3
    , Q71RE7, Q96PW5, Q9BSW6, Q9HA43
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3