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Protein

WD repeat-containing protein 59

Gene

WDR59

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway.

Enzyme and pathway databases

SignaLinkiQ6PJI9.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 59
Gene namesi
Name:WDR59
Synonyms:KIAA1923
ORF Names:FP977
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:25706. WDR59.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670593.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 974974WD repeat-containing protein 59PRO_0000280721Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei564 – 5641Phosphoserine1 Publication
Modified residuei821 – 8211Phosphoserine1 Publication
Modified residuei822 – 8221Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6PJI9.
PaxDbiQ6PJI9.
PRIDEiQ6PJI9.

PTM databases

PhosphoSiteiQ6PJI9.

Expressioni

Gene expression databases

BgeeiQ6PJI9.
CleanExiHS_WDR59.
ExpressionAtlasiQ6PJI9. baseline and differential.
GenevestigatoriQ6PJI9.

Organism-specific databases

HPAiHPA041084.

Interactioni

Subunit structurei

Interacts with DDB1-CUL4A/B E3 ligase complexes (By similarity). Within the GATOR complex, component of the GATOR2 subcomplex, made of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR complex strongly interacts with RRAGA/RRAGC and RRAGB/RRAGC heterodimers.By similarity1 Publication

Protein-protein interaction databases

BioGridi122841. 9 interactions.
IntActiQ6PJI9. 6 interactions.
STRINGi9606.ENSP00000262144.

Structurei

3D structure databases

ProteinModelPortaliQ6PJI9.
SMRiQ6PJI9. Positions 43-317.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati57 – 9842WD 1Add
BLAST
Repeati103 – 14341WD 2Add
BLAST
Repeati146 – 18540WD 3Add
BLAST
Repeati189 – 22941WD 4Add
BLAST
Repeati232 – 27645WD 5Add
BLAST
Repeati278 – 31841WD 6Add
BLAST
Repeati319 – 36244WD 7Add
BLAST
Domaini393 – 494102RWDPROSITE-ProRule annotationAdd
BLAST
Repeati668 – 70639WD 8Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat WDR59 family.Curated
Contains 1 RWD domain.PROSITE-ProRule annotation
Contains 8 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00770000120589.
HOGENOMiHOG000004834.
HOVERGENiHBG092820.
InParanoidiQ6PJI9.
OMAiSCLLPVH.
OrthoDBiEOG70S74N.
PhylomeDBiQ6PJI9.
TreeFamiTF314695.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
3.10.110.10. 1 hit.
InterProiIPR006575. RWD-domain.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00591. RWD. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF54495. SSF54495. 1 hit.
PROSITEiPS50908. RWD. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PJI9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAARWSSENV VVEFRDSQAT AMSVDCLGQH AVLSGRRFLY IVNLDAPFEG
60 70 80 90 100
HRKISRQSKW DIGAVQWNPH DSFAHYFAAS SNQRVDLYKW KDGSGEVGTT
110 120 130 140 150
LQGHTRVISD LDWAVFEPDL LVTSSVDTYI YIWDIKDTRK PTVALSAVAG
160 170 180 190 200
ASQVKWNKKN ANCLATSHDG DVRIWDKRKP STAVEYLAAH LSKIHGLDWH
210 220 230 240 250
PDSEHILATS SQDNSVKFWD YRQPRKYLNI LPCQVPVWKA RYTPFSNGLV
260 270 280 290 300
TVMVPQLRRE NSLLLWNVFD LNTPVHTFVG HDDVVLEFQW RKQKEGSKDY
310 320 330 340 350
QLVTWSRDQT LRMWRVDSQM QRLCANDILD GVDEFIESIS LLPEPEKTLH
360 370 380 390 400
TEDTDHQHTA SHGEEEALKE DPPRNLLEER KSDQLGLPQT LQQEFSLINV
410 420 430 440 450
QIRNVNVEMD AADRSCTVSV HCSNHRVKML VKFPAQYPNN AAPSFQFINP
460 470 480 490 500
TTITSTMKAK LLKILKDTAL QKVKRGQSCL EPCLRQLVSC LESFVNQEDS
510 520 530 540 550
ASSNPFALPN SVTPPLPTFA RVTTAYGSYQ DANIPFPRTS GARFCGAGYL
560 570 580 590 600
VYFTRPMTMH RAVSPTEPTP RSLSALSAYH TGLIAPMKIR TEAPGNLRLY
610 620 630 640 650
SGSPTRSEKE QVSISSFYYK ERKSRRWKSK REGSDSGNRQ IKAAGKVIIQ
660 670 680 690 700
DIACLLPVHK SLGELYILNV NDIQETCQKN AASALLVGRK DLVQVWSLAT
710 720 730 740 750
VATDLCLGPK SDPDLETPWA RHPFGRQLLE SLLAHYCRLR DVQTLAMLCS
760 770 780 790 800
VFEAQSRPQG LPNPFGPFPN RSSNLVVSHS RYPSFTSSGS CSSMSDPGLN
810 820 830 840 850
TGGWNIAGRE AEHLSSPWGE SSPEELRFGS LTYSDPRERE RDQHDKNKRL
860 870 880 890 900
LDPANTQQFD DFKKCYGEIL YRWGLREKRA EVLKFVSCPP DPHKGIEFGV
910 920 930 940 950
YCSHCRSEVR GTQCAICKGF TFQCAICHVA VRGSSNFCLT CGHGGHTSHM
960 970
MEWFRTQEVC PTGCGCHCLL ESTF
Length:974
Mass (Da):109,793
Last modified:March 19, 2007 - v2
Checksum:i72F651A38EA51CBA
GO
Isoform 2 (identifier: Q6PJI9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     572-974: Missing.

Note: No experimental confirmation available.

Show »
Length:571
Mass (Da):64,848
Checksum:i9F0F69BD39E3FB60
GO
Isoform 3 (identifier: Q6PJI9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-408: Missing.

Show »
Length:566
Mass (Da):62,908
Checksum:i9FF9AC7DFEFB28FE
GO
Isoform 4 (identifier: Q6PJI9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-556: Missing.
     557-571: MTMHRAVSPTEPTPR → MTGLQPVWIIIIFNYR

Note: No experimental confirmation available.

Show »
Length:419
Mass (Da):46,909
Checksum:iD9E96013D5098D33
GO

Sequence cautioni

The sequence BAB67816.1 differs from that shown. Reason: Frameshift at position 157. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti441 – 4411A → S in BAB67816 (PubMed:11572484).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti201 – 2011P → T.
Corresponds to variant rs11557260 [ dbSNP | Ensembl ].
VAR_053436

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 556556Missing in isoform 4. 1 PublicationVSP_023881Add
BLAST
Alternative sequencei1 – 408408Missing in isoform 3. 2 PublicationsVSP_023882Add
BLAST
Alternative sequencei557 – 57115MTMHR…EPTPR → MTGLQPVWIIIIFNYR in isoform 4. 1 PublicationVSP_023883Add
BLAST
Alternative sequencei572 – 974403Missing in isoform 2. 1 PublicationVSP_023884Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022332 mRNA. Translation: BAB14015.1.
AK091316 mRNA. Translation: BAG52335.1.
AF370390 mRNA. Translation: AAQ15226.1.
BC004519 mRNA. Translation: AAH04519.1.
BC014887 mRNA. Translation: AAH14887.2.
AB067510 mRNA. Translation: BAB67816.1. Frameshift.
CCDSiCCDS32488.1. [Q6PJI9-1]
RefSeqiNP_085058.3. NM_030581.3. [Q6PJI9-1]
UniGeneiHs.280951.

Genome annotation databases

EnsembliENST00000262144; ENSP00000262144; ENSG00000103091. [Q6PJI9-1]
ENST00000616369; ENSP00000482446; ENSG00000103091. [Q6PJI9-2]
GeneIDi79726.
KEGGihsa:79726.
UCSCiuc002fdf.1. human. [Q6PJI9-4]
uc002fdg.1. human. [Q6PJI9-1]

Polymorphism databases

DMDMi134035358.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022332 mRNA. Translation: BAB14015.1.
AK091316 mRNA. Translation: BAG52335.1.
AF370390 mRNA. Translation: AAQ15226.1.
BC004519 mRNA. Translation: AAH04519.1.
BC014887 mRNA. Translation: AAH14887.2.
AB067510 mRNA. Translation: BAB67816.1. Frameshift.
CCDSiCCDS32488.1. [Q6PJI9-1]
RefSeqiNP_085058.3. NM_030581.3. [Q6PJI9-1]
UniGeneiHs.280951.

3D structure databases

ProteinModelPortaliQ6PJI9.
SMRiQ6PJI9. Positions 43-317.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122841. 9 interactions.
IntActiQ6PJI9. 6 interactions.
STRINGi9606.ENSP00000262144.

PTM databases

PhosphoSiteiQ6PJI9.

Polymorphism databases

DMDMi134035358.

Proteomic databases

MaxQBiQ6PJI9.
PaxDbiQ6PJI9.
PRIDEiQ6PJI9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262144; ENSP00000262144; ENSG00000103091. [Q6PJI9-1]
ENST00000616369; ENSP00000482446; ENSG00000103091. [Q6PJI9-2]
GeneIDi79726.
KEGGihsa:79726.
UCSCiuc002fdf.1. human. [Q6PJI9-4]
uc002fdg.1. human. [Q6PJI9-1]

Organism-specific databases

CTDi79726.
GeneCardsiGC16M074908.
H-InvDBHIX0013239.
HGNCiHGNC:25706. WDR59.
HPAiHPA041084.
neXtProtiNX_Q6PJI9.
PharmGKBiPA142670593.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00770000120589.
HOGENOMiHOG000004834.
HOVERGENiHBG092820.
InParanoidiQ6PJI9.
OMAiSCLLPVH.
OrthoDBiEOG70S74N.
PhylomeDBiQ6PJI9.
TreeFamiTF314695.

Enzyme and pathway databases

SignaLinkiQ6PJI9.

Miscellaneous databases

ChiTaRSiWDR59. human.
GenomeRNAii79726.
NextBioi69094.
PROiQ6PJI9.

Gene expression databases

BgeeiQ6PJI9.
CleanExiHS_WDR59.
ExpressionAtlasiQ6PJI9. baseline and differential.
GenevestigatoriQ6PJI9.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
3.10.110.10. 1 hit.
InterProiIPR006575. RWD-domain.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00591. RWD. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF54495. SSF54495. 1 hit.
PROSITEiPS50908. RWD. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
    Tissue: Mammary gland.
  2. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 170-974 (ISOFORM 1).
    Tissue: Lung and Uterus.
  4. "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:179-187(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 143-974 (ISOFORM 1).
    Tissue: Brain.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-821 AND SER-822, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1."
    Bar-Peled L., Chantranupong L., Cherniack A.D., Chen W.W., Ottina K.A., Grabiner B.C., Spear E.D., Carter S.L., Meyerson M., Sabatini D.M.
    Science 340:1100-1106(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN GATOR COMPLEX, SUBUNIT.
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-564, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiWDR59_HUMAN
AccessioniPrimary (citable) accession number: Q6PJI9
Secondary accession number(s): B3KRC3
, Q71RE7, Q96PW5, Q9BSW6, Q9HA43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 19, 2007
Last sequence update: March 19, 2007
Last modified: March 3, 2015
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.