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Protein

Leucine-rich repeat and fibronectin type-III domain-containing protein 4

Gene

LRFN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery (By similarity).By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-8849932 Synaptic adhesion-like molecules

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat and fibronectin type-III domain-containing protein 4
Gene namesi
Name:LRFN4
Synonyms:SALM3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000173621.8
HGNCiHGNC:28456 LRFN4
MIMi612810 gene
neXtProtiNX_Q6PJG9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 518ExtracellularSequence analysisAdd BLAST502
Transmembranei519 – 539HelicalSequence analysisAdd BLAST21
Topological domaini540 – 635CytoplasmicSequence analysisAdd BLAST96

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi633 – 635Missing : Loss of DLG1-, DLG3- and DLG4-binding. 1 Publication3

Organism-specific databases

OpenTargetsiENSG00000173621
PharmGKBiPA134922153

Polymorphism and mutation databases

BioMutaiLRFN4
DMDMi62286924

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000001484317 – 635Leucine-rich repeat and fibronectin type-III domain-containing protein 4Add BLAST619

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi302 ↔ 351PROSITE-ProRule annotation
Glycosylationi324N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi333N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi376N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi440N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei585PhosphoserineCombined sources1
Modified residuei626PhosphoserineCombined sources1

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ6PJG9
PaxDbiQ6PJG9
PeptideAtlasiQ6PJG9
PRIDEiQ6PJG9
ProteomicsDBi67206

PTM databases

iPTMnetiQ6PJG9
PhosphoSitePlusiQ6PJG9

Expressioni

Gene expression databases

BgeeiENSG00000173621
CleanExiHS_LRFN4
ExpressionAtlasiQ6PJG9 baseline and differential
GenevisibleiQ6PJG9 HS

Interactioni

Subunit structurei

Can form heteromeric complexes with LRFN1, LRFN2, LRFN3 and LRFN5. Unable to form homophilic interactions across cell junctions (By similarity). Interacts with DLG1, DLG2, DLG3 and DLG4.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NOTCH2NLQ7Z3S95EBI-7910762,EBI-945833

Protein-protein interaction databases

BioGridi122470, 46 interactors
IntActiQ6PJG9, 31 interactors
MINTiQ6PJG9
STRINGi9606.ENSP00000312535

Structurei

3D structure databases

ProteinModelPortaliQ6PJG9
SMRiQ6PJG9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 48LRRNTAdd BLAST32
Repeati49 – 70LRR 1Add BLAST22
Repeati73 – 94LRR 2Add BLAST22
Repeati97 – 118LRR 3Add BLAST22
Repeati121 – 142LRR 4Add BLAST22
Repeati146 – 161LRR 5Add BLAST16
Repeati170 – 191LRR 6Add BLAST22
Repeati194 – 215LRR 7Add BLAST22
Domaini234 – 280LRRCTAdd BLAST47
Domaini281 – 367Ig-likeAdd BLAST87
Domaini405 – 502Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST98

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi632 – 635PDZ-binding4

Domaini

The PDZ-binding motif is required for neurite outgrowth promotion (By similarity). This motif is also involved in DLG1-, DLG3- and DLG4-binding.By similarity

Sequence similaritiesi

Belongs to the LRFN family.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118831
HOGENOMiHOG000237343
HOVERGENiHBG052352
InParanoidiQ6PJG9
KOiK16357
OMAiPVPTMHW
OrthoDBiEOG091G04B7
PhylomeDBiQ6PJG9
TreeFamiTF350185

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF00041 fn3, 1 hit
PF07679 I-set, 1 hit
PF13855 LRR_8, 2 hits
SMARTiView protein in SMART
SM00060 FN3, 1 hit
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00369 LRR_TYP, 6 hits
SM00082 LRRCT, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6PJG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPLLLLLL ASGAAACPLP CVCQNLSESL STLCAHRGLL FVPPNVDRRT
60 70 80 90 100
VELRLADNFI QALGPPDFRN MTGLVDLTLS RNAITRIGAR AFGDLESLRS
110 120 130 140 150
LHLDGNRLVE LGTGSLRGPV NLQHLILSGN QLGRIAPGAF DDFLESLEDL
160 170 180 190 200
DLSYNNLRQV PWAGIGAMPA LHTLNLDHNL IDALPPGAFA QLGQLSRLDL
210 220 230 240 250
TSNRLATLAP DPLFSRGRDA EASPAPLVLS FSGNPLHCNC ELLWLRRLAR
260 270 280 290 300
PDDLETCASP PGLAGRYFWA VPEGEFSCEP PLIARHTQRL WVLEGQRATL
310 320 330 340 350
RCRALGDPAP TMHWVGPDDR LVGNSSRARA FPNGTLEIGV TGAGDAGGYT
360 370 380 390 400
CIATNPAGEA TARVELRVLA LPHGGNSSAE GGRPGPSDIA ASARTAAEGE
410 420 430 440 450
GTLESEPAVQ VTEVTATSGL VSWGPGRPAD PVWMFQIQYN SSEDETLIYR
460 470 480 490 500
IVPASSHHFL LKHLVPGADY DLCLLALSPA AGPSDLTATR LLGCAHFSTL
510 520 530 540 550
PASPLCHALQ AHVLGGTLTV AVGGVLVAAL LVFTVALLVR GRGAGNGRLP
560 570 580 590 600
LKLSHVQSQT NGGPSPTPKA HPPRSPPPRP QRSCSLDLGD AGCYGYARRL
610 620 630
GGAWARRSHS VHGGLLGAGC RGVGGSAERL EESVV
Length:635
Mass (Da):66,860
Last modified:July 5, 2004 - v1
Checksum:i13E66645A17A92EE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024499340V → A2 PublicationsCorresponds to variant dbSNP:rs3741194Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC000207 mRNA Translation: AAH00207.2
BC015581 mRNA Translation: AAH15581.2
BC027475 mRNA Translation: AAH27475.2
BC094813 mRNA Translation: AAH94813.1
AB209005 mRNA Translation: BAD92242.1
CCDSiCCDS8153.1
RefSeqiNP_076941.2, NM_024036.4
XP_005274296.1, XM_005274239.3
UniGeneiHs.209979
Hs.714189

Genome annotation databases

EnsembliENST00000309602; ENSP00000312535; ENSG00000173621
GeneIDi78999
KEGGihsa:78999
UCSCiuc001ojr.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLRFN4_HUMAN
AccessioniPrimary (citable) accession number: Q6PJG9
Secondary accession number(s): Q4VBZ3
, Q59GV4, Q8N644, Q9BWJ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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