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Q6PJG6

- BRAT1_HUMAN

UniProt

Q6PJG6 - BRAT1_HUMAN

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Protein

BRCA1-associated ATM activator 1

Gene

BRAT1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Required for activation of ATM following ionizing radiation. May act by regulating dephosphorylation of ATM.1 Publication

GO - Biological processi

  1. response to ionizing radiation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BRCA1-associated ATM activator 1
Alternative name(s):
BRCA1-associated protein required for ATM activation protein 1
Gene namesi
Name:BRAT1
Synonyms:BAAT1, C7orf27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:21701. BRAT1.

Subcellular locationi

Nucleus 1 Publication
Note: Present at double strand breaks (DSBs) following ionizing radiation treatment.

GO - Cellular componenti

  1. membrane Source: UniProtKB
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Rigidity and multifocal seizure syndrome, lethal neonatal (RMFSL) [MIM:614498]: A lethal, neonatal, neurologic disorder characterized by episodic jerking that is apparent in utero, lack of psychomotor development, axial and limb rigidity, frequent multifocal seizures, and dysautonomia. At birth, affected individuals have small heads, overlapping cranial sutures, small or absent fontanels, and depressed frontal bones. Infants show poorly responsive focal jerks of the tongue, face and arms in a nearly continuous sequence throughout life.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.

Keywords - Diseasei

Epilepsy

Organism-specific databases

MIMi614498. phenotype.
PharmGKBiPA134959439.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 821821BRCA1-associated ATM activator 1PRO_0000255257Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei742 – 7421Phosphoserine4 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6PJG6.
PaxDbiQ6PJG6.
PRIDEiQ6PJG6.

PTM databases

PhosphoSiteiQ6PJG6.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiQ6PJG6.
CleanExiHS_C7orf27.
ExpressionAtlasiQ6PJG6. baseline and differential.
GenevestigatoriQ6PJG6.

Organism-specific databases

HPAiHPA029455.

Interactioni

Subunit structurei

Interacts with BRCA1 and ATM.1 Publication

Protein-protein interaction databases

BioGridi128767. 14 interactions.
MINTiMINT-4994139.
STRINGi9606.ENSP00000339637.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IFIX-ray2.20B268-273[»]
ProteinModelPortaliQ6PJG6.
SMRiQ6PJG6. Positions 422-574.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati495 – 53137HEAT 1Add
BLAST
Repeati544 – 57633HEAT 2Add
BLAST

Sequence similaritiesi

Contains 2 HEAT repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG27983.
GeneTreeiENSGT00390000017551.
HOVERGENiHBG062139.
InParanoidiQ6PJG6.
OMAiRLCSPCW.
OrthoDBiEOG779NXD.
PhylomeDBiQ6PJG6.
TreeFamiTF324349.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000357. HEAT.
[Graphical view]
PfamiPF02985. HEAT. 2 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6PJG6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPECAQLLP ALCAVLVDPR QPVADDTCLE KLLDWFKTVT EGESSVVLLQ
60 70 80 90 100
EHPCLVELLS HVLKVQDLSS GVLSFSLRLA GTFAAQENCF QYLQQGELLP
110 120 130 140 150
GLFGEPGPLG RATWAVPTVR SGWIQGLRSL AQHPSALRFL ADHGAVDTIF
160 170 180 190 200
SLQGDSSLFV ASAASQLLVH VLALSMRGGA EGQPCLPGGD WPACAQKIMD
210 220 230 240 250
HVEESLCSAA TPKVTQALNV LTTTFGRCQS PWTEALWVRL SPRVACLLER
260 270 280 290 300
DPIPAAHSFV DLLLCVARSP VFSSSDGSLW ETVARALSCL GPTHMGPLAL
310 320 330 340 350
GILKLEHCPQ ALRTQAFQVL LQPLACVLKA TVQAPGPPGL LDGTADDATT
360 370 380 390 400
VDTLLASKSS CAGLLCRTLA HLEELQPLPQ RPSPWPQASL LGATVTVLRL
410 420 430 440 450
CDGSAAPASS VGGHLCGTLA GCVRVQRAAL DFLGTLSQGT GPQELVTQAL
460 470 480 490 500
AVLLECLESP GSSPTVLKKA FQATLRWLLS SPKTPGCSDL GPLIPQFLRE
510 520 530 540 550
LFPVLQKRLC HPCWEVRDSA LEFLTQLSRH WGGQADFRCA LLASEVPQLA
560 570 580 590 600
LQLLQDPESY VRASAVTAMG QLSSQGLHAP TSPEHAEARQ SLFLELLHIL
610 620 630 640 650
SVDSEGFPRR AVMQVFTEWL RDGHADAAQD TEQFVATVLQ AASRDLDWEV
660 670 680 690 700
RAQGLELALV FLGQTLGPPR THCPYAVALP EVAPAQPLTE ALRALCHVGL
710 720 730 740 750
FDFAFCALFD CDRPVAQKSC DLLLFLRDKI ASYSSLREAR GSPNTASAEA
760 770 780 790 800
TLPRWRAGEQ AQPPGDQEPE AVLAMLRSLD LEGLRSTLAE SSDHVEKSPQ
810 820
SLLQDMLATG GFLQGDEADC Y
Length:821
Mass (Da):88,119
Last modified:March 20, 2007 - v2
Checksum:iC18FDDE8B13FEECD
GO
Isoform 2 (identifier: Q6PJG6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     270-286: PVFSSSDGSLWETVARA → GPRDAAGGPGWATVFLG
     287-821: Missing.

Note: No experimental confirmation available.

Show »
Length:286
Mass (Da):30,560
Checksum:iD72BCE177DB84E58
GO
Isoform 3 (identifier: Q6PJG6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-530: Missing.
     531-589: WGGQADFRCA...PTSPEHAEAR → MGKLRIGGPC...TNHPHLLPVP

Note: No experimental confirmation available.Curated

Show »
Length:291
Mass (Da):31,676
Checksum:i3707108370D007AC
GO

Sequence cautioni

The sequence BAB15772.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti644 – 6441R → Q in CAB61405. (PubMed:17974005)Curated
Isoform 3 (identifier: Q6PJG6-3)
Sequence conflicti49 – 491P → T in AAH40704. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti20 – 201R → G.1 Publication
Corresponds to variant rs17856488 [ dbSNP | Ensembl ].
VAR_031202
Natural varianti737 – 7371R → W.
Corresponds to variant rs60152725 [ dbSNP | Ensembl ].
VAR_061594

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 530530Missing in isoform 3. 1 PublicationVSP_021288Add
BLAST
Alternative sequencei270 – 28617PVFSS…TVARA → GPRDAAGGPGWATVFLG in isoform 2. 1 PublicationVSP_021289Add
BLAST
Alternative sequencei287 – 821535Missing in isoform 2. 1 PublicationVSP_021290Add
BLAST
Alternative sequencei531 – 58959WGGQA…HAEAR → MGKLRIGGPCAHCAAWEGVR AGCGPRLHVRGQPPSCTGVL LREPRSCHPTNHPHLLPVP in isoform 3. 1 PublicationVSP_021291Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024482 mRNA. Translation: BAB15772.1. Different initiation.
AC092488 Genomic DNA. No translation available.
CH236953 Genomic DNA. Translation: EAL23957.1.
CH471144 Genomic DNA. Translation: EAW87257.1.
CH471144 Genomic DNA. Translation: EAW87258.1.
BC007209 mRNA. Translation: AAH07209.1.
BC023561 mRNA. Translation: AAH23561.2.
BC040704 mRNA. Translation: AAH40704.1.
BC015632 mRNA. Translation: AAH15632.2.
AL133088 mRNA. Translation: CAB61405.1.
CCDSiCCDS5334.1. [Q6PJG6-1]
PIRiT42692.
RefSeqiNP_689956.2. NM_152743.3. [Q6PJG6-1]
UniGeneiHs.520623.

Genome annotation databases

EnsembliENST00000340611; ENSP00000339637; ENSG00000106009. [Q6PJG6-1]
GeneIDi221927.
KEGGihsa:221927.
UCSCiuc003smh.4. human. [Q6PJG6-3]
uc003smi.3. human. [Q6PJG6-1]
uc003smj.2. human. [Q6PJG6-2]

Polymorphism databases

DMDMi134047724.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024482 mRNA. Translation: BAB15772.1 . Different initiation.
AC092488 Genomic DNA. No translation available.
CH236953 Genomic DNA. Translation: EAL23957.1 .
CH471144 Genomic DNA. Translation: EAW87257.1 .
CH471144 Genomic DNA. Translation: EAW87258.1 .
BC007209 mRNA. Translation: AAH07209.1 .
BC023561 mRNA. Translation: AAH23561.2 .
BC040704 mRNA. Translation: AAH40704.1 .
BC015632 mRNA. Translation: AAH15632.2 .
AL133088 mRNA. Translation: CAB61405.1 .
CCDSi CCDS5334.1. [Q6PJG6-1 ]
PIRi T42692.
RefSeqi NP_689956.2. NM_152743.3. [Q6PJG6-1 ]
UniGenei Hs.520623.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4IFI X-ray 2.20 B 268-273 [» ]
ProteinModelPortali Q6PJG6.
SMRi Q6PJG6. Positions 422-574.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128767. 14 interactions.
MINTi MINT-4994139.
STRINGi 9606.ENSP00000339637.

PTM databases

PhosphoSitei Q6PJG6.

Polymorphism databases

DMDMi 134047724.

Proteomic databases

MaxQBi Q6PJG6.
PaxDbi Q6PJG6.
PRIDEi Q6PJG6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000340611 ; ENSP00000339637 ; ENSG00000106009 . [Q6PJG6-1 ]
GeneIDi 221927.
KEGGi hsa:221927.
UCSCi uc003smh.4. human. [Q6PJG6-3 ]
uc003smi.3. human. [Q6PJG6-1 ]
uc003smj.2. human. [Q6PJG6-2 ]

Organism-specific databases

CTDi 221927.
GeneCardsi GC07M002577.
HGNCi HGNC:21701. BRAT1.
HPAi HPA029455.
MIMi 614498. phenotype.
614506. gene.
neXtProti NX_Q6PJG6.
PharmGKBi PA134959439.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG27983.
GeneTreei ENSGT00390000017551.
HOVERGENi HBG062139.
InParanoidi Q6PJG6.
OMAi RLCSPCW.
OrthoDBi EOG779NXD.
PhylomeDBi Q6PJG6.
TreeFami TF324349.

Miscellaneous databases

GenomeRNAii 221927.
NextBioi 91494.
PROi Q6PJG6.
SOURCEi Search...

Gene expression databases

Bgeei Q6PJG6.
CleanExi HS_C7orf27.
ExpressionAtlasi Q6PJG6. baseline and differential.
Genevestigatori Q6PJG6.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000357. HEAT.
[Graphical view ]
Pfami PF02985. HEAT. 2 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 3 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Spleen.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT GLY-20.
    Tissue: Duodenum, Placenta and Skin.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 346-821.
    Tissue: Testis.
  7. "ATM activation by ionizing radiation requires BRCA1-associated BAAT1."
    Aglipay J.A., Martin S.A., Tawara H., Lee S.W., Ouchi T.
    J. Biol. Chem. 281:9710-9718(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH BRCA1 AND ATM.
  8. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-742, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-742, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-742, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-742, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. Cited for: INVOLVEMENT IN RMFSL.

Entry informationi

Entry nameiBRAT1_HUMAN
AccessioniPrimary (citable) accession number: Q6PJG6
Secondary accession number(s): A4D200
, C9JY24, Q8IW85, Q8IZ43, Q8WVR8, Q96IV9, Q9H7J8, Q9UFA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 20, 2007
Last modified: November 26, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3