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Q6PJG6

- BRAT1_HUMAN

UniProt

Q6PJG6 - BRAT1_HUMAN

Protein

BRCA1-associated ATM activator 1

Gene

BRAT1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    Required for activation of ATM following ionizing radiation. May act by regulating dephosphorylation of ATM.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. response to ionizing radiation Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    BRCA1-associated ATM activator 1
    Alternative name(s):
    BRCA1-associated protein required for ATM activation protein 1
    Gene namesi
    Name:BRAT1
    Synonyms:BAAT1, C7orf27
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:21701. BRAT1.

    Subcellular locationi

    Nucleus 1 Publication
    Note: Present at double strand breaks (DSBs) following ionizing radiation treatment.

    GO - Cellular componenti

    1. membrane Source: UniProtKB
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Rigidity and multifocal seizure syndrome, lethal neonatal (RMFSL) [MIM:614498]: A lethal, neonatal, neurologic disorder characterized by episodic jerking that is apparent in utero, lack of psychomotor development, axial and limb rigidity, frequent multifocal seizures, and dysautonomia. At birth, affected individuals have small heads, overlapping cranial sutures, small or absent fontanels, and depressed frontal bones. Infants show poorly responsive focal jerks of the tongue, face and arms in a nearly continuous sequence throughout life.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Keywords - Diseasei

    Epilepsy

    Organism-specific databases

    MIMi614498. phenotype.
    PharmGKBiPA134959439.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 821821BRCA1-associated ATM activator 1PRO_0000255257Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei742 – 7421Phosphoserine4 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ6PJG6.
    PaxDbiQ6PJG6.
    PRIDEiQ6PJG6.

    PTM databases

    PhosphoSiteiQ6PJG6.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ6PJG6.
    BgeeiQ6PJG6.
    CleanExiHS_C7orf27.
    GenevestigatoriQ6PJG6.

    Organism-specific databases

    HPAiHPA029455.

    Interactioni

    Subunit structurei

    Interacts with BRCA1 and ATM.1 Publication

    Protein-protein interaction databases

    BioGridi128767. 6 interactions.
    MINTiMINT-4994139.
    STRINGi9606.ENSP00000339637.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4IFIX-ray2.20B268-273[»]
    ProteinModelPortaliQ6PJG6.
    SMRiQ6PJG6. Positions 116-174, 422-573.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati495 – 53137HEAT 1Add
    BLAST
    Repeati544 – 57633HEAT 2Add
    BLAST

    Sequence similaritiesi

    Contains 2 HEAT repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG27983.
    HOVERGENiHBG062139.
    InParanoidiQ6PJG6.
    OMAiRLCSPCW.
    OrthoDBiEOG779NXD.
    PhylomeDBiQ6PJG6.
    TreeFamiTF324349.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000357. HEAT.
    [Graphical view]
    PfamiPF02985. HEAT. 2 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 3 hits.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6PJG6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDPECAQLLP ALCAVLVDPR QPVADDTCLE KLLDWFKTVT EGESSVVLLQ    50
    EHPCLVELLS HVLKVQDLSS GVLSFSLRLA GTFAAQENCF QYLQQGELLP 100
    GLFGEPGPLG RATWAVPTVR SGWIQGLRSL AQHPSALRFL ADHGAVDTIF 150
    SLQGDSSLFV ASAASQLLVH VLALSMRGGA EGQPCLPGGD WPACAQKIMD 200
    HVEESLCSAA TPKVTQALNV LTTTFGRCQS PWTEALWVRL SPRVACLLER 250
    DPIPAAHSFV DLLLCVARSP VFSSSDGSLW ETVARALSCL GPTHMGPLAL 300
    GILKLEHCPQ ALRTQAFQVL LQPLACVLKA TVQAPGPPGL LDGTADDATT 350
    VDTLLASKSS CAGLLCRTLA HLEELQPLPQ RPSPWPQASL LGATVTVLRL 400
    CDGSAAPASS VGGHLCGTLA GCVRVQRAAL DFLGTLSQGT GPQELVTQAL 450
    AVLLECLESP GSSPTVLKKA FQATLRWLLS SPKTPGCSDL GPLIPQFLRE 500
    LFPVLQKRLC HPCWEVRDSA LEFLTQLSRH WGGQADFRCA LLASEVPQLA 550
    LQLLQDPESY VRASAVTAMG QLSSQGLHAP TSPEHAEARQ SLFLELLHIL 600
    SVDSEGFPRR AVMQVFTEWL RDGHADAAQD TEQFVATVLQ AASRDLDWEV 650
    RAQGLELALV FLGQTLGPPR THCPYAVALP EVAPAQPLTE ALRALCHVGL 700
    FDFAFCALFD CDRPVAQKSC DLLLFLRDKI ASYSSLREAR GSPNTASAEA 750
    TLPRWRAGEQ AQPPGDQEPE AVLAMLRSLD LEGLRSTLAE SSDHVEKSPQ 800
    SLLQDMLATG GFLQGDEADC Y 821
    Length:821
    Mass (Da):88,119
    Last modified:March 20, 2007 - v2
    Checksum:iC18FDDE8B13FEECD
    GO
    Isoform 2 (identifier: Q6PJG6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         270-286: PVFSSSDGSLWETVARA → GPRDAAGGPGWATVFLG
         287-821: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:286
    Mass (Da):30,560
    Checksum:iD72BCE177DB84E58
    GO
    Isoform 3 (identifier: Q6PJG6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-530: Missing.
         531-589: WGGQADFRCA...PTSPEHAEAR → MGKLRIGGPC...TNHPHLLPVP

    Note: No experimental confirmation available.Curated

    Show »
    Length:291
    Mass (Da):31,676
    Checksum:i3707108370D007AC
    GO

    Sequence cautioni

    The sequence BAB15772.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti644 – 6441R → Q in CAB61405. (PubMed:17974005)Curated
    Isoform 3 (identifier: Q6PJG6-3)
    Sequence conflicti49 – 491P → T in AAH40704. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti20 – 201R → G.1 Publication
    Corresponds to variant rs17856488 [ dbSNP | Ensembl ].
    VAR_031202
    Natural varianti737 – 7371R → W.
    Corresponds to variant rs60152725 [ dbSNP | Ensembl ].
    VAR_061594

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 530530Missing in isoform 3. 1 PublicationVSP_021288Add
    BLAST
    Alternative sequencei270 – 28617PVFSS…TVARA → GPRDAAGGPGWATVFLG in isoform 2. 1 PublicationVSP_021289Add
    BLAST
    Alternative sequencei287 – 821535Missing in isoform 2. 1 PublicationVSP_021290Add
    BLAST
    Alternative sequencei531 – 58959WGGQA…HAEAR → MGKLRIGGPCAHCAAWEGVR AGCGPRLHVRGQPPSCTGVL LREPRSCHPTNHPHLLPVP in isoform 3. 1 PublicationVSP_021291Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK024482 mRNA. Translation: BAB15772.1. Different initiation.
    AC092488 Genomic DNA. No translation available.
    CH236953 Genomic DNA. Translation: EAL23957.1.
    CH471144 Genomic DNA. Translation: EAW87257.1.
    CH471144 Genomic DNA. Translation: EAW87258.1.
    BC007209 mRNA. Translation: AAH07209.1.
    BC023561 mRNA. Translation: AAH23561.2.
    BC040704 mRNA. Translation: AAH40704.1.
    BC015632 mRNA. Translation: AAH15632.2.
    AL133088 mRNA. Translation: CAB61405.1.
    CCDSiCCDS5334.1. [Q6PJG6-1]
    PIRiT42692.
    RefSeqiNP_689956.2. NM_152743.3. [Q6PJG6-1]
    UniGeneiHs.520623.

    Genome annotation databases

    EnsembliENST00000340611; ENSP00000339637; ENSG00000106009. [Q6PJG6-1]
    GeneIDi221927.
    KEGGihsa:221927.
    UCSCiuc003smh.4. human. [Q6PJG6-3]
    uc003smi.3. human. [Q6PJG6-1]
    uc003smj.2. human. [Q6PJG6-2]

    Polymorphism databases

    DMDMi134047724.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK024482 mRNA. Translation: BAB15772.1 . Different initiation.
    AC092488 Genomic DNA. No translation available.
    CH236953 Genomic DNA. Translation: EAL23957.1 .
    CH471144 Genomic DNA. Translation: EAW87257.1 .
    CH471144 Genomic DNA. Translation: EAW87258.1 .
    BC007209 mRNA. Translation: AAH07209.1 .
    BC023561 mRNA. Translation: AAH23561.2 .
    BC040704 mRNA. Translation: AAH40704.1 .
    BC015632 mRNA. Translation: AAH15632.2 .
    AL133088 mRNA. Translation: CAB61405.1 .
    CCDSi CCDS5334.1. [Q6PJG6-1 ]
    PIRi T42692.
    RefSeqi NP_689956.2. NM_152743.3. [Q6PJG6-1 ]
    UniGenei Hs.520623.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4IFI X-ray 2.20 B 268-273 [» ]
    ProteinModelPortali Q6PJG6.
    SMRi Q6PJG6. Positions 116-174, 422-573.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128767. 6 interactions.
    MINTi MINT-4994139.
    STRINGi 9606.ENSP00000339637.

    PTM databases

    PhosphoSitei Q6PJG6.

    Polymorphism databases

    DMDMi 134047724.

    Proteomic databases

    MaxQBi Q6PJG6.
    PaxDbi Q6PJG6.
    PRIDEi Q6PJG6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000340611 ; ENSP00000339637 ; ENSG00000106009 . [Q6PJG6-1 ]
    GeneIDi 221927.
    KEGGi hsa:221927.
    UCSCi uc003smh.4. human. [Q6PJG6-3 ]
    uc003smi.3. human. [Q6PJG6-1 ]
    uc003smj.2. human. [Q6PJG6-2 ]

    Organism-specific databases

    CTDi 221927.
    GeneCardsi GC07M002577.
    HGNCi HGNC:21701. BRAT1.
    HPAi HPA029455.
    MIMi 614498. phenotype.
    614506. gene.
    neXtProti NX_Q6PJG6.
    PharmGKBi PA134959439.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG27983.
    HOVERGENi HBG062139.
    InParanoidi Q6PJG6.
    OMAi RLCSPCW.
    OrthoDBi EOG779NXD.
    PhylomeDBi Q6PJG6.
    TreeFami TF324349.

    Miscellaneous databases

    GenomeRNAii 221927.
    NextBioi 91494.
    PROi Q6PJG6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6PJG6.
    Bgeei Q6PJG6.
    CleanExi HS_C7orf27.
    Genevestigatori Q6PJG6.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000357. HEAT.
    [Graphical view ]
    Pfami PF02985. HEAT. 2 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Spleen.
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT GLY-20.
      Tissue: Duodenum, Placenta and Skin.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 346-821.
      Tissue: Testis.
    7. "ATM activation by ionizing radiation requires BRCA1-associated BAAT1."
      Aglipay J.A., Martin S.A., Tawara H., Lee S.W., Ouchi T.
      J. Biol. Chem. 281:9710-9718(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH BRCA1 AND ATM.
    8. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-742, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-742, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-742, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-742, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. Cited for: INVOLVEMENT IN RMFSL.

    Entry informationi

    Entry nameiBRAT1_HUMAN
    AccessioniPrimary (citable) accession number: Q6PJG6
    Secondary accession number(s): A4D200
    , C9JY24, Q8IW85, Q8IZ43, Q8WVR8, Q96IV9, Q9H7J8, Q9UFA3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

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