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Q6PJF5

- RHDF2_HUMAN

UniProt

Q6PJF5 - RHDF2_HUMAN

Protein

Inactive rhomboid protein 2

Gene

RHBDF2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration By similarity.By similarity

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    GO - Biological processi

    1. negative regulation of protein secretion Source: UniProtKB
    2. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    Growth factor binding

    Protein family/group databases

    MEROPSiS54.953.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inactive rhomboid protein 2
    Short name:
    iRhom2
    Alternative name(s):
    Rhomboid 5 homolog 2
    Rhomboid family member 2
    Rhomboid veinlet-like protein 5
    Rhomboid veinlet-like protein 6
    Gene namesi
    Name:RHBDF2
    Synonyms:IRHOM2, RHBDL5, RHBDL6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:20788. RHBDF2.

    Subcellular locationi

    Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity. Cell membrane 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Tylosis with esophageal cancer (TOC) [MIM:148500]: An autosomal dominant syndrome characterized by diffuse palmoplantar keratoderma, oral leukokeratosis, and a high lifetime risk of esophageal cancer.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti186 – 1861I → T in TOC. 1 Publication
    VAR_067827
    Natural varianti189 – 1891P → L in TOC. 1 Publication
    VAR_067828

    Keywords - Diseasei

    Disease mutation, Palmoplantar keratoderma

    Organism-specific databases

    MIMi148500. phenotype.
    Orphaneti2198. Palmoplantar keratoderma-esophageal carcinoma syndrome.
    PharmGKBiPA134980674.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 856856Inactive rhomboid protein 2PRO_0000341938Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei90 – 901Phosphoserine1 Publication
    Modified residuei113 – 1131PhosphoserineBy similarity
    Modified residuei117 – 1171PhosphoserineBy similarity
    Modified residuei323 – 3231PhosphoserineBy similarity
    Modified residuei325 – 3251Phosphoserine1 Publication
    Modified residuei328 – 3281Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ6PJF5.
    PaxDbiQ6PJF5.
    PRIDEiQ6PJF5.

    PTM databases

    PhosphoSiteiQ6PJF5.

    Expressioni

    Tissue specificityi

    Found in the epidermis and esophageal epithelium.1 Publication

    Gene expression databases

    ArrayExpressiQ6PJF5.
    BgeeiQ6PJF5.
    CleanExiHS_RHBDF2.
    GenevestigatoriQ6PJF5.

    Organism-specific databases

    HPAiHPA018080.

    Interactioni

    Subunit structurei

    Interacts with EGF.By similarity

    Protein-protein interaction databases

    BioGridi122779. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PJF5.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 409409CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini431 – 660230LumenalSequence AnalysisAdd
    BLAST
    Topological domaini682 – 69211CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini714 – 7152LumenalSequence Analysis
    Topological domaini737 – 74711CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini769 – 7735LumenalSequence Analysis
    Topological domaini795 – 8028CytoplasmicSequence Analysis
    Topological domaini824 – 85633LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei410 – 43021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei661 – 68121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei693 – 71321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei716 – 73621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei748 – 76821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei774 – 79421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei803 – 82321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S54 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0705.
    HOGENOMiHOG000154118.
    HOVERGENiHBG059673.
    InParanoidiQ6PJF5.
    OMAiRGIPHSA.
    OrthoDBiEOG7288QH.
    PhylomeDBiQ6PJF5.
    TreeFamiTF312988.

    Family and domain databases

    Gene3Di1.20.1540.10. 2 hits.
    InterProiIPR002610. Peptidase_S54_rhomboid.
    IPR022764. Peptidase_S54_rhomboid_dom.
    IPR022241. Rhomboid_SP.
    [Graphical view]
    PANTHERiPTHR22936. PTHR22936. 1 hit.
    PfamiPF01694. Rhomboid. 1 hit.
    PF12595. Rhomboid_SP. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6PJF5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASADKNGGS VSSVSSSRLQ SRKPPNLSIT IPPPEKETQA PGEQDSMLPE    50
    GFQNRRLKKS QPRTWAAHTT ACPPSFLPKR KNPAYLKSVS LQEPRSRWQE 100
    SSEKRPGFRR QASLSQSIRK GAAQWFGVSG DWEGQRQQWQ RRSLHHCSMR 150
    YGRLKASCQR DLELPSQEAP SFQGTESPKP CKMPKIVDPL ARGRAFRHPE 200
    EMDRPHAPHP PLTPGVLSLT SFTSVRSGYS HLPRRKRMSV AHMSLQAAAA 250
    LLKGRSVLDA TGQRCRVVKR SFAFPSFLEE DVVDGADTFD SSFFSKEEMS 300
    SMPDDVFESP PLSASYFRGI PHSASPVSPD GVQIPLKEYG RAPVPGPRRG 350
    KRIASKVKHF AFDRKKRHYG LGVVGNWLNR SYRRSISSTV QRQLESFDSH 400
    RPYFTYWLTF VHVIITLLVI CTYGIAPVGF AQHVTTQLVL RNKGVYESVK 450
    YIQQENFWVG PSSIDLIHLG AKFSPCIRKD GQIEQLVLRE RDLERDSGCC 500
    VQNDHSGCIQ TQRKDCSETL ATFVKWQDDT GPPMDKSDLG QKRTSGAVCH 550
    QDPRTCEEPA SSGAHIWPDD ITKWPICTEQ ARSNHTGFLH MDCEIKGRPC 600
    CIGTKGSCEI TTREYCEFMH GYFHEEATLC SQVHCLDKVC GLLPFLNPEV 650
    PDQFYRLWLS LFLHAGVVHC LVSVVFQMTI LRDLEKLAGW HRIAIIFILS 700
    GITGNLASAI FLPYRAEVGP AGSQFGLLAC LFVELFQSWP LLERPWKAFL 750
    NLSAIVLFLF ICGLLPWIDN IAHIFGFLSG LLLAFAFLPY ITFGTSDKYR 800
    KRALILVSLL AFAGLFAALV LWLYIYPINW PWIEHLTCFP FTSRFCEKYE 850
    LDQVLH 856
    Length:856
    Mass (Da):96,686
    Last modified:July 1, 2008 - v2
    Checksum:i69C40A21EBDBDDC0
    GO
    Isoform 2 (identifier: Q6PJF5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         51-79: Missing.

    Show »
    Length:827
    Mass (Da):93,379
    Checksum:iEEE77126D9D48F86
    GO

    Sequence cautioni

    The sequence AAH35829.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence BAB15310.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti67 – 671A → S in BAF84824. (PubMed:14702039)Curated
    Sequence conflicti67 – 671A → S in AAH16034. (PubMed:15489334)Curated
    Sequence conflicti705 – 7051N → D in BAF84855. (PubMed:14702039)Curated
    Sequence conflicti852 – 8521D → G in BAF84855. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti186 – 1861I → T in TOC. 1 Publication
    VAR_067827
    Natural varianti189 – 1891P → L in TOC. 1 Publication
    VAR_067828
    Natural varianti208 – 2081P → L.3 Publications
    Corresponds to variant rs3744045 [ dbSNP | Ensembl ].
    VAR_044125
    Natural varianti249 – 2491A → T.
    Corresponds to variant rs34814954 [ dbSNP | Ensembl ].
    VAR_044126
    Natural varianti528 – 5281D → Y.
    Corresponds to variant rs11553545 [ dbSNP | Ensembl ].
    VAR_044127

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei51 – 7929Missing in isoform 2. 2 PublicationsVSP_034368Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY500247 mRNA. Translation: AAS77567.1.
    AK025994 mRNA. Translation: BAB15310.1. Different initiation.
    AK292135 mRNA. Translation: BAF84824.1.
    AK292166 mRNA. Translation: BAF84855.1.
    AC015802 Genomic DNA. No translation available.
    BC035829 mRNA. Translation: AAH35829.1. Different initiation.
    BC016034 mRNA. Translation: AAH16034.2.
    CCDSiCCDS32743.1. [Q6PJF5-1]
    CCDS32744.1. [Q6PJF5-2]
    RefSeqiNP_001005498.2. NM_001005498.3. [Q6PJF5-2]
    NP_078875.4. NM_024599.5. [Q6PJF5-1]
    XP_005257726.1. XM_005257669.1. [Q6PJF5-1]
    XP_005257727.1. XM_005257670.1. [Q6PJF5-2]
    UniGeneiHs.464157.

    Genome annotation databases

    EnsembliENST00000313080; ENSP00000322775; ENSG00000129667. [Q6PJF5-1]
    ENST00000591885; ENSP00000466867; ENSG00000129667. [Q6PJF5-2]
    GeneIDi79651.
    KEGGihsa:79651.
    UCSCiuc002jrq.2. human. [Q6PJF5-1]
    uc021udh.1. human. [Q6PJF5-2]

    Polymorphism databases

    DMDMi193806488.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY500247 mRNA. Translation: AAS77567.1 .
    AK025994 mRNA. Translation: BAB15310.1 . Different initiation.
    AK292135 mRNA. Translation: BAF84824.1 .
    AK292166 mRNA. Translation: BAF84855.1 .
    AC015802 Genomic DNA. No translation available.
    BC035829 mRNA. Translation: AAH35829.1 . Different initiation.
    BC016034 mRNA. Translation: AAH16034.2 .
    CCDSi CCDS32743.1. [Q6PJF5-1 ]
    CCDS32744.1. [Q6PJF5-2 ]
    RefSeqi NP_001005498.2. NM_001005498.3. [Q6PJF5-2 ]
    NP_078875.4. NM_024599.5. [Q6PJF5-1 ]
    XP_005257726.1. XM_005257669.1. [Q6PJF5-1 ]
    XP_005257727.1. XM_005257670.1. [Q6PJF5-2 ]
    UniGenei Hs.464157.

    3D structure databases

    ProteinModelPortali Q6PJF5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122779. 1 interaction.

    Protein family/group databases

    MEROPSi S54.953.

    PTM databases

    PhosphoSitei Q6PJF5.

    Polymorphism databases

    DMDMi 193806488.

    Proteomic databases

    MaxQBi Q6PJF5.
    PaxDbi Q6PJF5.
    PRIDEi Q6PJF5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000313080 ; ENSP00000322775 ; ENSG00000129667 . [Q6PJF5-1 ]
    ENST00000591885 ; ENSP00000466867 ; ENSG00000129667 . [Q6PJF5-2 ]
    GeneIDi 79651.
    KEGGi hsa:79651.
    UCSCi uc002jrq.2. human. [Q6PJF5-1 ]
    uc021udh.1. human. [Q6PJF5-2 ]

    Organism-specific databases

    CTDi 79651.
    GeneCardsi GC17M074466.
    HGNCi HGNC:20788. RHBDF2.
    HPAi HPA018080.
    MIMi 148500. phenotype.
    614404. gene.
    neXtProti NX_Q6PJF5.
    Orphaneti 2198. Palmoplantar keratoderma-esophageal carcinoma syndrome.
    PharmGKBi PA134980674.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0705.
    HOGENOMi HOG000154118.
    HOVERGENi HBG059673.
    InParanoidi Q6PJF5.
    OMAi RGIPHSA.
    OrthoDBi EOG7288QH.
    PhylomeDBi Q6PJF5.
    TreeFami TF312988.

    Miscellaneous databases

    GeneWikii RHBDF2.
    GenomeRNAii 79651.
    NextBioi 68812.
    PROi Q6PJF5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6PJF5.
    Bgeei Q6PJF5.
    CleanExi HS_RHBDF2.
    Genevestigatori Q6PJF5.

    Family and domain databases

    Gene3Di 1.20.1540.10. 2 hits.
    InterProi IPR002610. Peptidase_S54_rhomboid.
    IPR022764. Peptidase_S54_rhomboid_dom.
    IPR022241. Rhomboid_SP.
    [Graphical view ]
    PANTHERi PTHR22936. PTHR22936. 1 hit.
    Pfami PF01694. Rhomboid. 1 hit.
    PF12595. Rhomboid_SP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of human RHBDL5."
      Kong X., Teng X., Hu L.
      Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT LEU-208.
      Tissue: Liver.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT LEU-208.
      Tissue: Kidney epithelium, Spleen and Synovium.
    3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-208.
      Tissue: Eye and Uterus.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90; SER-325 AND SER-328, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, VARIANTS TOC THR-186 AND LEU-189.

    Entry informationi

    Entry nameiRHDF2_HUMAN
    AccessioniPrimary (citable) accession number: Q6PJF5
    Secondary accession number(s): A6NEM3
    , A8K801, Q5U607, Q5YGQ8, Q9H6E9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3