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Protein
Submitted name:

IGK@ protein

Gene

IGK@

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
IGK@ proteinImported
Gene namesi
Name:IGK@Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PRIDEiQ6PJF2.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DN0X-ray2.28A/C21-235[»]
1QLRX-ray2.83A/C21-235[»]
2AGJX-ray2.60L21-235[»]
3EYFX-ray2.30A/C21-235[»]
3EYOX-ray2.50A/C21-235[»]
ProteinModelPortaliQ6PJF2.
SMRiQ6PJF2. Positions 21-235.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6PJF2.

Family & Domainsi

Keywords - Domaini

Immunoglobulin domainSAAS annotation

Phylogenomic databases

HOVERGENiHBG018013.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 2 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PJF2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METPAQLLFL LLLWLPGTTG EIVLTQSPAT LSLSPGERAT LSCRASQIVS
60 70 80 90 100
SAYLAWYQQK PGQAPRLLMF GSSSRATGIP DRFSGSGSGT DFTLTISRLE
110 120 130 140 150
PEDFAVYYCQ QYGSSQGTFG PGTKVDIKRT VAAPSVFIFP PSDEQLKSGT
160 170 180 190 200
ASVVCLLNNF YPREAKVQWK VDNALQSGNS QESVTEQDSK DSTYSLSSTL
210 220 230
TLSKADYEKH KVYACEVTHQ GLSSPVTKSF NRGEC
Length:235
Mass (Da):25,521
Last modified:July 5, 2004 - v1
Checksum:iF33A145A396BA285
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC016380 mRNA. Translation: AAH16380.1.
UniGeneiHs.449609.
Hs.719895.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC016380 mRNA. Translation: AAH16380.1.
UniGeneiHs.449609.
Hs.719895.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DN0X-ray2.28A/C21-235[»]
1QLRX-ray2.83A/C21-235[»]
2AGJX-ray2.60L21-235[»]
3EYFX-ray2.30A/C21-235[»]
3EYOX-ray2.50A/C21-235[»]
ProteinModelPortaliQ6PJF2.
SMRiQ6PJF2. Positions 21-235.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ6PJF2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG018013.

Miscellaneous databases

EvolutionaryTraceiQ6PJF2.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 2 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Three-dimensional structure of the Fab from a human IgM cold agglutinin."
    Cauerhff A., Braden B.C., Carvalho J.G., Aparicio R., Polikarpov I., Leoni J., Goldbaum F.A.
    J. Immunol. 165:6422-6428(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.28 ANGSTROMS) OF 21-235, ACTIVE SITE.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: LungImported.
  3. "Crystal structure of a glycosylated Fab from an IgM cryoglobulin with properties of a natural proteolytic antibody."
    Ramsland P.A., Terzyan S.S., Cloud G., Bourne C.R., Farrugia W., Tribbick G., Geysen H.M., Moomaw C.R., Slaughter C.A., Edmundson A.B.
    Biochem. J. 395:473-481(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 21-235, ACTIVE SITE.
  4. "Germline V-genes sculpt the binding site of a family of antibodies neutralizing human cytomegalovirus."
    Thomson C.A., Bryson S., McLean G.R., Creagh A.L., Pai E.F., Schrader J.W.
    EMBO J. 27:2592-2602(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 21-235, ACTIVE SITE.

Entry informationi

Entry nameiQ6PJF2_HUMAN
AccessioniPrimary (citable) accession number: Q6PJF2
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.