Q6PJE2 (POZP3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
POM121 and ZP3 fusion protein
Short name=POM-ZP3

Gene names

Name:

POMZP3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	187 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Tissue specificity	Expressed in spleen, thymus, pancreas, testis, ovary, small intestine, colon and lymphocytes. Ref.1
Caution	The POM-ZP3 transcript appears to have arisen from a partial duplication and fusion of a 5' portion of a POM121 homolog and exons 5-8 of ZP3.
Sequence caution	The sequence AAA85788.1 differs from that shown. Reason: Frameshift at position 187.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6PJE2-4)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6PJE2-5)

The sequence of this isoform differs from the canonical sequence as follows:
     116-187: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 187	187	POM121 and ZP3 fusion protein		PRO_0000204909
Regions
	Compositional bias	52 – 57	6	Poly-Lys
Natural variations
	Alternative sequence	116 – 187	72	Missing in isoform 2.		VSP_046257
	Natural variant	176	1	R → H. Corresponds to variant rs17341271 [ dbSNP | Ensembl ].		VAR_056721

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 5, 2010. Version 4. Checksum: EF36674F9192196F	FASTA	187	20,620
	10 20 30 40 50 60 MVCSPVTLRI APPDRRFSRS AIPEQIISST LSSPSSNAPD PCAKETVLSA LKEKKKKRTV 70 80 90 100 110 120 EEEDQIFLDG QENKRSCLVD GLTDASSAFK VPRPGPDTLQ FTVDVFHFAN DSRNMIYITC 130 140 150 160 170 180 HLKVTLAEQD PDELNKACSF SKPSNSWFPV EGLADICQCC NKGDCGTPSH SRRQPRVVSQ WSTSASL
	Isoform 2 [UniParc]. Checksum: DF7C93B3494413DA	FASTA	115	12,695
	10 20 30 40 50 60 MVCSPVTLRI APPDRRFSRS AIPEQIISST LSSPSSNAPD PCAKETVLSA LKEKKKKRTV 70 80 90 100 110 EEEDQIFLDG QENKRSCLVD GLTDASSAFK VPRPGPDTLQ FTVDVFHFAN DSRNM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"POM-ZP3, a bipartite transcript derived from human ZP3 and a POM121 homologue." Kipersztok S., Osawa G.A., Liang L.-F., Modi W.S., Dean J. Genomics 25:354-359(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY. Tissue: Ovary.
[2]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U10099 mRNA. Translation: AAA85788.1. Frameshift. AC004980 Genomic DNA. No translation available.
IPI	IPI00171249.
PIR	A56844. B44365.
RefSeq	NP_036362.3. NM_012230.3. NP_694537.1. NM_152992.2.
UniGene	Hs.488877.
3D structure databases
ProteinModelPortal	Q6PJE2.
SMR	Q6PJE2. Positions 77-168.
ModBase	Search...
PTM databases
PhosphoSite	Q6PJE2.
Proteomic databases
PaxDb	Q6PJE2.
PRIDE	Q6PJE2.
Protocols and materials databases
DNASU	22932.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000275569; ENSP00000275569; ENSG00000146707. ENST00000310842; ENSP00000309233; ENSG00000146707.
GeneID	22932.
KEGG	hsa:22932.
UCSC	uc003uft.3. human.
Organism-specific databases
CTD	22932.
GeneCards	GC07M076239.
HGNC	HGNC:9203. POMZP3.
HPA	HPA049817.
MIM	600587. gene.
neXtProt	NX_Q6PJE2.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG43042.
HOVERGEN	HBG082160.
InParanoid	Q6PJE2.
OMA	QENKRSC.
Gene expression databases
ArrayExpress	Q6PJE2.
Bgee	Q6PJE2.
CleanEx	HS_POMZP3.
Genevestigator	Q6PJE2.
GermOnline	ENSG00000146707. Homo sapiens.
Family and domain databases
InterPro	IPR026054. Nucleoporin. IPR026090. POM121. IPR001507. ZP_dom. [Graphical view]
PANTHER	PTHR23193. PTHR23193. 1 hit. PTHR23193:SF5. PTHR23193:SF5. 1 hit.
Pfam	PF00100. Zona_pellucida. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	22932.
NextBio	43663.
SOURCE	Search...

Entry information

Entry name

POZP3_HUMAN

Accession

Primary (citable) accession number: Q6PJE2
Secondary accession number(s): F6STJ3, Q12903, Q9BWB4

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	October 5, 2010
Last modified:	May 1, 2013
This is version 72 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.