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Protein

POM121 and ZP3 fusion protein

Gene

POMZP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
POM121 and ZP3 fusion protein
Short name:
POM-ZP3
Gene namesi
Name:POMZP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:9203. POMZP3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiPOMZP3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 187187POM121 and ZP3 fusion proteinPRO_0000204909Add
BLAST

Proteomic databases

EPDiQ6PJE2.
PaxDbiQ6PJE2.
PRIDEiQ6PJE2.

PTM databases

iPTMnetiQ6PJE2.
PhosphoSiteiQ6PJE2.

Expressioni

Tissue specificityi

Expressed in spleen, thymus, pancreas, testis, ovary, small intestine, colon and lymphocytes.1 Publication

Gene expression databases

BgeeiQ6PJE2.
CleanExiHS_POMZP3.
ExpressionAtlasiQ6PJE2. baseline and differential.
GenevisibleiQ6PJE2. HS.

Organism-specific databases

HPAiHPA049817.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116592. 3 interactions.
IntActiQ6PJE2. 1 interaction.
STRINGi9606.ENSP00000309233.

Structurei

3D structure databases

ProteinModelPortaliQ6PJE2.
SMRiQ6PJE2. Positions 77-168.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi52 – 576Poly-Lys

Phylogenomic databases

eggNOGiENOG410KCME. Eukaryota.
ENOG4110NUC. LUCA.
GeneTreeiENSGT00530000063482.
HOVERGENiHBG082160.
InParanoidiQ6PJE2.
OMAiPRVVSQW.
OrthoDBiEOG7QG440.
PhylomeDBiQ6PJE2.

Family and domain databases

InterProiIPR001507. ZP_dom.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PJE2-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVCSPVTLRI APPDRRFSRS AIPEQIISST LSSPSSNAPD PCAKETVLSA
60 70 80 90 100
LKEKKKKRTV EEEDQIFLDG QENKRSCLVD GLTDASSAFK VPRPGPDTLQ
110 120 130 140 150
FTVDVFHFAN DSRNMIYITC HLKVTLAEQD PDELNKACSF SKPSNSWFPV
160 170 180
EGLADICQCC NKGDCGTPSH SRRQPRVVSQ WSTSASL
Length:187
Mass (Da):20,620
Last modified:October 5, 2010 - v4
Checksum:iEF36674F9192196F
GO
Isoform 2 (identifier: Q6PJE2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     116-187: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:115
Mass (Da):12,695
Checksum:iDF7C93B3494413DA
GO

Sequence cautioni

The sequence AAA85788.1 differs from that shown. Reason: Frameshift at position 187. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti176 – 1761R → H.
Corresponds to variant rs17341271 [ dbSNP | Ensembl ].
VAR_056721

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei116 – 18772Missing in isoform 2. CuratedVSP_046257Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10099 mRNA. Translation: AAA85788.1. Frameshift.
AC004980 Genomic DNA. No translation available.
CCDSiCCDS43606.1. [Q6PJE2-4]
CCDS5590.1. [Q6PJE2-5]
PIRiA56844.
B44365.
RefSeqiNP_036362.3. NM_012230.3. [Q6PJE2-4]
NP_694537.1. NM_152992.2. [Q6PJE2-5]
UniGeneiHs.488877.

Genome annotation databases

EnsembliENST00000275569; ENSP00000275569; ENSG00000146707. [Q6PJE2-5]
ENST00000310842; ENSP00000309233; ENSG00000146707. [Q6PJE2-4]
ENST00000615241; ENSP00000484663; ENSG00000276464. [Q6PJE2-5]
ENST00000619075; ENSP00000477906; ENSG00000276464. [Q6PJE2-4]
GeneIDi22932.
KEGGihsa:22932.
UCSCiuc003uft.4. human. [Q6PJE2-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10099 mRNA. Translation: AAA85788.1. Frameshift.
AC004980 Genomic DNA. No translation available.
CCDSiCCDS43606.1. [Q6PJE2-4]
CCDS5590.1. [Q6PJE2-5]
PIRiA56844.
B44365.
RefSeqiNP_036362.3. NM_012230.3. [Q6PJE2-4]
NP_694537.1. NM_152992.2. [Q6PJE2-5]
UniGeneiHs.488877.

3D structure databases

ProteinModelPortaliQ6PJE2.
SMRiQ6PJE2. Positions 77-168.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116592. 3 interactions.
IntActiQ6PJE2. 1 interaction.
STRINGi9606.ENSP00000309233.

PTM databases

iPTMnetiQ6PJE2.
PhosphoSiteiQ6PJE2.

Polymorphism and mutation databases

BioMutaiPOMZP3.

Proteomic databases

EPDiQ6PJE2.
PaxDbiQ6PJE2.
PRIDEiQ6PJE2.

Protocols and materials databases

DNASUi22932.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275569; ENSP00000275569; ENSG00000146707. [Q6PJE2-5]
ENST00000310842; ENSP00000309233; ENSG00000146707. [Q6PJE2-4]
ENST00000615241; ENSP00000484663; ENSG00000276464. [Q6PJE2-5]
ENST00000619075; ENSP00000477906; ENSG00000276464. [Q6PJE2-4]
GeneIDi22932.
KEGGihsa:22932.
UCSCiuc003uft.4. human. [Q6PJE2-4]

Organism-specific databases

CTDi22932.
GeneCardsiPOMZP3.
HGNCiHGNC:9203. POMZP3.
HPAiHPA049817.
MIMi600587. gene.
neXtProtiNX_Q6PJE2.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KCME. Eukaryota.
ENOG4110NUC. LUCA.
GeneTreeiENSGT00530000063482.
HOVERGENiHBG082160.
InParanoidiQ6PJE2.
OMAiPRVVSQW.
OrthoDBiEOG7QG440.
PhylomeDBiQ6PJE2.

Miscellaneous databases

GenomeRNAii22932.
PROiQ6PJE2.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PJE2.
CleanExiHS_POMZP3.
ExpressionAtlasiQ6PJE2. baseline and differential.
GenevisibleiQ6PJE2. HS.

Family and domain databases

InterProiIPR001507. ZP_dom.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "POM-ZP3, a bipartite transcript derived from human ZP3 and a POM121 homologue."
    Kipersztok S., Osawa G.A., Liang L.-F., Modi W.S., Dean J.
    Genomics 25:354-359(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Ovary.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPOZP3_HUMAN
AccessioniPrimary (citable) accession number: Q6PJE2
Secondary accession number(s): F6STJ3, Q12903, Q9BWB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 5, 2010
Last modified: June 8, 2016
This is version 97 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The POM-ZP3 transcript appears to have arisen from a partial duplication and fusion of a 5' portion of a POM121 homolog and exons 5-8 of ZP3.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.