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Q6PJ69

- TRI65_HUMAN

UniProt

Q6PJ69 - TRI65_HUMAN

Protein

Tripartite motif-containing protein 65

Gene

TRIM65

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri12 – 5140RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri90 – 13748B box-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tripartite motif-containing protein 65
    Gene namesi
    Name:TRIM65
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:27316. TRIM65.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134877726.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 517516Tripartite motif-containing protein 65PRO_0000249191Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine2 Publications

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ6PJ69.
    PaxDbiQ6PJ69.
    PRIDEiQ6PJ69.

    PTM databases

    PhosphoSiteiQ6PJ69.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6PJ69.
    BgeeiQ6PJ69.
    CleanExiHS_TRIM65.
    GenevestigatoriQ6PJ69.

    Organism-specific databases

    HPAiHPA021575.
    HPA021578.

    Interactioni

    Protein-protein interaction databases

    BioGridi128382. 11 interactions.
    IntActiQ6PJ69. 9 interactions.
    MINTiMINT-8247621.
    STRINGi9606.ENSP00000269383.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PJ69.
    SMRiQ6PJ69. Positions 6-51, 129-256, 372-500.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini313 – 506194B30.2/SPRYPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili139 – 22789Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRIM/RBCC family.Curated
    Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
    Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri12 – 5140RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri90 – 13748B box-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG306486.
    HOGENOMiHOG000231106.
    HOVERGENiHBG080119.
    InParanoidiQ6PJ69.
    KOiK12031.
    OMAiQPLYTFH.
    PhylomeDBiQ6PJ69.
    TreeFamiTF351090.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    4.10.45.10. 1 hit.
    InterProiIPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR003877. SPRY_rcpt.
    IPR000315. Znf_B-box.
    IPR018957. Znf_C3HC4_RING-type.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PfamiPF00622. SPRY. 1 hit.
    PF00643. zf-B_box. 1 hit.
    PF00097. zf-C3HC4. 1 hit.
    [Graphical view]
    PRINTSiPR01407. BUTYPHLNCDUF.
    SMARTiSM00184. RING. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS50188. B302_SPRY. 1 hit.
    PS50119. ZF_BBOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6PJ69-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAQLLEEKL TCAICLGLYQ DPVTLPCGHN FCGACIRDWW DRCGKACPEC    50
    REPFPDGAEL RRNVALSGVL EVVRAGPARD PGPDPGPGPD PAARCPRHGR 100
    PLELFCRTEG RCVCSVCTVR ECRLHERALL DAERLKREAQ LRASLEVTQQ 150
    QATQAEGQLL ELRKQSSQIQ NSACILASWV SGKFSSLLQA LEIQHTTALR 200
    SIEVAKTQAL AQARDEEQRL RVHLEAVARH GCRIRELLEQ VDEQTFLQES 250
    QLLQPPGPLG PLTPLQWDED QQLGDLKQLL SRLCGLLLEE GSHPGAPAKP 300
    VDLAPVEAPG PLAPVPSTVC PLRRKLWQNY RNLTFDPVSA NRHFYLSRQD 350
    QQVKHCRQSR GPGGPGSFEL WQVQCAQSFQ AGHHYWEVRA SDHSVTLGVS 400
    YPQLPRCRLG PHTDNIGRGP CSWGLCVQED SLQAWHNGEA QRLPGVSGRL 450
    LGMDLDLASG CLTFYSLEPQ TQPLYTFHAL FNQPLTPVFW LLEGRTLTLC 500
    HQPGAVFPLG PQEEVLS 517
    Length:517
    Mass (Da):57,353
    Last modified:May 18, 2010 - v3
    Checksum:i1382A178CB99BBBA
    GO

    Sequence cautioni

    The sequence AAH73831.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti222 – 2221V → G.1 Publication
    Corresponds to variant rs7222757 [ dbSNP | Ensembl ].
    VAR_060245
    Natural varianti364 – 3641G → R.
    Corresponds to variant rs34593741 [ dbSNP | Ensembl ].
    VAR_057224
    Natural varianti366 – 3661G → S.
    Corresponds to variant rs9892938 [ dbSNP | Ensembl ].
    VAR_057225
    Natural varianti509 – 5091L → P.1 Publication
    Corresponds to variant rs3760128 [ dbSNP | Ensembl ].
    VAR_060246

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC087289 Genomic DNA. No translation available.
    BC006138 mRNA. Translation: AAH06138.1.
    BC021259 mRNA. Translation: AAH21259.2.
    BC073831 mRNA. Translation: AAH73831.1. Different initiation.
    BC098412 mRNA. Translation: AAH98412.1.
    CCDSiCCDS11732.1.
    RefSeqiNP_001243053.1. NM_001256124.1.
    NP_775818.2. NM_173547.3.
    UniGeneiHs.189823.

    Genome annotation databases

    EnsembliENST00000269383; ENSP00000269383; ENSG00000141569.
    GeneIDi201292.
    KEGGihsa:201292.
    UCSCiuc002jpx.4. human.

    Polymorphism databases

    DMDMi296453004.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC087289 Genomic DNA. No translation available.
    BC006138 mRNA. Translation: AAH06138.1 .
    BC021259 mRNA. Translation: AAH21259.2 .
    BC073831 mRNA. Translation: AAH73831.1 . Different initiation.
    BC098412 mRNA. Translation: AAH98412.1 .
    CCDSi CCDS11732.1.
    RefSeqi NP_001243053.1. NM_001256124.1.
    NP_775818.2. NM_173547.3.
    UniGenei Hs.189823.

    3D structure databases

    ProteinModelPortali Q6PJ69.
    SMRi Q6PJ69. Positions 6-51, 129-256, 372-500.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128382. 11 interactions.
    IntActi Q6PJ69. 9 interactions.
    MINTi MINT-8247621.
    STRINGi 9606.ENSP00000269383.

    PTM databases

    PhosphoSitei Q6PJ69.

    Polymorphism databases

    DMDMi 296453004.

    Proteomic databases

    MaxQBi Q6PJ69.
    PaxDbi Q6PJ69.
    PRIDEi Q6PJ69.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000269383 ; ENSP00000269383 ; ENSG00000141569 .
    GeneIDi 201292.
    KEGGi hsa:201292.
    UCSCi uc002jpx.4. human.

    Organism-specific databases

    CTDi 201292.
    GeneCardsi GC17M073885.
    H-InvDB HIX0014178.
    HGNCi HGNC:27316. TRIM65.
    HPAi HPA021575.
    HPA021578.
    neXtProti NX_Q6PJ69.
    PharmGKBi PA134877726.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG306486.
    HOGENOMi HOG000231106.
    HOVERGENi HBG080119.
    InParanoidi Q6PJ69.
    KOi K12031.
    OMAi QPLYTFH.
    PhylomeDBi Q6PJ69.
    TreeFami TF351090.

    Miscellaneous databases

    GenomeRNAii 201292.
    NextBioi 90125.
    PROi Q6PJ69.

    Gene expression databases

    ArrayExpressi Q6PJ69.
    Bgeei Q6PJ69.
    CleanExi HS_TRIM65.
    Genevestigatori Q6PJ69.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    4.10.45.10. 1 hit.
    InterProi IPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR003877. SPRY_rcpt.
    IPR000315. Znf_B-box.
    IPR018957. Znf_C3HC4_RING-type.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    Pfami PF00622. SPRY. 1 hit.
    PF00643. zf-B_box. 1 hit.
    PF00097. zf-C3HC4. 1 hit.
    [Graphical view ]
    PRINTSi PR01407. BUTYPHLNCDUF.
    SMARTi SM00184. RING. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS50188. B302_SPRY. 1 hit.
    PS50119. ZF_BBOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-222 AND PRO-509.
      Tissue: Brain, Liver and Lymph.
    3. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    4. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTRI65_HUMAN
    AccessioniPrimary (citable) accession number: Q6PJ69
    Secondary accession number(s): Q4G0F0, Q6DKJ6, Q9BRP6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 97 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3