Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q6PJ69 (TRI65_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tripartite motif-containing protein 65
Gene names
Name:TRIM65
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length517 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the TRIM/RBCC family.

Contains 1 B box-type zinc finger.

Contains 1 B30.2/SPRY domain.

Contains 1 RING-type zinc finger.

Sequence caution

The sequence AAH73831.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainCoiled coil
Zinc-finger
   LigandMetal-binding
Zinc
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintracellular

Inferred from electronic annotation. Source: InterPro

   Molecular_functionzinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.3
Chain2 – 517516Tripartite motif-containing protein 65
PRO_0000249191

Regions

Domain313 – 506194B30.2/SPRY
Zinc finger12 – 5140RING-type
Zinc finger90 – 13748B box-type
Coiled coil139 – 22789 Potential

Amino acid modifications

Modified residue21N-acetylalanine Ref.3 Ref.4

Natural variations

Natural variant2221V → G. Ref.2
Corresponds to variant rs7222757 [ dbSNP | Ensembl ].
VAR_060245
Natural variant3641G → R.
Corresponds to variant rs34593741 [ dbSNP | Ensembl ].
VAR_057224
Natural variant3661G → S.
Corresponds to variant rs9892938 [ dbSNP | Ensembl ].
VAR_057225
Natural variant5091L → P. Ref.2
Corresponds to variant rs3760128 [ dbSNP | Ensembl ].
VAR_060246

Sequences

Sequence LengthMass (Da)Tools
Q6PJ69 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: 1382A178CB99BBBA

FASTA51757,353
        10         20         30         40         50         60 
MAAQLLEEKL TCAICLGLYQ DPVTLPCGHN FCGACIRDWW DRCGKACPEC REPFPDGAEL 

        70         80         90        100        110        120 
RRNVALSGVL EVVRAGPARD PGPDPGPGPD PAARCPRHGR PLELFCRTEG RCVCSVCTVR 

       130        140        150        160        170        180 
ECRLHERALL DAERLKREAQ LRASLEVTQQ QATQAEGQLL ELRKQSSQIQ NSACILASWV 

       190        200        210        220        230        240 
SGKFSSLLQA LEIQHTTALR SIEVAKTQAL AQARDEEQRL RVHLEAVARH GCRIRELLEQ 

       250        260        270        280        290        300 
VDEQTFLQES QLLQPPGPLG PLTPLQWDED QQLGDLKQLL SRLCGLLLEE GSHPGAPAKP 

       310        320        330        340        350        360 
VDLAPVEAPG PLAPVPSTVC PLRRKLWQNY RNLTFDPVSA NRHFYLSRQD QQVKHCRQSR 

       370        380        390        400        410        420 
GPGGPGSFEL WQVQCAQSFQ AGHHYWEVRA SDHSVTLGVS YPQLPRCRLG PHTDNIGRGP 

       430        440        450        460        470        480 
CSWGLCVQED SLQAWHNGEA QRLPGVSGRL LGMDLDLASG CLTFYSLEPQ TQPLYTFHAL 

       490        500        510 
FNQPLTPVFW LLEGRTLTLC HQPGAVFPLG PQEEVLS 

« Hide

References

[1]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-222 AND PRO-509.
Tissue: Brain, Liver and Lymph.
[3]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
[4]"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC087289 Genomic DNA. No translation available.
BC006138 mRNA. Translation: AAH06138.1.
BC021259 mRNA. Translation: AAH21259.2.
BC073831 mRNA. Translation: AAH73831.1. Different initiation.
BC098412 mRNA. Translation: AAH98412.1.
CCDSCCDS11732.1.
RefSeqNP_001243053.1. NM_001256124.1.
NP_775818.2. NM_173547.3.
UniGeneHs.189823.

3D structure databases

ProteinModelPortalQ6PJ69.
SMRQ6PJ69. Positions 6-51, 129-256, 372-500.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128382. 9 interactions.
IntActQ6PJ69. 9 interactions.
MINTMINT-8247621.
STRING9606.ENSP00000269383.

PTM databases

PhosphoSiteQ6PJ69.

Polymorphism databases

DMDM296453004.

Proteomic databases

MaxQBQ6PJ69.
PaxDbQ6PJ69.
PRIDEQ6PJ69.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000269383; ENSP00000269383; ENSG00000141569.
GeneID201292.
KEGGhsa:201292.
UCSCuc002jpx.4. human.

Organism-specific databases

CTD201292.
GeneCardsGC17M073885.
H-InvDBHIX0014178.
HGNCHGNC:27316. TRIM65.
HPAHPA021575.
HPA021578.
neXtProtNX_Q6PJ69.
PharmGKBPA134877726.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG306486.
HOGENOMHOG000231106.
HOVERGENHBG080119.
InParanoidQ6PJ69.
KOK12031.
OMAQPLYTFH.
PhylomeDBQ6PJ69.
TreeFamTF351090.

Gene expression databases

ArrayExpressQ6PJ69.
BgeeQ6PJ69.
CleanExHS_TRIM65.
GenevestigatorQ6PJ69.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR008985. ConA-like_lec_gl_sf.
IPR003877. SPRY_rcpt.
IPR000315. Znf_B-box.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamPF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
PRINTSPR01407. BUTYPHLNCDUF.
SMARTSM00184. RING. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi201292.
NextBio90125.
PROQ6PJ69.

Entry information

Entry nameTRI65_HUMAN
AccessionPrimary (citable) accession number: Q6PJ69
Secondary accession number(s): Q4G0F0, Q6DKJ6, Q9BRP6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM