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Protein

Tripartite motif-containing protein 65

Gene

TRIM65

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri12 – 51RING-typePROSITE-ProRule annotationAdd BLAST40
Zinc fingeri90 – 137B box-typePROSITE-ProRule annotationAdd BLAST48

GO - Molecular functioni

GO - Biological processi

  • positive regulation of autophagy Source: UniProtKB

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 65
Gene namesi
Name:TRIM65
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000141569.10
HGNCiHGNC:27316 TRIM65
neXtProtiNX_Q6PJ69

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000141569
PharmGKBiPA134877726

Polymorphism and mutation databases

BioMutaiTRIM65
DMDMi296453004

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002491912 – 517Tripartite motif-containing protein 65Add BLAST516

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei185PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6PJ69
MaxQBiQ6PJ69
PaxDbiQ6PJ69
PeptideAtlasiQ6PJ69
PRIDEiQ6PJ69

PTM databases

iPTMnetiQ6PJ69
PhosphoSitePlusiQ6PJ69

Expressioni

Gene expression databases

BgeeiENSG00000141569
CleanExiHS_TRIM65
ExpressionAtlasiQ6PJ69 baseline and differential
GenevisibleiQ6PJ69 HS

Organism-specific databases

HPAiHPA021575
HPA021578
HPA064820

Interactioni

Protein-protein interaction databases

BioGridi128382, 26 interactors
IntActiQ6PJ69, 11 interactors
MINTiQ6PJ69
STRINGi9606.ENSP00000269383

Structurei

3D structure databases

ProteinModelPortaliQ6PJ69
SMRiQ6PJ69
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini313 – 506B30.2/SPRYPROSITE-ProRule annotationAdd BLAST194

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili139 – 227Sequence analysisAdd BLAST89

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri12 – 51RING-typePROSITE-ProRule annotationAdd BLAST40
Zinc fingeri90 – 137B box-typePROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITG7 Eukaryota
ENOG410XWDC LUCA
GeneTreeiENSGT00760000118995
HOGENOMiHOG000231106
HOVERGENiHBG080119
InParanoidiQ6PJ69
KOiK12031
OMAiECRLHER
OrthoDBiEOG091G05NA
PhylomeDBiQ6PJ69
TreeFamiTF351090

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR018957 Znf_C3HC4_RING-type
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PF00097 zf-C3HC4, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6PJ69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQLLEEKL TCAICLGLYQ DPVTLPCGHN FCGACIRDWW DRCGKACPEC
60 70 80 90 100
REPFPDGAEL RRNVALSGVL EVVRAGPARD PGPDPGPGPD PAARCPRHGR
110 120 130 140 150
PLELFCRTEG RCVCSVCTVR ECRLHERALL DAERLKREAQ LRASLEVTQQ
160 170 180 190 200
QATQAEGQLL ELRKQSSQIQ NSACILASWV SGKFSSLLQA LEIQHTTALR
210 220 230 240 250
SIEVAKTQAL AQARDEEQRL RVHLEAVARH GCRIRELLEQ VDEQTFLQES
260 270 280 290 300
QLLQPPGPLG PLTPLQWDED QQLGDLKQLL SRLCGLLLEE GSHPGAPAKP
310 320 330 340 350
VDLAPVEAPG PLAPVPSTVC PLRRKLWQNY RNLTFDPVSA NRHFYLSRQD
360 370 380 390 400
QQVKHCRQSR GPGGPGSFEL WQVQCAQSFQ AGHHYWEVRA SDHSVTLGVS
410 420 430 440 450
YPQLPRCRLG PHTDNIGRGP CSWGLCVQED SLQAWHNGEA QRLPGVSGRL
460 470 480 490 500
LGMDLDLASG CLTFYSLEPQ TQPLYTFHAL FNQPLTPVFW LLEGRTLTLC
510
HQPGAVFPLG PQEEVLS
Length:517
Mass (Da):57,353
Last modified:May 18, 2010 - v3
Checksum:i1382A178CB99BBBA
GO

Sequence cautioni

The sequence AAH73831 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060245222V → G1 PublicationCorresponds to variant dbSNP:rs7222757Ensembl.1
Natural variantiVAR_057224364G → R. Corresponds to variant dbSNP:rs34593741Ensembl.1
Natural variantiVAR_057225366G → S. Corresponds to variant dbSNP:rs9892938Ensembl.1
Natural variantiVAR_060246509L → P1 PublicationCorresponds to variant dbSNP:rs3760128Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087289 Genomic DNA No translation available.
BC006138 mRNA Translation: AAH06138.1
BC021259 mRNA Translation: AAH21259.2
BC073831 mRNA Translation: AAH73831.1 Different initiation.
BC098412 mRNA Translation: AAH98412.1
CCDSiCCDS11732.1
RefSeqiNP_001243053.1, NM_001256124.1
NP_775818.2, NM_173547.3
UniGeneiHs.189823

Genome annotation databases

EnsembliENST00000269383; ENSP00000269383; ENSG00000141569
GeneIDi201292
KEGGihsa:201292
UCSCiuc002jpx.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTRI65_HUMAN
AccessioniPrimary (citable) accession number: Q6PJ69
Secondary accession number(s): Q4G0F0, Q6DKJ6, Q9BRP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: May 18, 2010
Last modified: April 25, 2018
This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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