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Q6PJ69

- TRI65_HUMAN

UniProt

Q6PJ69 - TRI65_HUMAN

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Protein

Tripartite motif-containing protein 65

Gene

TRIM65

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri12 – 5140RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri90 – 13748B box-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 65
Gene namesi
Name:TRIM65
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:27316. TRIM65.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134877726.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 517516Tripartite motif-containing protein 65PRO_0000249191Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine2 Publications

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ6PJ69.
PaxDbiQ6PJ69.
PRIDEiQ6PJ69.

PTM databases

PhosphoSiteiQ6PJ69.

Expressioni

Gene expression databases

BgeeiQ6PJ69.
CleanExiHS_TRIM65.
ExpressionAtlasiQ6PJ69. baseline and differential.
GenevestigatoriQ6PJ69.

Organism-specific databases

HPAiHPA021575.
HPA021578.

Interactioni

Protein-protein interaction databases

BioGridi128382. 14 interactions.
IntActiQ6PJ69. 9 interactions.
MINTiMINT-8247621.
STRINGi9606.ENSP00000269383.

Structurei

3D structure databases

ProteinModelPortaliQ6PJ69.
SMRiQ6PJ69. Positions 6-51, 95-254, 372-500.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini313 – 506194B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili139 – 22789Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri12 – 5140RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri90 – 13748B box-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG306486.
GeneTreeiENSGT00770000120605.
HOGENOMiHOG000231106.
HOVERGENiHBG080119.
InParanoidiQ6PJ69.
KOiK12031.
OMAiQPLYTFH.
PhylomeDBiQ6PJ69.
TreeFamiTF351090.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6PJ69-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAQLLEEKL TCAICLGLYQ DPVTLPCGHN FCGACIRDWW DRCGKACPEC
60 70 80 90 100
REPFPDGAEL RRNVALSGVL EVVRAGPARD PGPDPGPGPD PAARCPRHGR
110 120 130 140 150
PLELFCRTEG RCVCSVCTVR ECRLHERALL DAERLKREAQ LRASLEVTQQ
160 170 180 190 200
QATQAEGQLL ELRKQSSQIQ NSACILASWV SGKFSSLLQA LEIQHTTALR
210 220 230 240 250
SIEVAKTQAL AQARDEEQRL RVHLEAVARH GCRIRELLEQ VDEQTFLQES
260 270 280 290 300
QLLQPPGPLG PLTPLQWDED QQLGDLKQLL SRLCGLLLEE GSHPGAPAKP
310 320 330 340 350
VDLAPVEAPG PLAPVPSTVC PLRRKLWQNY RNLTFDPVSA NRHFYLSRQD
360 370 380 390 400
QQVKHCRQSR GPGGPGSFEL WQVQCAQSFQ AGHHYWEVRA SDHSVTLGVS
410 420 430 440 450
YPQLPRCRLG PHTDNIGRGP CSWGLCVQED SLQAWHNGEA QRLPGVSGRL
460 470 480 490 500
LGMDLDLASG CLTFYSLEPQ TQPLYTFHAL FNQPLTPVFW LLEGRTLTLC
510
HQPGAVFPLG PQEEVLS
Length:517
Mass (Da):57,353
Last modified:May 18, 2010 - v3
Checksum:i1382A178CB99BBBA
GO

Sequence cautioni

The sequence AAH73831.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti222 – 2221V → G.1 Publication
Corresponds to variant rs7222757 [ dbSNP | Ensembl ].
VAR_060245
Natural varianti364 – 3641G → R.
Corresponds to variant rs34593741 [ dbSNP | Ensembl ].
VAR_057224
Natural varianti366 – 3661G → S.
Corresponds to variant rs9892938 [ dbSNP | Ensembl ].
VAR_057225
Natural varianti509 – 5091L → P.1 Publication
Corresponds to variant rs3760128 [ dbSNP | Ensembl ].
VAR_060246

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087289 Genomic DNA. No translation available.
BC006138 mRNA. Translation: AAH06138.1.
BC021259 mRNA. Translation: AAH21259.2.
BC073831 mRNA. Translation: AAH73831.1. Different initiation.
BC098412 mRNA. Translation: AAH98412.1.
CCDSiCCDS11732.1.
RefSeqiNP_001243053.1. NM_001256124.1.
NP_775818.2. NM_173547.3.
UniGeneiHs.189823.

Genome annotation databases

EnsembliENST00000269383; ENSP00000269383; ENSG00000141569.
GeneIDi201292.
KEGGihsa:201292.
UCSCiuc002jpx.4. human.

Polymorphism databases

DMDMi296453004.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087289 Genomic DNA. No translation available.
BC006138 mRNA. Translation: AAH06138.1 .
BC021259 mRNA. Translation: AAH21259.2 .
BC073831 mRNA. Translation: AAH73831.1 . Different initiation.
BC098412 mRNA. Translation: AAH98412.1 .
CCDSi CCDS11732.1.
RefSeqi NP_001243053.1. NM_001256124.1.
NP_775818.2. NM_173547.3.
UniGenei Hs.189823.

3D structure databases

ProteinModelPortali Q6PJ69.
SMRi Q6PJ69. Positions 6-51, 95-254, 372-500.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128382. 14 interactions.
IntActi Q6PJ69. 9 interactions.
MINTi MINT-8247621.
STRINGi 9606.ENSP00000269383.

PTM databases

PhosphoSitei Q6PJ69.

Polymorphism databases

DMDMi 296453004.

Proteomic databases

MaxQBi Q6PJ69.
PaxDbi Q6PJ69.
PRIDEi Q6PJ69.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000269383 ; ENSP00000269383 ; ENSG00000141569 .
GeneIDi 201292.
KEGGi hsa:201292.
UCSCi uc002jpx.4. human.

Organism-specific databases

CTDi 201292.
GeneCardsi GC17M073885.
H-InvDB HIX0014178.
HGNCi HGNC:27316. TRIM65.
HPAi HPA021575.
HPA021578.
neXtProti NX_Q6PJ69.
PharmGKBi PA134877726.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG306486.
GeneTreei ENSGT00770000120605.
HOGENOMi HOG000231106.
HOVERGENi HBG080119.
InParanoidi Q6PJ69.
KOi K12031.
OMAi QPLYTFH.
PhylomeDBi Q6PJ69.
TreeFami TF351090.

Miscellaneous databases

GenomeRNAii 201292.
NextBioi 90125.
PROi Q6PJ69.

Gene expression databases

Bgeei Q6PJ69.
CleanExi HS_TRIM65.
ExpressionAtlasi Q6PJ69. baseline and differential.
Genevestigatori Q6PJ69.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProi IPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
Pfami PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view ]
PRINTSi PR01407. BUTYPHLNCDUF.
SMARTi SM00184. RING. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-222 AND PRO-509.
    Tissue: Brain, Liver and Lymph.
  3. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  4. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTRI65_HUMAN
AccessioniPrimary (citable) accession number: Q6PJ69
Secondary accession number(s): Q4G0F0, Q6DKJ6, Q9BRP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: May 18, 2010
Last modified: November 26, 2014
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3