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Protein

F-box only protein 46

Gene

FBXO46

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

Caution

The region from 1 to 163 was deduced from the genomic sequence and ESTs by similarity to the mouse sequence.Curated

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 46
Alternative name(s):
F-box only protein 34-like
Gene namesi
Name:FBXO46
Synonyms:FBX46, FBXO34L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000177051.5
HGNCiHGNC:25069 FBXO46
MIMi609117 gene
neXtProtiNX_Q6PJ61

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000177051

Polymorphism and mutation databases

BioMutaiFBXO46
DMDMi325511391

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199501 – 603F-box only protein 46Add BLAST603

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei338PhosphoserineCombined sources1
Modified residuei347PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PJ61
MaxQBiQ6PJ61
PaxDbiQ6PJ61
PeptideAtlasiQ6PJ61
PRIDEiQ6PJ61

PTM databases

iPTMnetiQ6PJ61
PhosphoSitePlusiQ6PJ61

Expressioni

Gene expression databases

BgeeiENSG00000177051
CleanExiHS_FBXO46
ExpressionAtlasiQ6PJ61 baseline and differential
GenevisibleiQ6PJ61 HS

Organism-specific databases

HPAiHPA049390

Interactioni

Subunit structurei

Interacts with SKP1 and CUL1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
SKP1P632084EBI-2322982,EBI-307486

Protein-protein interaction databases

BioGridi116976, 28 interactors
DIPiDIP-52907N
IntActiQ6PJ61, 11 interactors
STRINGi9606.ENSP00000410007

Structurei

3D structure databases

ProteinModelPortaliQ6PJ61
SMRiQ6PJ61
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini470 – 522F-boxPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

eggNOGiENOG410IFWE Eukaryota
ENOG410ZZJ3 LUCA
GeneTreeiENSGT00530000064222
HOGENOMiHOG000112549
HOVERGENiHBG051583
InParanoidiQ6PJ61
KOiK10320
OMAiFFVAHQC
OrthoDBiEOG091G04LZ
PhylomeDBiQ6PJ61
TreeFamiTF331673

Family and domain databases

InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SUPFAMiSSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit

Sequencei

Sequence statusi: Complete.

Q6PJ61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRGSLLPFQ LWCPRPFGTY SQNQPRPPSA ALKPSACPEP GGGAEPDHGP
60 70 80 90 100
AHSENTPPAL ATEVPASQPA PLLSAAAAGD EGRVLLDTWY VIKPGNTKEK
110 120 130 140 150
VAFFVAHQCG GGSRASSMKV KGHWGSDSSK AKRRRRCLDP TKAPPDPGGR
160 170 180 190 200
EGPPAAEEGP ASAGEDVDLL SVAEMVALVE QRAALALQSY PRPTTPAPVV
210 220 230 240 250
FVSAEQGGPA KGVGSERRSG GGDCSRVAEA VAHFEAQRDS PPTKGLRKEE
260 270 280 290 300
RPGPGPGEVR IAFRISNGRE PRAPDSGLPS GGGGRPGCAY PGSPGPGARA
310 320 330 340 350
KDKITCDLYQ LISPSRDALP SNVEFLLARA DEASEGDSPA PARPEDTPPA
360 370 380 390 400
PPPPPARDCG ASGFHVDVVV TGVVDECIFF GKDGTKNVKE ETVCLTVSPE
410 420 430 440 450
EPPPPGQLFF LQNRGPDGPP EPPPADSPAT APGPDDAEGT ADTSLCRLYR
460 470 480 490 500
HVSHDFLEIR FKIQRLLEPR QYMLLLPEHV LVKIFSFLPT RALAALKCTC
510 520 530 540 550
HHFKGIIEAF GVRATDSRWS RDPLYRDDPC KQCRKRYEKG DVSLCRWHPK
560 570 580 590 600
PYHHDLPYGR SYWMCCRRAD RETPGCRLGL HDNNWVLPCN GPGGGRAGRE

EGR
Length:603
Mass (Da):64,631
Last modified:March 8, 2011 - v3
Checksum:i1DF8A0985D698D2E
GO

Sequence cautioni

The sequence AAH21978 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH21978 differs from that shown. Reason: Erroneous termination at position 604. Translated as stop.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007191 Genomic DNA No translation available.
BQ068066 mRNA No translation available.
BC021978 mRNA Translation: AAH21978.1 Sequence problems.
CCDSiCCDS46116.1
RefSeqiNP_001073938.1, NM_001080469.1
NP_001316561.1, NM_001329632.1
NP_001316562.1, NM_001329633.1
NP_001316563.1, NM_001329634.1
UniGeneiHs.128702

Genome annotation databases

EnsembliENST00000317683; ENSP00000410007; ENSG00000177051
GeneIDi23403
KEGGihsa:23403
UCSCiuc002pcz.4 human

Similar proteinsi

Entry informationi

Entry nameiFBX46_HUMAN
AccessioniPrimary (citable) accession number: Q6PJ61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 8, 2011
Last modified: March 28, 2018
This is version 111 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health