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Protein

F-box only protein 46

Gene

FBXO46

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 46
Alternative name(s):
F-box only protein 34-like
Gene namesi
Name:FBXO46
Synonyms:FBX46, FBXO34L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25069. FBXO46.

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiFBXO46.
DMDMi325511391.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 603603F-box only protein 46PRO_0000119950Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei338 – 3381PhosphoserineCombined sources
Modified residuei347 – 3471PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PJ61.
MaxQBiQ6PJ61.
PaxDbiQ6PJ61.
PeptideAtlasiQ6PJ61.
PRIDEiQ6PJ61.

PTM databases

iPTMnetiQ6PJ61.
PhosphoSiteiQ6PJ61.

Expressioni

Gene expression databases

BgeeiQ6PJ61.
CleanExiHS_FBXO46.
ExpressionAtlasiQ6PJ61. baseline and differential.
GenevisibleiQ6PJ61. HS.

Organism-specific databases

HPAiHPA049390.

Interactioni

Subunit structurei

Interacts with SKP1 and CUL1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
SKP1P632083EBI-2322982,EBI-307486

Protein-protein interaction databases

BioGridi116976. 25 interactions.
DIPiDIP-52907N.
IntActiQ6PJ61. 11 interactions.
STRINGi9606.ENSP00000410007.

Structurei

3D structure databases

ProteinModelPortaliQ6PJ61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini470 – 52253F-boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IFWE. Eukaryota.
ENOG410ZZJ3. LUCA.
GeneTreeiENSGT00530000064222.
HOGENOMiHOG000112549.
HOVERGENiHBG051583.
InParanoidiQ6PJ61.
KOiK10320.
OMAiYSQNQPR.
OrthoDBiEOG7ZSHSN.
PhylomeDBiQ6PJ61.
TreeFamiTF331673.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PJ61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRGSLLPFQ LWCPRPFGTY SQNQPRPPSA ALKPSACPEP GGGAEPDHGP
60 70 80 90 100
AHSENTPPAL ATEVPASQPA PLLSAAAAGD EGRVLLDTWY VIKPGNTKEK
110 120 130 140 150
VAFFVAHQCG GGSRASSMKV KGHWGSDSSK AKRRRRCLDP TKAPPDPGGR
160 170 180 190 200
EGPPAAEEGP ASAGEDVDLL SVAEMVALVE QRAALALQSY PRPTTPAPVV
210 220 230 240 250
FVSAEQGGPA KGVGSERRSG GGDCSRVAEA VAHFEAQRDS PPTKGLRKEE
260 270 280 290 300
RPGPGPGEVR IAFRISNGRE PRAPDSGLPS GGGGRPGCAY PGSPGPGARA
310 320 330 340 350
KDKITCDLYQ LISPSRDALP SNVEFLLARA DEASEGDSPA PARPEDTPPA
360 370 380 390 400
PPPPPARDCG ASGFHVDVVV TGVVDECIFF GKDGTKNVKE ETVCLTVSPE
410 420 430 440 450
EPPPPGQLFF LQNRGPDGPP EPPPADSPAT APGPDDAEGT ADTSLCRLYR
460 470 480 490 500
HVSHDFLEIR FKIQRLLEPR QYMLLLPEHV LVKIFSFLPT RALAALKCTC
510 520 530 540 550
HHFKGIIEAF GVRATDSRWS RDPLYRDDPC KQCRKRYEKG DVSLCRWHPK
560 570 580 590 600
PYHHDLPYGR SYWMCCRRAD RETPGCRLGL HDNNWVLPCN GPGGGRAGRE

EGR
Length:603
Mass (Da):64,631
Last modified:March 8, 2011 - v3
Checksum:i1DF8A0985D698D2E
GO

Sequence cautioni

The sequence AAH21978.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH21978.1 differs from that shown. Reason: Erroneous termination at position 604. Translated as stop.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007191 Genomic DNA. No translation available.
BQ068066 mRNA. No translation available.
BC021978 mRNA. Translation: AAH21978.1. Sequence problems.
CCDSiCCDS46116.1.
RefSeqiNP_001073938.1. NM_001080469.1.
UniGeneiHs.128702.

Genome annotation databases

EnsembliENST00000317683; ENSP00000410007; ENSG00000177051.
GeneIDi23403.
KEGGihsa:23403.
UCSCiuc002pcz.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007191 Genomic DNA. No translation available.
BQ068066 mRNA. No translation available.
BC021978 mRNA. Translation: AAH21978.1. Sequence problems.
CCDSiCCDS46116.1.
RefSeqiNP_001073938.1. NM_001080469.1.
UniGeneiHs.128702.

3D structure databases

ProteinModelPortaliQ6PJ61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116976. 25 interactions.
DIPiDIP-52907N.
IntActiQ6PJ61. 11 interactions.
STRINGi9606.ENSP00000410007.

PTM databases

iPTMnetiQ6PJ61.
PhosphoSiteiQ6PJ61.

Polymorphism and mutation databases

BioMutaiFBXO46.
DMDMi325511391.

Proteomic databases

EPDiQ6PJ61.
MaxQBiQ6PJ61.
PaxDbiQ6PJ61.
PeptideAtlasiQ6PJ61.
PRIDEiQ6PJ61.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317683; ENSP00000410007; ENSG00000177051.
GeneIDi23403.
KEGGihsa:23403.
UCSCiuc002pcz.4. human.

Organism-specific databases

CTDi23403.
GeneCardsiFBXO46.
H-InvDBHIX0027506.
HGNCiHGNC:25069. FBXO46.
HPAiHPA049390.
MIMi609117. gene.
neXtProtiNX_Q6PJ61.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFWE. Eukaryota.
ENOG410ZZJ3. LUCA.
GeneTreeiENSGT00530000064222.
HOGENOMiHOG000112549.
HOVERGENiHBG051583.
InParanoidiQ6PJ61.
KOiK10320.
OMAiYSQNQPR.
OrthoDBiEOG7ZSHSN.
PhylomeDBiQ6PJ61.
TreeFamiTF331673.

Miscellaneous databases

GenomeRNAii23403.
PROiQ6PJ61.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PJ61.
CleanExiHS_FBXO46.
ExpressionAtlasiQ6PJ61. baseline and differential.
GenevisibleiQ6PJ61. HS.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. The MGC Project Team
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-180.
  3. Roechert B.
    Unpublished observations (APR-2004)
    Cited for: RECONSTRUCTION FROM ESTS, CONCEPTUAL TRANSLATION OF 1-163.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 164-603.
    Tissue: Placenta.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-338 AND THR-347, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-338 AND THR-347, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Erythroleukemia.

Entry informationi

Entry nameiFBX46_HUMAN
AccessioniPrimary (citable) accession number: Q6PJ61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 8, 2011
Last modified: July 6, 2016
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The region from 1 to 163 was deduced from the genomic sequence and ESTs by similarity to the mouse sequence.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.