Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

SPRY domain-containing SOCS box protein 3

Gene

SPSB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
SPRY domain-containing SOCS box protein 3
Short name:
SSB-3
Gene namesi
Name:SPSB3
Synonyms:C16orf31, SSB3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:30629. SPSB3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670873.

Polymorphism and mutation databases

BioMutaiSPSB3.
DMDMi126253805.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 355355SPRY domain-containing SOCS box protein 3PRO_0000278778Add
BLAST

Proteomic databases

MaxQBiQ6PJ21.
PaxDbiQ6PJ21.
PRIDEiQ6PJ21.

PTM databases

iPTMnetiQ6PJ21.
PhosphoSiteiQ6PJ21.

Expressioni

Gene expression databases

BgeeiQ6PJ21.
CleanExiHS_SPSB3.
ExpressionAtlasiQ6PJ21. baseline and differential.
GenevisibleiQ6PJ21. HS.

Organism-specific databases

HPAiHPA046602.

Interactioni

Subunit structurei

Interacts with MET.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
B7Z5W03EBI-3937206,EBI-10253951
ENKD1Q9H0I23EBI-3937206,EBI-744099

Protein-protein interaction databases

BioGridi124775. 18 interactions.
IntActiQ6PJ21. 5 interactions.
STRINGi9606.ENSP00000301717.

Structurei

3D structure databases

ProteinModelPortaliQ6PJ21.
SMRiQ6PJ21. Positions 107-258.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini85 – 274190B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST
Domaini264 – 31552SOCS boxPROSITE-ProRule annotationAdd
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Sequence similaritiesi

Belongs to the SPSB family.Curated
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IFM3. Eukaryota.
ENOG411113T. LUCA.
GeneTreeiENSGT00390000008062.
HOVERGENiHBG093988.
InParanoidiQ6PJ21.
KOiK10345.
OMAiDCQCGEE.
OrthoDBiEOG7KQ22V.
PhylomeDBiQ6PJ21.
TreeFamiTF312822.

Family and domain databases

InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR001496. SOCS_box.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF00622. SPRY. 1 hit.
[Graphical view]
SMARTiSM00969. SOCS_box. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PJ21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARRPRNSRA WHFVLSAARR DADARAVALA GSTNWGYDSD GQHSDSDSDP
60 70 80 90 100
EYSTLPPSIP SAVPVTGESF CDCAGQSEAS FCSSLHSAHR GRDCRCGEED
110 120 130 140 150
EYFDWVWDDL NKSSATLLSC DNRKVSFHME YSCGTAAIRG TKELGEGQHF
160 170 180 190 200
WEIKMTSPVY GTDMMVGIGT SDVDLDKYRH TFCSLLGRDE DSWGLSYTGL
210 220 230 240 250
LHHKGDKTSF SSRFGQGSII GVHLDTWHGT LTFFKNRKCI GVAATKLQNK
260 270 280 290 300
RFYPMVCSTA ARSSMKVTRS CASATSLQYL CCHRLRQLRP DSGDTLEGLP
310 320 330 340 350
LPPGLKQVLH NKLGWVLSMS CSRRKAPVSD PQAATSAHPS SREPRPCQRK

RCRRT
Length:355
Mass (Da):39,376
Last modified:February 20, 2007 - v2
Checksum:i56BFA7A1DA27E254
GO

Sequence cautioni

The sequence AAH41897.1 differs from that shown.Intron retention.Curated
The sequence AAK61293.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti211 – 2111S → P in AAH47441 (PubMed:15489334).Curated
Sequence conflicti269 – 2691R → S in AAH47441 (PubMed:15489334).Curated
Sequence conflicti339 – 3391P → H in AAH24244 (PubMed:15489334).Curated
Sequence conflicti339 – 3391P → R in AAH47441 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti171 – 1711S → L.
Corresponds to variant rs35816944 [ dbSNP | Ensembl ].
VAR_052034

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403028 mRNA. Translation: AAL57347.1.
AE006639 Genomic DNA. Translation: AAK61293.1. Sequence problems.
CH471112 Genomic DNA. Translation: EAW85619.1.
CH471112 Genomic DNA. Translation: EAW85620.1.
BC007588 mRNA. Translation: AAH07588.2.
BC024244 mRNA. Translation: AAH24244.1.
BC041897 mRNA. Translation: AAH41897.1. Sequence problems.
BC047441 mRNA. Translation: AAH47441.2.
CCDSiCCDS32365.1.
RefSeqiNP_543137.2. NM_080861.3.
XP_011521035.1. XM_011522733.1.
UniGeneiHs.592080.

Genome annotation databases

EnsembliENST00000301717; ENSP00000301717; ENSG00000162032.
ENST00000566339; ENSP00000457206; ENSG00000162032.
GeneIDi90864.
KEGGihsa:90864.
UCSCiuc002cmu.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403028 mRNA. Translation: AAL57347.1.
AE006639 Genomic DNA. Translation: AAK61293.1. Sequence problems.
CH471112 Genomic DNA. Translation: EAW85619.1.
CH471112 Genomic DNA. Translation: EAW85620.1.
BC007588 mRNA. Translation: AAH07588.2.
BC024244 mRNA. Translation: AAH24244.1.
BC041897 mRNA. Translation: AAH41897.1. Sequence problems.
BC047441 mRNA. Translation: AAH47441.2.
CCDSiCCDS32365.1.
RefSeqiNP_543137.2. NM_080861.3.
XP_011521035.1. XM_011522733.1.
UniGeneiHs.592080.

3D structure databases

ProteinModelPortaliQ6PJ21.
SMRiQ6PJ21. Positions 107-258.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124775. 18 interactions.
IntActiQ6PJ21. 5 interactions.
STRINGi9606.ENSP00000301717.

PTM databases

iPTMnetiQ6PJ21.
PhosphoSiteiQ6PJ21.

Polymorphism and mutation databases

BioMutaiSPSB3.
DMDMi126253805.

Proteomic databases

MaxQBiQ6PJ21.
PaxDbiQ6PJ21.
PRIDEiQ6PJ21.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301717; ENSP00000301717; ENSG00000162032.
ENST00000566339; ENSP00000457206; ENSG00000162032.
GeneIDi90864.
KEGGihsa:90864.
UCSCiuc002cmu.4. human.

Organism-specific databases

CTDi90864.
GeneCardsiSPSB3.
HGNCiHGNC:30629. SPSB3.
HPAiHPA046602.
MIMi611659. gene.
neXtProtiNX_Q6PJ21.
PharmGKBiPA142670873.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFM3. Eukaryota.
ENOG411113T. LUCA.
GeneTreeiENSGT00390000008062.
HOVERGENiHBG093988.
InParanoidiQ6PJ21.
KOiK10345.
OMAiDCQCGEE.
OrthoDBiEOG7KQ22V.
PhylomeDBiQ6PJ21.
TreeFamiTF312822.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

ChiTaRSiSPSB3. human.
GenomeRNAii90864.
NextBioi77012.
PROiQ6PJ21.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PJ21.
CleanExiHS_SPSB3.
ExpressionAtlasiQ6PJ21. baseline and differential.
GenevisibleiQ6PJ21. HS.

Family and domain databases

InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR001496. SOCS_box.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF00622. SPRY. 1 hit.
[Graphical view]
SMARTiSM00969. SOCS_box. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "SOCS box proteins."
    Friedel E.J., Nicholson S.E., Nicola N.A., Kile B.T., Hilton D.J.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
    Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
    Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye, Hypothalamus and Testis.
  5. "The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway."
    Wang D., Li Z., Messing E.M., Wu G.
    J. Biol. Chem. 280:16393-16401(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MET.

Entry informationi

Entry nameiSPSB3_HUMAN
AccessioniPrimary (citable) accession number: Q6PJ21
Secondary accession number(s): D3DU78
, Q49A96, Q86X18, Q8WXK5, Q96IE6, Q96RY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: May 11, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.