Q6PJ21 (SPSB3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SPRY domain-containing SOCS box protein 3
Short name=SSB-3

Gene names

Name:	SPSB3
Synonyms:	C16orf31, SSB3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	355 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins By similarity.
Pathway	Protein modification; protein ubiquitination.
Subunit structure	Interacts with MET. Ref.5
Domain	The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes By similarity.
Sequence similarities	Belongs to the SPSB family. Contains 1 B30.2/SPRY domain. Contains 1 SOCS box domain.
Sequence caution	The sequence AAH41897.1 differs from that shown. Reason: Intron retention. The sequence AAK61293.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro protein ubiquitination Inferred from electronic annotation. Source: UniProtKB-UniPathway
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 355	355	SPRY domain-containing SOCS box protein 3		PRO_0000278778
Regions
	Domain	85 – 274	190	B30.2/SPRY
	Domain	264 – 315	52	SOCS box
Natural variations
	Natural variant	171	1	S → L. Corresponds to variant rs35816944 [ dbSNP | Ensembl ].		VAR_052034
Experimental info
	Sequence conflict	211	1	S → P in AAH47441. Ref.4
	Sequence conflict	269	1	R → S in AAH47441. Ref.4
	Sequence conflict	339	1	P → H in AAH24244. Ref.4
	Sequence conflict	339	1	P → R in AAH47441. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q6PJ21 [UniParc]. Last modified February 20, 2007. Version 2. Checksum: 56BFA7A1DA27E254	FASTA	355	39,376
	10 20 30 40 50 60 MARRPRNSRA WHFVLSAARR DADARAVALA GSTNWGYDSD GQHSDSDSDP EYSTLPPSIP 70 80 90 100 110 120 SAVPVTGESF CDCAGQSEAS FCSSLHSAHR GRDCRCGEED EYFDWVWDDL NKSSATLLSC 130 140 150 160 170 180 DNRKVSFHME YSCGTAAIRG TKELGEGQHF WEIKMTSPVY GTDMMVGIGT SDVDLDKYRH 190 200 210 220 230 240 TFCSLLGRDE DSWGLSYTGL LHHKGDKTSF SSRFGQGSII GVHLDTWHGT LTFFKNRKCI 250 260 270 280 290 300 GVAATKLQNK RFYPMVCSTA ARSSMKVTRS CASATSLQYL CCHRLRQLRP DSGDTLEGLP 310 320 330 340 350 LPPGLKQVLH NKLGWVLSMS CSRRKAPVSD PQAATSAHPS SREPRPCQRK RCRRT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"SOCS box proteins." Friedel E.J., Nicholson S.E., Nicola N.A., Kile B.T., Hilton D.J. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16." Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R. Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye, Hypothalamus and Testis.
[5]	"The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway." Wang D., Li Z., Messing E.M., Wu G. J. Biol. Chem. 280:16393-16401(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH MET.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF403028 mRNA. Translation: AAL57347.1. AE006639 Genomic DNA. Translation: AAK61293.1. Sequence problems. CH471112 Genomic DNA. Translation: EAW85619.1. CH471112 Genomic DNA. Translation: EAW85620.1. BC007588 mRNA. Translation: AAH07588.2. BC024244 mRNA. Translation: AAH24244.1. BC041897 mRNA. Translation: AAH41897.1. Sequence problems. BC047441 mRNA. Translation: AAH47441.2.
IPI	IPI00412063.
RefSeq	NP_543137.2. NM_080861.3.
UniGene	Hs.592080.
3D structure databases
ProteinModelPortal	Q6PJ21.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6PJ21. 2 interactions.
STRING	9606.ENSP00000301717.
PTM databases
PhosphoSite	Q6PJ21.
Polymorphism databases
DMDM	126253805.
Proteomic databases
PaxDb	Q6PJ21.
PRIDE	Q6PJ21.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000301717; ENSP00000301717; ENSG00000162032. ENST00000566339; ENSP00000457206; ENSG00000162032.
GeneID	90864.
KEGG	hsa:90864.
UCSC	uc002cmt.3. human.
Organism-specific databases
CTD	90864.
GeneCards	GC16M001826.
HGNC	HGNC:30629. SPSB3.
HPA	HPA046602.
MIM	611659. gene.
neXtProt	NX_Q6PJ21.
PharmGKB	PA142670873.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG151085.
HOVERGEN	HBG093988.
InParanoid	Q6PJ21.
KO	K10345.
OMA	GWVLSMS.
OrthoDB	EOG42NJ0V.
Enzyme and pathway databases
UniPathway	UPA00143.
Gene expression databases
ArrayExpress	Q6PJ21.
Bgee	Q6PJ21.
CleanEx	HS_SPSB3.
Genevestigator	Q6PJ21.
Family and domain databases
InterPro	IPR001870. B30.2/SPRY. IPR008985. ConA-like_lec_gl_sf. IPR001496. SOCS_C. IPR003877. SPRY_rcpt. [Graphical view]
Pfam	PF00622. SPRY. 1 hit. [Graphical view]
SMART	SM00969. SOCS_box. 1 hit. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit.
PROSITE	PS50188. B302_SPRY. 1 hit. PS50225. SOCS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	90864.
NextBio	77012.
SOURCE	Search...

Entry information

Entry name

SPSB3_HUMAN

Accession

Primary (citable) accession number: Q6PJ21
Secondary accession number(s): D3DU78 , Q49A96, Q86X18, Q8WXK5, Q96IE6, Q96RY2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	February 20, 2007
Last modified:	May 1, 2013
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.