ID TRAT1_HUMAN Reviewed; 186 AA. AC Q6PIZ9; Q9NZX5; DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot. DT 05-JUL-2004, sequence version 1. DT 24-JUL-2007, entry version 29. DE T-cell receptor-associated transmembrane adapter 1 (T-cell receptor- DE interacting molecule) (TRIM) (pp29/30). GN Name=TRAT1; Synonyms=TCRIM; ORFNames=HSPC062; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 152-167, RP IDENTIFICATION BY MASS SPECTROMETRY, DIMERIZATION, INTERACTION WITH RP THE TCR COMPLEX AND PIK3R1, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, RP PHOSPHORYLATION, SUBCELLULAR LOCATION, AND MUTAGENESIS OF TYR-79. RX MEDLINE=98353541; PubMed=9687533; DOI=10.1084/jem.188.3.561; RA Bruyns E., Marie-Cardine A., Kirchgessner H., Sagolla K., RA Shevchenko A., Mann M., Autschbach F., Bensussan A., Meuer S., RA Schraven B.; RT "T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide- RT linked dimer associated with the TCR-CD3-zeta complex, recruits RT intracellular signaling proteins to the plasma membrane."; RL J. Exp. Med. 188:561-575(1998). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Umbilical cord blood; RX MEDLINE=20499367; PubMed=11042152; DOI=10.1101/gr.140200; RA Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., RA Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., RA Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.; RT "Cloning and functional analysis of cDNAs with open reading frames for RT 300 previously undefined genes expressed in CD34+ hematopoietic RT stem/progenitor cells."; RL Genome Res. 10:1546-1560(2000). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Pancreas; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP FUNCTION, AND INTERACTION WITH CD3Z. RX MEDLINE=21286433; PubMed=11390434; DOI=10.1084/jem.193.11.1269; RA Kirchgessner H., Dietrich J., Scherer J., Isomaeki P., Korinek V., RA Hilgert I., Bruyns E., Leo A., Cope A.P., Schraven B.; RT "The transmembrane adaptor protein TRIM regulates T-cell receptor RT (TCR) expression and TCR-mediated signaling via an association with RT the TCR zeta chain."; RL J. Exp. Med. 193:1269-1284(2001). RN [5] RP TISSUE SPECIFICITY. RX PubMed=16160011; DOI=10.1182/blood-2005-06-2273; RA Tedoldi S., Paterson J.C., Hansmann M.-L., Natkunam Y., Rudiger T., RA Angelisova P., Du M.Q., Roberton H., Roncador G., Sanchez L., RA Pozzobon M., Masir N., Barry R., Pileri S., Mason D.Y., Marafioti T., RA Horejsi V.; RT "Transmembrane adaptor molecules: a new category of lymphoid-cell RT markers."; RL Blood 107:213-221(2006). CC -!- FUNCTION: Stabilizes the TCR (T-cell antigen receptor)/CD3 complex CC at the surface of T-cells. CC -!- SUBUNIT: Homodimer; disulfide-linked. Interacts with CD3Z. When CC phosphorylated, interacts with PIK3R1. CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type III membrane CC protein. CC -!- TISSUE SPECIFICITY: Strongly expressed in thymus, and to a lesser CC extent in spleen, lymph node and peripheral blood lymphocytes. CC Present in T-cells and NK cells, but not B-cells (at protein CC level). CC -!- DEVELOPMENTAL STAGE: Strongly expressed in fetal thymus at weeks CC 17-24 of gestation. Undetectable in bone marrow and fetal liver. CC -!- PTM: Phosphorylated on tyrosines by LCK or FYN upon TCR CC activation. CC -!- SEQUENCE CAUTION: CC Sequence=AAF29034.1; Type=Frameshift; Positions=166; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF161547; AAF29034.1; ALT_FRAME; mRNA. DR EMBL; BC025713; AAH25713.1; -; mRNA. DR UniGene; Hs.138701; -. DR Ensembl; ENSG00000163519; Homo sapiens. DR HGNC; HGNC:30698; TRAT1. DR HPA; HPA002356; -. DR MIM; 604962; gene. DR PharmGKB; PA128394655; -. DR ArrayExpress; Q6PIZ9; -. DR GermOnline; ENSG00000163519; Homo sapiens. DR RZPD-ProtExp; IOH22617; -. DR RZPD-ProtExp; L0176; -. DR RZPD-ProtExp; RZPDo839B08139; -. DR RZPD-ProtExp; RZPDo839B08140; -. DR RZPD-ProtExp; T4889; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS:ProtInc. DR GO; GO:0042101; C:T cell receptor complex; IDA:MGI. DR GO; GO:0005068; F:transmembrane receptor protein tyrosine kin...; TAS:ProtInc. DR GO; GO:0006968; P:cellular defense response; TAS:ProtInc. DR GO; GO:0001920; P:negative regulation of receptor recycling; IDA:MGI. DR GO; GO:0051051; P:negative regulation of transport; IDA:MGI. DR GO; GO:0050850; P:positive regulation of calcium-mediated sig...; IDA:MGI. DR GO; GO:0050862; P:positive regulation of T cell receptor sign...; IDA:MGI. PE 1: Evidence at protein level; KW Direct protein sequencing; Immune response; Membrane; Phosphorylation; KW Signal-anchor; Transmembrane. FT CHAIN 1 186 T-cell receptor-associated transmembrane FT adapter 1. FT /FTId=PRO_0000083344. FT TOPO_DOM 1 7 Extracellular (Potential). FT TRANSMEM 8 28 Signal-anchor for type III membrane FT protein (Potential). FT TOPO_DOM 29 186 Cytoplasmic (Potential). FT REGION 79 82 Interaction with PIK3R1. FT MOD_RES 79 79 Phosphotyrosine (Probable). FT DISULFID 7 7 Interchain (Probable). FT MUTAGEN 79 79 Y->F: Abolishes interaction with PIK3R1. SQ SEQUENCE 186 AA; 21211 MW; 236A4BEFF427EA3E CRC64; MSGISGCPFF LWGLLALLGL ALVISLIFNI SHYVEKQRQD KMYSYSSDHT RVDEYYIEDT PIYGNLDDMI SEPMDENCYE QMKARPEKSV NKMQEATPSA QATNETQMCY ASLDHSVKGK RRKPRKQNTH FSDKDGDEQL HAIDASVSKT TLVDSFSPES QAVEENIHDD PIRLFGLIRA KREPIN //