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Protein

T-cell receptor-associated transmembrane adapter 1

Gene

TRAT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells.1 Publication

GO - Molecular functioni

GO - Biological processi

  • adaptive immune response Source: UniProtKB-KW
  • cellular defense response Source: ProtInc
  • negative regulation of receptor recycling Source: MGI
  • negative regulation of transport Source: MGI
  • phosphatidylinositol-mediated signaling Source: Reactome
  • positive regulation of calcium-mediated signaling Source: MGI
  • positive regulation of T cell receptor signaling pathway Source: MGI
  • regulation of phosphatidylinositol 3-kinase signaling Source: Reactome
  • signal transduction Source: ProtInc
  • T cell receptor signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-1257604. PIP3 activates AKT signaling.
R-HSA-202424. Downstream TCR signaling.
R-HSA-2219530. Constitutive Signaling by Aberrant PI3K in Cancer.
R-HSA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
SignaLinkiQ6PIZ9.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell receptor-associated transmembrane adapter 1
Alternative name(s):
T-cell receptor-interacting molecule
Short name:
TRIM
pp29/30
Gene namesi
Name:TRAT1
Synonyms:TCRIM
ORF Names:HSPC062
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:30698. TRAT1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77ExtracellularSequence analysis
Transmembranei8 – 2821Helical; Signal-anchor for type III membrane proteinSequence analysisAdd
BLAST
Topological domaini29 – 186158CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • intracellular Source: GOC
  • plasma membrane Source: MGI
  • T cell receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi79 – 791Y → F: Abolishes interaction with PIK3R1. 1 Publication

Organism-specific databases

PharmGKBiPA128394655.

Polymorphism and mutation databases

BioMutaiTRAT1.
DMDMi74749223.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 186186T-cell receptor-associated transmembrane adapter 1PRO_0000083344Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi7 – 7InterchainCurated
Modified residuei46 – 461PhosphoserineBy similarity
Modified residuei79 – 791Phosphotyrosine1 Publication

Post-translational modificationi

Phosphorylated on tyrosines by LCK or FYN upon TCR activation.1 Publication

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiQ6PIZ9.
PaxDbiQ6PIZ9.
PeptideAtlasiQ6PIZ9.
PRIDEiQ6PIZ9.

PTM databases

iPTMnetiQ6PIZ9.
PhosphoSiteiQ6PIZ9.

Expressioni

Tissue specificityi

Strongly expressed in thymus, and to a lesser extent in spleen, lymph node and peripheral blood lymphocytes. Present in T-cells and NK cells, but not B-cells (at protein level).2 Publications

Developmental stagei

Strongly expressed in fetal thymus at weeks 17-24 of gestation. Undetectable in bone marrow and fetal liver.1 Publication

Gene expression databases

BgeeiENSG00000163519.
CleanExiHS_TRAT1.
ExpressionAtlasiQ6PIZ9. baseline and differential.
GenevisibleiQ6PIZ9. HS.

Organism-specific databases

HPAiCAB026130.
HPA002356.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with CD3Z. When phosphorylated, interacts with PIK3R1.2 Publications

GO - Molecular functioni

  • transmembrane receptor protein tyrosine kinase adaptor activity Source: ProtInc

Protein-protein interaction databases

BioGridi119154. 10 interactions.
STRINGi9606.ENSP00000295756.

Structurei

3D structure databases

ProteinModelPortaliQ6PIZ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni79 – 824Interaction with PIK3R1

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW4V. Eukaryota.
ENOG410ZB8K. LUCA.
GeneTreeiENSGT00390000004910.
HOGENOMiHOG000129918.
HOVERGENiHBG083932.
InParanoidiQ6PIZ9.
OMAiPVDENCY.
OrthoDBiEOG091G0RRV.
PhylomeDBiQ6PIZ9.
TreeFamiTF336066.

Family and domain databases

InterProiIPR020399. T-cell_rcpt-assoc_TM_adapter-1.
[Graphical view]
PANTHERiPTHR15951. PTHR15951. 1 hit.
ProDomiPD306446. T-cell_rcpt-assoc_TM_adapter-1. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q6PIZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGISGCPFF LWGLLALLGL ALVISLIFNI SHYVEKQRQD KMYSYSSDHT
60 70 80 90 100
RVDEYYIEDT PIYGNLDDMI SEPMDENCYE QMKARPEKSV NKMQEATPSA
110 120 130 140 150
QATNETQMCY ASLDHSVKGK RRKPRKQNTH FSDKDGDEQL HAIDASVSKT
160 170 180
TLVDSFSPES QAVEENIHDD PIRLFGLIRA KREPIN
Length:186
Mass (Da):21,211
Last modified:July 5, 2004 - v1
Checksum:i236A4BEFF427EA3E
GO

Sequence cautioni

The sequence AAF29034 differs from that shown. Reason: Frameshift at position 166. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti137 – 1371D → G.
Corresponds to variant rs57744779 [ dbSNP | Ensembl ].
VAR_062195
Natural varianti148 – 1481S → P.
Corresponds to variant rs61585973 [ dbSNP | Ensembl ].
VAR_062196

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161547 mRNA. Translation: AAF29034.1. Frameshift.
BC025713 mRNA. Translation: AAH25713.1.
CCDSiCCDS33813.1.
RefSeqiNP_001304676.1. NM_001317747.1.
NP_057472.2. NM_016388.3.
UniGeneiHs.138701.

Genome annotation databases

EnsembliENST00000295756; ENSP00000295756; ENSG00000163519.
GeneIDi50852.
KEGGihsa:50852.
UCSCiuc003dxi.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161547 mRNA. Translation: AAF29034.1. Frameshift.
BC025713 mRNA. Translation: AAH25713.1.
CCDSiCCDS33813.1.
RefSeqiNP_001304676.1. NM_001317747.1.
NP_057472.2. NM_016388.3.
UniGeneiHs.138701.

3D structure databases

ProteinModelPortaliQ6PIZ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119154. 10 interactions.
STRINGi9606.ENSP00000295756.

PTM databases

iPTMnetiQ6PIZ9.
PhosphoSiteiQ6PIZ9.

Polymorphism and mutation databases

BioMutaiTRAT1.
DMDMi74749223.

Proteomic databases

MaxQBiQ6PIZ9.
PaxDbiQ6PIZ9.
PeptideAtlasiQ6PIZ9.
PRIDEiQ6PIZ9.

Protocols and materials databases

DNASUi50852.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295756; ENSP00000295756; ENSG00000163519.
GeneIDi50852.
KEGGihsa:50852.
UCSCiuc003dxi.2. human.

Organism-specific databases

CTDi50852.
GeneCardsiTRAT1.
HGNCiHGNC:30698. TRAT1.
HPAiCAB026130.
HPA002356.
MIMi604962. gene.
neXtProtiNX_Q6PIZ9.
PharmGKBiPA128394655.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IW4V. Eukaryota.
ENOG410ZB8K. LUCA.
GeneTreeiENSGT00390000004910.
HOGENOMiHOG000129918.
HOVERGENiHBG083932.
InParanoidiQ6PIZ9.
OMAiPVDENCY.
OrthoDBiEOG091G0RRV.
PhylomeDBiQ6PIZ9.
TreeFamiTF336066.

Enzyme and pathway databases

ReactomeiR-HSA-1257604. PIP3 activates AKT signaling.
R-HSA-202424. Downstream TCR signaling.
R-HSA-2219530. Constitutive Signaling by Aberrant PI3K in Cancer.
R-HSA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
SignaLinkiQ6PIZ9.

Miscellaneous databases

GeneWikiiTRAT1.
GenomeRNAii50852.
PROiQ6PIZ9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163519.
CleanExiHS_TRAT1.
ExpressionAtlasiQ6PIZ9. baseline and differential.
GenevisibleiQ6PIZ9. HS.

Family and domain databases

InterProiIPR020399. T-cell_rcpt-assoc_TM_adapter-1.
[Graphical view]
PANTHERiPTHR15951. PTHR15951. 1 hit.
ProDomiPD306446. T-cell_rcpt-assoc_TM_adapter-1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiTRAT1_HUMAN
AccessioniPrimary (citable) accession number: Q6PIZ9
Secondary accession number(s): Q9NZX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.