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Protein

T-cell receptor-associated transmembrane adapter 1

Gene

TRAT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells.1 Publication

GO - Molecular functioni

GO - Biological processi

  • adaptive immune response Source: UniProtKB-KW
  • cellular defense response Source: ProtInc
  • interleukin-7-mediated signaling pathway Source: Reactome
  • negative regulation of receptor recycling Source: MGI
  • negative regulation of transport Source: MGI
  • phosphatidylinositol-mediated signaling Source: Reactome
  • positive regulation of calcium-mediated signaling Source: MGI
  • positive regulation of T cell receptor signaling pathway Source: MGI
  • regulation of phosphatidylinositol 3-kinase signaling Source: Reactome
  • signal transduction Source: ProtInc
  • T cell receptor signaling pathway Source: Reactome

Keywordsi

Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-1257604. PIP3 activates AKT signaling.
R-HSA-202424. Downstream TCR signaling.
R-HSA-2219530. Constitutive Signaling by Aberrant PI3K in Cancer.
R-HSA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
SignaLinkiQ6PIZ9.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell receptor-associated transmembrane adapter 1
Alternative name(s):
T-cell receptor-interacting molecule
Short name:
TRIM
pp29/30
Gene namesi
Name:TRAT1
Synonyms:TCRIM
ORF Names:HSPC062
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163519.13.
HGNCiHGNC:30698. TRAT1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7ExtracellularSequence analysis7
Transmembranei8 – 28Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
Topological domaini29 – 186CytoplasmicSequence analysisAdd BLAST158

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi79Y → F: Abolishes interaction with PIK3R1. 1 Publication1

Organism-specific databases

DisGeNETi50852.
OpenTargetsiENSG00000163519.
PharmGKBiPA128394655.

Polymorphism and mutation databases

BioMutaiTRAT1.
DMDMi74749223.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000833441 – 186T-cell receptor-associated transmembrane adapter 1Add BLAST186

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi7InterchainCurated
Modified residuei46PhosphoserineBy similarity1
Modified residuei79Phosphotyrosine1 Publication1

Post-translational modificationi

Phosphorylated on tyrosines by LCK or FYN upon TCR activation.1 Publication

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiQ6PIZ9.
PaxDbiQ6PIZ9.
PeptideAtlasiQ6PIZ9.
PRIDEiQ6PIZ9.

PTM databases

iPTMnetiQ6PIZ9.
PhosphoSitePlusiQ6PIZ9.

Expressioni

Tissue specificityi

Strongly expressed in thymus, and to a lesser extent in spleen, lymph node and peripheral blood lymphocytes. Present in T-cells and NK cells, but not B-cells (at protein level).2 Publications

Developmental stagei

Strongly expressed in fetal thymus at weeks 17-24 of gestation. Undetectable in bone marrow and fetal liver.1 Publication

Gene expression databases

BgeeiENSG00000163519.
CleanExiHS_TRAT1.
ExpressionAtlasiQ6PIZ9. baseline and differential.
GenevisibleiQ6PIZ9. HS.

Organism-specific databases

HPAiCAB026130.
HPA002356.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with CD3Z. When phosphorylated, interacts with PIK3R1.2 Publications

GO - Molecular functioni

  • transmembrane receptor protein tyrosine kinase adaptor activity Source: ProtInc

Protein-protein interaction databases

BioGridi119154. 16 interactors.
STRINGi9606.ENSP00000295756.

Structurei

3D structure databases

ProteinModelPortaliQ6PIZ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni79 – 82Interaction with PIK3R11 Publication4

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW4V. Eukaryota.
ENOG410ZB8K. LUCA.
GeneTreeiENSGT00390000004910.
HOGENOMiHOG000129918.
HOVERGENiHBG083932.
InParanoidiQ6PIZ9.
OMAiPVDENCY.
OrthoDBiEOG091G0RRV.
PhylomeDBiQ6PIZ9.
TreeFamiTF336066.

Family and domain databases

InterProiView protein in InterPro
IPR020399. T-cell_rcpt-assoc_TM_adapter-1.
PANTHERiPTHR15951. PTHR15951. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD306446. T-cell_rcpt-assoc_TM_adapter-1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6PIZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGISGCPFF LWGLLALLGL ALVISLIFNI SHYVEKQRQD KMYSYSSDHT
60 70 80 90 100
RVDEYYIEDT PIYGNLDDMI SEPMDENCYE QMKARPEKSV NKMQEATPSA
110 120 130 140 150
QATNETQMCY ASLDHSVKGK RRKPRKQNTH FSDKDGDEQL HAIDASVSKT
160 170 180
TLVDSFSPES QAVEENIHDD PIRLFGLIRA KREPIN
Length:186
Mass (Da):21,211
Last modified:July 5, 2004 - v1
Checksum:i236A4BEFF427EA3E
GO

Sequence cautioni

Q6PIZ9: The sequence AAF29034 differs from that shown. Reason: Frameshift at position 166.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062195137D → G. Corresponds to variant dbSNP:rs57744779Ensembl.1
Natural variantiVAR_062196148S → P. Corresponds to variant dbSNP:rs61585973Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161547 mRNA. Translation: AAF29034.1. Frameshift.
BC025713 mRNA. Translation: AAH25713.1.
CCDSiCCDS33813.1.
RefSeqiNP_001304676.1. NM_001317747.1.
NP_057472.2. NM_016388.3.
UniGeneiHs.138701.

Genome annotation databases

EnsembliENST00000295756; ENSP00000295756; ENSG00000163519.
GeneIDi50852.
KEGGihsa:50852.
UCSCiuc003dxi.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTRAT1_HUMAN
AccessioniPrimary (citable) accession number: Q6PIZ9
Secondary accession number(s): Q9NZX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2004
Last modified: September 27, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot