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Protein

Fidgetin-like protein 1

Gene

FIGNL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation.1 Publication

Catalytic activityi

ATP + H2O = ADP + phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei404ATP; via amide nitrogen and carbonyl oxygen1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi444 – 449ATP1 Publication6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fidgetin-like protein 1 (EC:3.6.4.-)
Gene namesi
Name:FIGNL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:13286. FIGNL1.

Subcellular locationi

  • Nucleus 1 Publication

  • Note: Together with RAD51 and a subset of H2A histone proteins, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) treatment.

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • nuclear chromosome Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi295F → E: Reduces interaction with RAD51 and inhibits HR-mediated DNA repair. Strongly reduce, but does abolish, interaction with RAD51; when associated with E-340. 1 Publication1
Mutagenesisi340F → E: Reduces weakly interaction with RAD51. Strongly reduce, but does abolish, interaction with RAD51; when associated with E-295. 1 Publication1
Mutagenesisi447K → A: Inhibits HR-mediated DNA repair. 1 Publication1
Mutagenesisi500D → A: Inhibits HR-mediated DNA repair. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000132436.
PharmGKBiPA28148.

Polymorphism and mutation databases

BioMutaiFIGNL1.
DMDMi158563967.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003027231 – 674Fidgetin-like protein 1Add BLAST674

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei259PhosphoserineCombined sources1
Modified residuei339N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6PIW4.
MaxQBiQ6PIW4.
PaxDbiQ6PIW4.
PeptideAtlasiQ6PIW4.
PRIDEiQ6PIW4.

PTM databases

iPTMnetiQ6PIW4.
PhosphoSitePlusiQ6PIW4.

Expressioni

Gene expression databases

BgeeiENSG00000132436.
CleanExiHS_FIGNL1.
ExpressionAtlasiQ6PIW4. baseline and differential.
GenevisibleiQ6PIW4. HS.

Organism-specific databases

HPAiHPA055542.

Interactioni

Subunit structurei

Hexamer (By similarity). Interacts (via N-terminal one-half region) with RAD51; the interaction is direct. Interacts (via N-terminal one-half region) with SPIDR (via the C-terminal region); the interaction is direct.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ITGB1BP1O147133EBI-8468390,EBI-2127319

Protein-protein interaction databases

BioGridi122026. 30 interactors.
IntActiQ6PIW4. 10 interactors.
MINTiMINT-4908266.
STRINGi9606.ENSP00000349356.

Structurei

Secondary structure

1674
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi381 – 390Combined sources10
Helixi400 – 402Combined sources3
Helixi407 – 416Combined sources10
Helixi418 – 422Combined sources5
Turni424 – 426Combined sources3
Helixi429 – 431Combined sources3
Beta strandi435 – 442Combined sources8
Helixi447 – 457Combined sources11
Beta strandi461 – 466Combined sources6
Helixi467 – 470Combined sources4
Helixi477 – 491Combined sources15
Beta strandi494 – 500Combined sources7
Helixi502 – 505Combined sources4
Helixi516 – 529Combined sources14
Beta strandi539 – 546Combined sources8
Helixi548 – 550Combined sources3
Helixi553 – 556Combined sources4
Beta strandi561 – 564Combined sources4
Helixi570 – 582Combined sources13
Helixi590 – 599Combined sources10
Turni600 – 602Combined sources3
Helixi605 – 616Combined sources12
Helixi618 – 622Combined sources5
Helixi633 – 635Combined sources3
Helixi641 – 651Combined sources11
Helixi652 – 654Combined sources3
Helixi660 – 670Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3D8BX-ray2.00A/B341-674[»]
ProteinModelPortaliQ6PIW4.
SMRiQ6PIW4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6PIW4.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni295 – 344Necessary and sufficient for interaction with RAD511 PublicationAdd BLAST50

Domaini

The N-terminus is necessary for its recruitment to DNA damage sites.

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

eggNOGiKOG0740. Eukaryota.
COG0464. LUCA.
GeneTreeiENSGT00570000078874.
HOGENOMiHOG000225145.
HOVERGENiHBG061204.
InParanoidiQ6PIW4.
OMAiQILRIQY.
OrthoDBiEOG091G0Q8J.
PhylomeDBiQ6PIW4.
TreeFamiTF105013.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PIW4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQTSSSRSVH LSEWQKNYFA ITSGICTGPK ADAYRAQILR IQYAWANSEI
60 70 80 90 100
SQVCATKLFK KYAEKYSAII DSDNVESGLN NYAENILTLA GSQQTDSDKW
110 120 130 140 150
QSGLSINNVF KMSSVQKMMQ AGKKFKDSLL EPALASVVIH KEATVFDLPK
160 170 180 190 200
FSVCGSSQES DSLPNSAHDR DRTQDFPESN RLKLLQNAQP PMVTNTARTC
210 220 230 240 250
PTFSAPVGES ATAKFHVTPL FGNVKKENHS SAKENIGLNV FLSNQSCFPA
260 270 280 290 300
ACENPQRKSF YGSGTIDALS NPILNKACSK TEDNGPKEDS SLPTFKTAKE
310 320 330 340 350
QLWVDQQKKY HQPQRASGSS YGGVKKSLGA SRSRGILGKF VPPIPKQDGG
360 370 380 390 400
EQNGGMQCKP YGAGPTEPAH PVDERLKNLE PKMIELIMNE IMDHGPPVNW
410 420 430 440 450
EDIAGVEFAK ATIKEIVVWP MLRPDIFTGL RGPPKGILLF GPPGTGKTLI
460 470 480 490 500
GKCIASQSGA TFFSISASSL TSKWVGEGEK MVRALFAVAR CQQPAVIFID
510 520 530 540 550
EIDSLLSQRG DGEHESSRRI KTEFLVQLDG ATTSSEDRIL VVGATNRPQE
560 570 580 590 600
IDEAARRRLV KRLYIPLPEA SARKQIVINL MSKEQCCLSE EEIEQIVQQS
610 620 630 640 650
DAFSGADMTQ LCREASLGPI RSLQTADIAT ITPDQVRPIA YIDFENAFRT
660 670
VRPSVSPKDL ELYENWNKTF GCGK
Length:674
Mass (Da):74,077
Last modified:September 11, 2007 - v2
Checksum:i2EB812B407495BF2
GO
Isoform 2 (identifier: Q6PIW4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: Missing.

Show »
Length:563
Mass (Da):61,686
Checksum:iDD30D9C1EEC2DEA3
GO

Sequence cautioni

The sequence BAB14567 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti614E → G in BAB14426 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034941137V → M.1 PublicationCorresponds to variant rs10235371dbSNPEnsembl.1
Natural variantiVAR_034942216H → Y.Corresponds to variant rs35929700dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0279371 – 111Missing in isoform 2. 1 PublicationAdd BLAST111

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023142 mRNA. Translation: BAB14426.1.
AK023411 mRNA. Translation: BAB14567.1. Different initiation.
AL834387 mRNA. Translation: CAD39050.1.
AC018705 Genomic DNA. Translation: AAS01996.1.
CH236955 Genomic DNA. Translation: EAL23899.1.
CH471128 Genomic DNA. Translation: EAW60975.1.
CH471128 Genomic DNA. Translation: EAW60976.1.
BC051867 mRNA. Translation: AAH51867.1.
CCDSiCCDS5510.1. [Q6PIW4-1]
RefSeqiNP_001036227.1. NM_001042762.2. [Q6PIW4-1]
NP_001274421.1. NM_001287492.1. [Q6PIW4-1]
NP_001274422.1. NM_001287493.1. [Q6PIW4-1]
NP_001274423.1. NM_001287494.1. [Q6PIW4-1]
NP_001274424.1. NM_001287495.1. [Q6PIW4-1]
NP_001274425.1. NM_001287496.1. [Q6PIW4-2]
NP_071399.2. NM_022116.4. [Q6PIW4-1]
XP_011513772.1. XM_011515470.2. [Q6PIW4-1]
XP_016867990.1. XM_017012501.1. [Q6PIW4-1]
XP_016867991.1. XM_017012502.1. [Q6PIW4-1]
UniGeneiHs.137516.

Genome annotation databases

EnsembliENST00000356889; ENSP00000349356; ENSG00000132436. [Q6PIW4-1]
ENST00000395556; ENSP00000378924; ENSG00000132436. [Q6PIW4-1]
ENST00000419119; ENSP00000410811; ENSG00000132436. [Q6PIW4-1]
ENST00000433017; ENSP00000399997; ENSG00000132436. [Q6PIW4-1]
ENST00000611938; ENSP00000484551; ENSG00000132436. [Q6PIW4-1]
ENST00000613602; ENSP00000481751; ENSG00000132436. [Q6PIW4-1]
ENST00000615084; ENSP00000483543; ENSG00000132436. [Q6PIW4-1]
ENST00000617389; ENSP00000483126; ENSG00000132436. [Q6PIW4-1]
GeneIDi63979.
KEGGihsa:63979.
UCSCiuc003tpc.5. human. [Q6PIW4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023142 mRNA. Translation: BAB14426.1.
AK023411 mRNA. Translation: BAB14567.1. Different initiation.
AL834387 mRNA. Translation: CAD39050.1.
AC018705 Genomic DNA. Translation: AAS01996.1.
CH236955 Genomic DNA. Translation: EAL23899.1.
CH471128 Genomic DNA. Translation: EAW60975.1.
CH471128 Genomic DNA. Translation: EAW60976.1.
BC051867 mRNA. Translation: AAH51867.1.
CCDSiCCDS5510.1. [Q6PIW4-1]
RefSeqiNP_001036227.1. NM_001042762.2. [Q6PIW4-1]
NP_001274421.1. NM_001287492.1. [Q6PIW4-1]
NP_001274422.1. NM_001287493.1. [Q6PIW4-1]
NP_001274423.1. NM_001287494.1. [Q6PIW4-1]
NP_001274424.1. NM_001287495.1. [Q6PIW4-1]
NP_001274425.1. NM_001287496.1. [Q6PIW4-2]
NP_071399.2. NM_022116.4. [Q6PIW4-1]
XP_011513772.1. XM_011515470.2. [Q6PIW4-1]
XP_016867990.1. XM_017012501.1. [Q6PIW4-1]
XP_016867991.1. XM_017012502.1. [Q6PIW4-1]
UniGeneiHs.137516.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3D8BX-ray2.00A/B341-674[»]
ProteinModelPortaliQ6PIW4.
SMRiQ6PIW4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122026. 30 interactors.
IntActiQ6PIW4. 10 interactors.
MINTiMINT-4908266.
STRINGi9606.ENSP00000349356.

PTM databases

iPTMnetiQ6PIW4.
PhosphoSitePlusiQ6PIW4.

Polymorphism and mutation databases

BioMutaiFIGNL1.
DMDMi158563967.

Proteomic databases

EPDiQ6PIW4.
MaxQBiQ6PIW4.
PaxDbiQ6PIW4.
PeptideAtlasiQ6PIW4.
PRIDEiQ6PIW4.

Protocols and materials databases

DNASUi63979.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356889; ENSP00000349356; ENSG00000132436. [Q6PIW4-1]
ENST00000395556; ENSP00000378924; ENSG00000132436. [Q6PIW4-1]
ENST00000419119; ENSP00000410811; ENSG00000132436. [Q6PIW4-1]
ENST00000433017; ENSP00000399997; ENSG00000132436. [Q6PIW4-1]
ENST00000611938; ENSP00000484551; ENSG00000132436. [Q6PIW4-1]
ENST00000613602; ENSP00000481751; ENSG00000132436. [Q6PIW4-1]
ENST00000615084; ENSP00000483543; ENSG00000132436. [Q6PIW4-1]
ENST00000617389; ENSP00000483126; ENSG00000132436. [Q6PIW4-1]
GeneIDi63979.
KEGGihsa:63979.
UCSCiuc003tpc.5. human. [Q6PIW4-1]

Organism-specific databases

CTDi63979.
GeneCardsiFIGNL1.
HGNCiHGNC:13286. FIGNL1.
HPAiHPA055542.
MIMi615383. gene.
neXtProtiNX_Q6PIW4.
OpenTargetsiENSG00000132436.
PharmGKBiPA28148.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0740. Eukaryota.
COG0464. LUCA.
GeneTreeiENSGT00570000078874.
HOGENOMiHOG000225145.
HOVERGENiHBG061204.
InParanoidiQ6PIW4.
OMAiQILRIQY.
OrthoDBiEOG091G0Q8J.
PhylomeDBiQ6PIW4.
TreeFamiTF105013.

Miscellaneous databases

EvolutionaryTraceiQ6PIW4.
GenomeRNAii63979.
PROiQ6PIW4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132436.
CleanExiHS_FIGNL1.
ExpressionAtlasiQ6PIW4. baseline and differential.
GenevisibleiQ6PIW4. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFIGL1_HUMAN
AccessioniPrimary (citable) accession number: Q6PIW4
Secondary accession number(s): D3DVM6
, Q86V18, Q8ND59, Q9H8P1, Q9H917
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: November 2, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.