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Protein
Submitted name:

CAPN9 protein

Gene

CAPN9

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi511 – 522PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi541 – 552PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalciumPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
CAPN9 proteinImported
Submitted name:
Calpain 9, isoform CRA_aImported
Gene namesi
Name:CAPN9Imported
ORF Names:hCG_15929Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26066.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 274Calpain catalyticInterPro annotationAdd BLAST203
Domaini455 – 489EF-handInterPro annotationAdd BLAST35
Domaini498 – 526EF-handInterPro annotationAdd BLAST29
Domaini528 – 563EF-handInterPro annotationAdd BLAST36

Sequence similaritiesi

Belongs to the peptidase C2 family.SAAS annotation

Phylogenomic databases

eggNOGiKOG0045. Eukaryota.
ENOG410XP0B. LUCA.
HOVERGENiHBG012645.
KOiK08578.

Family and domain databases

CDDicd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
InterProiView protein in InterPro
IPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR036213. Calpain_III_sf.
IPR029542. CAPN9.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001300. Peptidase_C2_calpain_cat.
PANTHERiPTHR10183:SF385. PTHR10183:SF385. 2 hits.
PfamiView protein in Pfam
PF01067. Calpain_III. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF00648. Peptidase_C2. 1 hit.
PRINTSiPR00704. CALPAIN.
SMARTiView protein in SMART
SM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00054. EFh. 2 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiView protein in PROSITE
PS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.

Sequencei

Sequence statusi: Complete.

Q6PIV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYLYRAPGP QAHPVPKDAR ITHSSGQSFE QMRQECLQRG TLFEDADFPA
60 70 80 90 100
SNSSLFYSER PQIPFVWKRP GFWQHSEWLD VVIDDRLPTF RDRLVFLHSA
110 120 130 140 150
DHNEFWSALL EKAYAKLNGS YEALKGGSAI EAMEDFTGGV AETFQTKEAP
160 170 180 190 200
ENFYEILEKA LKRGSLLGCF IDTRSAAESE ARTPFGLIKG HAYSVTGIDQ
210 220 230 240 250
VSFRGQRIEL IRIRNPWGQV EWNGSWSDSS PEWRSVGPAE QKRLCHTALD
260 270 280 290 300
DGEFWMAFQD FKAHFDKVEI CNLTPDALEE DAIHKWEVTV HQGSWVRGST
310 320 330 340 350
AGGCRNFLDT FWTNPQIKLS LTEKDEGQEE CSFLVALMQK DRRKLKRFGA
360 370 380 390 400
NVLTIGYAIY ECPDKDEHLN KDFFRYHASR ARSKTFINLR EVSDRFKLPP
410 420 430 440 450
GEYILIPSTF EPHQEADFCL RIFSEKKAIT RDMDGNVDID LPEPPKPTPP
460 470 480 490 500
DQETEEEQRF RALFEQVAGE DMEVTAEELE YVLNAVLQKK KDIKFKKLSL
510 520 530 540 550
ISCKNIISLM DTSGNGKLEF DEFKVFWDKL KQWINLFLRF DADKSGTMST
560 570 580 590 600
YELRTALKAA GFQLSSHLLQ LIVLRYADEE LQLDFDDFLN CLVRLENASR
610 620
VFQALSTKNK EFIHLNINEF IHLTMNI
Length:627
Mass (Da):72,310
Last modified:July 5, 2004 - v1
Checksum:i936ECC6134CD7211
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC027993 mRNA. Translation: AAH27993.1.
CH471098 Genomic DNA. Translation: EAW69920.1.
RefSeqiNP_006606.1. NM_006615.2.
UniGeneiHs.498021.

Genome annotation databases

GeneIDi10753.
KEGGihsa:10753.

Similar proteinsi

Entry informationi

Entry nameiQ6PIV8_HUMAN
AccessioniPrimary (citable) accession number: Q6PIV8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation