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Protein
Submitted name:

CAPN9 protein

Gene

CAPN9

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
CAPN9 proteinImported
Submitted name:
Calpain 9, isoform CRA_aImported
Gene namesi
Name:CAPN9Imported
ORF Names:hCG_15929Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26066.

PTM / Processingi

Proteomic databases

PeptideAtlasiQ6PIV8.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000271971.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini72 – 274203Calpain catalyticInterPro annotationAdd
BLAST
Domaini455 – 48935EF-handInterPro annotationAdd
BLAST
Domaini498 – 52629EF-handInterPro annotationAdd
BLAST
Domaini528 – 56336EF-handInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C2 family.SAAS annotation

Phylogenomic databases

eggNOGiKOG0045. Eukaryota.
ENOG410XP0B. LUCA.
HOVERGENiHBG012645.
KOiK08578.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR029542. CAPN9.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PANTHERiPTHR10183:SF311. PTHR10183:SF311. 1 hit.
PfamiPF01067. Calpain_III. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PIV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYLYRAPGP QAHPVPKDAR ITHSSGQSFE QMRQECLQRG TLFEDADFPA
60 70 80 90 100
SNSSLFYSER PQIPFVWKRP GFWQHSEWLD VVIDDRLPTF RDRLVFLHSA
110 120 130 140 150
DHNEFWSALL EKAYAKLNGS YEALKGGSAI EAMEDFTGGV AETFQTKEAP
160 170 180 190 200
ENFYEILEKA LKRGSLLGCF IDTRSAAESE ARTPFGLIKG HAYSVTGIDQ
210 220 230 240 250
VSFRGQRIEL IRIRNPWGQV EWNGSWSDSS PEWRSVGPAE QKRLCHTALD
260 270 280 290 300
DGEFWMAFQD FKAHFDKVEI CNLTPDALEE DAIHKWEVTV HQGSWVRGST
310 320 330 340 350
AGGCRNFLDT FWTNPQIKLS LTEKDEGQEE CSFLVALMQK DRRKLKRFGA
360 370 380 390 400
NVLTIGYAIY ECPDKDEHLN KDFFRYHASR ARSKTFINLR EVSDRFKLPP
410 420 430 440 450
GEYILIPSTF EPHQEADFCL RIFSEKKAIT RDMDGNVDID LPEPPKPTPP
460 470 480 490 500
DQETEEEQRF RALFEQVAGE DMEVTAEELE YVLNAVLQKK KDIKFKKLSL
510 520 530 540 550
ISCKNIISLM DTSGNGKLEF DEFKVFWDKL KQWINLFLRF DADKSGTMST
560 570 580 590 600
YELRTALKAA GFQLSSHLLQ LIVLRYADEE LQLDFDDFLN CLVRLENASR
610 620
VFQALSTKNK EFIHLNINEF IHLTMNI
Length:627
Mass (Da):72,310
Last modified:July 5, 2004 - v1
Checksum:i936ECC6134CD7211
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC027993 mRNA. Translation: AAH27993.1.
CH471098 Genomic DNA. Translation: EAW69920.1.
RefSeqiNP_006606.1. NM_006615.2.
UniGeneiHs.498021.

Genome annotation databases

GeneIDi10753.
KEGGihsa:10753.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC027993 mRNA. Translation: AAH27993.1.
CH471098 Genomic DNA. Translation: EAW69920.1.
RefSeqiNP_006606.1. NM_006615.2.
UniGeneiHs.498021.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000271971.

Proteomic databases

PeptideAtlasiQ6PIV8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi10753.
KEGGihsa:10753.

Organism-specific databases

CTDi10753.
PharmGKBiPA26066.

Phylogenomic databases

eggNOGiKOG0045. Eukaryota.
ENOG410XP0B. LUCA.
HOVERGENiHBG012645.
KOiK08578.

Miscellaneous databases

GenomeRNAii10753.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR029542. CAPN9.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PANTHERiPTHR10183:SF311. PTHR10183:SF311. 1 hit.
PfamiPF01067. Calpain_III. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6PIV8_HUMAN
AccessioniPrimary (citable) accession number: Q6PIV8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.