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Protein

Solute carrier family 25 member 34

Gene

SLC25A34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.29.15.3. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 34
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:27653. SLC25A34.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 27Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei45 – 65Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei98 – 120Helical; Name=3Sequence analysisAdd BLAST23
Transmembranei170 – 191Helical; Name=4Sequence analysisAdd BLAST22
Transmembranei206 – 226Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei278 – 301Helical; Name=6Sequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162461.
PharmGKBiPA142670906.

Polymorphism and mutation databases

BioMutaiSLC25A34.
DMDMi74758372.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002917891 – 304Solute carrier family 25 member 34Add BLAST304

Proteomic databases

PaxDbiQ6PIV7.
PRIDEiQ6PIV7.

Expressioni

Gene expression databases

BgeeiENSG00000162461.
CleanExiHS_SLC25A34.
GenevisibleiQ6PIV7. HS.

Organism-specific databases

HPAiHPA069806.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000294454.

Structurei

3D structure databases

ProteinModelPortaliQ6PIV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati4 – 97Solcar 1Add BLAST94
Repeati101 – 194Solcar 2Add BLAST94
Repeati204 – 295Solcar 3Add BLAST92

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0755. Eukaryota.
ENOG410XS37. LUCA.
GeneTreeiENSGT00550000074760.
HOGENOMiHOG000165141.
HOVERGENiHBG108440.
InParanoidiQ6PIV7.
KOiK15117.
OMAiARGTYPR.
OrthoDBiEOG091G0MCY.
PhylomeDBiQ6PIV7.
TreeFamiTF324506.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PIV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METVPPAVDL VLGASACCLA CVFTNPLEVV KTRLQLQGEL QARGTYPRPY
60 70 80 90 100
HGFIASVAAV ARADGLWGLQ KGLAAGLLYQ GLMNGVRFYC YSLACQAGLT
110 120 130 140 150
QQPGGTVVAG AVAGALGAFV GSPAYLIKTQ LQAQTVAAVA VGHQHNHQTV
160 170 180 190 200
LGALETIWRQ QGLLGLWQGV GGAVPRVMVG SAAQLATFAS AKAWVQKQQW
210 220 230 240 250
LPEDSWLVAL AGGMISSIAV VVVMTPFDVV STRLYNQPVD TAGRGQLYGG
260 270 280 290 300
LTDCMVKIWR QEGPLALYKG LGPAYLRLGP HTILSMLFWD ELRKLAGRAQ

HKGT
Length:304
Mass (Da):32,224
Last modified:July 5, 2004 - v1
Checksum:i1C35741714D219ED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198Q → P in CAH18120 (PubMed:17974005).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL450998 Genomic DNA. Translation: CAH70849.1.
BC027998 mRNA. Translation: AAH27998.1.
CR749264 mRNA. Translation: CAH18120.1.
CCDSiCCDS162.1.
RefSeqiNP_997231.1. NM_207348.2.
UniGeneiHs.631867.

Genome annotation databases

EnsembliENST00000294454; ENSP00000294454; ENSG00000162461.
GeneIDi284723.
KEGGihsa:284723.
UCSCiuc001axb.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL450998 Genomic DNA. Translation: CAH70849.1.
BC027998 mRNA. Translation: AAH27998.1.
CR749264 mRNA. Translation: CAH18120.1.
CCDSiCCDS162.1.
RefSeqiNP_997231.1. NM_207348.2.
UniGeneiHs.631867.

3D structure databases

ProteinModelPortaliQ6PIV7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000294454.

Protein family/group databases

TCDBi2.A.29.15.3. the mitochondrial carrier (mc) family.

Polymorphism and mutation databases

BioMutaiSLC25A34.
DMDMi74758372.

Proteomic databases

PaxDbiQ6PIV7.
PRIDEiQ6PIV7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294454; ENSP00000294454; ENSG00000162461.
GeneIDi284723.
KEGGihsa:284723.
UCSCiuc001axb.2. human.

Organism-specific databases

CTDi284723.
GeneCardsiSLC25A34.
HGNCiHGNC:27653. SLC25A34.
HPAiHPA069806.
MIMi610817. gene.
neXtProtiNX_Q6PIV7.
OpenTargetsiENSG00000162461.
PharmGKBiPA142670906.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0755. Eukaryota.
ENOG410XS37. LUCA.
GeneTreeiENSGT00550000074760.
HOGENOMiHOG000165141.
HOVERGENiHBG108440.
InParanoidiQ6PIV7.
KOiK15117.
OMAiARGTYPR.
OrthoDBiEOG091G0MCY.
PhylomeDBiQ6PIV7.
TreeFamiTF324506.

Miscellaneous databases

GenomeRNAii284723.
PROiQ6PIV7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162461.
CleanExiHS_SLC25A34.
GenevisibleiQ6PIV7. HS.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS2534_HUMAN
AccessioniPrimary (citable) accession number: Q6PIV7
Secondary accession number(s): Q68DV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.