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Protein

Forkhead box protein R1

Gene

FOXR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi173 – 272100Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: GO_Central

GO - Biological processi

  1. regulation of transcription from RNA polymerase II promoter Source: GO_Central
  2. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein R1
Alternative name(s):
Forkhead box protein N5
Gene namesi
Name:FOXR1
Synonyms:FOXN5
ORF Names:DLNB13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:29980. FOXR1.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134959382.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Forkhead box protein R1PRO_0000253778Add
BLAST

Proteomic databases

PaxDbiQ6PIV2.
PRIDEiQ6PIV2.

Expressioni

Gene expression databases

BgeeiQ6PIV2.
CleanExiHS_FOXR1.
ExpressionAtlasiQ6PIV2. baseline.
GenevestigatoriQ6PIV2.

Interactioni

Protein-protein interaction databases

BioGridi129476. 20 interactions.
STRINGi9606.ENSP00000314806.

Structurei

3D structure databases

ProteinModelPortaliQ6PIV2.
SMRiQ6PIV2. Positions 178-234.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00780000121868.
HOGENOMiHOG000004846.
HOVERGENiHBG080262.
InParanoidiQ6PIV2.
OMAiVPVSMQG.
PhylomeDBiQ6PIV2.
TreeFamiTF329867.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6PIV2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNELFLAFT TSHLPLAEQK LARYKLRIVK PPKLPLEKKP NPDKDGPDYE
60 70 80 90 100
PNLWMWVNPN IVYPPGKLEV SGRRKREDLT STLPSSQPPQ KEEDASCSEA
110 120 130 140 150
AGVESLSQSS SKRSPPRKRF AFSPSTWELT EEEEAEDQED SSSMALPSPH
160 170 180 190 200
KRAPLQSRRL RQASSQAGRL WSRPPLNYFH LIALALRNSS PCGLNVQQIY
210 220 230 240 250
SFTRKHFPFF RTAPEGWKNT VRHNLCFRDS FEKVPVSMQG GASTRPRSCL
260 270 280 290
WKLTEEGHRR FAEEARALAS TRLESIQQCM SQPDVMPFLF DL
Length:292
Mass (Da):33,310
Last modified:October 17, 2006 - v2
Checksum:i6516C9DB714F5A65
GO
Isoform 2 (identifier: Q6PIV2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     129-205: LTEEEEAEDQ...VQQIYSFTRK → GPPPESEASA...PGPSEGGRVQ
     206-291: Missing.

Note: No experimental confirmation available.

Show »
Length:206
Mass (Da):22,529
Checksum:i9A87D46EFF232027
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei129 – 20577LTEEE…SFTRK → GPPPESEASASQQPGGEALV PAPSQLLPPNCPGIKKQFPL WPQRATDLQFHSELLGLILL CSCCGPSPGPSEGGRVQ in isoform 2. 1 PublicationVSP_056600Add
BLAST
Alternative sequencei206 – 29186Missing in isoform 2. 1 PublicationVSP_056601Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB094092 mRNA. Translation: BAC76046.1.
EF444979 Genomic DNA. Translation: ACA05993.1.
AP003392 Genomic DNA. No translation available.
AP004609 Genomic DNA. No translation available.
BC028191 mRNA. Translation: AAH28191.2.
BC038969 mRNA. Translation: AAH38969.2.
BC125040 mRNA. Translation: AAI25041.1.
CCDSiCCDS31688.1. [Q6PIV2-1]
RefSeqiNP_859072.1. NM_181721.2. [Q6PIV2-1]
UniGeneiHs.116679.

Genome annotation databases

EnsembliENST00000317011; ENSP00000314806; ENSG00000176302. [Q6PIV2-1]
ENST00000531539; ENSP00000433394; ENSG00000176302. [Q6PIV2-2]
GeneIDi283150.
KEGGihsa:283150.
UCSCiuc001pui.3. human. [Q6PIV2-1]

Polymorphism databases

DMDMi116247781.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB094092 mRNA. Translation: BAC76046.1.
EF444979 Genomic DNA. Translation: ACA05993.1.
AP003392 Genomic DNA. No translation available.
AP004609 Genomic DNA. No translation available.
BC028191 mRNA. Translation: AAH28191.2.
BC038969 mRNA. Translation: AAH38969.2.
BC125040 mRNA. Translation: AAI25041.1.
CCDSiCCDS31688.1. [Q6PIV2-1]
RefSeqiNP_859072.1. NM_181721.2. [Q6PIV2-1]
UniGeneiHs.116679.

3D structure databases

ProteinModelPortaliQ6PIV2.
SMRiQ6PIV2. Positions 178-234.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129476. 20 interactions.
STRINGi9606.ENSP00000314806.

Polymorphism databases

DMDMi116247781.

Proteomic databases

PaxDbiQ6PIV2.
PRIDEiQ6PIV2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317011; ENSP00000314806; ENSG00000176302. [Q6PIV2-1]
ENST00000531539; ENSP00000433394; ENSG00000176302. [Q6PIV2-2]
GeneIDi283150.
KEGGihsa:283150.
UCSCiuc001pui.3. human. [Q6PIV2-1]

Organism-specific databases

CTDi283150.
GeneCardsiGC11P118843.
HGNCiHGNC:29980. FOXR1.
MIMi615755. gene.
neXtProtiNX_Q6PIV2.
PharmGKBiPA134959382.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00780000121868.
HOGENOMiHOG000004846.
HOVERGENiHBG080262.
InParanoidiQ6PIV2.
OMAiVPVSMQG.
PhylomeDBiQ6PIV2.
TreeFamiTF329867.

Miscellaneous databases

ChiTaRSiFOXR1. human.
GenomeRNAii283150.
NextBioi93662.
PROiQ6PIV2.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PIV2.
CleanExiHS_FOXR1.
ExpressionAtlasiQ6PIV2. baseline.
GenevestigatoriQ6PIV2.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a 500-kb region of common allelic loss in chromosome 11q23 in non-MYCN amplified type of neuroblastoma."
    Kubo T., Arai Y., Ohira M., Gamou T., Maeno G., Sakiyama T., Toyoda A., Hattori M., Sakaki Y., Nakagawara A., Ohki M.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. NHLBI resequencing and genotyping service (RS&G)
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.

Entry informationi

Entry nameiFOXR1_HUMAN
AccessioniPrimary (citable) accession number: Q6PIV2
Secondary accession number(s): B0YJ15
, Q08AS8, Q86UT9, Q8IXX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: February 4, 2015
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.