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Q6PIV2

- FOXR1_HUMAN

UniProt

Q6PIV2 - FOXR1_HUMAN

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Protein
Forkhead box protein R1
Gene
FOXR1, FOXN5, DLNB13
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi173 – 272100Fork-head
Add
BLAST

GO - Molecular functioni

  1. DNA binding, bending Source: RefGenome
  2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: RefGenome
  3. double-stranded DNA binding Source: RefGenome
  4. sequence-specific DNA binding Source: InterPro
  5. transcription factor binding Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: RefGenome
  2. organ development Source: RefGenome
  3. pattern specification process Source: RefGenome
  4. regulation of sequence-specific DNA binding transcription factor activity Source: RefGenome
  5. tissue development Source: RefGenome
  6. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein R1
Alternative name(s):
Forkhead box protein N5
Gene namesi
Name:FOXR1
Synonyms:FOXN5
ORF Names:DLNB13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:29980. FOXR1.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. transcription factor complex Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134959382.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Forkhead box protein R1
PRO_0000253778Add
BLAST

Proteomic databases

PaxDbiQ6PIV2.
PRIDEiQ6PIV2.

Expressioni

Gene expression databases

ArrayExpressiQ6PIV2.
BgeeiQ6PIV2.
CleanExiHS_FOXR1.
GenevestigatoriQ6PIV2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000314806.

Structurei

3D structure databases

ProteinModelPortaliQ6PIV2.
SMRiQ6PIV2. Positions 176-257.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5025.
HOGENOMiHOG000004846.
HOVERGENiHBG080262.
InParanoidiQ6PIV2.
OMAiVPVSMQG.
PhylomeDBiQ6PIV2.
TreeFamiTF329867.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PIV2-1 [UniParc]FASTAAdd to Basket

« Hide

MGNELFLAFT TSHLPLAEQK LARYKLRIVK PPKLPLEKKP NPDKDGPDYE    50
PNLWMWVNPN IVYPPGKLEV SGRRKREDLT STLPSSQPPQ KEEDASCSEA 100
AGVESLSQSS SKRSPPRKRF AFSPSTWELT EEEEAEDQED SSSMALPSPH 150
KRAPLQSRRL RQASSQAGRL WSRPPLNYFH LIALALRNSS PCGLNVQQIY 200
SFTRKHFPFF RTAPEGWKNT VRHNLCFRDS FEKVPVSMQG GASTRPRSCL 250
WKLTEEGHRR FAEEARALAS TRLESIQQCM SQPDVMPFLF DL 292
Length:292
Mass (Da):33,310
Last modified:October 17, 2006 - v2
Checksum:i6516C9DB714F5A65
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB094092 mRNA. Translation: BAC76046.1.
EF444979 Genomic DNA. Translation: ACA05993.1.
BC028191 mRNA. Translation: AAH28191.2.
BC038969 mRNA. Translation: AAH38969.2.
CCDSiCCDS31688.1.
RefSeqiNP_859072.1. NM_181721.2.
UniGeneiHs.116679.

Genome annotation databases

EnsembliENST00000317011; ENSP00000314806; ENSG00000176302.
ENST00000575308; ENSP00000458801; ENSG00000262245.
GeneIDi283150.
KEGGihsa:283150.
UCSCiuc001pui.3. human.

Polymorphism databases

DMDMi116247781.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB094092 mRNA. Translation: BAC76046.1 .
EF444979 Genomic DNA. Translation: ACA05993.1 .
BC028191 mRNA. Translation: AAH28191.2 .
BC038969 mRNA. Translation: AAH38969.2 .
CCDSi CCDS31688.1.
RefSeqi NP_859072.1. NM_181721.2.
UniGenei Hs.116679.

3D structure databases

ProteinModelPortali Q6PIV2.
SMRi Q6PIV2. Positions 176-257.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000314806.

Polymorphism databases

DMDMi 116247781.

Proteomic databases

PaxDbi Q6PIV2.
PRIDEi Q6PIV2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000317011 ; ENSP00000314806 ; ENSG00000176302 .
ENST00000575308 ; ENSP00000458801 ; ENSG00000262245 .
GeneIDi 283150.
KEGGi hsa:283150.
UCSCi uc001pui.3. human.

Organism-specific databases

CTDi 283150.
GeneCardsi GC11P118843.
HGNCi HGNC:29980. FOXR1.
MIMi 615755. gene.
neXtProti NX_Q6PIV2.
PharmGKBi PA134959382.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5025.
HOGENOMi HOG000004846.
HOVERGENi HBG080262.
InParanoidi Q6PIV2.
OMAi VPVSMQG.
PhylomeDBi Q6PIV2.
TreeFami TF329867.

Miscellaneous databases

ChiTaRSi FOXR1. human.
GenomeRNAii 283150.
NextBioi 93662.
PROi Q6PIV2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6PIV2.
Bgeei Q6PIV2.
CleanExi HS_FOXR1.
Genevestigatori Q6PIV2.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a 500-kb region of common allelic loss in chromosome 11q23 in non-MYCN amplified type of neuroblastoma."
    Kubo T., Arai Y., Ohira M., Gamou T., Maeno G., Sakiyama T., Toyoda A., Hattori M., Sakaki Y., Nakagawara A., Ohki M.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NHLBI resequencing and genotyping service (RS&G)
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiFOXR1_HUMAN
AccessioniPrimary (citable) accession number: Q6PIV2
Secondary accession number(s): B0YJ15, Q86UT9, Q8IXX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: July 9, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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