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Q6PIV2 (FOXR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Forkhead box protein R1
Alternative name(s):
Forkhead box protein N5
Gene names
Name:FOXR1
Synonyms:FOXN5
ORF Names:DLNB13
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus Probable.

Sequence similarities

Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnegative regulation of transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: RefGenome

organ development

Inferred from Biological aspect of Ancestor. Source: RefGenome

pattern specification process

Inferred from Biological aspect of Ancestor. Source: RefGenome

regulation of sequence-specific DNA binding transcription factor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

tissue development

Inferred from Biological aspect of Ancestor. Source: RefGenome

transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: GOC

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

transcription factor complex

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionDNA binding, bending

Inferred from Biological aspect of Ancestor. Source: RefGenome

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

double-stranded DNA binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

transcription factor binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 292292Forkhead box protein R1
PRO_0000253778

Regions

DNA binding173 – 272100Fork-head

Sequences

Sequence LengthMass (Da)Tools
Q6PIV2 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: 6516C9DB714F5A65

FASTA29233,310
        10         20         30         40         50         60 
MGNELFLAFT TSHLPLAEQK LARYKLRIVK PPKLPLEKKP NPDKDGPDYE PNLWMWVNPN 

        70         80         90        100        110        120 
IVYPPGKLEV SGRRKREDLT STLPSSQPPQ KEEDASCSEA AGVESLSQSS SKRSPPRKRF 

       130        140        150        160        170        180 
AFSPSTWELT EEEEAEDQED SSSMALPSPH KRAPLQSRRL RQASSQAGRL WSRPPLNYFH 

       190        200        210        220        230        240 
LIALALRNSS PCGLNVQQIY SFTRKHFPFF RTAPEGWKNT VRHNLCFRDS FEKVPVSMQG 

       250        260        270        280        290 
GASTRPRSCL WKLTEEGHRR FAEEARALAS TRLESIQQCM SQPDVMPFLF DL 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a 500-kb region of common allelic loss in chromosome 11q23 in non-MYCN amplified type of neuroblastoma."
Kubo T., Arai Y., Ohira M., Gamou T., Maeno G., Sakiyama T., Toyoda A., Hattori M., Sakaki Y., Nakagawara A., Ohki M.
Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]NHLBI resequencing and genotyping service (RS&G)
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB094092 mRNA. Translation: BAC76046.1.
EF444979 Genomic DNA. Translation: ACA05993.1.
BC028191 mRNA. Translation: AAH28191.2.
BC038969 mRNA. Translation: AAH38969.2.
CCDSCCDS31688.1.
RefSeqNP_859072.1. NM_181721.2.
UniGeneHs.116679.

3D structure databases

ProteinModelPortalQ6PIV2.
SMRQ6PIV2. Positions 176-257.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000314806.

Polymorphism databases

DMDM116247781.

Proteomic databases

PaxDbQ6PIV2.
PRIDEQ6PIV2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000317011; ENSP00000314806; ENSG00000176302.
ENST00000575308; ENSP00000458801; ENSG00000262245.
GeneID283150.
KEGGhsa:283150.
UCSCuc001pui.3. human.

Organism-specific databases

CTD283150.
GeneCardsGC11P118843.
HGNCHGNC:29980. FOXR1.
MIM615755. gene.
neXtProtNX_Q6PIV2.
PharmGKBPA134959382.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5025.
HOGENOMHOG000004846.
HOVERGENHBG080262.
InParanoidQ6PIV2.
OMAVPVSMQG.
PhylomeDBQ6PIV2.
TreeFamTF329867.

Gene expression databases

ArrayExpressQ6PIV2.
BgeeQ6PIV2.
CleanExHS_FOXR1.
GenevestigatorQ6PIV2.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR001766. TF_fork_head.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSPR00053. FORKHEAD.
SMARTSM00339. FH. 1 hit.
[Graphical view]
PROSITEPS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFOXR1. human.
GenomeRNAi283150.
NextBio93662.
PROQ6PIV2.
SOURCESearch...

Entry information

Entry nameFOXR1_HUMAN
AccessionPrimary (citable) accession number: Q6PIV2
Secondary accession number(s): B0YJ15, Q86UT9, Q8IXX2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: July 9, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM