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Q6PIV2

- FOXR1_HUMAN

UniProt

Q6PIV2 - FOXR1_HUMAN

Protein

Forkhead box protein R1

Gene

FOXR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi173 – 272100Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein R1
    Alternative name(s):
    Forkhead box protein N5
    Gene namesi
    Name:FOXR1
    Synonyms:FOXN5
    ORF Names:DLNB13
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:29980. FOXR1.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134959382.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292Forkhead box protein R1PRO_0000253778Add
    BLAST

    Proteomic databases

    PaxDbiQ6PIV2.
    PRIDEiQ6PIV2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6PIV2.
    BgeeiQ6PIV2.
    CleanExiHS_FOXR1.
    GenevestigatoriQ6PIV2.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000314806.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PIV2.
    SMRiQ6PIV2. Positions 176-257.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5025.
    HOGENOMiHOG000004846.
    HOVERGENiHBG080262.
    InParanoidiQ6PIV2.
    OMAiVPVSMQG.
    PhylomeDBiQ6PIV2.
    TreeFamiTF329867.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    [Graphical view]
    PROSITEiPS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6PIV2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGNELFLAFT TSHLPLAEQK LARYKLRIVK PPKLPLEKKP NPDKDGPDYE    50
    PNLWMWVNPN IVYPPGKLEV SGRRKREDLT STLPSSQPPQ KEEDASCSEA 100
    AGVESLSQSS SKRSPPRKRF AFSPSTWELT EEEEAEDQED SSSMALPSPH 150
    KRAPLQSRRL RQASSQAGRL WSRPPLNYFH LIALALRNSS PCGLNVQQIY 200
    SFTRKHFPFF RTAPEGWKNT VRHNLCFRDS FEKVPVSMQG GASTRPRSCL 250
    WKLTEEGHRR FAEEARALAS TRLESIQQCM SQPDVMPFLF DL 292
    Length:292
    Mass (Da):33,310
    Last modified:October 17, 2006 - v2
    Checksum:i6516C9DB714F5A65
    GO
    Isoform 2 (identifier: Q6PIV2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         129-205: LTEEEEAEDQ...VQQIYSFTRK → GPPPESEASA...PGPSEGGRVQ
         206-291: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:206
    Mass (Da):22,529
    Checksum:i9A87D46EFF232027
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei129 – 20577LTEEE…SFTRK → GPPPESEASASQQPGGEALV PAPSQLLPPNCPGIKKQFPL WPQRATDLQFHSELLGLILL CSCCGPSPGPSEGGRVQ in isoform 2. 1 PublicationVSP_056600Add
    BLAST
    Alternative sequencei206 – 29186Missing in isoform 2. 1 PublicationVSP_056601Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB094092 mRNA. Translation: BAC76046.1.
    EF444979 Genomic DNA. Translation: ACA05993.1.
    AP003392 Genomic DNA. No translation available.
    AP004609 Genomic DNA. No translation available.
    BC028191 mRNA. Translation: AAH28191.2.
    BC038969 mRNA. Translation: AAH38969.2.
    BC125040 mRNA. Translation: AAI25041.1.
    CCDSiCCDS31688.1.
    RefSeqiNP_859072.1. NM_181721.2.
    UniGeneiHs.116679.

    Genome annotation databases

    EnsembliENST00000317011; ENSP00000314806; ENSG00000176302.
    ENST00000531539; ENSP00000433394; ENSG00000176302.
    GeneIDi283150.
    KEGGihsa:283150.
    UCSCiuc001pui.3. human.

    Polymorphism databases

    DMDMi116247781.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB094092 mRNA. Translation: BAC76046.1 .
    EF444979 Genomic DNA. Translation: ACA05993.1 .
    AP003392 Genomic DNA. No translation available.
    AP004609 Genomic DNA. No translation available.
    BC028191 mRNA. Translation: AAH28191.2 .
    BC038969 mRNA. Translation: AAH38969.2 .
    BC125040 mRNA. Translation: AAI25041.1 .
    CCDSi CCDS31688.1.
    RefSeqi NP_859072.1. NM_181721.2.
    UniGenei Hs.116679.

    3D structure databases

    ProteinModelPortali Q6PIV2.
    SMRi Q6PIV2. Positions 176-257.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000314806.

    Polymorphism databases

    DMDMi 116247781.

    Proteomic databases

    PaxDbi Q6PIV2.
    PRIDEi Q6PIV2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000317011 ; ENSP00000314806 ; ENSG00000176302 .
    ENST00000531539 ; ENSP00000433394 ; ENSG00000176302 .
    GeneIDi 283150.
    KEGGi hsa:283150.
    UCSCi uc001pui.3. human.

    Organism-specific databases

    CTDi 283150.
    GeneCardsi GC11P118843.
    HGNCi HGNC:29980. FOXR1.
    MIMi 615755. gene.
    neXtProti NX_Q6PIV2.
    PharmGKBi PA134959382.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5025.
    HOGENOMi HOG000004846.
    HOVERGENi HBG080262.
    InParanoidi Q6PIV2.
    OMAi VPVSMQG.
    PhylomeDBi Q6PIV2.
    TreeFami TF329867.

    Miscellaneous databases

    ChiTaRSi FOXR1. human.
    GenomeRNAii 283150.
    NextBioi 93662.
    PROi Q6PIV2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6PIV2.
    Bgeei Q6PIV2.
    CleanExi HS_FOXR1.
    Genevestigatori Q6PIV2.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    [Graphical view ]
    PROSITEi PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a 500-kb region of common allelic loss in chromosome 11q23 in non-MYCN amplified type of neuroblastoma."
      Kubo T., Arai Y., Ohira M., Gamou T., Maeno G., Sakiyama T., Toyoda A., Hattori M., Sakaki Y., Nakagawara A., Ohki M.
      Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. NHLBI resequencing and genotyping service (RS&G)
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain.

    Entry informationi

    Entry nameiFOXR1_HUMAN
    AccessioniPrimary (citable) accession number: Q6PIV2
    Secondary accession number(s): B0YJ15
    , Q08AS8, Q86UT9, Q8IXX2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3