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Q6PIV2

- FOXR1_HUMAN

UniProt

Q6PIV2 - FOXR1_HUMAN

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Protein

Forkhead box protein R1

Gene

FOXR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi173 – 272100Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein R1
Alternative name(s):
Forkhead box protein N5
Gene namesi
Name:FOXR1
Synonyms:FOXN5
ORF Names:DLNB13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:29980. FOXR1.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134959382.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Forkhead box protein R1PRO_0000253778Add
BLAST

Proteomic databases

PaxDbiQ6PIV2.
PRIDEiQ6PIV2.

Expressioni

Gene expression databases

BgeeiQ6PIV2.
CleanExiHS_FOXR1.
ExpressionAtlasiQ6PIV2. baseline.
GenevestigatoriQ6PIV2.

Interactioni

Protein-protein interaction databases

BioGridi129476. 16 interactions.
STRINGi9606.ENSP00000314806.

Structurei

3D structure databases

ProteinModelPortaliQ6PIV2.
SMRiQ6PIV2. Positions 178-234.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00760000118794.
HOGENOMiHOG000004846.
HOVERGENiHBG080262.
InParanoidiQ6PIV2.
OMAiVPVSMQG.
PhylomeDBiQ6PIV2.
TreeFamiTF329867.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6PIV2) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNELFLAFT TSHLPLAEQK LARYKLRIVK PPKLPLEKKP NPDKDGPDYE
60 70 80 90 100
PNLWMWVNPN IVYPPGKLEV SGRRKREDLT STLPSSQPPQ KEEDASCSEA
110 120 130 140 150
AGVESLSQSS SKRSPPRKRF AFSPSTWELT EEEEAEDQED SSSMALPSPH
160 170 180 190 200
KRAPLQSRRL RQASSQAGRL WSRPPLNYFH LIALALRNSS PCGLNVQQIY
210 220 230 240 250
SFTRKHFPFF RTAPEGWKNT VRHNLCFRDS FEKVPVSMQG GASTRPRSCL
260 270 280 290
WKLTEEGHRR FAEEARALAS TRLESIQQCM SQPDVMPFLF DL
Length:292
Mass (Da):33,310
Last modified:October 17, 2006 - v2
Checksum:i6516C9DB714F5A65
GO
Isoform 2 (identifier: Q6PIV2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     129-205: LTEEEEAEDQ...VQQIYSFTRK → GPPPESEASA...PGPSEGGRVQ
     206-291: Missing.

Note: No experimental confirmation available.

Show »
Length:206
Mass (Da):22,529
Checksum:i9A87D46EFF232027
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei129 – 20577LTEEE…SFTRK → GPPPESEASASQQPGGEALV PAPSQLLPPNCPGIKKQFPL WPQRATDLQFHSELLGLILL CSCCGPSPGPSEGGRVQ in isoform 2. 1 PublicationVSP_056600Add
BLAST
Alternative sequencei206 – 29186Missing in isoform 2. 1 PublicationVSP_056601Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB094092 mRNA. Translation: BAC76046.1.
EF444979 Genomic DNA. Translation: ACA05993.1.
AP003392 Genomic DNA. No translation available.
AP004609 Genomic DNA. No translation available.
BC028191 mRNA. Translation: AAH28191.2.
BC038969 mRNA. Translation: AAH38969.2.
BC125040 mRNA. Translation: AAI25041.1.
CCDSiCCDS31688.1. [Q6PIV2-1]
RefSeqiNP_859072.1. NM_181721.2.
UniGeneiHs.116679.

Genome annotation databases

EnsembliENST00000317011; ENSP00000314806; ENSG00000176302. [Q6PIV2-1]
ENST00000531539; ENSP00000433394; ENSG00000176302. [Q6PIV2-2]
GeneIDi283150.
KEGGihsa:283150.
UCSCiuc001pui.3. human. [Q6PIV2-1]

Polymorphism databases

DMDMi116247781.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB094092 mRNA. Translation: BAC76046.1 .
EF444979 Genomic DNA. Translation: ACA05993.1 .
AP003392 Genomic DNA. No translation available.
AP004609 Genomic DNA. No translation available.
BC028191 mRNA. Translation: AAH28191.2 .
BC038969 mRNA. Translation: AAH38969.2 .
BC125040 mRNA. Translation: AAI25041.1 .
CCDSi CCDS31688.1. [Q6PIV2-1 ]
RefSeqi NP_859072.1. NM_181721.2.
UniGenei Hs.116679.

3D structure databases

ProteinModelPortali Q6PIV2.
SMRi Q6PIV2. Positions 178-234.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 129476. 16 interactions.
STRINGi 9606.ENSP00000314806.

Polymorphism databases

DMDMi 116247781.

Proteomic databases

PaxDbi Q6PIV2.
PRIDEi Q6PIV2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000317011 ; ENSP00000314806 ; ENSG00000176302 . [Q6PIV2-1 ]
ENST00000531539 ; ENSP00000433394 ; ENSG00000176302 . [Q6PIV2-2 ]
GeneIDi 283150.
KEGGi hsa:283150.
UCSCi uc001pui.3. human. [Q6PIV2-1 ]

Organism-specific databases

CTDi 283150.
GeneCardsi GC11P118843.
HGNCi HGNC:29980. FOXR1.
MIMi 615755. gene.
neXtProti NX_Q6PIV2.
PharmGKBi PA134959382.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5025.
GeneTreei ENSGT00760000118794.
HOGENOMi HOG000004846.
HOVERGENi HBG080262.
InParanoidi Q6PIV2.
OMAi VPVSMQG.
PhylomeDBi Q6PIV2.
TreeFami TF329867.

Miscellaneous databases

ChiTaRSi FOXR1. human.
GenomeRNAii 283150.
NextBioi 93662.
PROi Q6PIV2.
SOURCEi Search...

Gene expression databases

Bgeei Q6PIV2.
CleanExi HS_FOXR1.
ExpressionAtlasi Q6PIV2. baseline.
Genevestigatori Q6PIV2.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a 500-kb region of common allelic loss in chromosome 11q23 in non-MYCN amplified type of neuroblastoma."
    Kubo T., Arai Y., Ohira M., Gamou T., Maeno G., Sakiyama T., Toyoda A., Hattori M., Sakaki Y., Nakagawara A., Ohki M.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. NHLBI resequencing and genotyping service (RS&G)
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.

Entry informationi

Entry nameiFOXR1_HUMAN
AccessioniPrimary (citable) accession number: Q6PIV2
Secondary accession number(s): B0YJ15
, Q08AS8, Q86UT9, Q8IXX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: October 29, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3