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Q6PIU1

- KCNV1_HUMAN

UniProt

Q6PIU1 - KCNV1_HUMAN

Protein

Potassium voltage-gated channel subfamily V member 1

Gene

KCNV1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.2 Publications

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: RefGenome
    2. ion channel inhibitor activity Source: ProtInc
    3. potassium channel regulator activity Source: ProtInc

    GO - Biological processi

    1. potassium ion transport Source: ProtInc
    2. protein homooligomerization Source: InterPro
    3. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_75770. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily V member 1
    Alternative name(s):
    Neuronal potassium channel alpha subunit HNKA
    Voltage-gated potassium channel subunit Kv8.1
    Gene namesi
    Name:KCNV1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:18861. KCNV1.

    Subcellular locationi

    Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications
    Note: Has to be associated with another potassium channel subunit to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB2.

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome
    3. voltage-gated potassium channel complex Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38721.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 500500Potassium voltage-gated channel subfamily V member 1PRO_0000308350Add
    BLAST

    Proteomic databases

    PaxDbiQ6PIU1.
    PRIDEiQ6PIU1.

    Expressioni

    Tissue specificityi

    Detected in brain.1 Publication

    Gene expression databases

    ArrayExpressiQ6PIU1.
    BgeeiQ6PIU1.
    CleanExiHS_KCNV1.
    GenevestigatoriQ6PIU1.

    Interactioni

    Subunit structurei

    Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.2 Publications

    Protein-protein interaction databases

    BioGridi117954. 2 interactions.
    STRINGi9606.ENSP00000297404.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PIU1.
    SMRiQ6PIU1. Positions 43-435.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 210210CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini232 – 2387ExtracellularSequence Analysis
    Topological domaini260 – 27617CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini298 – 30912ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini332 – 34514CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini428 – 50073CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei211 – 23121Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei239 – 25921Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei277 – 29721Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei310 – 33122Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei346 – 36621Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei407 – 42721Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi392 – 3976Selectivity filterBy similarity

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    HOGENOMiHOG000231016.
    HOVERGENiHBG052230.
    InParanoidiQ6PIU1.
    KOiK04934.
    OMAiGMTIAQC.
    OrthoDBiEOG7CRTPP.
    PhylomeDBiQ6PIU1.
    TreeFamiTF313103.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003970. K_chnl_volt-dep_Kv8.1.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PTHR11537:SF38. PTHR11537:SF38. 1 hit.
    PfamiPF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01493. KV8CHANNEL.
    PR01491. KVCHANNEL.
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6PIU1-1 [UniParc]FASTAAdd to Basket

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    MPSSGRALLD SPLDSGSLTS LDSSVFCSEG EGEPLALGDC FTVNVGGSRF    50
    VLSQQALSCF PHTRLGKLAV VVASYRRPGA LAAVPSPLEL CDDANPVDNE 100
    YFFDRSSQAF RYVLHYYRTG RLHVMEQLCA LSFLQEIQYW GIDELSIDSC 150
    CRDRYFRRKE LSETLDFKKD TEDQESQHES EQDFSQGPCP TVRQKLWNIL 200
    EKPGSSTAAR IFGVISIIFV VVSIINMALM SAELSWLDLQ LLEILEYVCI 250
    SWFTGEFVLR FLCVRDRCRF LRKVPNIIDL LAILPFYITL LVESLSGSQT 300
    TQELENVGRI VQVLRLLRAL RMLKLGRHST GLRSLGMTIT QCYEEVGLLL 350
    LFLSVGISIF STVEYFAEQS IPDTTFTSVP CAWWWATTSM TTVGYGDIRP 400
    DTTTGKIVAF MCILSGILVL ALPIAIINDR FSACYFTLKL KEAAVRQREA 450
    LKKLTKNIAT DSYISVNLRD VYARSIMEML RLKGRERAST RSSGGDDFWF 500
    Length:500
    Mass (Da):56,304
    Last modified:October 23, 2007 - v2
    Checksum:iC229E21ABC869C73
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti22 – 221D → G.1 Publication
    Corresponds to variant rs17852611 [ dbSNP | Ensembl ].
    VAR_036804

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB032013 Genomic DNA. Translation: BAA92316.1.
    AF167082 mRNA. Translation: AAD48031.2.
    BC028739 mRNA. Translation: AAH28739.1.
    CCDSiCCDS6314.1.
    RefSeqiNP_055194.1. NM_014379.2.
    XP_005250923.1. XM_005250866.1.
    UniGeneiHs.13285.

    Genome annotation databases

    EnsembliENST00000297404; ENSP00000297404; ENSG00000164794.
    ENST00000524391; ENSP00000435954; ENSG00000164794.
    GeneIDi27012.
    KEGGihsa:27012.
    UCSCiuc003ynr.4. human.

    Polymorphism databases

    DMDMi160013825.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB032013 Genomic DNA. Translation: BAA92316.1 .
    AF167082 mRNA. Translation: AAD48031.2 .
    BC028739 mRNA. Translation: AAH28739.1 .
    CCDSi CCDS6314.1.
    RefSeqi NP_055194.1. NM_014379.2.
    XP_005250923.1. XM_005250866.1.
    UniGenei Hs.13285.

    3D structure databases

    ProteinModelPortali Q6PIU1.
    SMRi Q6PIU1. Positions 43-435.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117954. 2 interactions.
    STRINGi 9606.ENSP00000297404.

    Chemistry

    ChEMBLi CHEMBL2362996.

    Polymorphism databases

    DMDMi 160013825.

    Proteomic databases

    PaxDbi Q6PIU1.
    PRIDEi Q6PIU1.

    Protocols and materials databases

    DNASUi 27012.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000297404 ; ENSP00000297404 ; ENSG00000164794 .
    ENST00000524391 ; ENSP00000435954 ; ENSG00000164794 .
    GeneIDi 27012.
    KEGGi hsa:27012.
    UCSCi uc003ynr.4. human.

    Organism-specific databases

    CTDi 27012.
    GeneCardsi GC08M111048.
    HGNCi HGNC:18861. KCNV1.
    MIMi 608164. gene.
    neXtProti NX_Q6PIU1.
    PharmGKBi PA38721.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1226.
    HOGENOMi HOG000231016.
    HOVERGENi HBG052230.
    InParanoidi Q6PIU1.
    KOi K04934.
    OMAi GMTIAQC.
    OrthoDBi EOG7CRTPP.
    PhylomeDBi Q6PIU1.
    TreeFami TF313103.

    Enzyme and pathway databases

    Reactomei REACT_75770. Voltage gated Potassium channels.

    Miscellaneous databases

    GeneWikii KCNV1.
    GenomeRNAii 27012.
    NextBioi 49524.
    PROi Q6PIU1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6PIU1.
    Bgeei Q6PIU1.
    CleanExi HS_KCNV1.
    Genevestigatori Q6PIU1.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003970. K_chnl_volt-dep_Kv8.1.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    PTHR11537:SF38. PTHR11537:SF38. 1 hit.
    Pfami PF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01493. KV8CHANNEL.
    PR01491. KVCHANNEL.
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels."
      Hugnot J.-P., Salinas M., Lesage F., Guillemare E., de Weille J., Heurteaux C., Mattei M.-G., Lazdunski M.
      EMBO J. 15:3322-3331(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH KCNB1; KCNB2; KCNC4 AND KCND1.
    2. "Positional candidate approach for the gene responsible for benign adult familial myoclonic epilepsy."
      Sano A., Mikami M., Nakamura M., Ueno S., Tanabe H., Kaneko S.
      Epilepsia 43:26-31(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    3. "Molecular cloning of human neuronal potassium channel alpha subunit (HNKA)."
      Xia J.-H., Zheng D., Tang X.-X., Yu K.-P., Tan S.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Kidney.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-22.
      Tissue: Brain.
    5. "Modes of regulation of shab K+ channel activity by the Kv8.1 subunit."
      Salinas M., de Weille J., Guillemare E., Lazdunski M., Hugnot J.-P.
      J. Biol. Chem. 272:8774-8780(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH KCNB1 AND KCNB2.

    Entry informationi

    Entry nameiKCNV1_HUMAN
    AccessioniPrimary (citable) accession number: Q6PIU1
    Secondary accession number(s): Q9UHJ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3