Potassium voltage-gated channel subfamily V member 1

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Q6PIU1 (KCNV1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 86. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Potassium voltage-gated channel subfamily V member 1

Alternative name(s):
Neuronal potassium channel alpha subunit HNKA
Voltage-gated potassium channel subunit Kv8.1

Gene names

Name:

KCNV1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	500 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes. Ref.1 Ref.5
Subunit structure	Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1. Ref.1 Ref.5
Subcellular location	Cell membrane; Multi-pass membrane protein. Note: Has to be associated with another potassium channel subunit to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB2. Ref.1 Ref.5
Tissue specificity	Detected in brain. Ref.2
Domain	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position By similarity.
Sequence similarities	Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Potassium channel Voltage-gated channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein homooligomerization Inferred from electronic annotation. Source: InterPro synaptic transmission Traceable author statement. Source: Reactome
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc voltage-gated potassium channel complex Inferred from electronic annotation. Source: InterPro
Molecular_function	delayed rectifier potassium channel activity Inferred from Biological aspect of Ancestor. Source: RefGenome ion channel inhibitor activity Traceable author statement Ref.1. Source: ProtInc potassium channel regulator activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 500

500

Potassium voltage-gated channel subfamily V member 1

PRO_0000308350

Regions

Topological domain

1 – 210

210

Cytoplasmic Potential

Transmembrane

211 – 231

Helical; Name=Segment S1; Potential

Topological domain

232 – 238

Extracellular Potential

Transmembrane

239 – 259

Helical; Name=Segment S2; Potential

Topological domain

260 – 276

Cytoplasmic Potential

Transmembrane

277 – 297

Helical; Name=Segment S3; Potential

Topological domain

298 – 309

Extracellular Potential

Transmembrane

310 – 331

Helical; Voltage-sensor; Name=Segment S4; Potential

Topological domain

332 – 345

Cytoplasmic Potential

Transmembrane

346 – 366

Helical; Name=Segment S5; Potential

Transmembrane

407 – 427

Helical; Name=Segment S6; Potential

Topological domain

428 – 500

Cytoplasmic Potential

Motif

392 – 397

Selectivity filter By similarity

Natural variations

Natural variant

D → G. Ref.4
Corresponds to variant rs17852611 [ dbSNP | Ensembl ].

VAR_036804

Sequences

Sequence

Length

Mass (Da)

Tools

Q6PIU1 [UniParc].

Last modified October 23, 2007. Version 2.
Checksum: C229E21ABC869C73
Show »

FASTA

500

56,304

        10         20         30         40         50         60 
MPSSGRALLD SPLDSGSLTS LDSSVFCSEG EGEPLALGDC FTVNVGGSRF VLSQQALSCF 

        70         80         90        100        110        120 
PHTRLGKLAV VVASYRRPGA LAAVPSPLEL CDDANPVDNE YFFDRSSQAF RYVLHYYRTG 

       130        140        150        160        170        180 
RLHVMEQLCA LSFLQEIQYW GIDELSIDSC CRDRYFRRKE LSETLDFKKD TEDQESQHES 

       190        200        210        220        230        240 
EQDFSQGPCP TVRQKLWNIL EKPGSSTAAR IFGVISIIFV VVSIINMALM SAELSWLDLQ 

       250        260        270        280        290        300 
LLEILEYVCI SWFTGEFVLR FLCVRDRCRF LRKVPNIIDL LAILPFYITL LVESLSGSQT 

       310        320        330        340        350        360 
TQELENVGRI VQVLRLLRAL RMLKLGRHST GLRSLGMTIT QCYEEVGLLL LFLSVGISIF 

       370        380        390        400        410        420 
STVEYFAEQS IPDTTFTSVP CAWWWATTSM TTVGYGDIRP DTTTGKIVAF MCILSGILVL 

       430        440        450        460        470        480 
ALPIAIINDR FSACYFTLKL KEAAVRQREA LKKLTKNIAT DSYISVNLRD VYARSIMEML 

       490        500 
RLKGRERAST RSSGGDDFWF

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels." Hugnot J.-P., Salinas M., Lesage F., Guillemare E., de Weille J., Heurteaux C., Mattei M.-G., Lazdunski M. EMBO J. 15:3322-3331(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH KCNB1; KCNB2; KCNC4 AND KCND1.
[2]	"Positional candidate approach for the gene responsible for benign adult familial myoclonic epilepsy." Sano A., Mikami M., Nakamura M., Ueno S., Tanabe H., Kaneko S. Epilepsia 43:26-31(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
[3]	"Molecular cloning of human neuronal potassium channel alpha subunit (HNKA)." Xia J.-H., Zheng D., Tang X.-X., Yu K.-P., Tan S. Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-22. Tissue: Brain.
[5]	"Modes of regulation of shab K+ channel activity by the Kv8.1 subunit." Salinas M., de Weille J., Guillemare E., Lazdunski M., Hugnot J.-P. J. Biol. Chem. 272:8774-8780(1997) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH KCNB1 AND KCNB2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB032013 Genomic DNA. Translation: BAA92316.1. AF167082 mRNA. Translation: AAD48031.2. BC028739 mRNA. Translation: AAH28739.1.
IPI	IPI00164159.
RefSeq	NP_055194.1. NM_014379.2.
UniGene	Hs.13285.
3D structure databases
HSSP	HSSP built from PDB template 2A79 based on UniProtKB P63142.
ProteinModelPortal	Q6PIU1.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000297404.
Polymorphism databases
DMDM	160013825.
Proteomic databases
PaxDb	Q6PIU1.
PRIDE	Q6PIU1.
Protocols and materials databases
DNASU	27012.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000297404; ENSP00000297404; ENSG00000164794. ENST00000524391; ENSP00000435954; ENSG00000164794.
GeneID	27012.
KEGG	hsa:27012.
UCSC	uc003ynr.4. human.
Organism-specific databases
CTD	27012.
GeneCards	GC08M111048.
HGNC	HGNC:18861. KCNV1.
MIM	608164. gene.
neXtProt	NX_Q6PIU1.
PharmGKB	PA38721.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1226.
HOGENOM	HOG000231016.
HOVERGEN	HBG052230.
InParanoid	Q6PIU1.
KO	K04934.
OMA	DRCHFLR.
OrthoDB	EOG4BRWKP.
PhylomeDB	Q6PIU1.
Enzyme and pathway databases
Reactome	REACT_13685. Neuronal System.
Gene expression databases
ArrayExpress	Q6PIU1.
Bgee	Q6PIU1.
CleanEx	HS_KCNV1.
Genevestigator	Q6PIU1.
Family and domain databases
Gene3D	3.30.710.10. 1 hit.
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR005821. Ion_trans_dom. IPR003091. K_chnl. IPR003968. K_chnl_volt-dep_Kv. IPR003970. K_chnl_volt-dep_Kv8. IPR003131. T1-type_BTB. [Graphical view]
PANTHER	PTHR11537. PTHR11537. 1 hit. PTHR11537:SF38. PTHR11537:SF38. 1 hit.
Pfam	PF00520. Ion_trans. 1 hit. PF02214. K_tetra. 1 hit. [Graphical view]
PRINTS	PR00169. KCHANNEL. PR01493. KV8CHANNEL. PR01491. KVCHANNEL.
SMART	SM00225. BTB. 1 hit. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	27012.
NextBio	49524.
SOURCE	Search...

Entry information

Entry name

KCNV1_HUMAN

Accession

Primary (citable) accession number: Q6PIU1
Secondary accession number(s): Q9UHJ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	October 23, 2007
Last modified:	May 1, 2013
This is version 86 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Human chromosome 8: entries, gene names and cross-references to MIM

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List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents