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Q6PIU1 (KCNV1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily V member 1
Alternative name(s):
Neuronal potassium channel alpha subunit HNKA
Voltage-gated potassium channel subunit Kv8.1
Gene names
Name:KCNV1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes. Ref.1 Ref.5

Subunit structure

Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1. Ref.1 Ref.5

Subcellular location

Cell membrane; Multi-pass membrane protein. Note: Has to be associated with another potassium channel subunit to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB2. Ref.1 Ref.5

Tissue specificity

Detected in brain. Ref.2

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position By similarity.

Sequence similarities

Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 500500Potassium voltage-gated channel subfamily V member 1
PRO_0000308350

Regions

Topological domain1 – 210210Cytoplasmic Potential
Transmembrane211 – 23121Helical; Name=Segment S1; Potential
Topological domain232 – 2387Extracellular Potential
Transmembrane239 – 25921Helical; Name=Segment S2; Potential
Topological domain260 – 27617Cytoplasmic Potential
Transmembrane277 – 29721Helical; Name=Segment S3; Potential
Topological domain298 – 30912Extracellular Potential
Transmembrane310 – 33122Helical; Voltage-sensor; Name=Segment S4; Potential
Topological domain332 – 34514Cytoplasmic Potential
Transmembrane346 – 36621Helical; Name=Segment S5; Potential
Transmembrane407 – 42721Helical; Name=Segment S6; Potential
Topological domain428 – 50073Cytoplasmic Potential
Motif392 – 3976Selectivity filter By similarity

Natural variations

Natural variant221D → G. Ref.4
Corresponds to variant rs17852611 [ dbSNP | Ensembl ].
VAR_036804

Sequences

Sequence LengthMass (Da)Tools
Q6PIU1 [UniParc].

Last modified October 23, 2007. Version 2.
Checksum: C229E21ABC869C73

FASTA50056,304
        10         20         30         40         50         60 
MPSSGRALLD SPLDSGSLTS LDSSVFCSEG EGEPLALGDC FTVNVGGSRF VLSQQALSCF 

        70         80         90        100        110        120 
PHTRLGKLAV VVASYRRPGA LAAVPSPLEL CDDANPVDNE YFFDRSSQAF RYVLHYYRTG 

       130        140        150        160        170        180 
RLHVMEQLCA LSFLQEIQYW GIDELSIDSC CRDRYFRRKE LSETLDFKKD TEDQESQHES 

       190        200        210        220        230        240 
EQDFSQGPCP TVRQKLWNIL EKPGSSTAAR IFGVISIIFV VVSIINMALM SAELSWLDLQ 

       250        260        270        280        290        300 
LLEILEYVCI SWFTGEFVLR FLCVRDRCRF LRKVPNIIDL LAILPFYITL LVESLSGSQT 

       310        320        330        340        350        360 
TQELENVGRI VQVLRLLRAL RMLKLGRHST GLRSLGMTIT QCYEEVGLLL LFLSVGISIF 

       370        380        390        400        410        420 
STVEYFAEQS IPDTTFTSVP CAWWWATTSM TTVGYGDIRP DTTTGKIVAF MCILSGILVL 

       430        440        450        460        470        480 
ALPIAIINDR FSACYFTLKL KEAAVRQREA LKKLTKNIAT DSYISVNLRD VYARSIMEML 

       490        500 
RLKGRERAST RSSGGDDFWF 

« Hide

References

« Hide 'large scale' references
[1]"Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels."
Hugnot J.-P., Salinas M., Lesage F., Guillemare E., de Weille J., Heurteaux C., Mattei M.-G., Lazdunski M.
EMBO J. 15:3322-3331(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH KCNB1; KCNB2; KCNC4 AND KCND1.
[2]"Positional candidate approach for the gene responsible for benign adult familial myoclonic epilepsy."
Sano A., Mikami M., Nakamura M., Ueno S., Tanabe H., Kaneko S.
Epilepsia 43:26-31(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
[3]"Molecular cloning of human neuronal potassium channel alpha subunit (HNKA)."
Xia J.-H., Zheng D., Tang X.-X., Yu K.-P., Tan S.
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Kidney.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-22.
Tissue: Brain.
[5]"Modes of regulation of shab K+ channel activity by the Kv8.1 subunit."
Salinas M., de Weille J., Guillemare E., Lazdunski M., Hugnot J.-P.
J. Biol. Chem. 272:8774-8780(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH KCNB1 AND KCNB2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB032013 Genomic DNA. Translation: BAA92316.1.
AF167082 mRNA. Translation: AAD48031.2.
BC028739 mRNA. Translation: AAH28739.1.
CCDSCCDS6314.1.
RefSeqNP_055194.1. NM_014379.2.
XP_005250923.1. XM_005250866.1.
UniGeneHs.13285.

3D structure databases

ProteinModelPortalQ6PIU1.
SMRQ6PIU1. Positions 43-435.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117954. 2 interactions.
STRING9606.ENSP00000297404.

Chemistry

ChEMBLCHEMBL2362996.

Polymorphism databases

DMDM160013825.

Proteomic databases

PaxDbQ6PIU1.
PRIDEQ6PIU1.

Protocols and materials databases

DNASU27012.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000297404; ENSP00000297404; ENSG00000164794.
ENST00000524391; ENSP00000435954; ENSG00000164794.
GeneID27012.
KEGGhsa:27012.
UCSCuc003ynr.4. human.

Organism-specific databases

CTD27012.
GeneCardsGC08M111048.
HGNCHGNC:18861. KCNV1.
MIM608164. gene.
neXtProtNX_Q6PIU1.
PharmGKBPA38721.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1226.
HOGENOMHOG000231016.
HOVERGENHBG052230.
InParanoidQ6PIU1.
KOK04934.
OMAGMTIAQC.
OrthoDBEOG7CRTPP.
PhylomeDBQ6PIU1.
TreeFamTF313103.

Enzyme and pathway databases

ReactomeREACT_13685. Neuronal System.

Gene expression databases

ArrayExpressQ6PIU1.
BgeeQ6PIU1.
CleanExHS_KCNV1.
GenevestigatorQ6PIU1.

Family and domain databases

Gene3D1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003970. K_chnl_volt-dep_Kv8.1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PTHR11537:SF38. PTHR11537:SF38. 1 hit.
PfamPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01493. KV8CHANNEL.
PR01491. KVCHANNEL.
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
ProtoNetSearch...

Other

GeneWikiKCNV1.
GenomeRNAi27012.
NextBio49524.
PROQ6PIU1.
SOURCESearch...

Entry information

Entry nameKCNV1_HUMAN
AccessionPrimary (citable) accession number: Q6PIU1
Secondary accession number(s): Q9UHJ4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: July 9, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM