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Protein

Potassium voltage-gated channel subfamily V member 1

Gene

KCNV1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.2 Publications

GO - Molecular functioni

  • delayed rectifier potassium channel activity Source: GO_Central
  • ion channel inhibitor activity Source: ProtInc
  • potassium channel regulator activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_75770. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily V member 1
Alternative name(s):
Neuronal potassium channel alpha subunit HNKA
Voltage-gated potassium channel subunit Kv8.1
Gene namesi
Name:KCNV1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:18861. KCNV1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 210210CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei211 – 23121Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Topological domaini232 – 2387ExtracellularSequence Analysis
Transmembranei239 – 25921Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Topological domaini260 – 27617CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei277 – 29721Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Topological domaini298 – 30912ExtracellularSequence AnalysisAdd
BLAST
Transmembranei310 – 33122Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
BLAST
Topological domaini332 – 34514CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei346 – 36621Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Transmembranei407 – 42721Helical; Name=Segment S6Sequence AnalysisAdd
BLAST
Topological domaini428 – 50073CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
  • voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38721.

Polymorphism and mutation databases

BioMutaiKCNV1.
DMDMi160013825.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Potassium voltage-gated channel subfamily V member 1PRO_0000308350Add
BLAST

Proteomic databases

PaxDbiQ6PIU1.
PRIDEiQ6PIU1.

Expressioni

Tissue specificityi

Detected in brain.1 Publication

Gene expression databases

BgeeiQ6PIU1.
CleanExiHS_KCNV1.
GenevisibleiQ6PIU1. HS.

Interactioni

Subunit structurei

Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.2 Publications

Protein-protein interaction databases

BioGridi117954. 2 interactions.
STRINGi9606.ENSP00000297404.

Structurei

3D structure databases

ProteinModelPortaliQ6PIU1.
SMRiQ6PIU1. Positions 43-435.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi392 – 3976Selectivity filterBy similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231016.
HOVERGENiHBG052230.
InParanoidiQ6PIU1.
KOiK04934.
OMAiGMTIAQC.
OrthoDBiEOG7CRTPP.
PhylomeDBiQ6PIU1.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003970. K_chnl_volt-dep_Kv8.1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PTHR11537:SF38. PTHR11537:SF38. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01493. KV8CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6PIU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSSGRALLD SPLDSGSLTS LDSSVFCSEG EGEPLALGDC FTVNVGGSRF
60 70 80 90 100
VLSQQALSCF PHTRLGKLAV VVASYRRPGA LAAVPSPLEL CDDANPVDNE
110 120 130 140 150
YFFDRSSQAF RYVLHYYRTG RLHVMEQLCA LSFLQEIQYW GIDELSIDSC
160 170 180 190 200
CRDRYFRRKE LSETLDFKKD TEDQESQHES EQDFSQGPCP TVRQKLWNIL
210 220 230 240 250
EKPGSSTAAR IFGVISIIFV VVSIINMALM SAELSWLDLQ LLEILEYVCI
260 270 280 290 300
SWFTGEFVLR FLCVRDRCRF LRKVPNIIDL LAILPFYITL LVESLSGSQT
310 320 330 340 350
TQELENVGRI VQVLRLLRAL RMLKLGRHST GLRSLGMTIT QCYEEVGLLL
360 370 380 390 400
LFLSVGISIF STVEYFAEQS IPDTTFTSVP CAWWWATTSM TTVGYGDIRP
410 420 430 440 450
DTTTGKIVAF MCILSGILVL ALPIAIINDR FSACYFTLKL KEAAVRQREA
460 470 480 490 500
LKKLTKNIAT DSYISVNLRD VYARSIMEML RLKGRERAST RSSGGDDFWF
Length:500
Mass (Da):56,304
Last modified:October 23, 2007 - v2
Checksum:iC229E21ABC869C73
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti22 – 221D → G.1 Publication
Corresponds to variant rs17852611 [ dbSNP | Ensembl ].
VAR_036804

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032013 Genomic DNA. Translation: BAA92316.1.
AF167082 mRNA. Translation: AAD48031.2.
BC028739 mRNA. Translation: AAH28739.1.
CCDSiCCDS6314.1.
RefSeqiNP_055194.1. NM_014379.2.
XP_005250923.1. XM_005250866.2.
UniGeneiHs.13285.

Genome annotation databases

EnsembliENST00000297404; ENSP00000297404; ENSG00000164794.
ENST00000524391; ENSP00000435954; ENSG00000164794.
GeneIDi27012.
KEGGihsa:27012.
UCSCiuc003ynr.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032013 Genomic DNA. Translation: BAA92316.1.
AF167082 mRNA. Translation: AAD48031.2.
BC028739 mRNA. Translation: AAH28739.1.
CCDSiCCDS6314.1.
RefSeqiNP_055194.1. NM_014379.2.
XP_005250923.1. XM_005250866.2.
UniGeneiHs.13285.

3D structure databases

ProteinModelPortaliQ6PIU1.
SMRiQ6PIU1. Positions 43-435.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117954. 2 interactions.
STRINGi9606.ENSP00000297404.

Chemistry

ChEMBLiCHEMBL2362996.

Polymorphism and mutation databases

BioMutaiKCNV1.
DMDMi160013825.

Proteomic databases

PaxDbiQ6PIU1.
PRIDEiQ6PIU1.

Protocols and materials databases

DNASUi27012.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297404; ENSP00000297404; ENSG00000164794.
ENST00000524391; ENSP00000435954; ENSG00000164794.
GeneIDi27012.
KEGGihsa:27012.
UCSCiuc003ynr.4. human.

Organism-specific databases

CTDi27012.
GeneCardsiGC08M111048.
HGNCiHGNC:18861. KCNV1.
MIMi608164. gene.
neXtProtiNX_Q6PIU1.
PharmGKBiPA38721.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231016.
HOVERGENiHBG052230.
InParanoidiQ6PIU1.
KOiK04934.
OMAiGMTIAQC.
OrthoDBiEOG7CRTPP.
PhylomeDBiQ6PIU1.
TreeFamiTF313103.

Enzyme and pathway databases

ReactomeiREACT_75770. Voltage gated Potassium channels.

Miscellaneous databases

GeneWikiiKCNV1.
GenomeRNAii27012.
NextBioi49524.
PROiQ6PIU1.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PIU1.
CleanExiHS_KCNV1.
GenevisibleiQ6PIU1. HS.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003970. K_chnl_volt-dep_Kv8.1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PTHR11537:SF38. PTHR11537:SF38. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01493. KV8CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels."
    Hugnot J.-P., Salinas M., Lesage F., Guillemare E., de Weille J., Heurteaux C., Mattei M.-G., Lazdunski M.
    EMBO J. 15:3322-3331(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH KCNB1; KCNB2; KCNC4 AND KCND1.
  2. "Positional candidate approach for the gene responsible for benign adult familial myoclonic epilepsy."
    Sano A., Mikami M., Nakamura M., Ueno S., Tanabe H., Kaneko S.
    Epilepsia 43:26-31(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
  3. "Molecular cloning of human neuronal potassium channel alpha subunit (HNKA)."
    Xia J.-H., Zheng D., Tang X.-X., Yu K.-P., Tan S.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-22.
    Tissue: Brain.
  5. "Modes of regulation of shab K+ channel activity by the Kv8.1 subunit."
    Salinas M., de Weille J., Guillemare E., Lazdunski M., Hugnot J.-P.
    J. Biol. Chem. 272:8774-8780(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH KCNB1 AND KCNB2.

Entry informationi

Entry nameiKCNV1_HUMAN
AccessioniPrimary (citable) accession number: Q6PIU1
Secondary accession number(s): Q9UHJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: June 24, 2015
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.