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Protein

Solute carrier family 23 member 3

Gene

SLC23A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

TCDBi2.A.40.6.4. the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 23 member 3
Alternative name(s):
HPC E2-binding protein 3
Na(+)/L-ascorbic acid transporter 3
Sodium-dependent vitamin C transporter 3
Gene namesi
Name:SLC23A3
Synonyms:E2BP3, SVCT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:20601. SLC23A3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4949CytoplasmicSequence analysisAdd
BLAST
Transmembranei50 – 7021HelicalSequence analysisAdd
BLAST
Topological domaini71 – 8515ExtracellularSequence analysisAdd
BLAST
Transmembranei86 – 10621HelicalSequence analysisAdd
BLAST
Topological domaini107 – 16458CytoplasmicSequence analysisAdd
BLAST
Transmembranei165 – 18521HelicalSequence analysisAdd
BLAST
Topological domaini186 – 1872ExtracellularSequence analysis
Transmembranei188 – 20821HelicalSequence analysisAdd
BLAST
Topological domaini209 – 2113CytoplasmicSequence analysis
Transmembranei212 – 23221HelicalSequence analysisAdd
BLAST
Topological domaini233 – 26634ExtracellularSequence analysisAdd
BLAST
Transmembranei267 – 28721HelicalSequence analysisAdd
BLAST
Topological domaini288 – 31629CytoplasmicSequence analysisAdd
BLAST
Transmembranei317 – 33721HelicalSequence analysisAdd
BLAST
Topological domaini338 – 35518ExtracellularSequence analysisAdd
BLAST
Transmembranei356 – 37621HelicalSequence analysisAdd
BLAST
Topological domaini377 – 39418CytoplasmicSequence analysisAdd
BLAST
Transmembranei395 – 41420HelicalSequence analysisAdd
BLAST
Topological domaini415 – 4239ExtracellularSequence analysis
Transmembranei424 – 44623HelicalSequence analysisAdd
BLAST
Topological domaini447 – 4526CytoplasmicSequence analysis
Transmembranei453 – 47220HelicalSequence analysisAdd
BLAST
Topological domaini473 – 48614ExtracellularSequence analysisAdd
BLAST
Transmembranei487 – 50721HelicalSequence analysisAdd
BLAST
Topological domaini508 – 610103CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134932069.

Polymorphism and mutation databases

BioMutaiSLC23A3.
DMDMi189046185.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 610610Solute carrier family 23 member 3PRO_0000337203Add
BLAST

Proteomic databases

PaxDbiQ6PIS1.
PRIDEiQ6PIS1.

PTM databases

PhosphoSiteiQ6PIS1.

Expressioni

Gene expression databases

BgeeiQ6PIS1.
CleanExiHS_SLC23A3.
ExpressionAtlasiQ6PIS1. baseline and differential.
GenevisibleiQ6PIS1. HS.

Organism-specific databases

HPAiHPA019059.

Interactioni

Protein-protein interaction databases

BioGridi127365. 2 interactions.
IntActiQ6PIS1. 1 interaction.
STRINGi9606.ENSP00000406546.

Structurei

3D structure databases

ProteinModelPortaliQ6PIS1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1292. Eukaryota.
COG2233. LUCA.
GeneTreeiENSGT00390000015686.
HOGENOMiHOG000082411.
HOVERGENiHBG108439.
InParanoidiQ6PIS1.
KOiK14612.
OMAiGCYALCG.
OrthoDBiEOG7GN2MF.
PhylomeDBiQ6PIS1.
TreeFamiTF313272.

Family and domain databases

InterProiIPR006043. Xant/urac/vitC.
[Graphical view]
PANTHERiPTHR11119. PTHR11119. 1 hit.
PfamiPF00860. Xan_ur_permease. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PIS1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRSPLNPSQ LRSVGSQDAL APLPPPAPQN PSTHSWDPLC GSLPWGLSCL
60 70 80 90 100
LALQHVLVMA SLLCVSHLLL LCSLSPGGLS YSPSQLLASS FFSCGMSTIL
110 120 130 140 150
QTWMGSRLPL VQAPSLEFLI PALVLTSQKL PRAIQTPGNS SLMLHLCRGP
160 170 180 190 200
SCHGLGHWNT SLQEVSGAVV VSGLLQGMMG LLGSPGHVFP HCGPLVLAPS
210 220 230 240 250
LVVAGLSAHR EVAQFCFTHW GLALLVILLM VVCSQHLGSC QFHVCPWRRA
260 270 280 290 300
STSSTHTPLP VFRLLSVLIP VACVWIVSAF VGFSVIPQEL SAPTKAPWIW
310 320 330 340 350
LPHPGEWNWP LLTPRALAAG ISMALAASTS SLGCYALCGR LLHLPPPPPH
360 370 380 390 400
ACSRGLSLEG LGSVLAGLLG SPMGTASSFP NVGKVGLIQA GSQQVAHLVG
410 420 430 440 450
LLCVGLGLSP RLAQLLTTIP LPVVGGVLGV TQAVVLSAGF SSFYLADIDS
460 470 480 490 500
GRNIFIVGFS IFMALLLPRW FREAPVLFST GWSPLDVLLH SLLTQPIFLA
510 520 530 540 550
GLSGFLLENT IPGTQLERGL GQGLPSPFTA QEARMPQKPR EKAAQVYRLP
560 570 580 590 600
FPIQNLCPCI PQPLHCLCPL PEDPGDEEGG SSEPEEMADL LPGSGEPCPE
610
SSREGFRSQK
Length:610
Mass (Da):64,531
Last modified:May 20, 2008 - v2
Checksum:i962A3E1CBA895D10
GO
Isoform 2 (identifier: Q6PIS1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     226-388: VILLMVVCSQ...FPNVGKVGLI → TWAPASFMCA...PRHHGFGCLT

Note: No experimental confirmation available.
Show »
Length:493
Mass (Da):52,361
Checksum:i9D2C4F7331D7A12D
GO
Isoform 3 (identifier: Q6PIS1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     140-140: S → CEHRARARA

Note: No experimental confirmation available.
Show »
Length:618
Mass (Da):65,495
Checksum:i07ACDE463CD90F4B
GO

Sequence cautioni

The sequence ABC17635.1 differs from that shown.Fragment of a potential novel isoform.Curated
The sequence BAB70999.1 differs from that shown.Intron retention.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti179 – 1791M → V in ABC17635 (Ref. 4) Curated
Sequence conflicti543 – 5431Missing in AAH30243 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei140 – 1401S → CEHRARARA in isoform 3. 1 PublicationVSP_043670
Alternative sequencei226 – 388163VILLM…KVGLI → TWAPASFMCAPGGELQRHQL TLLSLSSGSFRNCLPPPRHH GFGCLT in isoform 2. 1 PublicationVSP_033970Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055730 mRNA. Translation: BAB70999.1. Sequence problems.
AK298277 mRNA. Translation: BAH12748.1.
AC020575 Genomic DNA. No translation available.
AC068946 Genomic DNA. No translation available.
AC097468 Genomic DNA. No translation available.
BC030243 mRNA. Translation: AAH30243.1.
DQ294736 mRNA. Translation: ABC17635.1. Sequence problems.
CCDSiCCDS42819.1. [Q6PIS1-2]
CCDS46517.1. [Q6PIS1-5]
CCDS46518.1. [Q6PIS1-1]
RefSeqiNP_001138361.1. NM_001144889.1. [Q6PIS1-1]
NP_001138362.1. NM_001144890.1. [Q6PIS1-5]
NP_653313.3. NM_144712.4. [Q6PIS1-2]
UniGeneiHs.124565.

Genome annotation databases

EnsembliENST00000295738; ENSP00000295738; ENSG00000213901. [Q6PIS1-2]
ENST00000409878; ENSP00000386473; ENSG00000213901. [Q6PIS1-1]
ENST00000455516; ENSP00000406546; ENSG00000213901. [Q6PIS1-5]
GeneIDi151295.
KEGGihsa:151295.
UCSCiuc010fwb.4. human. [Q6PIS1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055730 mRNA. Translation: BAB70999.1. Sequence problems.
AK298277 mRNA. Translation: BAH12748.1.
AC020575 Genomic DNA. No translation available.
AC068946 Genomic DNA. No translation available.
AC097468 Genomic DNA. No translation available.
BC030243 mRNA. Translation: AAH30243.1.
DQ294736 mRNA. Translation: ABC17635.1. Sequence problems.
CCDSiCCDS42819.1. [Q6PIS1-2]
CCDS46517.1. [Q6PIS1-5]
CCDS46518.1. [Q6PIS1-1]
RefSeqiNP_001138361.1. NM_001144889.1. [Q6PIS1-1]
NP_001138362.1. NM_001144890.1. [Q6PIS1-5]
NP_653313.3. NM_144712.4. [Q6PIS1-2]
UniGeneiHs.124565.

3D structure databases

ProteinModelPortaliQ6PIS1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127365. 2 interactions.
IntActiQ6PIS1. 1 interaction.
STRINGi9606.ENSP00000406546.

Protein family/group databases

TCDBi2.A.40.6.4. the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family.

PTM databases

PhosphoSiteiQ6PIS1.

Polymorphism and mutation databases

BioMutaiSLC23A3.
DMDMi189046185.

Proteomic databases

PaxDbiQ6PIS1.
PRIDEiQ6PIS1.

Protocols and materials databases

DNASUi151295.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295738; ENSP00000295738; ENSG00000213901. [Q6PIS1-2]
ENST00000409878; ENSP00000386473; ENSG00000213901. [Q6PIS1-1]
ENST00000455516; ENSP00000406546; ENSG00000213901. [Q6PIS1-5]
GeneIDi151295.
KEGGihsa:151295.
UCSCiuc010fwb.4. human. [Q6PIS1-1]

Organism-specific databases

CTDi151295.
GeneCardsiSLC23A3.
HGNCiHGNC:20601. SLC23A3.
HPAiHPA019059.
neXtProtiNX_Q6PIS1.
PharmGKBiPA134932069.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1292. Eukaryota.
COG2233. LUCA.
GeneTreeiENSGT00390000015686.
HOGENOMiHOG000082411.
HOVERGENiHBG108439.
InParanoidiQ6PIS1.
KOiK14612.
OMAiGCYALCG.
OrthoDBiEOG7GN2MF.
PhylomeDBiQ6PIS1.
TreeFamiTF313272.

Miscellaneous databases

GenomeRNAii151295.
PROiQ6PIS1.

Gene expression databases

BgeeiQ6PIS1.
CleanExiHS_SLC23A3.
ExpressionAtlasiQ6PIS1. baseline and differential.
GenevisibleiQ6PIS1. HS.

Family and domain databases

InterProiIPR006043. Xant/urac/vitC.
[Graphical view]
PANTHERiPTHR11119. PTHR11119. 1 hit.
PfamiPF00860. Xan_ur_permease. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-225 (ISOFORM 1).
    Tissue: Kidney.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Colon.
  4. "Cloning and analysis of the cDNA of Hepatitis C virus E2-binding protein 3."
    Cheng J., Lan X.-Y., Zhang L.-Y., Guo J.
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 108-225 (ISOFORM 1).

Entry informationi

Entry nameiS23A3_HUMAN
AccessioniPrimary (citable) accession number: Q6PIS1
Secondary accession number(s): B7Z512, Q2PYN6, Q96NA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: June 8, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.