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Q6PIL8

- Q6PIL8_HUMAN

UniProt

Q6PIL8 - Q6PIL8_HUMAN

Protein
Submitted name:

IGK@ protein

Gene

IGK@

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Protein family/group databases

    MEROPSiI43.001.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    IGK@ proteinImported
    Gene namesi
    Name:IGK@Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    PTM / Processingi

    Proteomic databases

    PRIDEiQ6PIL8.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1U6AX-ray2.81L21-236[»]
    3DVGX-ray2.60A40-236[»]
    3DVNX-ray2.70A/L40-236[»]
    3EYQX-ray2.40C21-236[»]
    3HI1X-ray2.90A/L21-236[»]
    4OQTX-ray3.23L25-236[»]
    ProteinModelPortaliQ6PIL8.
    SMRiQ6PIL8. Positions 21-236.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ6PIL8.

    Family & Domainsi

    Keywords - Domaini

    Immunoglobulin domainSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG018013.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00407. IGc1. 1 hit.
    SM00406. IGv. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 2 hits.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6PIL8-1 [UniParc]FASTAAdd to Basket

    « Hide

    METPAQLLFL LLLWLPDSTG ENVLTQSPGT LSLSPGERAT LSCRASQSLS    50
    SSYLAWYQQK PGQAPRLLIY GVSSRATGIP DRFSGSGSGT DFTLTISRLE 100
    PEDFAVYYCQ QYGTSRPITF GQGTRLDIKR TVAAPSVFIF PPSDEQLKSG 150
    TASVVCLLNN FYPREAKVQW KVDNALQSGN SQESVTEQDS KDSTYSLSST 200
    LTLSKADYEK HKVYACEVTH QGLSSPVTKS FNRGEC 236
    Length:236
    Mass (Da):25,834
    Last modified:July 5, 2004 - v1
    Checksum:i6647A9E77A3C0053
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC032451 mRNA. Translation: AAH32451.1.
    UniGeneiHs.449609.
    Hs.719895.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC032451 mRNA. Translation: AAH32451.1 .
    UniGenei Hs.449609.
    Hs.719895.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1U6A X-ray 2.81 L 21-236 [» ]
    3DVG X-ray 2.60 A 40-236 [» ]
    3DVN X-ray 2.70 A/L 40-236 [» ]
    3EYQ X-ray 2.40 C 21-236 [» ]
    3HI1 X-ray 2.90 A/L 21-236 [» ]
    4OQT X-ray 3.23 L 25-236 [» ]
    ProteinModelPortali Q6PIL8.
    SMRi Q6PIL8. Positions 21-236.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I43.001.

    Proteomic databases

    PRIDEi Q6PIL8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG018013.

    Miscellaneous databases

    EvolutionaryTracei Q6PIL8.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00407. IGc1. 1 hit.
    SM00406. IGv. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 2 hits.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: BrainImported.
    2. "Structure of the Fab fragment of F105, a broadly reactive anti-human immunodeficiency virus (HIV) antibody that recognizes the CD4 binding site of HIV type 1 gp120."
      Wilkinson R.A., Piscitelli C., Teintze M., Cavacini L.A., Posner M.R., Lawrence C.M.
      J. Virol. 79:13060-13069(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.81 ANGSTROMS) OF 21-236.
    3. Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 40-236.
    4. "Germline V-genes sculpt the binding site of a family of antibodies neutralizing human cytomegalovirus."
      Thomson C.A., Bryson S., McLean G.R., Creagh A.L., Pai E.F., Schrader J.W.
      EMBO J. 27:2592-2602(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 21-236.
    5. Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 21-236.
    6. "Structure of the LINGO-1-anti-LINGO-1 Li81 antibody complex provides insights into the biology of LINGO-1 and the mechanism of action of the antibody therapy."
      Pepinsky R.B., Arndt J.W., Quan C., Gao Y., Quintero-Monzon O., Lee X., Mi S.
      J. Pharmacol. Exp. Ther. 350:110-123(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.23 ANGSTROMS) OF 25-236.

    Entry informationi

    Entry nameiQ6PIL8_HUMAN
    AccessioniPrimary (citable) accession number: Q6PIL8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3