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Q6PII5 (HAGHL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyacylglutathione hydrolase-like protein

EC=3.1.2.-
Gene names
Name:HAGHL
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length290 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Hydrolase acting on ester bonds Potential.

Cofactor

Binds 2 zinc ions per subunit By similarity.

Sequence similarities

Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

Sequence caution

The sequence AAK61250.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence BAD92568.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence BAD92568.1 differs from that shown. Reason: Sequence of unknown origin at the C-terminus.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglutathione biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionhydroxyacylglutathione hydrolase activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6PII5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6PII5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     201-290: ARPLSRRGKR...RKASGDCVLG → KRDEDDVPTV...WGLLSAAPHD
Isoform 3 (identifier: Q6PII5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     134-202: DALSVAGCGS...RAKLSWAKAR → TRSAERAHPA...EGVLRPRAHA
     203-290: Missing.
Isoform 4 (identifier: Q6PII5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     97-203: FGAIHVRCLL...AKLSWAKARP → VSARSREGRG...EGVLRPRAHA
     204-290: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 290290Hydroxyacylglutathione hydrolase-like protein
PRO_0000313601

Sites

Metal binding541Zinc 1 By similarity
Metal binding561Zinc 1 By similarity
Metal binding581Zinc 2 By similarity
Metal binding591Zinc 2 By similarity
Metal binding1101Zinc 1 By similarity
Metal binding1341Zinc 1 By similarity
Metal binding1341Zinc 2 By similarity
Metal binding1721Zinc 2 By similarity

Natural variations

Alternative sequence97 – 203107FGAIH…AKARP → VSARSREGRGGRPGSTRPHR SACSSAAVRGHPRALPPDAR PHRRPHELLPVGGRLPGPTR PVLGRRAVGGRLRLVPGGQR PADVPEPGRAGYPAPRDEGV LRPRAHA in isoform 4.
VSP_030052
Alternative sequence134 – 20269DALSV…WAKAR → TRSAERAHPASRRPRPICSD PPSPARRRAVGGRLRLVPGG QRPADVPEPGRAGYPAPRDE GVLRPRAHA in isoform 3.
VSP_030053
Alternative sequence201 – 29090ARPLS…DCVLG → KRDEDDVPTVPSTLGEERLY NPFLRVAEEPVRKFTGKAVP ADVLEALCKERARFEQAGEP RQPQARALLALQWGLLSAAP HD in isoform 2.
VSP_030054
Alternative sequence203 – 29088Missing in isoform 3.
VSP_030055
Alternative sequence204 – 29087Missing in isoform 4.
VSP_030056

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: C0B2D01D53262AB2

FASTA29031,557
        10         20         30         40         50         60 
MKVKVIPVLE DNYMYLVIEE LTREAVAVDV AVPKRLLEIV GREGVSLTAV LTTHHHWDHA 

        70         80         90        100        110        120 
RGNPELARLR PGLAVLGADE RIFSLTRRLA HGEELRFGAI HVRCLLTPGH TAGHMSYFLW 

       130        140        150        160        170        180 
EDDCPDPPAL FSGDALSVAG CGSCLEGSAQ QMYQSLAELG TLPPETKVFC GHEHTLSNLE 

       190        200        210        220        230        240 
FAQKVEPCND HVRAKLSWAK ARPLSRRGKR VGGEGTGFGV GGALRQGLMV TGACGHSRRG 

       250        260        270        280        290 
MRMTCPLCRR LWARSASTTP SCGWREYGCC PGASTVTWTL RKASGDCVLG 

« Hide

Isoform 2 [UniParc].

Checksum: CB35208CEA7A56F6
Show »

FASTA28231,234
Isoform 3 [UniParc].

Checksum: B4C7D5AA1381C724
Show »

FASTA20222,286
Isoform 4 [UniParc].

Checksum: AAB41E336052526D
Show »

FASTA20322,143

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Cerebellum.
[2]"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The sequence and analysis of duplication-rich human chromosome 16."
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. expand/collapse author list , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4).
Tissue: Brain, Eye and Skin.
[6]Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-191.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK054841 mRNA. Translation: BAB70814.1.
AE006464 Genomic DNA. Translation: AAK61250.1. Sequence problems.
Z98258 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85726.1.
CH471112 Genomic DNA. Translation: EAW85730.1.
CH471112 Genomic DNA. Translation: EAW85731.1.
CH471112 Genomic DNA. Translation: EAW85732.1.
CH471112 Genomic DNA. Translation: EAW85733.1.
BC004353 mRNA. Translation: AAH04353.1.
BC015008 mRNA. Translation: AAH15008.1.
BC033796 mRNA. Translation: AAH33796.1.
AB209331 mRNA. Translation: BAD92568.1. Sequence problems.
RefSeqNP_115680.1. NM_032304.2.
XP_005255688.1. XM_005255631.2.
UniGeneHs.124015.

3D structure databases

ProteinModelPortalQ6PII5.
SMRQ6PII5. Positions 1-202.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123991. 2 interactions.
IntActQ6PII5. 1 interaction.
STRING9606.ENSP00000341952.

PTM databases

PhosphoSiteQ6PII5.

Polymorphism databases

DMDM74737738.

Proteomic databases

PaxDbQ6PII5.
PRIDEQ6PII5.

Protocols and materials databases

DNASU84264.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000341413; ENSP00000341952; ENSG00000103253. [Q6PII5-1]
ENST00000389703; ENSP00000374353; ENSG00000103253. [Q6PII5-2]
ENST00000549114; ENSP00000447170; ENSG00000103253. [Q6PII5-3]
ENST00000564537; ENSP00000457219; ENSG00000103253. [Q6PII5-3]
GeneID84264.
KEGGhsa:84264.
UCSCuc002cjl.1. human. [Q6PII5-1]
uc002cjn.1. human. [Q6PII5-3]
uc002cjo.1. human. [Q6PII5-2]

Organism-specific databases

CTD84264.
GeneCardsGC16P000832.
HGNCHGNC:14177. HAGHL.
neXtProtNX_Q6PII5.
PharmGKBPA29180.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0491.
HOVERGENHBG001152.
InParanoidQ6PII5.
KOK01069.
OMAALCKERA.
OrthoDBEOG789CBX.
PhylomeDBQ6PII5.
TreeFamTF105273.

Gene expression databases

ArrayExpressQ6PII5.
BgeeQ6PII5.
CleanExHS_HAGHL.
GenevestigatorQ6PII5.

Family and domain databases

Gene3D3.60.15.10. 1 hit.
InterProIPR001279. Beta-lactamas-like.
IPR017782. Hydroxyacylglutathione_Hdrlase.
[Graphical view]
PANTHERPTHR11935:SF7. PTHR11935:SF7. 1 hit.
PfamPF00753. Lactamase_B. 1 hit.
[Graphical view]
SMARTSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMSSF56281. SSF56281. 1 hit.
ProtoNetSearch...

Other

ChiTaRSHAGHL. human.
GenomeRNAi84264.
NextBio73802.
PROQ6PII5.

Entry information

Entry nameHAGHL_HUMAN
AccessionPrimary (citable) accession number: Q6PII5
Secondary accession number(s): A6NCC4 expand/collapse secondary AC list , D3DU64, Q59FX8, Q96BZ3, Q96NR5, Q96S11, Q9BT45
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM