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Protein

Hydroxyacylglutathione hydrolase-like protein

Gene

HAGHL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Hydrolase acting on ester bonds.Curated

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi54 – 541Zinc 1By similarity
Metal bindingi56 – 561Zinc 1By similarity
Metal bindingi58 – 581Zinc 2By similarity
Metal bindingi59 – 591Zinc 2By similarity
Metal bindingi110 – 1101Zinc 1By similarity
Metal bindingi134 – 1341Zinc 1By similarity
Metal bindingi134 – 1341Zinc 2By similarity
Metal bindingi172 – 1721Zinc 2By similarity

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyacylglutathione hydrolase-like protein (EC:3.1.2.-)
Gene namesi
Name:HAGHL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:14177. HAGHL.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29180.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Hydroxyacylglutathione hydrolase-like proteinPRO_0000313601Add
BLAST

Proteomic databases

MaxQBiQ6PII5.
PaxDbiQ6PII5.
PRIDEiQ6PII5.

PTM databases

PhosphoSiteiQ6PII5.

Expressioni

Gene expression databases

BgeeiQ6PII5.
CleanExiHS_HAGHL.
ExpressionAtlasiQ6PII5. baseline and differential.
GenevestigatoriQ6PII5.

Interactioni

Protein-protein interaction databases

BioGridi123991. 2 interactions.
IntActiQ6PII5. 1 interaction.
STRINGi9606.ENSP00000341952.

Structurei

3D structure databases

ProteinModelPortaliQ6PII5.
SMRiQ6PII5. Positions 1-202.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0491.
GeneTreeiENSGT00530000063033.
HOVERGENiHBG001152.
InParanoidiQ6PII5.
KOiK01069.
OMAiHARGNAE.
OrthoDBiEOG789CBX.
PhylomeDBiQ6PII5.
TreeFamiTF105273.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR001279. Beta-lactamas-like.
[Graphical view]
PfamiPF00753. Lactamase_B. 1 hit.
[Graphical view]
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PII5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKVKVIPVLE DNYMYLVIEE LTREAVAVDV AVPKRLLEIV GREGVSLTAV
60 70 80 90 100
LTTHHHWDHA RGNPELARLR PGLAVLGADE RIFSLTRRLA HGEELRFGAI
110 120 130 140 150
HVRCLLTPGH TAGHMSYFLW EDDCPDPPAL FSGDALSVAG CGSCLEGSAQ
160 170 180 190 200
QMYQSLAELG TLPPETKVFC GHEHTLSNLE FAQKVEPCND HVRAKLSWAK
210 220 230 240 250
ARPLSRRGKR VGGEGTGFGV GGALRQGLMV TGACGHSRRG MRMTCPLCRR
260 270 280 290
LWARSASTTP SCGWREYGCC PGASTVTWTL RKASGDCVLG
Length:290
Mass (Da):31,557
Last modified:July 5, 2004 - v1
Checksum:iC0B2D01D53262AB2
GO
Isoform 2 (identifier: Q6PII5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-290: ARPLSRRGKR...RKASGDCVLG → KRDEDDVPTV...WGLLSAAPHD

Show »
Length:282
Mass (Da):31,234
Checksum:iCB35208CEA7A56F6
GO
Isoform 3 (identifier: Q6PII5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-202: DALSVAGCGS...RAKLSWAKAR → TRSAERAHPA...EGVLRPRAHA
     203-290: Missing.

Show »
Length:202
Mass (Da):22,286
Checksum:iB4C7D5AA1381C724
GO
Isoform 4 (identifier: Q6PII5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     97-203: FGAIHVRCLL...AKLSWAKARP → VSARSREGRG...EGVLRPRAHA
     204-290: Missing.

Show »
Length:203
Mass (Da):22,143
Checksum:iAAB41E336052526D
GO

Sequence cautioni

The sequence AAK61250.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence BAD92568.1 differs from that shown.Sequence of unknown origin at the C-terminus.Curated
The sequence BAD92568.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei97 – 203107FGAIH…AKARP → VSARSREGRGGRPGSTRPHR SACSSAAVRGHPRALPPDAR PHRRPHELLPVGGRLPGPTR PVLGRRAVGGRLRLVPGGQR PADVPEPGRAGYPAPRDEGV LRPRAHA in isoform 4. 1 PublicationVSP_030052Add
BLAST
Alternative sequencei134 – 20269DALSV…WAKAR → TRSAERAHPASRRPRPICSD PPSPARRRAVGGRLRLVPGG QRPADVPEPGRAGYPAPRDE GVLRPRAHA in isoform 3. 1 PublicationVSP_030053Add
BLAST
Alternative sequencei201 – 29090ARPLS…DCVLG → KRDEDDVPTVPSTLGEERLY NPFLRVAEEPVRKFTGKAVP ADVLEALCKERARFEQAGEP RQPQARALLALQWGLLSAAP HD in isoform 2. 1 PublicationVSP_030054Add
BLAST
Alternative sequencei203 – 29088Missing in isoform 3. 1 PublicationVSP_030055Add
BLAST
Alternative sequencei204 – 29087Missing in isoform 4. 1 PublicationVSP_030056Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054841 mRNA. Translation: BAB70814.1.
AE006464 Genomic DNA. Translation: AAK61250.1. Sequence problems.
Z98258 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85726.1.
CH471112 Genomic DNA. Translation: EAW85730.1.
CH471112 Genomic DNA. Translation: EAW85731.1.
CH471112 Genomic DNA. Translation: EAW85732.1.
CH471112 Genomic DNA. Translation: EAW85733.1.
BC004353 mRNA. Translation: AAH04353.1.
BC015008 mRNA. Translation: AAH15008.1.
BC033796 mRNA. Translation: AAH33796.1.
AB209331 mRNA. Translation: BAD92568.1. Sequence problems.
CCDSiCCDS32354.1. [Q6PII5-2]
RefSeqiNP_001277066.1. NM_001290137.1. [Q6PII5-2]
NP_001277068.1. NM_001290139.1. [Q6PII5-2]
NP_115680.1. NM_032304.3. [Q6PII5-2]
XP_005255688.1. XM_005255631.2. [Q6PII5-1]
UniGeneiHs.124015.

Genome annotation databases

EnsembliENST00000341413; ENSP00000341952; ENSG00000103253. [Q6PII5-1]
ENST00000389703; ENSP00000374353; ENSG00000103253. [Q6PII5-2]
ENST00000549114; ENSP00000447170; ENSG00000103253. [Q6PII5-3]
ENST00000564537; ENSP00000457219; ENSG00000103253. [Q6PII5-3]
GeneIDi84264.
KEGGihsa:84264.
UCSCiuc002cjl.1. human. [Q6PII5-1]
uc002cjn.1. human. [Q6PII5-3]
uc002cjo.1. human. [Q6PII5-2]

Polymorphism databases

DMDMi74737738.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054841 mRNA. Translation: BAB70814.1.
AE006464 Genomic DNA. Translation: AAK61250.1. Sequence problems.
Z98258 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85726.1.
CH471112 Genomic DNA. Translation: EAW85730.1.
CH471112 Genomic DNA. Translation: EAW85731.1.
CH471112 Genomic DNA. Translation: EAW85732.1.
CH471112 Genomic DNA. Translation: EAW85733.1.
BC004353 mRNA. Translation: AAH04353.1.
BC015008 mRNA. Translation: AAH15008.1.
BC033796 mRNA. Translation: AAH33796.1.
AB209331 mRNA. Translation: BAD92568.1. Sequence problems.
CCDSiCCDS32354.1. [Q6PII5-2]
RefSeqiNP_001277066.1. NM_001290137.1. [Q6PII5-2]
NP_001277068.1. NM_001290139.1. [Q6PII5-2]
NP_115680.1. NM_032304.3. [Q6PII5-2]
XP_005255688.1. XM_005255631.2. [Q6PII5-1]
UniGeneiHs.124015.

3D structure databases

ProteinModelPortaliQ6PII5.
SMRiQ6PII5. Positions 1-202.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123991. 2 interactions.
IntActiQ6PII5. 1 interaction.
STRINGi9606.ENSP00000341952.

PTM databases

PhosphoSiteiQ6PII5.

Polymorphism databases

DMDMi74737738.

Proteomic databases

MaxQBiQ6PII5.
PaxDbiQ6PII5.
PRIDEiQ6PII5.

Protocols and materials databases

DNASUi84264.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341413; ENSP00000341952; ENSG00000103253. [Q6PII5-1]
ENST00000389703; ENSP00000374353; ENSG00000103253. [Q6PII5-2]
ENST00000549114; ENSP00000447170; ENSG00000103253. [Q6PII5-3]
ENST00000564537; ENSP00000457219; ENSG00000103253. [Q6PII5-3]
GeneIDi84264.
KEGGihsa:84264.
UCSCiuc002cjl.1. human. [Q6PII5-1]
uc002cjn.1. human. [Q6PII5-3]
uc002cjo.1. human. [Q6PII5-2]

Organism-specific databases

CTDi84264.
GeneCardsiGC16P000851.
HGNCiHGNC:14177. HAGHL.
neXtProtiNX_Q6PII5.
PharmGKBiPA29180.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0491.
GeneTreeiENSGT00530000063033.
HOVERGENiHBG001152.
InParanoidiQ6PII5.
KOiK01069.
OMAiHARGNAE.
OrthoDBiEOG789CBX.
PhylomeDBiQ6PII5.
TreeFamiTF105273.

Miscellaneous databases

ChiTaRSiHAGHL. human.
GenomeRNAii84264.
NextBioi73802.
PROiQ6PII5.

Gene expression databases

BgeeiQ6PII5.
CleanExiHS_HAGHL.
ExpressionAtlasiQ6PII5. baseline and differential.
GenevestigatoriQ6PII5.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR001279. Beta-lactamas-like.
[Graphical view]
PfamiPF00753. Lactamase_B. 1 hit.
[Graphical view]
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Cerebellum.
  2. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
    Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
    Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4).
    Tissue: Brain, Eye and Skin.
  6. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-191.
    Tissue: Brain.

Entry informationi

Entry nameiHAGHL_HUMAN
AccessioniPrimary (citable) accession number: Q6PII5
Secondary accession number(s): A6NCC4
, D3DU64, Q59FX8, Q96BZ3, Q96NR5, Q96S11, Q9BT45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.