Q6PII5 (HAGHL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hydroxyacylglutathione hydrolase-like protein
EC=3.1.2.-

Gene names

Name:

HAGHL

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Hydrolase acting on ester bonds Potential.
Cofactor	Binds 2 zinc ions per subunit By similarity.
Sequence similarities	Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Sequence caution	The sequence AAK61250.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAD92568.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAD92568.1 differs from that shown. Reason: Sequence of unknown origin at the C-terminus.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glutathione biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	hydroxyacylglutathione hydrolase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6PII5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6PII5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     201-290: ARPLSRRGKR...RKASGDCVLG → KRDEDDVPTV...WGLLSAAPHD

Isoform 3 (identifier: Q6PII5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     134-202: DALSVAGCGS...RAKLSWAKAR → TRSAERAHPA...EGVLRPRAHA
     203-290: Missing.

Isoform 4 (identifier: Q6PII5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     97-203: FGAIHVRCLL...AKLSWAKARP → VSARSREGRG...EGVLRPRAHA
     204-290: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 290	290	Hydroxyacylglutathione hydrolase-like protein		PRO_0000313601
Sites
	Metal binding	54	1	Zinc 1 By similarity
	Metal binding	56	1	Zinc 1 By similarity
	Metal binding	58	1	Zinc 2 By similarity
	Metal binding	59	1	Zinc 2 By similarity
	Metal binding	110	1	Zinc 1 By similarity
	Metal binding	134	1	Zinc 1 By similarity
	Metal binding	134	1	Zinc 2 By similarity
	Metal binding	172	1	Zinc 2 By similarity
Natural variations
	Alternative sequence	97 – 203	107	FGAIH…AKARP → VSARSREGRGGRPGSTRPHR SACSSAAVRGHPRALPPDAR PHRRPHELLPVGGRLPGPTR PVLGRRAVGGRLRLVPGGQR PADVPEPGRAGYPAPRDEGV LRPRAHA in isoform 4.		VSP_030052
	Alternative sequence	134 – 202	69	DALSV…WAKAR → TRSAERAHPASRRPRPICSD PPSPARRRAVGGRLRLVPGG QRPADVPEPGRAGYPAPRDE GVLRPRAHA in isoform 3.		VSP_030053
	Alternative sequence	201 – 290	90	ARPLS…DCVLG → KRDEDDVPTVPSTLGEERLY NPFLRVAEEPVRKFTGKAVP ADVLEALCKERARFEQAGEP RQPQARALLALQWGLLSAAP HD in isoform 2.		VSP_030054
	Alternative sequence	203 – 290	88	Missing in isoform 3.		VSP_030055
	Alternative sequence	204 – 290	87	Missing in isoform 4.		VSP_030056

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: C0B2D01D53262AB2	FASTA	290	31,557
	10 20 30 40 50 60 MKVKVIPVLE DNYMYLVIEE LTREAVAVDV AVPKRLLEIV GREGVSLTAV LTTHHHWDHA 70 80 90 100 110 120 RGNPELARLR PGLAVLGADE RIFSLTRRLA HGEELRFGAI HVRCLLTPGH TAGHMSYFLW 130 140 150 160 170 180 EDDCPDPPAL FSGDALSVAG CGSCLEGSAQ QMYQSLAELG TLPPETKVFC GHEHTLSNLE 190 200 210 220 230 240 FAQKVEPCND HVRAKLSWAK ARPLSRRGKR VGGEGTGFGV GGALRQGLMV TGACGHSRRG 250 260 270 280 290 MRMTCPLCRR LWARSASTTP SCGWREYGCC PGASTVTWTL RKASGDCVLG
	Isoform 2 [UniParc]. Checksum: CB35208CEA7A56F6	FASTA	282	31,234
	10 20 30 40 50 60 MKVKVIPVLE DNYMYLVIEE LTREAVAVDV AVPKRLLEIV GREGVSLTAV LTTHHHWDHA 70 80 90 100 110 120 RGNPELARLR PGLAVLGADE RIFSLTRRLA HGEELRFGAI HVRCLLTPGH TAGHMSYFLW 130 140 150 160 170 180 EDDCPDPPAL FSGDALSVAG CGSCLEGSAQ QMYQSLAELG TLPPETKVFC GHEHTLSNLE 190 200 210 220 230 240 FAQKVEPCND HVRAKLSWAK KRDEDDVPTV PSTLGEERLY NPFLRVAEEP VRKFTGKAVP 250 260 270 280 ADVLEALCKE RARFEQAGEP RQPQARALLA LQWGLLSAAP HD
	Isoform 3 [UniParc]. Checksum: B4C7D5AA1381C724	FASTA	202	22,286
	10 20 30 40 50 60 MKVKVIPVLE DNYMYLVIEE LTREAVAVDV AVPKRLLEIV GREGVSLTAV LTTHHHWDHA 70 80 90 100 110 120 RGNPELARLR PGLAVLGADE RIFSLTRRLA HGEELRFGAI HVRCLLTPGH TAGHMSYFLW 130 140 150 160 170 180 EDDCPDPPAL FSGTRSAERA HPASRRPRPI CSDPPSPARR RAVGGRLRLV PGGQRPADVP 190 200 EPGRAGYPAP RDEGVLRPRA HA
	Isoform 4 [UniParc]. Checksum: AAB41E336052526D	FASTA	203	22,143
	10 20 30 40 50 60 MKVKVIPVLE DNYMYLVIEE LTREAVAVDV AVPKRLLEIV GREGVSLTAV LTTHHHWDHA 70 80 90 100 110 120 RGNPELARLR PGLAVLGADE RIFSLTRRLA HGEELRVSAR SREGRGGRPG STRPHRSACS 130 140 150 160 170 180 SAAVRGHPRA LPPDARPHRR PHELLPVGGR LPGPTRPVLG RRAVGGRLRL VPGGQRPADV 190 200 PEPGRAGYPA PRDEGVLRPR AHA

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Cerebellum.
[2]	"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16." Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R. Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4). Tissue: Brain, Eye and Skin.
[6]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-191. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK054841 mRNA. Translation: BAB70814.1. AE006464 Genomic DNA. Translation: AAK61250.1. Sequence problems. Z98258 Genomic DNA. No translation available. CH471112 Genomic DNA. Translation: EAW85726.1. CH471112 Genomic DNA. Translation: EAW85730.1. CH471112 Genomic DNA. Translation: EAW85731.1. CH471112 Genomic DNA. Translation: EAW85732.1. CH471112 Genomic DNA. Translation: EAW85733.1. BC004353 mRNA. Translation: AAH04353.1. BC015008 mRNA. Translation: AAH15008.1. BC033796 mRNA. Translation: AAH33796.1. AB209331 mRNA. Translation: BAD92568.1. Sequence problems.
IPI	IPI00329667. IPI00382519. IPI00386405. IPI00410184.
RefSeq	NP_115680.1. NM_032304.2.
UniGene	Hs.124015.
3D structure databases
HSSP	HSSP built from PDB template 1QH5 based on UniProtKB Q16775.
ProteinModelPortal	Q6PII5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6PII5. 1 interaction.
STRING	9606.ENSP00000341952.
PTM databases
PhosphoSite	Q6PII5.
Polymorphism databases
DMDM	74737738.
Proteomic databases
PaxDb	Q6PII5.
PRIDE	Q6PII5.
Protocols and materials databases
DNASU	84264.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000341413; ENSP00000341952; ENSG00000103253. ENST00000389703; ENSP00000374353; ENSG00000103253. ENST00000549114; ENSP00000447170; ENSG00000103253. ENST00000564537; ENSP00000457219; ENSG00000103253.
GeneID	84264.
KEGG	hsa:84264.
UCSC	uc002cjl.1. human. uc002cjn.1. human. uc002cjo.1. human.
Organism-specific databases
CTD	84264.
GeneCards	GC16P000789.
HGNC	HGNC:14177. HAGHL.
neXtProt	NX_Q6PII5.
PharmGKB	PA29180.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0491.
HOVERGEN	HBG001152.
InParanoid	Q6PII5.
KO	K01069.
OMA	HILTTHH.
Gene expression databases
ArrayExpress	Q6PII5.
Bgee	Q6PII5.
CleanEx	HS_HAGHL.
Genevestigator	Q6PII5.
Family and domain databases
InterPro	IPR001279. Beta-lactamas-like. IPR017782. Hydroxyacylglutathione_Hdrlase. [Graphical view]
PANTHER	PTHR11935:SF7. PTHR11935:SF7. 1 hit.
Pfam	PF00753. Lactamase_B. 1 hit. [Graphical view]
SMART	SM00849. Lactamase_B. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	HAGHL. human.
GenomeRNAi	84264.
NextBio	73802.

Entry information

Entry name

HAGHL_HUMAN

Accession

Primary (citable) accession number: Q6PII5
Secondary accession number(s): A6NCC4 , D3DU64, Q59FX8, Q96BZ3, Q96NR5, Q96S11, Q9BT45

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.