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Q6PII5

- HAGHL_HUMAN

UniProt

Q6PII5 - HAGHL_HUMAN

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Protein
Hydroxyacylglutathione hydrolase-like protein
Gene
HAGHL
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Hydrolase acting on ester bonds Reviewed prediction.

Cofactori

Binds 2 zinc ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi54 – 541Zinc 1 By similarity
Metal bindingi56 – 561Zinc 1 By similarity
Metal bindingi58 – 581Zinc 2 By similarity
Metal bindingi59 – 591Zinc 2 By similarity
Metal bindingi110 – 1101Zinc 1 By similarity
Metal bindingi134 – 1341Zinc 1 By similarity
Metal bindingi134 – 1341Zinc 2 By similarity
Metal bindingi172 – 1721Zinc 2 By similarity

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxyacylglutathione hydrolase-like protein (EC:3.1.2.-)
    Gene namesi
    Name:HAGHL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:14177. HAGHL.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29180.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 290290Hydroxyacylglutathione hydrolase-like protein
    PRO_0000313601Add
    BLAST

    Proteomic databases

    MaxQBiQ6PII5.
    PaxDbiQ6PII5.
    PRIDEiQ6PII5.

    PTM databases

    PhosphoSiteiQ6PII5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6PII5.
    BgeeiQ6PII5.
    CleanExiHS_HAGHL.
    GenevestigatoriQ6PII5.

    Interactioni

    Protein-protein interaction databases

    BioGridi123991. 2 interactions.
    IntActiQ6PII5. 1 interaction.
    STRINGi9606.ENSP00000341952.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PII5.
    SMRiQ6PII5. Positions 1-202.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0491.
    HOVERGENiHBG001152.
    InParanoidiQ6PII5.
    KOiK01069.
    OMAiYLEDITP.
    OrthoDBiEOG789CBX.
    PhylomeDBiQ6PII5.
    TreeFamiTF105273.

    Family and domain databases

    Gene3Di3.60.15.10. 1 hit.
    InterProiIPR001279. Beta-lactamas-like.
    [Graphical view]
    PfamiPF00753. Lactamase_B. 1 hit.
    [Graphical view]
    SMARTiSM00849. Lactamase_B. 1 hit.
    [Graphical view]
    SUPFAMiSSF56281. SSF56281. 1 hit.

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6PII5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKVKVIPVLE DNYMYLVIEE LTREAVAVDV AVPKRLLEIV GREGVSLTAV    50
    LTTHHHWDHA RGNPELARLR PGLAVLGADE RIFSLTRRLA HGEELRFGAI 100
    HVRCLLTPGH TAGHMSYFLW EDDCPDPPAL FSGDALSVAG CGSCLEGSAQ 150
    QMYQSLAELG TLPPETKVFC GHEHTLSNLE FAQKVEPCND HVRAKLSWAK 200
    ARPLSRRGKR VGGEGTGFGV GGALRQGLMV TGACGHSRRG MRMTCPLCRR 250
    LWARSASTTP SCGWREYGCC PGASTVTWTL RKASGDCVLG 290
    Length:290
    Mass (Da):31,557
    Last modified:July 5, 2004 - v1
    Checksum:iC0B2D01D53262AB2
    GO
    Isoform 2 (identifier: Q6PII5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         201-290: ARPLSRRGKR...RKASGDCVLG → KRDEDDVPTV...WGLLSAAPHD

    Show »
    Length:282
    Mass (Da):31,234
    Checksum:iCB35208CEA7A56F6
    GO
    Isoform 3 (identifier: Q6PII5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         134-202: DALSVAGCGS...RAKLSWAKAR → TRSAERAHPA...EGVLRPRAHA
         203-290: Missing.

    Show »
    Length:202
    Mass (Da):22,286
    Checksum:iB4C7D5AA1381C724
    GO
    Isoform 4 (identifier: Q6PII5-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         97-203: FGAIHVRCLL...AKLSWAKARP → VSARSREGRG...EGVLRPRAHA
         204-290: Missing.

    Show »
    Length:203
    Mass (Da):22,143
    Checksum:iAAB41E336052526D
    GO

    Sequence cautioni

    The sequence BAD92568.1 differs from that shown. Reason: Sequence of unknown origin at the C-terminus.
    The sequence BAD92568.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence AAK61250.1 differs from that shown. Reason: Erroneous gene model prediction.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei97 – 203107FGAIH…AKARP → VSARSREGRGGRPGSTRPHR SACSSAAVRGHPRALPPDAR PHRRPHELLPVGGRLPGPTR PVLGRRAVGGRLRLVPGGQR PADVPEPGRAGYPAPRDEGV LRPRAHA in isoform 4.
    VSP_030052Add
    BLAST
    Alternative sequencei134 – 20269DALSV…WAKAR → TRSAERAHPASRRPRPICSD PPSPARRRAVGGRLRLVPGG QRPADVPEPGRAGYPAPRDE GVLRPRAHA in isoform 3.
    VSP_030053Add
    BLAST
    Alternative sequencei201 – 29090ARPLS…DCVLG → KRDEDDVPTVPSTLGEERLY NPFLRVAEEPVRKFTGKAVP ADVLEALCKERARFEQAGEP RQPQARALLALQWGLLSAAP HD in isoform 2.
    VSP_030054Add
    BLAST
    Alternative sequencei203 – 29088Missing in isoform 3.
    VSP_030055Add
    BLAST
    Alternative sequencei204 – 29087Missing in isoform 4.
    VSP_030056Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK054841 mRNA. Translation: BAB70814.1.
    AE006464 Genomic DNA. Translation: AAK61250.1. Sequence problems.
    Z98258 Genomic DNA. No translation available.
    CH471112 Genomic DNA. Translation: EAW85726.1.
    CH471112 Genomic DNA. Translation: EAW85730.1.
    CH471112 Genomic DNA. Translation: EAW85731.1.
    CH471112 Genomic DNA. Translation: EAW85732.1.
    CH471112 Genomic DNA. Translation: EAW85733.1.
    BC004353 mRNA. Translation: AAH04353.1.
    BC015008 mRNA. Translation: AAH15008.1.
    BC033796 mRNA. Translation: AAH33796.1.
    AB209331 mRNA. Translation: BAD92568.1. Sequence problems.
    CCDSiCCDS32354.1. [Q6PII5-2]
    RefSeqiNP_001277066.1. NM_001290137.1. [Q6PII5-2]
    NP_001277068.1. NM_001290139.1. [Q6PII5-2]
    NP_115680.1. NM_032304.3. [Q6PII5-2]
    XP_005255688.1. XM_005255631.2. [Q6PII5-1]
    UniGeneiHs.124015.

    Genome annotation databases

    EnsembliENST00000341413; ENSP00000341952; ENSG00000103253. [Q6PII5-1]
    ENST00000389703; ENSP00000374353; ENSG00000103253. [Q6PII5-2]
    ENST00000549114; ENSP00000447170; ENSG00000103253. [Q6PII5-3]
    ENST00000564537; ENSP00000457219; ENSG00000103253. [Q6PII5-3]
    GeneIDi84264.
    KEGGihsa:84264.
    UCSCiuc002cjl.1. human. [Q6PII5-1]
    uc002cjn.1. human. [Q6PII5-3]
    uc002cjo.1. human. [Q6PII5-2]

    Polymorphism databases

    DMDMi74737738.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK054841 mRNA. Translation: BAB70814.1 .
    AE006464 Genomic DNA. Translation: AAK61250.1 . Sequence problems.
    Z98258 Genomic DNA. No translation available.
    CH471112 Genomic DNA. Translation: EAW85726.1 .
    CH471112 Genomic DNA. Translation: EAW85730.1 .
    CH471112 Genomic DNA. Translation: EAW85731.1 .
    CH471112 Genomic DNA. Translation: EAW85732.1 .
    CH471112 Genomic DNA. Translation: EAW85733.1 .
    BC004353 mRNA. Translation: AAH04353.1 .
    BC015008 mRNA. Translation: AAH15008.1 .
    BC033796 mRNA. Translation: AAH33796.1 .
    AB209331 mRNA. Translation: BAD92568.1 . Sequence problems.
    CCDSi CCDS32354.1. [Q6PII5-2 ]
    RefSeqi NP_001277066.1. NM_001290137.1. [Q6PII5-2 ]
    NP_001277068.1. NM_001290139.1. [Q6PII5-2 ]
    NP_115680.1. NM_032304.3. [Q6PII5-2 ]
    XP_005255688.1. XM_005255631.2. [Q6PII5-1 ]
    UniGenei Hs.124015.

    3D structure databases

    ProteinModelPortali Q6PII5.
    SMRi Q6PII5. Positions 1-202.
    ModBasei Search...

    Protein-protein interaction databases

    BioGridi 123991. 2 interactions.
    IntActi Q6PII5. 1 interaction.
    STRINGi 9606.ENSP00000341952.

    PTM databases

    PhosphoSitei Q6PII5.

    Polymorphism databases

    DMDMi 74737738.

    Proteomic databases

    MaxQBi Q6PII5.
    PaxDbi Q6PII5.
    PRIDEi Q6PII5.

    Protocols and materials databases

    DNASUi 84264.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000341413 ; ENSP00000341952 ; ENSG00000103253 . [Q6PII5-1 ]
    ENST00000389703 ; ENSP00000374353 ; ENSG00000103253 . [Q6PII5-2 ]
    ENST00000549114 ; ENSP00000447170 ; ENSG00000103253 . [Q6PII5-3 ]
    ENST00000564537 ; ENSP00000457219 ; ENSG00000103253 . [Q6PII5-3 ]
    GeneIDi 84264.
    KEGGi hsa:84264.
    UCSCi uc002cjl.1. human. [Q6PII5-1 ]
    uc002cjn.1. human. [Q6PII5-3 ]
    uc002cjo.1. human. [Q6PII5-2 ]

    Organism-specific databases

    CTDi 84264.
    GeneCardsi GC16P000832.
    HGNCi HGNC:14177. HAGHL.
    neXtProti NX_Q6PII5.
    PharmGKBi PA29180.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0491.
    HOVERGENi HBG001152.
    InParanoidi Q6PII5.
    KOi K01069.
    OMAi YLEDITP.
    OrthoDBi EOG789CBX.
    PhylomeDBi Q6PII5.
    TreeFami TF105273.

    Miscellaneous databases

    ChiTaRSi HAGHL. human.
    GenomeRNAii 84264.
    NextBioi 73802.
    PROi Q6PII5.

    Gene expression databases

    ArrayExpressi Q6PII5.
    Bgeei Q6PII5.
    CleanExi HS_HAGHL.
    Genevestigatori Q6PII5.

    Family and domain databases

    Gene3Di 3.60.15.10. 1 hit.
    InterProi IPR001279. Beta-lactamas-like.
    [Graphical view ]
    Pfami PF00753. Lactamase_B. 1 hit.
    [Graphical view ]
    SMARTi SM00849. Lactamase_B. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56281. SSF56281. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Cerebellum.
    2. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
      Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
      Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4).
      Tissue: Brain, Eye and Skin.
    6. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-191.
      Tissue: Brain.

    Entry informationi

    Entry nameiHAGHL_HUMAN
    AccessioniPrimary (citable) accession number: Q6PII5
    Secondary accession number(s): A6NCC4
    , D3DU64, Q59FX8, Q96BZ3, Q96NR5, Q96S11, Q9BT45
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 5, 2004
    Last modified: July 9, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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