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Protein

Coiled-coil domain-containing protein 174

Gene

CCDC174

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 174
Gene namesi
Name:CCDC174
Synonyms:C3orf19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:28033. CCDC174.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134914840.

Polymorphism and mutation databases

BioMutaiCCDC174.
DMDMi126302528.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 467467Coiled-coil domain-containing protein 174PRO_0000251956Add
BLAST

Proteomic databases

EPDiQ6PII3.
MaxQBiQ6PII3.
PaxDbiQ6PII3.
PRIDEiQ6PII3.

PTM databases

PhosphoSiteiQ6PII3.

Expressioni

Gene expression databases

BgeeiQ6PII3.
CleanExiHS_C3orf19.
ExpressionAtlasiQ6PII3. baseline and differential.
GenevisibleiQ6PII3. HS.

Organism-specific databases

HPAiHPA043468.
HPA060129.

Interactioni

Protein-protein interaction databases

BioGridi119402. 12 interactions.
IntActiQ6PII3. 12 interactions.
MINTiMINT-1460637.
STRINGi9606.ENSP00000373304.

Structurei

3D structure databases

ProteinModelPortaliQ6PII3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili63 – 9937Sequence analysisAdd
BLAST
Coiled coili267 – 30943Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi219 – 2246Poly-Glu

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGB1. Eukaryota.
ENOG410Y526. LUCA.
GeneTreeiENSGT00440000033958.
HOGENOMiHOG000111357.
HOVERGENiHBG055105.
InParanoidiQ6PII3.
OMAiIWSKQNV.
OrthoDBiEOG7QC7WB.
PhylomeDBiQ6PII3.
TreeFamiTF323679.

Family and domain databases

InterProiIPR025066. DUF4078.
[Graphical view]
PfamiPF13300. DUF4078. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PII3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRRKKPLDV TASSLVDLKA ELFRKQEEFK QEKLLKDSGV FGKPKTTNKK
60 70 80 90 100
PSIWSKQNVG VSNRAEKDAE QKIEEQKTLD KAREKLEEKA KLYEKMTKGD
110 120 130 140 150
FIDEEVEDMY LVDFTQKIID KRKEMEASGA HRDSQKAGER DDDEENLPEG
160 170 180 190 200
EIPPPQDPSE EWVDYVDSLG RSRRCMRKDL PDLLEMDKNL QGRLFISPAN
210 220 230 240 250
EKTLLSEDMR KELQRQQWEE EEREALKRPM GPVHYEDIRE NEARQLGVGY
260 270 280 290 300
FAFARDKELR NKQMKTLEML REQTTDQRTK RENIKEKRKA ILEARLAKLR
310 320 330 340 350
QKKMKKSKEG GTEEENRDGD VIGPLPPEPE AVPTPRPAAQ SSKVEVIVQE
360 370 380 390 400
RKDTKPGVPH IREWDRGKEF SFGYWSKRQS DLRAERDPEF APPSDYFVGQ
410 420 430 440 450
KRTGFSSSQA WSRPGPAQSD PGQCPDQSHG PSPEHTSPTP APDNPPQAPT
460
VTFKTLDDMI SYYKQVT
Length:467
Mass (Da):53,958
Last modified:February 20, 2007 - v3
Checksum:iB106979B7AC37028
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti158 – 1581P → H in AAH33897 (PubMed:16641997).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti436 – 4361T → M.
Corresponds to variant rs60239620 [ dbSNP | Ensembl ].
VAR_061573

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090952 Genomic DNA. No translation available.
BC013999 mRNA. Translation: AAH13999.2.
BC033897 mRNA. Translation: AAH33897.2.
CCDSiCCDS2620.2.
RefSeqiNP_057558.3. NM_016474.4.
UniGeneiHs.517820.

Genome annotation databases

EnsembliENST00000383794; ENSP00000373304; ENSG00000154781.
GeneIDi51244.
KEGGihsa:51244.
UCSCiuc003byw.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090952 Genomic DNA. No translation available.
BC013999 mRNA. Translation: AAH13999.2.
BC033897 mRNA. Translation: AAH33897.2.
CCDSiCCDS2620.2.
RefSeqiNP_057558.3. NM_016474.4.
UniGeneiHs.517820.

3D structure databases

ProteinModelPortaliQ6PII3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119402. 12 interactions.
IntActiQ6PII3. 12 interactions.
MINTiMINT-1460637.
STRINGi9606.ENSP00000373304.

PTM databases

PhosphoSiteiQ6PII3.

Polymorphism and mutation databases

BioMutaiCCDC174.
DMDMi126302528.

Proteomic databases

EPDiQ6PII3.
MaxQBiQ6PII3.
PaxDbiQ6PII3.
PRIDEiQ6PII3.

Protocols and materials databases

DNASUi51244.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383794; ENSP00000373304; ENSG00000154781.
GeneIDi51244.
KEGGihsa:51244.
UCSCiuc003byw.4. human.

Organism-specific databases

CTDi51244.
GeneCardsiCCDC174.
HGNCiHGNC:28033. CCDC174.
HPAiHPA043468.
HPA060129.
neXtProtiNX_Q6PII3.
PharmGKBiPA134914840.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGB1. Eukaryota.
ENOG410Y526. LUCA.
GeneTreeiENSGT00440000033958.
HOGENOMiHOG000111357.
HOVERGENiHBG055105.
InParanoidiQ6PII3.
OMAiIWSKQNV.
OrthoDBiEOG7QC7WB.
PhylomeDBiQ6PII3.
TreeFamiTF323679.

Miscellaneous databases

GenomeRNAii51244.
NextBioi54366.
PROiQ6PII3.

Gene expression databases

BgeeiQ6PII3.
CleanExiHS_C3orf19.
ExpressionAtlasiQ6PII3. baseline and differential.
GenevisibleiQ6PII3. HS.

Family and domain databases

InterProiIPR025066. DUF4078.
[Graphical view]
PfamiPF13300. DUF4078. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCC174_HUMAN
AccessioniPrimary (citable) accession number: Q6PII3
Secondary accession number(s): Q96CS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: February 20, 2007
Last modified: May 11, 2016
This is version 87 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.