Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q6PIF6 (MYO7B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Unconventional myosin-VIIb
Gene names
Name:MYO7B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2116 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be have a role in the apical membranes of transporting epithelia By similarity.

Subcellular location

Apical cell membrane By similarity.

Sequence similarities

Contains 2 FERM domains.

Contains 6 IQ domains.

Contains 1 myosin head-like domain.

Contains 3 MyTH4 domains.

Contains 2 SH3 domains.

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-7 (MYH7).

Sequence caution

The sequence AAH35615.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
SH3 domain
   LigandActin-binding
ATP-binding
Nucleotide-binding
   Molecular functionMotor protein
Myosin
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentapical plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

myosin complex

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

motor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6PIF6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6PIF6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1851-1957: ISQKEGDFFF...SQLASVPKIL → GRAGAGQTVG...HQPEGGRLLL
     1958-2116: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 21162116Unconventional myosin-VIIb
PRO_0000329046

Regions

Domain67 – 729663Myosin head-like
Domain745 – 76521IQ 1
Domain763 – 79230IQ 2
Domain786 – 81530IQ 3
Domain814 – 83421IQ 4
Domain832 – 86130IQ 5
Domain855 – 88430IQ 6
Domain989 – 1192204MyTH4 1
Domain1197 – 1506310FERM 1
Domain1501 – 156767SH3 1
Domain1606 – 167065SH3 2
Domain1644 – 1793150MyTH4 2
Domain1790 – 1896107MyTH4 3
Domain1799 – 2102304FERM 2

Natural variations

Alternative sequence1851 – 1957107ISQKE…VPKIL → GRAGAGQTVGGRAVSEALGA ACGGLSLPGAPMLDQAAGTE VGGVLEQSQLHTPIAHAQPT PAQHPGRRRPLDQNPAGSQE DSPRKPPNFPVPSPSPGHQP EGGRLLL in isoform 2.
VSP_032930
Alternative sequence1958 – 2116159Missing in isoform 2.
VSP_032931
Natural variant211G → S.
Corresponds to variant rs2404991 [ dbSNP | Ensembl ].
VAR_042626
Natural variant12641R → Q.
Corresponds to variant rs2245408 [ dbSNP | Ensembl ].
VAR_042627
Natural variant16471E → D.
Corresponds to variant rs13025959 [ dbSNP | Ensembl ].
VAR_042628
Natural variant21051Q → R.
Corresponds to variant rs11686946 [ dbSNP | Ensembl ].
VAR_042629

Experimental info

Sequence conflict1821H → D in AAA20910. Ref.2
Sequence conflict1102 – 11065LRPSL → WSVSF in BAB85009. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 8, 2008. Version 2.
Checksum: 18E908998470E4FD

FASTA2,116241,599
        10         20         30         40         50         60 
MSGFRLGDHV WLEPPSTHKT GVAIGGIIKE AKPGKVLVED DEGKEHWIRA EDFGVLSPMH 

        70         80         90        100        110        120 
PNSVQGVDDM IRLGDLNEAG MVHNLLIRYQ QHKIYTYTGS ILVAVNPFQV LPLYTLEQVQ 

       130        140        150        160        170        180 
LYYSRHMGEL PPHVFAIANN CYFSMKRNKR DQCCIISGES GAGKTETTKL ILQFLATISG 

       190        200        210        220        230        240 
QHSWIEQQVL EANPILEAFG NAKTIRNDNS SRFGKYIDIY FNPSGVIEGA RIEQFLLEKS 

       250        260        270        280        290        300 
RVCRQAPEER NYHIFYCMLM GVSAEDKQLL SLGTPSEYHY LTMGNCTSCE GLNDAKDYAH 

       310        320        330        340        350        360 
IRSAMKILQF SDSESWDVIK LLAAILHLGN VGFMASVFEN LDASDVMETP AFPTVMKLLE 

       370        380        390        400        410        420 
VQHQELRDCL IKHTILIRGE FVTRSLNIAQ AADRRDAFVK GIYGHLFLWI VKKINAAIFT 

       430        440        450        460        470        480 
PPAQDPKNVR RAIGLLDIFG FENFENNSFE QLCINFANEH LQQFFVQHVF TMEQEEYRSE 

       490        500        510        520        530        540 
NISWDYIHYT DNRPTLDLLA LKPMSIISLL DEESRFPQGT DLTMLQKLNS VHANNKAFLQ 

       550        560        570        580        590        600 
PKNIHDARFG IAHFAGEVYY QAEGFLEKNR DVLSTDILTL VYSSKNKFLR EIFNLELAET 

       610        620        630        640        650        660 
KLGHGTIRQA KAGNHLFKSA DSNKRPSTLG SQFKQSLDQL MKILTNCQPY FIRCIKPNEY 

       670        680        690        700        710        720 
KKPLLFDREL CLRQLRYSGM METVHIRKSG FPIRYTFEEF SQRFGVLLPN AMRMQLQGKL 

       730        740        750        760        770        780 
RQMTLGITDV WLRTDKDWKA GKTKIFLRDH QDTLLEVQRS QVLDRAALSI QKVLRGYRYR 

       790        800        810        820        830        840 
KEFLRQRRAA VTLQAWWRGY CNRRNFKLIL VGFERLQAIA RSQPLARQYQ AMRQRTVQLQ 

       850        860        870        880        890        900 
ALCRGYLVRQ QVQAKRRAVV VIQAHARGMA ARRNFQQRKA NAPLVIPAEG QKSQGALPAK 

       910        920        930        940        950        960 
KRRSIYDTVT DTEMVEKVFG FLPAMIGGQE GQASPHFEDL ESKTQKLLEV DLDTVPMAEE 

       970        980        990       1000       1010       1020 
PEEDVDGLAE YTFPKFAVTY FQKSASHTHI RRPLRYPLLY HEDDTDCLAA LVIWNVILRF 

      1030       1040       1050       1060       1070       1080 
MGDLPEPVLY ARSSQQGSSV MRQIHDTLGR EHGAQVPQHS RSAQVASQLN IGEEALEPDG 

      1090       1100       1110       1120       1130       1140 
LGADRPMSNL EKVHFIVGYA ILRPSLRDEI YCQICKQLSE NFKTSSLARG WILLSLCLGC 

      1150       1160       1170       1180       1190       1200 
FPPSERFMKY LLNFIGQGPA TYGPFCAERL RRTYANGVRA EPPTWLELQA VKSKKHIPIQ 

      1210       1220       1230       1240       1250       1260 
VILATGESLT VPVDSASTSR EMCMHIAHKQ GLSDHLGFSL QVAVYDKFWS LGSGRDHMMD 

      1270       1280       1290       1300       1310       1320 
AIARCEQMAQ ERGESQRQSP WRIYFRKEFF TPWHDSREDP VSTELIYRQV LRGVWSGEYS 

      1330       1340       1350       1360       1370       1380 
FEKEEELVEL LARHCYVQLG ASAESKAVQE LLPSCIPHKL YRTKPPDRWA SLVTAACAKA 

      1390       1400       1410       1420       1430       1440 
PYTQKQVTPL AVREQVVDAA RLQWPLLFSR LFEVITLSGP RLPKTQLILA VNWKGLCFLD 

      1450       1460       1470       1480       1490       1500 
QQEKMLLELS FPEVMGLATN REAQGGQRLL LSTMHEEYEF VSPSSVAIAE LVALFLEGLK 

      1510       1520       1530       1540       1550       1560 
ERSIFAMALQ DRKATDDTTL LAFKKGDLLV LTKKQGLLAS ENWTLGQNDR TGKTGLVPMA 

      1570       1580       1590       1600       1610       1620 
CLYTIPTVTK PSAQLLSLLA MSPEKRKLAA QEGQFTEPRP EEPPKEKLHT LEEFSYEFFR 

      1630       1640       1650       1660       1670       1680 
APEKDMVSMA VLPLARARGH LWAYSCEPLR QPLLKRVHAN VDLWDIACQI FVAILRYMGD 

      1690       1700       1710       1720       1730       1740 
YPSRQAWPTL ELTDQIFTLA LQHPALQDEV YCQILKQLTH NSNRHSEERG WQLLWLCTGL 

      1750       1760       1770       1780       1790       1800 
FPPSKGLLPH AQKFIDTRRG KLLAPDCSRR IQKVLRTGPR KQPPHQVEVE AAEQNVSRIC 

      1810       1820       1830       1840       1850       1860 
HKIYFPNDTS EMLEVVANTR VRDVCDSIAT RLQLASWEGC SLFIKISDKV ISQKEGDFFF 

      1870       1880       1890       1900       1910       1920 
DSLREVSDWV KKNKPQKEGA PVTLPYQVYF MRKLWLNISP GKDVNADTIL HYHQELPKYL 

      1930       1940       1950       1960       1970       1980 
RGFHKCSRED AIHLAGLIYK AQFNNDRSQL ASVPKILREL VPENLTRLMS SEEWKKSILL 

      1990       2000       2010       2020       2030       2040 
AYDKHKDKTV EEAKVAFLKW ICRWPTFGSA FFEVKQTSEP SYPDVILIAI NRHGVLLIHP 

      2050       2060       2070       2080       2090       2100 
KTKDLLTTYP FTKISSWSSG STYFHMALGS LGRGSRLLCE TSLGYKMDDL LTSYVQQLLS 

      2110 
AMNKQRGSKA PALAST 

« Hide

Isoform 2 [UniParc].

Checksum: 7A0F293FD197B482
Show »

FASTA1,957221,893

References

« Hide 'large scale' references
[1]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types."
Bement W.M., Hasson T., Wirth J.A., Cheney R.E., Mooseker M.S.
Proc. Natl. Acad. Sci. U.S.A. 91:6549-6553(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 166-196 (ISOFORMS 1/2).
[3]Erratum
Bement W.M., Hasson T., Wirth J.A., Cheney R.E., Mooseker M.S.
Proc. Natl. Acad. Sci. U.S.A. 91:11767-11767(1994) [PubMed] [Europe PMC] [Abstract]
[4]"The nucleotide sequence of a long cDNA clone isolated from human spleen."
Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1102-2116 (ISOFORM 2).
Tissue: Spleen.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1451-2116 (ISOFORM 1).
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC010976 Genomic DNA. No translation available.
L29147 mRNA. Translation: AAA20910.1.
AK074183 mRNA. Translation: BAB85009.1.
BC035615 mRNA. Translation: AAH35615.2. Different initiation.
RefSeqNP_001073996.1. NM_001080527.1.
UniGeneHs.154578.
Hs.677195.

3D structure databases

ProteinModelPortalQ6PIF6.
SMRQ6PIF6. Positions 4-882, 962-1581, 1606-2098.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110732. 1 interaction.
STRING9606.ENSP00000415090.

Polymorphism databases

DMDM182667924.

Proteomic databases

PaxDbQ6PIF6.
PRIDEQ6PIF6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000409816; ENSP00000386461; ENSG00000169994. [Q6PIF6-1]
ENST00000428314; ENSP00000415090; ENSG00000169994. [Q6PIF6-1]
GeneID4648.
KEGGhsa:4648.
UCSCuc002top.3. human. [Q6PIF6-1]

Organism-specific databases

CTD4648.
GeneCardsGC02P128282.
H-InvDBHIX0002437.
HGNCHGNC:7607. MYO7B.
HPAHPA039131.
MIM606541. gene.
neXtProtNX_Q6PIF6.
PharmGKBPA31412.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5022.
HOGENOMHOG000007836.
HOVERGENHBG052557.
KOK10359.
OrthoDBEOG7QG433.
PhylomeDBQ6PIF6.
TreeFamTF335306.

Gene expression databases

ArrayExpressQ6PIF6.
BgeeQ6PIF6.
CleanExHS_MYO7B.
GenevestigatorQ6PIF6.

Family and domain databases

Gene3D1.20.80.10. 2 hits.
2.30.29.30. 1 hit.
InterProIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR000857. MyTH4_dom.
IPR027417. P-loop_NTPase.
IPR011993. PH_like_dom.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamPF00373. FERM_M. 1 hit.
PF00612. IQ. 4 hits.
PF00063. Myosin_head. 1 hit.
PF00784. MyTH4. 2 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSPR00193. MYOSINHEAVY.
SMARTSM00295. B41. 2 hits.
SM00015. IQ. 4 hits.
SM00242. MYSc. 1 hit.
SM00139. MyTH4. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF47031. SSF47031. 2 hits.
SSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEPS50057. FERM_3. 2 hits.
PS50096. IQ. 4 hits.
PS51016. MYTH4. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMYO7B. human.
GenomeRNAi4648.
NextBio17916.
PROQ6PIF6.
SOURCESearch...

Entry information

Entry nameMYO7B_HUMAN
AccessionPrimary (citable) accession number: Q6PIF6
Secondary accession number(s): Q14786, Q8TEE1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: April 16, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM