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Protein

Unconventional myosin-VIIb

Gene

MYO7B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. May link the complex to the actin core bundle of microvilli (Probable).2 Publications

GO - Molecular functioni

GO - Biological processi

  • brush border assembly Source: UniProtKB
  • cell differentiation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Biological processi

Differentiation

Keywords - Ligandi

Actin-binding, ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-VIIb
Gene namesi
Name:MYO7B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:7607. MYO7B.

Subcellular locationi

GO - Cellular componenti

  • apical cytoplasm Source: UniProtKB
  • brush border Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • microvillus Source: UniProtKB
  • myosin complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi4648.
OpenTargetsiENSG00000169994.
PharmGKBiPA31412.

Polymorphism and mutation databases

BioMutaiMYO7B.
DMDMi182667924.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003290461 – 2116Unconventional myosin-VIIbAdd BLAST2116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei904PhosphoserineBy similarity1
Modified residuei1371PhosphoserineBy similarity1
Modified residuei1645PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PIF6.
MaxQBiQ6PIF6.
PaxDbiQ6PIF6.
PeptideAtlasiQ6PIF6.
PRIDEiQ6PIF6.

PTM databases

iPTMnetiQ6PIF6.
PhosphoSitePlusiQ6PIF6.

Expressioni

Gene expression databases

BgeeiENSG00000169994.
CleanExiHS_MYO7B.
ExpressionAtlasiQ6PIF6. baseline and differential.
GenevisibleiQ6PIF6. HS.

Organism-specific databases

HPAiHPA039131.

Interactioni

Subunit structurei

Part of the IMAC/intermicrovillar adhesion complex/intermicrovillar tip-link complex composed of ANKS4B, MYO7B, USH1C, CDHR2 and CDHR5 (PubMed:24725409, PubMed:26812018). Interacts with CDHR2 (PubMed:24725409). Interacts with CDHR5 (PubMed:24725409). Interacts with USH1C (PubMed:24725409, PubMed:26812017, PubMed:26812018). Interacts with ANKS4B; requires initial interaction with USH1C (PubMed:26812018).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CDHR2Q9BYE93EBI-4400912,EBI-493793

Protein-protein interaction databases

IntActiQ6PIF6. 3 interactors.
STRINGi9606.ENSP00000386461.

Structurei

3D structure databases

ProteinModelPortaliQ6PIF6.
SMRiQ6PIF6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 760Myosin motorAdd BLAST696
Domaini745 – 765IQ 1PROSITE-ProRule annotationAdd BLAST21
Domaini763 – 792IQ 2PROSITE-ProRule annotationAdd BLAST30
Domaini786 – 815IQ 3PROSITE-ProRule annotationAdd BLAST30
Domaini814 – 834IQ 4PROSITE-ProRule annotationAdd BLAST21
Domaini832 – 861IQ 5PROSITE-ProRule annotationAdd BLAST30
Domaini855 – 884IQ 6PROSITE-ProRule annotationAdd BLAST30
Domaini989 – 1192MyTH4 1PROSITE-ProRule annotationAdd BLAST204
Domaini1197 – 1506FERM 1PROSITE-ProRule annotationAdd BLAST310
Domaini1501 – 1567SH3 1PROSITE-ProRule annotationAdd BLAST67
Domaini1606 – 1670SH3 2PROSITE-ProRule annotationAdd BLAST65
Domaini1644 – 1793MyTH4 2PROSITE-ProRule annotationAdd BLAST150
Domaini1790 – 1896MyTH4 3PROSITE-ProRule annotationAdd BLAST107
Domaini1799 – 2102FERM 2PROSITE-ProRule annotationAdd BLAST304

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni916 – 1542Mediates interaction with ANKS4B1 PublicationAdd BLAST627
Regioni1501 – 2116Mediates interaction with CDHR2, CDHR5 and USH1C2 PublicationsAdd BLAST616

Sequence similaritiesi

Contains 2 FERM domains.PROSITE-ProRule annotation
Contains 6 IQ domains.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated
Contains 3 MyTH4 domains.PROSITE-ProRule annotation
Contains 2 SH3 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG4229. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129687.
HOGENOMiHOG000007836.
HOVERGENiHBG052557.
InParanoidiQ6PIF6.
KOiK10359.
OMAiKEFFTPW.
OrthoDBiEOG091G00BB.
PhylomeDBiQ6PIF6.
TreeFamiTF335306.

Family and domain databases

Gene3Di1.20.80.10. 2 hits.
2.30.29.30. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR000857. MyTH4_dom.
IPR027417. P-loop_NTPase.
IPR011993. PH_dom-like.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00373. FERM_M. 1 hit.
PF00612. IQ. 4 hits.
PF00063. Myosin_head. 1 hit.
PF00784. MyTH4. 2 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00295. B41. 2 hits.
SM00015. IQ. 4 hits.
SM00242. MYSc. 1 hit.
SM00139. MyTH4. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 2 hits.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF54236. SSF54236. 2 hits.
PROSITEiPS50057. FERM_3. 2 hits.
PS50096. IQ. 4 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51016. MYTH4. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PIF6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGFRLGDHV WLEPPSTHKT GVAIGGIIKE AKPGKVLVED DEGKEHWIRA
60 70 80 90 100
EDFGVLSPMH PNSVQGVDDM IRLGDLNEAG MVHNLLIRYQ QHKIYTYTGS
110 120 130 140 150
ILVAVNPFQV LPLYTLEQVQ LYYSRHMGEL PPHVFAIANN CYFSMKRNKR
160 170 180 190 200
DQCCIISGES GAGKTETTKL ILQFLATISG QHSWIEQQVL EANPILEAFG
210 220 230 240 250
NAKTIRNDNS SRFGKYIDIY FNPSGVIEGA RIEQFLLEKS RVCRQAPEER
260 270 280 290 300
NYHIFYCMLM GVSAEDKQLL SLGTPSEYHY LTMGNCTSCE GLNDAKDYAH
310 320 330 340 350
IRSAMKILQF SDSESWDVIK LLAAILHLGN VGFMASVFEN LDASDVMETP
360 370 380 390 400
AFPTVMKLLE VQHQELRDCL IKHTILIRGE FVTRSLNIAQ AADRRDAFVK
410 420 430 440 450
GIYGHLFLWI VKKINAAIFT PPAQDPKNVR RAIGLLDIFG FENFENNSFE
460 470 480 490 500
QLCINFANEH LQQFFVQHVF TMEQEEYRSE NISWDYIHYT DNRPTLDLLA
510 520 530 540 550
LKPMSIISLL DEESRFPQGT DLTMLQKLNS VHANNKAFLQ PKNIHDARFG
560 570 580 590 600
IAHFAGEVYY QAEGFLEKNR DVLSTDILTL VYSSKNKFLR EIFNLELAET
610 620 630 640 650
KLGHGTIRQA KAGNHLFKSA DSNKRPSTLG SQFKQSLDQL MKILTNCQPY
660 670 680 690 700
FIRCIKPNEY KKPLLFDREL CLRQLRYSGM METVHIRKSG FPIRYTFEEF
710 720 730 740 750
SQRFGVLLPN AMRMQLQGKL RQMTLGITDV WLRTDKDWKA GKTKIFLRDH
760 770 780 790 800
QDTLLEVQRS QVLDRAALSI QKVLRGYRYR KEFLRQRRAA VTLQAWWRGY
810 820 830 840 850
CNRRNFKLIL VGFERLQAIA RSQPLARQYQ AMRQRTVQLQ ALCRGYLVRQ
860 870 880 890 900
QVQAKRRAVV VIQAHARGMA ARRNFQQRKA NAPLVIPAEG QKSQGALPAK
910 920 930 940 950
KRRSIYDTVT DTEMVEKVFG FLPAMIGGQE GQASPHFEDL ESKTQKLLEV
960 970 980 990 1000
DLDTVPMAEE PEEDVDGLAE YTFPKFAVTY FQKSASHTHI RRPLRYPLLY
1010 1020 1030 1040 1050
HEDDTDCLAA LVIWNVILRF MGDLPEPVLY ARSSQQGSSV MRQIHDTLGR
1060 1070 1080 1090 1100
EHGAQVPQHS RSAQVASQLN IGEEALEPDG LGADRPMSNL EKVHFIVGYA
1110 1120 1130 1140 1150
ILRPSLRDEI YCQICKQLSE NFKTSSLARG WILLSLCLGC FPPSERFMKY
1160 1170 1180 1190 1200
LLNFIGQGPA TYGPFCAERL RRTYANGVRA EPPTWLELQA VKSKKHIPIQ
1210 1220 1230 1240 1250
VILATGESLT VPVDSASTSR EMCMHIAHKQ GLSDHLGFSL QVAVYDKFWS
1260 1270 1280 1290 1300
LGSGRDHMMD AIARCEQMAQ ERGESQRQSP WRIYFRKEFF TPWHDSREDP
1310 1320 1330 1340 1350
VSTELIYRQV LRGVWSGEYS FEKEEELVEL LARHCYVQLG ASAESKAVQE
1360 1370 1380 1390 1400
LLPSCIPHKL YRTKPPDRWA SLVTAACAKA PYTQKQVTPL AVREQVVDAA
1410 1420 1430 1440 1450
RLQWPLLFSR LFEVITLSGP RLPKTQLILA VNWKGLCFLD QQEKMLLELS
1460 1470 1480 1490 1500
FPEVMGLATN REAQGGQRLL LSTMHEEYEF VSPSSVAIAE LVALFLEGLK
1510 1520 1530 1540 1550
ERSIFAMALQ DRKATDDTTL LAFKKGDLLV LTKKQGLLAS ENWTLGQNDR
1560 1570 1580 1590 1600
TGKTGLVPMA CLYTIPTVTK PSAQLLSLLA MSPEKRKLAA QEGQFTEPRP
1610 1620 1630 1640 1650
EEPPKEKLHT LEEFSYEFFR APEKDMVSMA VLPLARARGH LWAYSCEPLR
1660 1670 1680 1690 1700
QPLLKRVHAN VDLWDIACQI FVAILRYMGD YPSRQAWPTL ELTDQIFTLA
1710 1720 1730 1740 1750
LQHPALQDEV YCQILKQLTH NSNRHSEERG WQLLWLCTGL FPPSKGLLPH
1760 1770 1780 1790 1800
AQKFIDTRRG KLLAPDCSRR IQKVLRTGPR KQPPHQVEVE AAEQNVSRIC
1810 1820 1830 1840 1850
HKIYFPNDTS EMLEVVANTR VRDVCDSIAT RLQLASWEGC SLFIKISDKV
1860 1870 1880 1890 1900
ISQKEGDFFF DSLREVSDWV KKNKPQKEGA PVTLPYQVYF MRKLWLNISP
1910 1920 1930 1940 1950
GKDVNADTIL HYHQELPKYL RGFHKCSRED AIHLAGLIYK AQFNNDRSQL
1960 1970 1980 1990 2000
ASVPKILREL VPENLTRLMS SEEWKKSILL AYDKHKDKTV EEAKVAFLKW
2010 2020 2030 2040 2050
ICRWPTFGSA FFEVKQTSEP SYPDVILIAI NRHGVLLIHP KTKDLLTTYP
2060 2070 2080 2090 2100
FTKISSWSSG STYFHMALGS LGRGSRLLCE TSLGYKMDDL LTSYVQQLLS
2110
AMNKQRGSKA PALAST
Length:2,116
Mass (Da):241,599
Last modified:April 8, 2008 - v2
Checksum:i18E908998470E4FD
GO
Isoform 2 (identifier: Q6PIF6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1851-1957: ISQKEGDFFF...SQLASVPKIL → GRAGAGQTVG...HQPEGGRLLL
     1958-2116: Missing.

Note: No experimental confirmation available.
Show »
Length:1,957
Mass (Da):221,893
Checksum:i7A0F293FD197B482
GO

Sequence cautioni

The sequence AAH35615 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti182H → D in AAA20910 (PubMed:8022818).Curated1
Sequence conflicti1102 – 1106LRPSL → WSVSF in BAB85009 (Ref. 3) Curated5

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04262621G → S.Corresponds to variant rs2404991dbSNPEnsembl.1
Natural variantiVAR_0426271264R → Q.Corresponds to variant rs2245408dbSNPEnsembl.1
Natural variantiVAR_0426281647E → D.Corresponds to variant rs13025959dbSNPEnsembl.1
Natural variantiVAR_0426292105Q → R.Corresponds to variant rs11686946dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0329301851 – 1957ISQKE…VPKIL → GRAGAGQTVGGRAVSEALGA ACGGLSLPGAPMLDQAAGTE VGGVLEQSQLHTPIAHAQPT PAQHPGRRRPLDQNPAGSQE DSPRKPPNFPVPSPSPGHQP EGGRLLL in isoform 2. 1 PublicationAdd BLAST107
Alternative sequenceiVSP_0329311958 – 2116Missing in isoform 2. 1 PublicationAdd BLAST159

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010976 Genomic DNA. No translation available.
L29147 mRNA. Translation: AAA20910.1.
AK074183 mRNA. Translation: BAB85009.1.
BC035615 mRNA. Translation: AAH35615.2. Different initiation.
CCDSiCCDS46405.1. [Q6PIF6-1]
RefSeqiNP_001073996.1. NM_001080527.1. [Q6PIF6-1]
UniGeneiHs.154578.

Genome annotation databases

EnsembliENST00000409816; ENSP00000386461; ENSG00000169994. [Q6PIF6-1]
ENST00000428314; ENSP00000415090; ENSG00000169994. [Q6PIF6-1]
GeneIDi4648.
KEGGihsa:4648.
UCSCiuc002top.3. human. [Q6PIF6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010976 Genomic DNA. No translation available.
L29147 mRNA. Translation: AAA20910.1.
AK074183 mRNA. Translation: BAB85009.1.
BC035615 mRNA. Translation: AAH35615.2. Different initiation.
CCDSiCCDS46405.1. [Q6PIF6-1]
RefSeqiNP_001073996.1. NM_001080527.1. [Q6PIF6-1]
UniGeneiHs.154578.

3D structure databases

ProteinModelPortaliQ6PIF6.
SMRiQ6PIF6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6PIF6. 3 interactors.
STRINGi9606.ENSP00000386461.

PTM databases

iPTMnetiQ6PIF6.
PhosphoSitePlusiQ6PIF6.

Polymorphism and mutation databases

BioMutaiMYO7B.
DMDMi182667924.

Proteomic databases

EPDiQ6PIF6.
MaxQBiQ6PIF6.
PaxDbiQ6PIF6.
PeptideAtlasiQ6PIF6.
PRIDEiQ6PIF6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409816; ENSP00000386461; ENSG00000169994. [Q6PIF6-1]
ENST00000428314; ENSP00000415090; ENSG00000169994. [Q6PIF6-1]
GeneIDi4648.
KEGGihsa:4648.
UCSCiuc002top.3. human. [Q6PIF6-1]

Organism-specific databases

CTDi4648.
DisGeNETi4648.
GeneCardsiMYO7B.
H-InvDBHIX0002437.
HGNCiHGNC:7607. MYO7B.
HPAiHPA039131.
MIMi606541. gene.
neXtProtiNX_Q6PIF6.
OpenTargetsiENSG00000169994.
PharmGKBiPA31412.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4229. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129687.
HOGENOMiHOG000007836.
HOVERGENiHBG052557.
InParanoidiQ6PIF6.
KOiK10359.
OMAiKEFFTPW.
OrthoDBiEOG091G00BB.
PhylomeDBiQ6PIF6.
TreeFamiTF335306.

Miscellaneous databases

ChiTaRSiMYO7B. human.
GenomeRNAii4648.
PROiQ6PIF6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169994.
CleanExiHS_MYO7B.
ExpressionAtlasiQ6PIF6. baseline and differential.
GenevisibleiQ6PIF6. HS.

Family and domain databases

Gene3Di1.20.80.10. 2 hits.
2.30.29.30. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR000857. MyTH4_dom.
IPR027417. P-loop_NTPase.
IPR011993. PH_dom-like.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00373. FERM_M. 1 hit.
PF00612. IQ. 4 hits.
PF00063. Myosin_head. 1 hit.
PF00784. MyTH4. 2 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00295. B41. 2 hits.
SM00015. IQ. 4 hits.
SM00242. MYSc. 1 hit.
SM00139. MyTH4. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 2 hits.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF54236. SSF54236. 2 hits.
PROSITEiPS50057. FERM_3. 2 hits.
PS50096. IQ. 4 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51016. MYTH4. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYO7B_HUMAN
AccessioniPrimary (citable) accession number: Q6PIF6
Secondary accession number(s): Q14786, Q8TEE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: November 30, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-7 (MYH7).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.