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Protein

Synaptonemal complex central element protein 2

Gene

SYCE2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination (By similarity).By similarity

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • synaptonemal complex assembly Source: BHF-UCL

Keywordsi

Biological processCell cycle, Cell division, Meiosis

Enzyme and pathway databases

ReactomeiR-HSA-1221632. Meiotic synapsis.

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptonemal complex central element protein 2
Alternative name(s):
Central element synaptonemal complex protein 1
Gene namesi
Name:SYCE2
Synonyms:CESC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000161860.7.
HGNCiHGNC:27411. SYCE2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000161860.
PharmGKBiPA142670849.

Polymorphism and mutation databases

BioMutaiSYCE2.
DMDMi118573898.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002625621 – 218Synaptonemal complex central element protein 2Add BLAST218

Proteomic databases

PaxDbiQ6PIF2.
PeptideAtlasiQ6PIF2.
PRIDEiQ6PIF2.

PTM databases

iPTMnetiQ6PIF2.
PhosphoSitePlusiQ6PIF2.

Expressioni

Gene expression databases

BgeeiENSG00000161860.
CleanExiHS_SYCE2.
ExpressionAtlasiQ6PIF2. baseline and differential.
GenevisibleiQ6PIF2. HS.

Organism-specific databases

HPAiHPA042080.
HPA062919.

Interactioni

Subunit structurei

Homodimer. Found in a complex with SYCP1 and SYCE1. Interacts with SYCP1, SYCE1 and SYCE3 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
LINC00238A0A1B0GWI14EBI-11958386,EBI-10181422

Protein-protein interaction databases

IntActiQ6PIF2. 10 interactors.
STRINGi9606.ENSP00000293695.

Structurei

3D structure databases

ProteinModelPortaliQ6PIF2.
SMRiQ6PIF2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili61 – 87Sequence analysisAdd BLAST27

Sequence similaritiesi

Belongs to the SYCE family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J5YK. Eukaryota.
ENOG410XUQ9. LUCA.
GeneTreeiENSGT00390000004872.
HOGENOMiHOG000154464.
HOVERGENiHBG080707.
InParanoidiQ6PIF2.
KOiK19535.
OMAiQPLGESK.
OrthoDBiEOG091G17DE.
PhylomeDBiQ6PIF2.
TreeFamiTF333776.

Family and domain databases

InterProiView protein in InterPro
IPR034609. Syce2.
PANTHERiPTHR28398. PTHR28398. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6PIF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERQGVDVPH VKCKDQEPQP LGESKEHPRW EENCEEEAGG GPASASCQLT
60 70 80 90 100
VLEGKSGLYF SSLDSSIDIL QKRAQELIEN INKSRQKDHA LMTNFRNSLK
110 120 130 140 150
TKVSDLTEKL EERIYQIYND HNKIIQEKLQ EFTQKMAKIS HLETELKQVC
160 170 180 190 200
HSVETVYKDL CLQPEQSLRL RWGPDHSRGK SPPRPGNSQP PDVFVSSVAE
210
TTSQATASEV QTNRDGEC
Length:218
Mass (Da):24,690
Last modified:November 28, 2006 - v2
Checksum:i8E95680492B0E5C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302373 mRNA. Translation: BAG63695.1.
AD000092 Genomic DNA. No translation available.
AC092069 Genomic DNA. No translation available.
CR746484 mRNA. No translation available.
BC035819 mRNA. Translation: AAH35819.1.
CCDSiCCDS42509.1.
RefSeqiNP_001099048.1. NM_001105578.1.
UniGeneiHs.655173.

Genome annotation databases

EnsembliENST00000293695; ENSP00000293695; ENSG00000161860.
GeneIDi256126.
KEGGihsa:256126.
UCSCiuc002mvr.3. human.

Similar proteinsi

Entry informationi

Entry nameiSYCE2_HUMAN
AccessioniPrimary (citable) accession number: Q6PIF2
Secondary accession number(s): B4DYD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: September 27, 2017
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families