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Protein

Kelch domain-containing protein 10

Gene

KLHDC10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch domain-containing protein 10
Gene namesi
Name:KLHDC10
Synonyms:KIAA0265
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:22194. KLHDC10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi409 – 4091A → P: Loss of interaction with CUL2. No effect on MAP3K5 activation. 1 Publication

Organism-specific databases

PharmGKBiPA164721976.

Polymorphism and mutation databases

BioMutaiKLHDC10.
DMDMi74737721.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 442442Kelch domain-containing protein 10PRO_0000319436Add
BLAST

Proteomic databases

EPDiQ6PID8.
MaxQBiQ6PID8.
PaxDbiQ6PID8.
PRIDEiQ6PID8.

PTM databases

iPTMnetiQ6PID8.
PhosphoSiteiQ6PID8.

Expressioni

Developmental stagei

Expressed in fetal brain, liver, lung, kidney and placenta.1 Publication

Gene expression databases

BgeeiQ6PID8.
CleanExiHS_KLHDC10.
ExpressionAtlasiQ6PID8. baseline and differential.
GenevisibleiQ6PID8. HS.

Organism-specific databases

HPAiHPA020119.

Interactioni

Subunit structurei

Interacts with CUL2, TCEB1 and TCEB2; may be the substrate recognition component of an E3 ubiquitin ligase complex. Interacts (via the 6 Kelch repeats) with PPP5C.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NUDCD3Q8IVD92EBI-3201175,EBI-744342

Protein-protein interaction databases

BioGridi116652. 14 interactions.
IntActiQ6PID8. 5 interactions.
STRINGi9606.ENSP00000334140.

Structurei

3D structure databases

ProteinModelPortaliQ6PID8.
SMRiQ6PID8. Positions 139-343.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati103 – 16462Kelch 1Add
BLAST
Repeati166 – 21752Kelch 2Add
BLAST
Repeati218 – 27053Kelch 3Add
BLAST
Repeati271 – 31949Kelch 4Add
BLAST
Repeati327 – 37347Kelch 5Add
BLAST
Repeati376 – 41944Kelch 6Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni401 – 44242Interaction with CUL2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi14 – 4027Gly-richAdd
BLAST

Sequence similaritiesi

Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG0379. Eukaryota.
ENOG410Y5WM. LUCA.
GeneTreeiENSGT00760000119086.
HOGENOMiHOG000008131.
HOVERGENiHBG108065.
InParanoidiQ6PID8.
OMAiVKYKRWS.
OrthoDBiEOG7KQ21J.
PhylomeDBiQ6PID8.
TreeFamiTF314081.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiIPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF01344. Kelch_1. 2 hits.
[Graphical view]
SMARTiSM00612. Kelch. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PID8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAAQGWDRN RRRGGGAAGA GGGGSGAGGG SGGSGGRGTG QLNRFVQLSG
60 70 80 90 100
RPHLPGKKKI RWDPVRRRFI QSCPIIRIPN RFLRGHRPPP ARSGHRCVAD
110 120 130 140 150
NTNLYVFGGY NPDYDESGGP DNEDYPLFRE LWRYHFATGV WHQMGTDGYM
160 170 180 190 200
PRELASMSLV LHGNNLLVFG GTGIPFGESN GNDVHVCNVK YKRWALLSCR
210 220 230 240 250
GKKPSRIYGQ AMAIINGSLY VFGGTTGYIY STDLHKLDLN TREWTQLKPN
260 270 280 290 300
NLSCDLPEER YRHEIAHDGQ RIYILGGGTS WTAYSLNKIH AYNLETNAWE
310 320 330 340 350
EIATKPHEKI GFPAARRCHS CVQIKNDVFI CGGYNGEVIL GDIWKLNLQT
360 370 380 390 400
FQWVKLPATM PEPVYFHCAA VTPAGCMYIH GGVVNIHENK RTGSLFKIWL
410 420 430 440
VVPSLLELAW EKLLAAFPNL ANLSRTQLLH LGLTQGLIER LK
Length:442
Mass (Da):49,098
Last modified:July 5, 2004 - v1
Checksum:i8D8AF4A6302A7A86
GO
Isoform 2 (identifier: Q6PID8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-143: Missing.

Note: No experimental confirmation available.
Show »
Length:299
Mass (Da):33,488
Checksum:i3A4CA8E72358878A
GO

Sequence cautioni

The sequence BAA13395.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 21S → L.
Corresponds to variant rs3734928 [ dbSNP | Ensembl ].
VAR_039005
Natural varianti183 – 1831D → G.1 Publication
Corresponds to variant rs17854337 [ dbSNP | Ensembl ].
VAR_039006
Natural varianti274 – 2741I → V.1 Publication
Corresponds to variant rs17854336 [ dbSNP | Ensembl ].
VAR_039007
Natural varianti295 – 2951E → G.1 Publication
Corresponds to variant rs17857292 [ dbSNP | Ensembl ].
VAR_039008
Natural varianti437 – 4371L → I.
Corresponds to variant rs10241894 [ dbSNP | Ensembl ].
VAR_039009

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 143143Missing in isoform 2. 1 PublicationVSP_031484Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87454 mRNA. Translation: BAA13395.1. Different initiation.
CH236950 Genomic DNA. Translation: EAL24096.1.
CH471070 Genomic DNA. Translation: EAW83744.1.
BC036464 mRNA. Translation: AAH36464.1.
BC044884 mRNA. Translation: AAH44884.1.
CCDSiCCDS5815.1. [Q6PID8-1]
RefSeqiNP_055812.1. NM_014997.3. [Q6PID8-1]
UniGeneiHs.520710.

Genome annotation databases

EnsembliENST00000335420; ENSP00000334140; ENSG00000128607. [Q6PID8-1]
GeneIDi23008.
KEGGihsa:23008.
UCSCiuc003vpj.3. human. [Q6PID8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87454 mRNA. Translation: BAA13395.1. Different initiation.
CH236950 Genomic DNA. Translation: EAL24096.1.
CH471070 Genomic DNA. Translation: EAW83744.1.
BC036464 mRNA. Translation: AAH36464.1.
BC044884 mRNA. Translation: AAH44884.1.
CCDSiCCDS5815.1. [Q6PID8-1]
RefSeqiNP_055812.1. NM_014997.3. [Q6PID8-1]
UniGeneiHs.520710.

3D structure databases

ProteinModelPortaliQ6PID8.
SMRiQ6PID8. Positions 139-343.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116652. 14 interactions.
IntActiQ6PID8. 5 interactions.
STRINGi9606.ENSP00000334140.

PTM databases

iPTMnetiQ6PID8.
PhosphoSiteiQ6PID8.

Polymorphism and mutation databases

BioMutaiKLHDC10.
DMDMi74737721.

Proteomic databases

EPDiQ6PID8.
MaxQBiQ6PID8.
PaxDbiQ6PID8.
PRIDEiQ6PID8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335420; ENSP00000334140; ENSG00000128607. [Q6PID8-1]
GeneIDi23008.
KEGGihsa:23008.
UCSCiuc003vpj.3. human. [Q6PID8-1]

Organism-specific databases

CTDi23008.
GeneCardsiKLHDC10.
HGNCiHGNC:22194. KLHDC10.
HPAiHPA020119.
MIMi615152. gene.
neXtProtiNX_Q6PID8.
PharmGKBiPA164721976.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0379. Eukaryota.
ENOG410Y5WM. LUCA.
GeneTreeiENSGT00760000119086.
HOGENOMiHOG000008131.
HOVERGENiHBG108065.
InParanoidiQ6PID8.
OMAiVKYKRWS.
OrthoDBiEOG7KQ21J.
PhylomeDBiQ6PID8.
TreeFamiTF314081.

Miscellaneous databases

ChiTaRSiKLHDC10. human.
GenomeRNAii23008.
PROiQ6PID8.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PID8.
CleanExiHS_KLHDC10.
ExpressionAtlasiQ6PID8. baseline and differential.
GenevisibleiQ6PID8. HS.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiIPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF01344. Kelch_1. 2 hits.
[Graphical view]
SMARTiSM00612. Kelch. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
    Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
    DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Bone marrow.
  2. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLY-183; VAL-274 AND GLY-295.
    Tissue: Testis.
  5. "Imprinting analysis of 10 genes and/or transcripts in a 1.5-Mb MEST-flanking region at human chromosome 7q32."
    Yamada T., Mitsuya K., Kayashima T., Yamasaki K., Ohta T., Yoshiura K., Matsumoto N., Yamada H., Minakami H., Oshimura M., Niikawa N., Kishino T.
    Genomics 83:402-412(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, DEVELOPMENTAL STAGE.
  6. "The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5."
    Sekine Y., Hatanaka R., Watanabe T., Sono N., Iemura S., Natsume T., Kuranaga E., Miura M., Takeda K., Ichijo H.
    Mol. Cell 48:692-704(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CUL2; PPP5C; TCEB1 AND TCEB2, SUBCELLULAR LOCATION, MUTAGENESIS OF ALA-409.

Entry informationi

Entry nameiKLD10_HUMAN
AccessioniPrimary (citable) accession number: Q6PID8
Secondary accession number(s): Q86Y99, Q92554
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.