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Protein

Kelch domain-containing protein 10

Gene

KLHDC10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch domain-containing protein 10
Gene namesi
Name:KLHDC10
Synonyms:KIAA0265
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:22194. KLHDC10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi409A → P: Loss of interaction with CUL2. No effect on MAP3K5 activation. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000128607.
PharmGKBiPA164721976.

Polymorphism and mutation databases

BioMutaiKLHDC10.
DMDMi74737721.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003194361 – 442Kelch domain-containing protein 10Add BLAST442

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

EPDiQ6PID8.
MaxQBiQ6PID8.
PaxDbiQ6PID8.
PeptideAtlasiQ6PID8.
PRIDEiQ6PID8.

PTM databases

iPTMnetiQ6PID8.
PhosphoSitePlusiQ6PID8.

Expressioni

Developmental stagei

Expressed in fetal brain, liver, lung, kidney and placenta.1 Publication

Gene expression databases

BgeeiENSG00000128607.
CleanExiHS_KLHDC10.
ExpressionAtlasiQ6PID8. baseline and differential.
GenevisibleiQ6PID8. HS.

Organism-specific databases

HPAiHPA020119.

Interactioni

Subunit structurei

Interacts with CUL2, TCEB1 and TCEB2; may be the substrate recognition component of an E3 ubiquitin ligase complex. Interacts (via the 6 Kelch repeats) with PPP5C.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NUDCD3Q8IVD92EBI-3201175,EBI-744342

Protein-protein interaction databases

BioGridi116652. 15 interactors.
IntActiQ6PID8. 5 interactors.
STRINGi9606.ENSP00000334140.

Structurei

3D structure databases

ProteinModelPortaliQ6PID8.
SMRiQ6PID8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati103 – 164Kelch 1Add BLAST62
Repeati166 – 217Kelch 2Add BLAST52
Repeati218 – 270Kelch 3Add BLAST53
Repeati271 – 319Kelch 4Add BLAST49
Repeati327 – 373Kelch 5Add BLAST47
Repeati376 – 419Kelch 6Add BLAST44

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni401 – 442Interaction with CUL21 PublicationAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi14 – 40Gly-richAdd BLAST27

Sequence similaritiesi

Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG0379. Eukaryota.
ENOG410Y5WM. LUCA.
GeneTreeiENSGT00760000119086.
HOGENOMiHOG000008131.
HOVERGENiHBG108065.
InParanoidiQ6PID8.
OMAiVKYKRWS.
OrthoDBiEOG091G09PK.
PhylomeDBiQ6PID8.
TreeFamiTF314081.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiIPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF01344. Kelch_1. 2 hits.
[Graphical view]
SMARTiSM00612. Kelch. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PID8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAAQGWDRN RRRGGGAAGA GGGGSGAGGG SGGSGGRGTG QLNRFVQLSG
60 70 80 90 100
RPHLPGKKKI RWDPVRRRFI QSCPIIRIPN RFLRGHRPPP ARSGHRCVAD
110 120 130 140 150
NTNLYVFGGY NPDYDESGGP DNEDYPLFRE LWRYHFATGV WHQMGTDGYM
160 170 180 190 200
PRELASMSLV LHGNNLLVFG GTGIPFGESN GNDVHVCNVK YKRWALLSCR
210 220 230 240 250
GKKPSRIYGQ AMAIINGSLY VFGGTTGYIY STDLHKLDLN TREWTQLKPN
260 270 280 290 300
NLSCDLPEER YRHEIAHDGQ RIYILGGGTS WTAYSLNKIH AYNLETNAWE
310 320 330 340 350
EIATKPHEKI GFPAARRCHS CVQIKNDVFI CGGYNGEVIL GDIWKLNLQT
360 370 380 390 400
FQWVKLPATM PEPVYFHCAA VTPAGCMYIH GGVVNIHENK RTGSLFKIWL
410 420 430 440
VVPSLLELAW EKLLAAFPNL ANLSRTQLLH LGLTQGLIER LK
Length:442
Mass (Da):49,098
Last modified:July 5, 2004 - v1
Checksum:i8D8AF4A6302A7A86
GO
Isoform 2 (identifier: Q6PID8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-143: Missing.

Note: No experimental confirmation available.
Show »
Length:299
Mass (Da):33,488
Checksum:i3A4CA8E72358878A
GO

Sequence cautioni

The sequence BAA13395 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0390052S → L.Corresponds to variant rs3734928dbSNPEnsembl.1
Natural variantiVAR_039006183D → G.1 PublicationCorresponds to variant rs17854337dbSNPEnsembl.1
Natural variantiVAR_039007274I → V.1 PublicationCorresponds to variant rs17854336dbSNPEnsembl.1
Natural variantiVAR_039008295E → G.1 PublicationCorresponds to variant rs17857292dbSNPEnsembl.1
Natural variantiVAR_039009437L → I.Corresponds to variant rs10241894dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0314841 – 143Missing in isoform 2. 1 PublicationAdd BLAST143

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87454 mRNA. Translation: BAA13395.1. Different initiation.
CH236950 Genomic DNA. Translation: EAL24096.1.
CH471070 Genomic DNA. Translation: EAW83744.1.
BC036464 mRNA. Translation: AAH36464.1.
BC044884 mRNA. Translation: AAH44884.1.
CCDSiCCDS5815.1. [Q6PID8-1]
RefSeqiNP_055812.1. NM_014997.3. [Q6PID8-1]
UniGeneiHs.520710.

Genome annotation databases

EnsembliENST00000335420; ENSP00000334140; ENSG00000128607. [Q6PID8-1]
GeneIDi23008.
KEGGihsa:23008.
UCSCiuc003vpj.3. human. [Q6PID8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87454 mRNA. Translation: BAA13395.1. Different initiation.
CH236950 Genomic DNA. Translation: EAL24096.1.
CH471070 Genomic DNA. Translation: EAW83744.1.
BC036464 mRNA. Translation: AAH36464.1.
BC044884 mRNA. Translation: AAH44884.1.
CCDSiCCDS5815.1. [Q6PID8-1]
RefSeqiNP_055812.1. NM_014997.3. [Q6PID8-1]
UniGeneiHs.520710.

3D structure databases

ProteinModelPortaliQ6PID8.
SMRiQ6PID8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116652. 15 interactors.
IntActiQ6PID8. 5 interactors.
STRINGi9606.ENSP00000334140.

PTM databases

iPTMnetiQ6PID8.
PhosphoSitePlusiQ6PID8.

Polymorphism and mutation databases

BioMutaiKLHDC10.
DMDMi74737721.

Proteomic databases

EPDiQ6PID8.
MaxQBiQ6PID8.
PaxDbiQ6PID8.
PeptideAtlasiQ6PID8.
PRIDEiQ6PID8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335420; ENSP00000334140; ENSG00000128607. [Q6PID8-1]
GeneIDi23008.
KEGGihsa:23008.
UCSCiuc003vpj.3. human. [Q6PID8-1]

Organism-specific databases

CTDi23008.
GeneCardsiKLHDC10.
HGNCiHGNC:22194. KLHDC10.
HPAiHPA020119.
MIMi615152. gene.
neXtProtiNX_Q6PID8.
OpenTargetsiENSG00000128607.
PharmGKBiPA164721976.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0379. Eukaryota.
ENOG410Y5WM. LUCA.
GeneTreeiENSGT00760000119086.
HOGENOMiHOG000008131.
HOVERGENiHBG108065.
InParanoidiQ6PID8.
OMAiVKYKRWS.
OrthoDBiEOG091G09PK.
PhylomeDBiQ6PID8.
TreeFamiTF314081.

Miscellaneous databases

ChiTaRSiKLHDC10. human.
GenomeRNAii23008.
PROiQ6PID8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128607.
CleanExiHS_KLHDC10.
ExpressionAtlasiQ6PID8. baseline and differential.
GenevisibleiQ6PID8. HS.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiIPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF01344. Kelch_1. 2 hits.
[Graphical view]
SMARTiSM00612. Kelch. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLD10_HUMAN
AccessioniPrimary (citable) accession number: Q6PID8
Secondary accession number(s): Q86Y99, Q92554
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.