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Protein

Tetratricopeptide repeat protein 33

Gene

TTC33

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 33
Short name:
TPR repeat protein 33
Alternative name(s):
Osmosis-responsive factor
Gene namesi
Name:TTC33
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:29959. TTC33.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162407196.

Polymorphism and mutation databases

BioMutaiTTC33.
DMDMi147737109.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 262262Tetratricopeptide repeat protein 33PRO_0000287515Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei197 – 1971PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PID6.
MaxQBiQ6PID6.
PaxDbiQ6PID6.
PRIDEiQ6PID6.

PTM databases

iPTMnetiQ6PID6.
PhosphoSiteiQ6PID6.

Expressioni

Gene expression databases

BgeeiQ6PID6.
CleanExiHS_TTC33.
GenevisibleiQ6PID6. HS.

Organism-specific databases

HPAiHPA038252.
HPA038253.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TCL1AP562793EBI-2555404,EBI-749995

Protein-protein interaction databases

BioGridi117092. 15 interactions.
IntActiQ6PID6. 4 interactions.
STRINGi9606.ENSP00000338533.

Structurei

3D structure databases

ProteinModelPortaliQ6PID6.
SMRiQ6PID6. Positions 73-164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati59 – 9234TPR 1Add
BLAST
Repeati93 – 12634TPR 2Add
BLAST
Repeati127 – 16034TPR 3Add
BLAST

Sequence similaritiesi

Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiENOG410IMN5. Eukaryota.
ENOG4111N4C. LUCA.
GeneTreeiENSGT00390000017462.
HOGENOMiHOG000059551.
HOVERGENiHBG053253.
InParanoidiQ6PID6.
OMAiDLSWARK.
OrthoDBiEOG7Q2N66.
PhylomeDBiQ6PID6.
TreeFamiTF332142.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SMARTiSM00028. TPR. 2 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PID6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASFGWKRKI GEKVSKVTSQ QFEAEAADEK DVVDNDEGNW LHAIKRRKEI
60 70 80 90 100
LLEGCAEKSK QLKDEGASLA ENKRYREAIQ KWDEALQLTP NDATLYEMKS
110 120 130 140 150
QVLMSLHEMF PAVHAAEMAV QQNPHSWESW QTLGRAQLGL GEIILAIRSF
160 170 180 190 200
QVALHIYPMN PEIWKEDLSW ARTLQEQQKV AQRIKKSEAP AEVTHFSPKS
210 220 230 240 250
IPDYDFESDE IVAVCAAIAE KEKTVSANKT MVIVSASGAI ETVTEKEDGA
260
TPPDGSVFIK AR
Length:262
Mass (Da):29,411
Last modified:May 15, 2007 - v2
Checksum:iA5549AC3973FABC9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131K → R in AAH36536 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti69 – 691L → M.
Corresponds to variant rs837105 [ dbSNP | Ensembl ].
VAR_032317

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF023244 mRNA. Translation: AAD09341.1.
AK312560 mRNA. Translation: BAG35457.1.
CH471119 Genomic DNA. Translation: EAW55998.1.
BC015701 mRNA. Translation: AAH15701.1.
BC036536 mRNA. Translation: AAH36536.1.
CCDSiCCDS3931.1.
RefSeqiNP_036514.1. NM_012382.2.
XP_011512305.1. XM_011514003.1.
UniGeneiHs.348915.
Hs.621357.

Genome annotation databases

EnsembliENST00000337702; ENSP00000338533; ENSG00000113638.
GeneIDi23548.
KEGGihsa:23548.
UCSCiuc003jma.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF023244 mRNA. Translation: AAD09341.1.
AK312560 mRNA. Translation: BAG35457.1.
CH471119 Genomic DNA. Translation: EAW55998.1.
BC015701 mRNA. Translation: AAH15701.1.
BC036536 mRNA. Translation: AAH36536.1.
CCDSiCCDS3931.1.
RefSeqiNP_036514.1. NM_012382.2.
XP_011512305.1. XM_011514003.1.
UniGeneiHs.348915.
Hs.621357.

3D structure databases

ProteinModelPortaliQ6PID6.
SMRiQ6PID6. Positions 73-164.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117092. 15 interactions.
IntActiQ6PID6. 4 interactions.
STRINGi9606.ENSP00000338533.

PTM databases

iPTMnetiQ6PID6.
PhosphoSiteiQ6PID6.

Polymorphism and mutation databases

BioMutaiTTC33.
DMDMi147737109.

Proteomic databases

EPDiQ6PID6.
MaxQBiQ6PID6.
PaxDbiQ6PID6.
PRIDEiQ6PID6.

Protocols and materials databases

DNASUi23548.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337702; ENSP00000338533; ENSG00000113638.
GeneIDi23548.
KEGGihsa:23548.
UCSCiuc003jma.4. human.

Organism-specific databases

CTDi23548.
GeneCardsiTTC33.
HGNCiHGNC:29959. TTC33.
HPAiHPA038252.
HPA038253.
neXtProtiNX_Q6PID6.
PharmGKBiPA162407196.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMN5. Eukaryota.
ENOG4111N4C. LUCA.
GeneTreeiENSGT00390000017462.
HOGENOMiHOG000059551.
HOVERGENiHBG053253.
InParanoidiQ6PID6.
OMAiDLSWARK.
OrthoDBiEOG7Q2N66.
PhylomeDBiQ6PID6.
TreeFamiTF332142.

Miscellaneous databases

ChiTaRSiTTC33. human.
GenomeRNAii23548.
NextBioi46088.
PROiQ6PID6.

Gene expression databases

BgeeiQ6PID6.
CleanExiHS_TTC33.
GenevisibleiQ6PID6. HS.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SMARTiSM00028. TPR. 2 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Giot J.F.
    Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiTTC33_HUMAN
AccessioniPrimary (citable) accession number: Q6PID6
Secondary accession number(s): B2R6G0, O95105
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: May 11, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.