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Q6PIC6

- AT1A3_MOUSE

UniProt

Q6PIC6 - AT1A3_MOUSE

Protein

Sodium/potassium-transporting ATPase subunit alpha-3

Gene

Atp1a3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients By similarity.By similarity

    Catalytic activityi

    ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei366 – 36614-aspartylphosphate intermediateBy similarity
    Metal bindingi707 – 7071MagnesiumBy similarity
    Metal bindingi711 – 7111MagnesiumBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sodium:potassium-exchanging ATPase activity Source: UniProtKB

    GO - Biological processi

    1. adult locomotory behavior Source: MGI
    2. ATP biosynthetic process Source: InterPro
    3. ionotropic glutamate receptor signaling pathway Source: MGI
    4. memory Source: MGI
    5. response to drug Source: MGI
    6. sodium ion transmembrane transport Source: GOC
    7. visual learning Source: MGI

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/potassium-transporting ATPase subunit alpha-3 (EC:3.6.3.9)
    Short name:
    Na(+)/K(+) ATPase alpha-3 subunit
    Alternative name(s):
    Na(+)/K(+) ATPase alpha(III) subunit
    Sodium pump subunit alpha-3
    Gene namesi
    Name:Atp1a3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:88107. Atp1a3.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. endoplasmic reticulum Source: UniProtKB
    3. Golgi apparatus Source: UniProtKB
    4. integral component of membrane Source: UniProtKB-KW
    5. nucleus Source: MGI
    6. plasma membrane Source: UniProtKB
    7. synapse Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10131013Sodium/potassium-transporting ATPase subunit alpha-3PRO_0000046299Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei265 – 2651Phosphoserine1 Publication
    Modified residuei548 – 5481Phosphotyrosine1 Publication
    Modified residuei933 – 9331Phosphoserine; by PKABy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ6PIC6.
    PaxDbiQ6PIC6.
    PRIDEiQ6PIC6.

    PTM databases

    PhosphoSiteiQ6PIC6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6PIC6.
    BgeeiQ6PIC6.
    CleanExiMM_ATP1A3.
    GenevestigatoriQ6PIC6.

    Interactioni

    Subunit structurei

    Composed of three subunits: alpha (catalytic), beta and gamma.By similarity

    Protein-protein interaction databases

    IntActiQ6PIC6. 6 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PIC6.
    SMRiQ6PIC6. Positions 20-1013.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7777CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini99 – 12123ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini143 – 278136CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini299 – 31012ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini329 – 762434CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini783 – 79210ExtracellularSequence Analysis
    Topological domaini814 – 83320CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini857 – 90852ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini929 – 94113CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini961 – 97515ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini997 – 101317CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei78 – 9821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei122 – 14221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei279 – 29820HelicalSequence AnalysisAdd
    BLAST
    Transmembranei311 – 32818HelicalSequence AnalysisAdd
    BLAST
    Transmembranei763 – 78220HelicalSequence AnalysisAdd
    BLAST
    Transmembranei793 – 81321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei834 – 85623HelicalSequence AnalysisAdd
    BLAST
    Transmembranei909 – 92820HelicalSequence AnalysisAdd
    BLAST
    Transmembranei942 – 96019HelicalSequence AnalysisAdd
    BLAST
    Transmembranei976 – 99621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni72 – 743Interaction with phosphoinositide-3 kinaseBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0474.
    GeneTreeiENSGT00560000076866.
    HOGENOMiHOG000265622.
    HOVERGENiHBG004298.

    Family and domain databases

    Gene3Di1.20.1110.10. 2 hits.
    2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR005775. ATPase_P-typ_Na/K_IIC.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PfamiPF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view]
    PRINTSiPR00119. CATATPASE.
    SMARTiSM00831. Cation_ATPase_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 3 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6PIC6-1 [UniParc]FASTAAdd to Basket

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    MGDKKDDKSS PKKSKAKERR DLDDLKKEVA MTEHKMSVEE VCRKYNTDCV     50
    QGLTHSKAQE ILARDGPNAL TPPPTTPEWV KFCRQLFGGF SILLWIGAIL 100
    CFLAYGIQAG TEDDPSGDNL YLGIVLAAVV IITGCFSYYQ EAKSSKIMES 150
    FKNMVPQQAL VIREGEKMQV NAEEVVVGDL VEIKGGDRVP ADLRIISAHG 200
    CKVDNSSLTG ESEPQTRSPD CTHDNPLETR NITFFSTNCV EGTARGVVVA 250
    TGDRTVMGRI ATLASGLEVG KTPIAIEIEH FIQLITGVAV FLGVSFFILS 300
    LILGYTWLEA VIFLIGIIVA NVPEGLLATV TVCLTLTAKR MARKNCLVKN 350
    LEAVETLGST STICSDKTGT LTQNRMTVAH MWFDNQIHEA DTTEDQSGTS 400
    FDKSSHTWVA LSHIAGLCNR AVFKGGQDNI PVLKRDVAGD ASESALLKCI 450
    ELSSGSVKLM RERNKKVAEI PFNSTNKYQL SIHETEDPND NRYLLVMKGA 500
    PERILDRCAT ILLQGKEQPL DEEMKEAFQN AYLELGGLGE RVLGFCHYYL 550
    PEEQFPKGFA FDCDDVNFTT DNLCFVGLMS MIDPPRAAVP DAVGKCRSAG 600
    IKVIMVTGDH PITAKAIAKG VGIISEGNET VEDIAARLNI PVSQVNPRDA 650
    KACVIHGTDL KDFTSEQIDE ILQNHTEIVF ARTSPQQKLI IVEGCQRQGA 700
    IVAVTGDGVN DSPALKKADI GVAMGIAGSD VSKQAADMIL LDDNFASIVT 750
    GVEEGRLIFD NLKKSIAYTL TSNIPEITPF LLFIMANIPL PLGTITILCI 800
    DLGTDMVPAI SLAYEAAESD IMKRQPRNPR TDKLVNERLI SMAYGQIGMI 850
    QALGGFFSYF VILAENGFLP GNLVGIRLNW DDRTVNDLED SYGQQWTYEQ 900
    RKVVEFTCHT AFFVSIVVVQ WADLIICKTR RNSVFQQGMK NKILIFGLFE 950
    ETALAAFLSY CPGMDVALRM YPLKPSWWFC AFPYSFLIFV YDEIRKLILR 1000
    RNPGGWVEKE TYY 1013
    Length:1,013
    Mass (Da):111,692
    Last modified:July 5, 2004 - v1
    Checksum:i72F051406284EA8A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC034645 mRNA. Translation: AAH34645.1.
    BC037206 mRNA. Translation: AAH37206.1.
    BC042894 mRNA. Translation: AAH42894.1.
    CCDSiCCDS20969.1.
    RefSeqiNP_001277398.1. NM_001290469.1.
    UniGeneiMm.44101.

    Genome annotation databases

    EnsembliENSMUST00000080882; ENSMUSP00000079691; ENSMUSG00000040907.
    GeneIDi232975.
    UCSCiuc009frf.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC034645 mRNA. Translation: AAH34645.1 .
    BC037206 mRNA. Translation: AAH37206.1 .
    BC042894 mRNA. Translation: AAH42894.1 .
    CCDSi CCDS20969.1.
    RefSeqi NP_001277398.1. NM_001290469.1.
    UniGenei Mm.44101.

    3D structure databases

    ProteinModelPortali Q6PIC6.
    SMRi Q6PIC6. Positions 20-1013.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q6PIC6. 6 interactions.

    PTM databases

    PhosphoSitei Q6PIC6.

    Proteomic databases

    MaxQBi Q6PIC6.
    PaxDbi Q6PIC6.
    PRIDEi Q6PIC6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000080882 ; ENSMUSP00000079691 ; ENSMUSG00000040907 .
    GeneIDi 232975.
    UCSCi uc009frf.1. mouse.

    Organism-specific databases

    MGIi MGI:88107. Atp1a3.

    Phylogenomic databases

    eggNOGi COG0474.
    GeneTreei ENSGT00560000076866.
    HOGENOMi HOG000265622.
    HOVERGENi HBG004298.

    Miscellaneous databases

    ChiTaRSi ATP1A3. mouse.
    PROi Q6PIC6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6PIC6.
    Bgeei Q6PIC6.
    CleanExi MM_ATP1A3.
    Genevestigatori Q6PIC6.

    Family and domain databases

    Gene3Di 1.20.1110.10. 2 hits.
    2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR005775. ATPase_P-typ_Na/K_IIC.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    Pfami PF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view ]
    PRINTSi PR00119. CATATPASE.
    SMARTi SM00831. Cation_ATPase_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 3 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    2. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Strain: C57BL/6.
      Tissue: Brain.
    3. "Quantitative analysis of both protein expression and serine / threonine post-translational modifications through stable isotope labeling with dithiothreitol."
      Vosseller K., Hansen K.C., Chalkley R.J., Trinidad J.C., Wells L., Hart G.W., Burlingame A.L.
      Proteomics 5:388-398(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-265, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
      Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
      J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-548, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.

    Entry informationi

    Entry nameiAT1A3_MOUSE
    AccessioniPrimary (citable) accession number: Q6PIC6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3