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Protein

Sodium/potassium-transporting ATPase subunit alpha-3

Gene

Atp1a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (By similarity).By similarity

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3664-aspartylphosphate intermediateBy similarity1
Metal bindingi707MagnesiumBy similarity1
Metal bindingi711MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

  • adult locomotory behavior Source: MGI
  • cardiac muscle contraction Source: BHF-UCL
  • cellular potassium ion homeostasis Source: MGI
  • cellular response to retinoic acid Source: Ensembl
  • cellular response to thyroid hormone stimulus Source: Ensembl
  • cellular sodium ion homeostasis Source: BHF-UCL
  • cerebral cortex development Source: Ensembl
  • ionotropic glutamate receptor signaling pathway Source: MGI
  • memory Source: MGI
  • potassium ion import Source: MGI
  • regulation of cardiac muscle cell membrane potential Source: BHF-UCL
  • response to drug Source: MGI
  • sodium ion export from cell Source: BHF-UCL
  • visual learning Source: MGI

Keywordsi

Molecular functionHydrolase
Biological processIon transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Enzyme and pathway databases

ReactomeiR-MMU-5578775. Ion homeostasis.
R-MMU-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha-3 (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha-3 subunit
Alternative name(s):
Na(+)/K(+) ATPase alpha(III) subunit
Sodium pump subunit alpha-3
Gene namesi
Name:Atp1a3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:88107. Atp1a3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 77CytoplasmicSequence analysisAdd BLAST77
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Topological domaini99 – 121ExtracellularSequence analysisAdd BLAST23
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Topological domaini143 – 278CytoplasmicSequence analysisAdd BLAST136
Transmembranei279 – 298HelicalSequence analysisAdd BLAST20
Topological domaini299 – 310ExtracellularSequence analysisAdd BLAST12
Transmembranei311 – 328HelicalSequence analysisAdd BLAST18
Topological domaini329 – 762CytoplasmicSequence analysisAdd BLAST434
Transmembranei763 – 782HelicalSequence analysisAdd BLAST20
Topological domaini783 – 792ExtracellularSequence analysis10
Transmembranei793 – 813HelicalSequence analysisAdd BLAST21
Topological domaini814 – 833CytoplasmicSequence analysisAdd BLAST20
Transmembranei834 – 856HelicalSequence analysisAdd BLAST23
Topological domaini857 – 908ExtracellularSequence analysisAdd BLAST52
Transmembranei909 – 928HelicalSequence analysisAdd BLAST20
Topological domaini929 – 941CytoplasmicSequence analysisAdd BLAST13
Transmembranei942 – 960HelicalSequence analysisAdd BLAST19
Topological domaini961 – 975ExtracellularSequence analysisAdd BLAST15
Transmembranei976 – 996HelicalSequence analysisAdd BLAST21
Topological domaini997 – 1013CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

  • axon Source: MGI
  • cytoplasm Source: MGI
  • dendritic spine head Source: Ensembl
  • dendritic spine neck Source: Ensembl
  • endoplasmic reticulum Source: UniProtKB
  • extracellular vesicle Source: MGI
  • Golgi apparatus Source: UniProtKB
  • myelin sheath Source: UniProtKB
  • neuronal cell body Source: MGI
  • nucleus Source: MGI
  • plasma membrane Source: UniProtKB
  • sarcolemma Source: BHF-UCL
  • sodium:potassium-exchanging ATPase complex Source: BHF-UCL
  • synapse Source: UniProtKB

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000462991 – 1013Sodium/potassium-transporting ATPase subunit alpha-3Add BLAST1013

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37PhosphoserineBy similarity1
Modified residuei56PhosphoserineCombined sources1
Modified residuei218PhosphoserineCombined sources1
Modified residuei265PhosphoserineCombined sources1
Modified residuei442PhosphoserineBy similarity1
Modified residuei548PhosphotyrosineCombined sources1
Modified residuei933Phosphoserine; by PKABy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6PIC6.
PaxDbiQ6PIC6.
PeptideAtlasiQ6PIC6.
PRIDEiQ6PIC6.

PTM databases

iPTMnetiQ6PIC6.
PhosphoSitePlusiQ6PIC6.
SwissPalmiQ6PIC6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000040907.
CleanExiMM_ATP1A3.
ExpressionAtlasiQ6PIC6. baseline and differential.
GenevisibleiQ6PIC6. MM.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.By similarity

GO - Molecular functioni

  • chaperone binding Source: MGI
  • D1 dopamine receptor binding Source: Ensembl
  • heparan sulfate proteoglycan binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi231339. 6 interactors.
IntActiQ6PIC6. 12 interactors.
STRINGi10090.ENSMUSP00000099922.

Structurei

3D structure databases

ProteinModelPortaliQ6PIC6.
SMRiQ6PIC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni72 – 74Interaction with phosphoinositide-3 kinaseBy similarity3

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0203. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00890000139334.
HOGENOMiHOG000265622.
HOVERGENiHBG004298.
InParanoidiQ6PIC6.
KOiK01539.

Family and domain databases

CDDicd02608. P-type_ATPase_Na-K_like. 1 hit.
Gene3Di3.40.1110.10. 2 hits.
InterProiView protein in InterPro
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
PfamiView protein in Pfam
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
SMARTiView protein in SMART
SM00831. Cation_ATPase_N. 1 hit.
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81653. SSF81653. 1 hit.
SSF81660. SSF81660. 1 hit.
SSF81665. SSF81665. 3 hits.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiView protein in PROSITE
PS00154. ATPASE_E1_E2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6PIC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDKKDDKSS PKKSKAKERR DLDDLKKEVA MTEHKMSVEE VCRKYNTDCV
60 70 80 90 100
QGLTHSKAQE ILARDGPNAL TPPPTTPEWV KFCRQLFGGF SILLWIGAIL
110 120 130 140 150
CFLAYGIQAG TEDDPSGDNL YLGIVLAAVV IITGCFSYYQ EAKSSKIMES
160 170 180 190 200
FKNMVPQQAL VIREGEKMQV NAEEVVVGDL VEIKGGDRVP ADLRIISAHG
210 220 230 240 250
CKVDNSSLTG ESEPQTRSPD CTHDNPLETR NITFFSTNCV EGTARGVVVA
260 270 280 290 300
TGDRTVMGRI ATLASGLEVG KTPIAIEIEH FIQLITGVAV FLGVSFFILS
310 320 330 340 350
LILGYTWLEA VIFLIGIIVA NVPEGLLATV TVCLTLTAKR MARKNCLVKN
360 370 380 390 400
LEAVETLGST STICSDKTGT LTQNRMTVAH MWFDNQIHEA DTTEDQSGTS
410 420 430 440 450
FDKSSHTWVA LSHIAGLCNR AVFKGGQDNI PVLKRDVAGD ASESALLKCI
460 470 480 490 500
ELSSGSVKLM RERNKKVAEI PFNSTNKYQL SIHETEDPND NRYLLVMKGA
510 520 530 540 550
PERILDRCAT ILLQGKEQPL DEEMKEAFQN AYLELGGLGE RVLGFCHYYL
560 570 580 590 600
PEEQFPKGFA FDCDDVNFTT DNLCFVGLMS MIDPPRAAVP DAVGKCRSAG
610 620 630 640 650
IKVIMVTGDH PITAKAIAKG VGIISEGNET VEDIAARLNI PVSQVNPRDA
660 670 680 690 700
KACVIHGTDL KDFTSEQIDE ILQNHTEIVF ARTSPQQKLI IVEGCQRQGA
710 720 730 740 750
IVAVTGDGVN DSPALKKADI GVAMGIAGSD VSKQAADMIL LDDNFASIVT
760 770 780 790 800
GVEEGRLIFD NLKKSIAYTL TSNIPEITPF LLFIMANIPL PLGTITILCI
810 820 830 840 850
DLGTDMVPAI SLAYEAAESD IMKRQPRNPR TDKLVNERLI SMAYGQIGMI
860 870 880 890 900
QALGGFFSYF VILAENGFLP GNLVGIRLNW DDRTVNDLED SYGQQWTYEQ
910 920 930 940 950
RKVVEFTCHT AFFVSIVVVQ WADLIICKTR RNSVFQQGMK NKILIFGLFE
960 970 980 990 1000
ETALAAFLSY CPGMDVALRM YPLKPSWWFC AFPYSFLIFV YDEIRKLILR
1010
RNPGGWVEKE TYY
Length:1,013
Mass (Da):111,692
Last modified:July 5, 2004 - v1
Checksum:i72F051406284EA8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC034645 mRNA. Translation: AAH34645.1.
BC037206 mRNA. Translation: AAH37206.1.
BC042894 mRNA. Translation: AAH42894.1.
CCDSiCCDS20969.2.
RefSeqiNP_001277398.1. NM_001290469.1.
UniGeneiMm.44101.

Genome annotation databases

EnsembliENSMUST00000080882; ENSMUSP00000079691; ENSMUSG00000040907.
GeneIDi232975.
KEGGimmu:232975.
UCSCiuc009frf.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiAT1A3_MOUSE
AccessioniPrimary (citable) accession number: Q6PIC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: July 5, 2004
Last modified: August 30, 2017
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families