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Protein
Submitted name:

MLL2 protein

Gene

MLL2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferaseSAAS annotation, Transferase
LigandS-adenosyl-L-methionineSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
MLL2 proteinImported
Gene namesi
Name:MLL2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30846.

PTM / Processingi

Proteomic databases

PaxDbiQ6PIA1.
PeptideAtlasiQ6PIA1.

Expressioni

Gene expression databases

GenevisibleiQ6PIA1. HS.

Structurei

3D structure databases

ProteinModelPortaliQ6PIA1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 93FYR N-terminalInterPro annotationAdd BLAST61
Domaini94 – 179FYR C-terminalInterPro annotationAdd BLAST86
Domaini255 – 371SETInterPro annotationAdd BLAST117
Domaini379 – 395Post-SETInterPro annotationAdd BLAST17

Phylogenomic databases

eggNOGiKOG4443. Eukaryota.
COG2940. LUCA.
HOVERGENiHBG084660.
KOiK09187.

Family and domain databases

InterProiView protein in InterPro
IPR003889. FYrich_C.
IPR003888. FYrich_N.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
PfamiView protein in Pfam
PF05965. FYRC. 1 hit.
PF05964. FYRN. 1 hit.
PF00856. SET. 1 hit.
SMARTiView protein in SMART
SM00542. FYRC. 1 hit.
SM00541. FYRN. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
PROSITEiView protein in PROSITE
PS51543. FYRC. 1 hit.
PS51542. FYRN. 1 hit.
PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q6PIA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EQELSSFAVF RRVYIERDEV KQIASIIQRG ERLHMFRVGG LVFHAIGQLL
60 70 80 90 100
PHQMADFHSA TALYPVGYEA TRIYWSLRTN NRRCCYRCSI GENNGRPEFV
110 120 130 140 150
IKVIEQGLED LVFTDASPQA VWNRIIEPVA AMRKEADMLR LFPEYLKGEE
160 170 180 190 200
LFGLTVHAVL RIAESLPGVE SCQNYLFRYG RHPLMELPLM INPTGCARSE
210 220 230 240 250
PKILTHYKRP HTLNSTSMSK AYQSTFTGET NTPYSKQFVH SKSSQYRRLR
260 270 280 290 300
TEWKNNVYLA RSRIQGLGLY AAKDLEKHTM VIEYIGTIIR NEVANRREKI
310 320 330 340 350
YEEQNRGIYM FRINNEHVID ATLTGGPARY INHSCAPNCV AEVVTFDKED
360 370 380 390
KIIIISSRRI PKGEELTYDY QFDFEDDQHK IPCHCGAWNC RKWMN
Length:395
Mass (Da):45,887
Last modified:July 5, 2004 - v1
Checksum:iFFFB100760B8623B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC039197 mRNA. Translation: AAH39197.1.
RefSeqiNP_003473.3. NM_003482.3.
UniGeneiHs.731384.

Genome annotation databases

GeneIDi8085.
KEGGihsa:8085.

Similar proteinsi

Entry informationi

Entry nameiQ6PIA1_HUMAN
AccessioniPrimary (citable) accession number: Q6PIA1
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: August 30, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.