Reviewed, UniProtKB/Swiss-Prot Q6PI98 (IN80C_HUMAN)

Names and origin

Protein names

Recommended name:
    INO80 complex subunit C

Gene names

Name:	INO80C
Synonyms:	C18orf37

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	192 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subunit structure

Component of the chromatin-remodeling INO80 complex, at least composed of ACTL6A, ACTR5, ACTR8, RVBL1, RVBL2, INO80, INO80B, INO80C, INO80D and INO80E.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
PTM	Ubl conjugation
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6PI98-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Notes: No experimental confirmation available.

Isoform 2 (identifier: Q6PI98-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-55: Missing.

Notes: No experimental confirmation available.

Isoform 3 (identifier: Q6PI98-3)

The sequence of this isoform differs from the canonical sequence as follows:
     150-192: ANYTDPQSKL...ALRKATSIVP → EPPNCFPQRL...FIMAILVGVK

Notes: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 192	192	INO80 complex subunit C		PRO_0000079317
Amino acid modifications
	Cross-link	21		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
	Cross-link	22		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
	Cross-link	41		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Natural variations
	Alternative sequence	1 – 55	55	Missing in isoform 2.		VSP_014530
	Alternative sequence	150 – 192	43	ANYTD…TSIVP → EPPNCFPQRLHQLTFPLAMD EGSNFSRCSPTLVNFGFVFI MAILVGVK in isoform 3.		VSP_014531

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 6EED290EB9E4E68E	FASTA	192	20,643
	10 20 30 40 50 60 MAAQIPIVAT TSTPGIVRNS KKRPASPSHN GSSGGGYGAS KKKKASASSF AQGISMEAMS 70 80 90 100 110 120 ENKMVPSEFS TGPVEKAAKP LPFKDPNFVH SGHGGAVAGK KNRTWKNLKQ ILASERALPW 130 140 150 160 170 180 QLNDPNYFSI DAPPSFKPAK KYSDVSGLLA NYTDPQSKLR FSTIEEFSYI RRLPSDVVTG 190 YLALRKATSI VP
	Isoform 2 [UniParc]. Checksum: 1C0E97AAE1431AF6		137	15,229
	10 20 30 40 50 60 MEAMSENKMV PSEFSTGPVE KAAKPLPFKD PNFVHSGHGG AVAGKKNRTW KNLKQILASE 70 80 90 100 110 120 RALPWQLNDP NYFSIDAPPS FKPAKKYSDV SGLLANYTDP QSKLRFSTIE EFSYIRRLPS 130 DVVTGYLALR KATSIVP
	Isoform 3 [UniParc]. Checksum: 779928BE6DB701E0		197	21,108
	10 20 30 40 50 60 MAAQIPIVAT TSTPGIVRNS KKRPASPSHN GSSGGGYGAS KKKKASASSF AQGISMEAMS 70 80 90 100 110 120 ENKMVPSEFS TGPVEKAAKP LPFKDPNFVH SGHGGAVAGK KNRTWKNLKQ ILASERALPW 130 140 150 160 170 180 QLNDPNYFSI DAPPSFKPAK KYSDVSGLLE PPNCFPQRLH QLTFPLAMDE GSNFSRCSPT 190 LVNFGFVFIM AILVGVK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain and Testis.
[3]	"A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex." Jin J., Cai Y., Yao T., Gottschalk A.J., Florens L., Swanson S.K., Gutierrez J.L., Coleman M.K., Workman J.L., Mushegian A., Washburn M.P., Conaway R.C., Conaway J.W. J. Biol. Chem. 280:41207-41212(2005) [PubMed: 16230350] [Abstract] Cited for: MASS SPECTROMETRY, IDENTIFICATION IN INO80 COMPLEX.
[4]	"Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry." Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D. Proteomics 7:868-874(2007) [PubMed: 17370265] [Abstract] Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-21; LYS-22 AND LYS-41, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK095502 mRNA. Translation: BAC04560.1. BC039404 mRNA. Translation: AAH39404.1. BC048989 mRNA. Translation: AAH48989.1.
RefSeq	NP_919257.2.
UniGene	Hs.464903
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6PI98.
PTM databases
PhosphoSite	Q6PI98.
Genome annotation databases
Ensembl	ENSG00000153391. Homo sapiens. [Contig view]
GeneID	125476.
Organism-specific databases
HGNC	HGNC:26994. INO80C.
PharmGKB	PA134972129.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q6PI98.
Gene expression databases
ArrayExpress	Q6PI98.
CleanEx	HS_C18orf37.
GermOnline	ENSG00000153391. Homo sapiens.
Family and domain databases
InterPro	IPR013272. YL1_C. [Graphical view]
Pfam	PF08265. YL1_C. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	81538.

Entry information

Entry name

IN80C_HUMAN

Accession

Primary (citable) accession number: Q6PI98
Secondary accession number(s): Q86WR1, Q8N994

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	July 5, 2004
Last modified:	November 25, 2008
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)