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Reviewed, UniProtKB/Swiss-Prot Q6PI98 (IN80C_HUMAN)

Last modified November 25, 2008. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    INO80 complex subunit C
Gene names
Name: INO80C
Synonyms: C18orf37
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length192 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Subunit structure

Component of the chromatin-remodeling INO80 complex, at least composed of ACTL6A, ACTR5, ACTR8, RVBL1, RVBL2, INO80, INO80B, INO80C, INO80D and INO80E.

Ontologies

Keywords

   Coding sequence diversityAlternative splicing
   PTMUbl conjugation

Gene Ontology (GO)

None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6PI98-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Notes: No experimental confirmation available.
Isoform 2 (identifier: Q6PI98-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-55: Missing.
Notes: No experimental confirmation available.
Isoform 3 (identifier: Q6PI98-3)

The sequence of this isoform differs from the canonical sequence as follows:
     150-192: ANYTDPQSKL...ALRKATSIVP → EPPNCFPQRL...FIMAILVGVK
Notes: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 192192INO80 complex subunit C
PRO_0000079317

Amino acid modifications

Cross-link21Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Cross-link22Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Cross-link41Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Natural variations

Alternative sequence1 – 5555Missing in isoform 2.
VSP_014530
Alternative sequence150 – 19243ANYTD…TSIVP → EPPNCFPQRLHQLTFPLAMD EGSNFSRCSPTLVNFGFVFI MAILVGVK in isoform 3.
VSP_014531

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 6EED290EB9E4E68E

FASTA19220,643
        10         20         30         40         50         60 
MAAQIPIVAT TSTPGIVRNS KKRPASPSHN GSSGGGYGAS KKKKASASSF AQGISMEAMS 

        70         80         90        100        110        120 
ENKMVPSEFS TGPVEKAAKP LPFKDPNFVH SGHGGAVAGK KNRTWKNLKQ ILASERALPW 

       130        140        150        160        170        180 
QLNDPNYFSI DAPPSFKPAK KYSDVSGLLA NYTDPQSKLR FSTIEEFSYI RRLPSDVVTG 

       190 
YLALRKATSI VP 

« Hide

Isoform 2 [UniParc].

Checksum: 1C0E97AAE1431AF6
Show »

13715,229
Isoform 3 [UniParc].

Checksum: 779928BE6DB701E0
Show »

19721,108

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain and Testis.
[3]"A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex."
Jin J., Cai Y., Yao T., Gottschalk A.J., Florens L., Swanson S.K., Gutierrez J.L., Coleman M.K., Workman J.L., Mushegian A., Washburn M.P., Conaway R.C., Conaway J.W.
J. Biol. Chem. 280:41207-41212(2005) [PubMed: 16230350] [Abstract]
Cited for: MASS SPECTROMETRY, IDENTIFICATION IN INO80 COMPLEX.
[4]"Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.
Proteomics 7:868-874(2007) [PubMed: 17370265] [Abstract]
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-21; LYS-22 AND LYS-41, MASS SPECTROMETRY.

Cross-references

Sequence databases

AK095502 mRNA. Translation: BAC04560.1.
BC039404 mRNA. Translation: AAH39404.1.
BC048989 mRNA. Translation: AAH48989.1.
RefSeqNP_919257.2.
UniGeneHs.464903

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ6PI98.

PTM databases

PhosphoSiteQ6PI98.

Genome annotation databases

EnsemblENSG00000153391. Homo sapiens. [Contig view]
GeneID125476.

Organism-specific databases

HGNCHGNC:26994. INO80C.
PharmGKBPA134972129.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOVERGENQ6PI98.

Gene expression databases

ArrayExpressQ6PI98.
CleanExHS_C18orf37.
GermOnlineENSG00000153391. Homo sapiens.

Family and domain databases

InterProIPR013272. YL1_C.
[Graphical view]
PfamPF08265. YL1_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio81538.

Entry information

Entry nameIN80C_HUMAN
AccessionPrimary (citable) accession number: Q6PI98
Secondary accession number(s): Q86WR1, Q8N994
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2004
Last modified: November 25, 2008
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents