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Q6PI98

- IN80C_HUMAN

UniProt

Q6PI98 - IN80C_HUMAN

Protein

INO80 complex subunit C

Gene

INO80C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

    GO - Biological processi

    1. DNA recombination Source: UniProtKB-KW
    2. DNA repair Source: UniProtKB-KW
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    DNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    INO80 complex subunit C
    Alternative name(s):
    IES6 homolog
    Short name:
    hIes6
    Gene namesi
    Name:INO80C
    Synonyms:C18orf37
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:26994. INO80C.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. Ino80 complex Source: UniProtKB
    2. MLL1 complex Source: UniProtKB
    3. nucleolus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162392132.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 192192INO80 complex subunit CPRO_0000079317Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki21 – 21Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Cross-linki22 – 22Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Cross-linki41 – 41Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    MaxQBiQ6PI98.
    PaxDbiQ6PI98.
    PRIDEiQ6PI98.

    PTM databases

    PhosphoSiteiQ6PI98.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6PI98.
    BgeeiQ6PI98.
    CleanExiHS_INO80C.
    GenevestigatoriQ6PI98.

    Organism-specific databases

    HPAiHPA049060.

    Interactioni

    Subunit structurei

    Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the helicase ATP-binding and the helicase C-terminal domain of INO80. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10.4 Publications

    Protein-protein interaction databases

    BioGridi125928. 22 interactions.
    IntActiQ6PI98. 9 interactions.
    MINTiMINT-1398756.
    STRINGi9606.ENSP00000391457.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PI98.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG5195.
    HOGENOMiHOG000039089.
    HOVERGENiHBG103414.
    KOiK11667.
    OMAiTGPMEKA.
    OrthoDBiEOG786H5F.
    PhylomeDBiQ6PI98.
    TreeFamiTF323529.

    Family and domain databases

    InterProiIPR029525. INO80C/Ies6.
    IPR013272. YL1_C.
    [Graphical view]
    PANTHERiPTHR31200:SF1. PTHR31200:SF1. 1 hit.
    PfamiPF08265. YL1_C. 1 hit.
    [Graphical view]
    SMARTiSM00993. YL1_C. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6PI98-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAQIPIVAT TSTPGIVRNS KKRPASPSHN GSSGGGYGAS KKKKASASSF    50
    AQGISMEAMS ENKMVPSEFS TGPVEKAAKP LPFKDPNFVH SGHGGAVAGK 100
    KNRTWKNLKQ ILASERALPW QLNDPNYFSI DAPPSFKPAK KYSDVSGLLA 150
    NYTDPQSKLR FSTIEEFSYI RRLPSDVVTG YLALRKATSI VP 192

    Note: No experimental confirmation available.

    Length:192
    Mass (Da):20,643
    Last modified:July 5, 2004 - v1
    Checksum:i6EED290EB9E4E68E
    GO
    Isoform 2 (identifier: Q6PI98-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         150-192: ANYTDPQSKL...ALRKATSIVP → EPPNCFPQRL...FIMAILVGVK

    Note: No experimental confirmation available.

    Show »
    Length:197
    Mass (Da):21,108
    Checksum:i779928BE6DB701E0
    GO
    Isoform 3 (identifier: Q6PI98-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         52-52: Q → QTCLSPSTMIVRPPQPRGTTCLLPSAMIVRPPQPRGN

    Note: No experimental confirmation available.

    Show »
    Length:228
    Mass (Da):24,498
    Checksum:i7B3654DA04302E6C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti107 – 1071N → Y in BAG62346. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei52 – 521Q → QTCLSPSTMIVRPPQPRGTT CLLPSAMIVRPPQPRGN in isoform 3. 1 PublicationVSP_044967
    Alternative sequencei150 – 19243ANYTD…TSIVP → EPPNCFPQRLHQLTFPLAMD EGSNFSRCSPTLVNFGFVFI MAILVGVK in isoform 2. 1 PublicationVSP_014531Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK095502 mRNA. Translation: BAC04560.1.
    AK300660 mRNA. Translation: BAG62346.1.
    AC007998 Genomic DNA. No translation available.
    BC039404 mRNA. Translation: AAH39404.1.
    CCDSiCCDS11914.1. [Q6PI98-1]
    CCDS45853.1. [Q6PI98-4]
    RefSeqiNP_001092287.1. NM_001098817.1. [Q6PI98-4]
    NP_919257.2. NM_194281.3. [Q6PI98-1]
    XP_005258252.1. XM_005258195.2. [Q6PI98-3]
    UniGeneiHs.464903.

    Genome annotation databases

    EnsembliENST00000334598; ENSP00000334473; ENSG00000153391. [Q6PI98-1]
    ENST00000441607; ENSP00000391457; ENSG00000153391. [Q6PI98-4]
    ENST00000592173; ENSP00000465273; ENSG00000153391. [Q6PI98-3]
    GeneIDi125476.
    KEGGihsa:125476.
    UCSCiuc002kyw.1. human. [Q6PI98-3]
    uc002kyx.4. human. [Q6PI98-1]

    Polymorphism databases

    DMDMi68565181.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK095502 mRNA. Translation: BAC04560.1 .
    AK300660 mRNA. Translation: BAG62346.1 .
    AC007998 Genomic DNA. No translation available.
    BC039404 mRNA. Translation: AAH39404.1 .
    CCDSi CCDS11914.1. [Q6PI98-1 ]
    CCDS45853.1. [Q6PI98-4 ]
    RefSeqi NP_001092287.1. NM_001098817.1. [Q6PI98-4 ]
    NP_919257.2. NM_194281.3. [Q6PI98-1 ]
    XP_005258252.1. XM_005258195.2. [Q6PI98-3 ]
    UniGenei Hs.464903.

    3D structure databases

    ProteinModelPortali Q6PI98.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125928. 22 interactions.
    IntActi Q6PI98. 9 interactions.
    MINTi MINT-1398756.
    STRINGi 9606.ENSP00000391457.

    PTM databases

    PhosphoSitei Q6PI98.

    Polymorphism databases

    DMDMi 68565181.

    Proteomic databases

    MaxQBi Q6PI98.
    PaxDbi Q6PI98.
    PRIDEi Q6PI98.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000334598 ; ENSP00000334473 ; ENSG00000153391 . [Q6PI98-1 ]
    ENST00000441607 ; ENSP00000391457 ; ENSG00000153391 . [Q6PI98-4 ]
    ENST00000592173 ; ENSP00000465273 ; ENSG00000153391 . [Q6PI98-3 ]
    GeneIDi 125476.
    KEGGi hsa:125476.
    UCSCi uc002kyw.1. human. [Q6PI98-3 ]
    uc002kyx.4. human. [Q6PI98-1 ]

    Organism-specific databases

    CTDi 125476.
    GeneCardsi GC18M033034.
    H-InvDB HIX0022660.
    HGNCi HGNC:26994. INO80C.
    HPAi HPA049060.
    neXtProti NX_Q6PI98.
    PharmGKBi PA162392132.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5195.
    HOGENOMi HOG000039089.
    HOVERGENi HBG103414.
    KOi K11667.
    OMAi TGPMEKA.
    OrthoDBi EOG786H5F.
    PhylomeDBi Q6PI98.
    TreeFami TF323529.

    Miscellaneous databases

    GenomeRNAii 125476.
    NextBioi 35475194.
    PROi Q6PI98.

    Gene expression databases

    ArrayExpressi Q6PI98.
    Bgeei Q6PI98.
    CleanExi HS_INO80C.
    Genevestigatori Q6PI98.

    Family and domain databases

    InterProi IPR029525. INO80C/Ies6.
    IPR013272. YL1_C.
    [Graphical view ]
    PANTHERi PTHR31200:SF1. PTHR31200:SF1. 1 hit.
    Pfami PF08265. YL1_C. 1 hit.
    [Graphical view ]
    SMARTi SM00993. YL1_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Fetal brain and Skeletal muscle.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Hypothalamus.
    4. "Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF."
      Dou Y., Milne T.A., Tackett A.J., Smith E.R., Fukuda A., Wysocka J., Allis C.D., Chait B.T., Hess J.L., Roeder R.G.
      Cell 121:873-885(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE MLL1/MLL COMPLEX.
    5. Cited for: IDENTIFICATION IN INO80 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    6. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
      Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.
      Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-21; LYS-22 AND LYS-41.
      Tissue: Mammary cancer.
    7. "Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex."
      Yao T., Song L., Jin J., Cai Y., Takahashi H., Swanson S.K., Washburn M.P., Florens L., Conaway R.C., Cohen R.E., Conaway J.W.
      Mol. Cell 31:909-917(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE INO80 COMPLEX, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
    8. "Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling."
      Chen L., Cai Y., Jin J., Florens L., Swanson S.K., Washburn M.P., Conaway J.W., Conaway R.C.
      J. Biol. Chem. 286:11283-11289(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE INO80 COMPLEX.

    Entry informationi

    Entry nameiIN80C_HUMAN
    AccessioniPrimary (citable) accession number: Q6PI98
    Secondary accession number(s): B4DUI4
    , E9PCS7, Q86WR1, Q8N994
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM

    External Data

    Dasty 3