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Q6PI98

- IN80C_HUMAN

UniProt

Q6PI98 - IN80C_HUMAN

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Protein

INO80 complex subunit C

Gene

INO80C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

GO - Biological processi

  1. chromatin remodeling Source: InterPro
  2. DNA recombination Source: UniProtKB-KW
  3. DNA repair Source: UniProtKB-KW
  4. regulation of transcription, DNA-templated Source: UniProtKB-KW
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
INO80 complex subunit C
Alternative name(s):
IES6 homolog
Short name:
hIes6
Gene namesi
Name:INO80C
Synonyms:C18orf37
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:26994. INO80C.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. Ino80 complex Source: UniProtKB
  2. MLL1 complex Source: UniProtKB
  3. nucleolus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162392132.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 192192INO80 complex subunit CPRO_0000079317Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki21 – 21Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki22 – 22Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki41 – 41Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ6PI98.
PaxDbiQ6PI98.
PRIDEiQ6PI98.

PTM databases

PhosphoSiteiQ6PI98.

Expressioni

Gene expression databases

BgeeiQ6PI98.
CleanExiHS_INO80C.
ExpressionAtlasiQ6PI98. baseline and differential.
GenevestigatoriQ6PI98.

Organism-specific databases

HPAiHPA049060.

Interactioni

Subunit structurei

Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the helicase ATP-binding and the helicase C-terminal domain of INO80. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10.4 Publications

Protein-protein interaction databases

BioGridi125928. 23 interactions.
IntActiQ6PI98. 9 interactions.
MINTiMINT-1398756.
STRINGi9606.ENSP00000391457.

Structurei

3D structure databases

ProteinModelPortaliQ6PI98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG5195.
GeneTreeiENSGT00390000014303.
HOGENOMiHOG000039089.
HOVERGENiHBG103414.
InParanoidiQ6PI98.
KOiK11667.
OMAiTGPMEKA.
OrthoDBiEOG786H5F.
PhylomeDBiQ6PI98.
TreeFamiTF323529.

Family and domain databases

InterProiIPR029525. INO80C/Ies6.
IPR013272. YL1_C.
[Graphical view]
PANTHERiPTHR31200:SF1. PTHR31200:SF1. 1 hit.
PfamiPF08265. YL1_C. 1 hit.
[Graphical view]
SMARTiSM00993. YL1_C. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6PI98-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAQIPIVAT TSTPGIVRNS KKRPASPSHN GSSGGGYGAS KKKKASASSF
60 70 80 90 100
AQGISMEAMS ENKMVPSEFS TGPVEKAAKP LPFKDPNFVH SGHGGAVAGK
110 120 130 140 150
KNRTWKNLKQ ILASERALPW QLNDPNYFSI DAPPSFKPAK KYSDVSGLLA
160 170 180 190
NYTDPQSKLR FSTIEEFSYI RRLPSDVVTG YLALRKATSI VP

Note: No experimental confirmation available.

Length:192
Mass (Da):20,643
Last modified:July 5, 2004 - v1
Checksum:i6EED290EB9E4E68E
GO
Isoform 2 (identifier: Q6PI98-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-192: ANYTDPQSKL...ALRKATSIVP → EPPNCFPQRL...FIMAILVGVK

Note: No experimental confirmation available.

Show »
Length:197
Mass (Da):21,108
Checksum:i779928BE6DB701E0
GO
Isoform 3 (identifier: Q6PI98-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-52: Q → QTCLSPSTMIVRPPQPRGTTCLLPSAMIVRPPQPRGN

Note: No experimental confirmation available.

Show »
Length:228
Mass (Da):24,498
Checksum:i7B3654DA04302E6C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti107 – 1071N → Y in BAG62346. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei52 – 521Q → QTCLSPSTMIVRPPQPRGTT CLLPSAMIVRPPQPRGN in isoform 3. 1 PublicationVSP_044967
Alternative sequencei150 – 19243ANYTD…TSIVP → EPPNCFPQRLHQLTFPLAMD EGSNFSRCSPTLVNFGFVFI MAILVGVK in isoform 2. 1 PublicationVSP_014531Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095502 mRNA. Translation: BAC04560.1.
AK300660 mRNA. Translation: BAG62346.1.
AC007998 Genomic DNA. No translation available.
BC039404 mRNA. Translation: AAH39404.1.
CCDSiCCDS11914.1. [Q6PI98-1]
CCDS45853.1. [Q6PI98-4]
RefSeqiNP_001092287.1. NM_001098817.1. [Q6PI98-4]
NP_919257.2. NM_194281.3. [Q6PI98-1]
XP_005258252.1. XM_005258195.2. [Q6PI98-3]
UniGeneiHs.464903.

Genome annotation databases

EnsembliENST00000334598; ENSP00000334473; ENSG00000153391. [Q6PI98-1]
ENST00000441607; ENSP00000391457; ENSG00000153391. [Q6PI98-4]
ENST00000592173; ENSP00000465273; ENSG00000153391. [Q6PI98-3]
GeneIDi125476.
KEGGihsa:125476.
UCSCiuc002kyw.1. human. [Q6PI98-3]
uc002kyx.4. human. [Q6PI98-1]

Polymorphism databases

DMDMi68565181.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095502 mRNA. Translation: BAC04560.1 .
AK300660 mRNA. Translation: BAG62346.1 .
AC007998 Genomic DNA. No translation available.
BC039404 mRNA. Translation: AAH39404.1 .
CCDSi CCDS11914.1. [Q6PI98-1 ]
CCDS45853.1. [Q6PI98-4 ]
RefSeqi NP_001092287.1. NM_001098817.1. [Q6PI98-4 ]
NP_919257.2. NM_194281.3. [Q6PI98-1 ]
XP_005258252.1. XM_005258195.2. [Q6PI98-3 ]
UniGenei Hs.464903.

3D structure databases

ProteinModelPortali Q6PI98.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125928. 23 interactions.
IntActi Q6PI98. 9 interactions.
MINTi MINT-1398756.
STRINGi 9606.ENSP00000391457.

PTM databases

PhosphoSitei Q6PI98.

Polymorphism databases

DMDMi 68565181.

Proteomic databases

MaxQBi Q6PI98.
PaxDbi Q6PI98.
PRIDEi Q6PI98.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000334598 ; ENSP00000334473 ; ENSG00000153391 . [Q6PI98-1 ]
ENST00000441607 ; ENSP00000391457 ; ENSG00000153391 . [Q6PI98-4 ]
ENST00000592173 ; ENSP00000465273 ; ENSG00000153391 . [Q6PI98-3 ]
GeneIDi 125476.
KEGGi hsa:125476.
UCSCi uc002kyw.1. human. [Q6PI98-3 ]
uc002kyx.4. human. [Q6PI98-1 ]

Organism-specific databases

CTDi 125476.
GeneCardsi GC18M033034.
H-InvDB HIX0022660.
HGNCi HGNC:26994. INO80C.
HPAi HPA049060.
neXtProti NX_Q6PI98.
PharmGKBi PA162392132.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5195.
GeneTreei ENSGT00390000014303.
HOGENOMi HOG000039089.
HOVERGENi HBG103414.
InParanoidi Q6PI98.
KOi K11667.
OMAi TGPMEKA.
OrthoDBi EOG786H5F.
PhylomeDBi Q6PI98.
TreeFami TF323529.

Miscellaneous databases

GenomeRNAii 125476.
NextBioi 35475194.
PROi Q6PI98.

Gene expression databases

Bgeei Q6PI98.
CleanExi HS_INO80C.
ExpressionAtlasi Q6PI98. baseline and differential.
Genevestigatori Q6PI98.

Family and domain databases

InterProi IPR029525. INO80C/Ies6.
IPR013272. YL1_C.
[Graphical view ]
PANTHERi PTHR31200:SF1. PTHR31200:SF1. 1 hit.
Pfami PF08265. YL1_C. 1 hit.
[Graphical view ]
SMARTi SM00993. YL1_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Fetal brain and Skeletal muscle.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Hypothalamus.
  4. "Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF."
    Dou Y., Milne T.A., Tackett A.J., Smith E.R., Fukuda A., Wysocka J., Allis C.D., Chait B.T., Hess J.L., Roeder R.G.
    Cell 121:873-885(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE MLL1/MLL COMPLEX.
  5. Cited for: IDENTIFICATION IN INO80 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  6. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
    Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.
    Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-21; LYS-22 AND LYS-41.
    Tissue: Mammary cancer.
  7. "Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex."
    Yao T., Song L., Jin J., Cai Y., Takahashi H., Swanson S.K., Washburn M.P., Florens L., Conaway R.C., Cohen R.E., Conaway J.W.
    Mol. Cell 31:909-917(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE INO80 COMPLEX, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
  8. "Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling."
    Chen L., Cai Y., Jin J., Florens L., Swanson S.K., Washburn M.P., Conaway J.W., Conaway R.C.
    J. Biol. Chem. 286:11283-11289(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE INO80 COMPLEX.

Entry informationi

Entry nameiIN80C_HUMAN
AccessioniPrimary (citable) accession number: Q6PI98
Secondary accession number(s): B4DUI4
, E9PCS7, Q86WR1, Q8N994
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM

External Data

Dasty 3