ID   GASP3_HUMAN             Reviewed;         547 AA.
AC   Q6PI77; Q9C0G2;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 149.
DE   RecName: Full=G protein-coupled receptor associated sorting protein 3 {ECO:0000305};
DE   AltName: Full=Protein BHLHb9;
DE            Short=bHLHb9;
DE   AltName: Full=Transcription regulator of 60 kDa {ECO:0000303|PubMed:15034937};
DE            Short=p60TRP {ECO:0000303|PubMed:15034937};
GN   Name=GPRASP3 {ECO:0000312|HGNC:HGNC:29353}; Synonyms=BHLHB9, KIAA1701;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE FUNCTION, SUBCELLULAR LOCATION, AND
RP   TISSUE SPECIFICITY.
RX   PubMed=15034937; DOI=10.1002/jcb.20010;
RA   Heese K., Yamada T., Akatsu H., Yamamoto T., Kosaka K., Nagai Y.,
RA   Sawada T.;
RT   "Characterizing the new transcription regulator protein p60TRP.";
RL   J. Cell. Biochem. 91:1030-1042(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=11214970; DOI=10.1093/dnares/7.6.347;
RA   Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XIX. The
RT   complete sequences of 100 new cDNA clones from brain which code for large
RT   proteins in vitro.";
RL   DNA Res. 7:347-355(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   INDUCTION.
RX   PubMed=18089774; DOI=10.1158/0008-5472.can-07-2687;
RA   Jacinto F.V., Ballestar E., Ropero S., Esteller M.;
RT   "Discovery of epigenetically silenced genes by methylated DNA
RT   immunoprecipitation in colon cancer cells.";
RL   Cancer Res. 67:11481-11486(2007).
CC   -!- FUNCTION: Survival and differentiation promoting protein that plays a
CC       role in the regulation of neurosynaptogenesis. Induces phosphatase PP2A
CC       activity which results in APP dephosphorylation and inhibits BACE1-
CC       mediated processing of APP. {ECO:0000250|UniProtKB:Q6PB60}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q6PB60}.
CC   -!- INTERACTION:
CC       Q6PI77; X5D778: ANKRD11; NbExp=3; IntAct=EBI-11519926, EBI-17183751;
CC       Q6PI77; P29972: AQP1; NbExp=3; IntAct=EBI-11519926, EBI-745213;
CC       Q6PI77; Q7L5A3: ATOSB; NbExp=3; IntAct=EBI-11519926, EBI-745689;
CC       Q6PI77; Q9BXY8: BEX2; NbExp=3; IntAct=EBI-11519926, EBI-745073;
CC       Q6PI77; Q53TS8: C2CD6; NbExp=3; IntAct=EBI-11519926, EBI-739879;
CC       Q6PI77; Q96HB5: CCDC120; NbExp=3; IntAct=EBI-11519926, EBI-744556;
CC       Q6PI77; Q9UJX2: CDC23; NbExp=3; IntAct=EBI-11519926, EBI-396137;
CC       Q6PI77; Q16543: CDC37; NbExp=3; IntAct=EBI-11519926, EBI-295634;
CC       Q6PI77; Q96GN5: CDCA7L; NbExp=3; IntAct=EBI-11519926, EBI-5278764;
CC       Q6PI77; Q8WUE5: CT55; NbExp=3; IntAct=EBI-11519926, EBI-6873363;
CC       Q6PI77; P26196: DDX6; NbExp=3; IntAct=EBI-11519926, EBI-351257;
CC       Q6PI77; Q96JC9: EAF1; NbExp=3; IntAct=EBI-11519926, EBI-769261;
CC       Q6PI77; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-11519926, EBI-744099;
CC       Q6PI77; Q9H5Z6-2: FAM124B; NbExp=3; IntAct=EBI-11519926, EBI-11986315;
CC       Q6PI77; Q3B820: FAM161A; NbExp=3; IntAct=EBI-11519926, EBI-719941;
CC       Q6PI77; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-11519926, EBI-6658203;
CC       Q6PI77; O95995: GAS8; NbExp=3; IntAct=EBI-11519926, EBI-1052570;
CC       Q6PI77; P55040: GEM; NbExp=3; IntAct=EBI-11519926, EBI-744104;
CC       Q6PI77; O95872: GPANK1; NbExp=3; IntAct=EBI-11519926, EBI-751540;
CC       Q6PI77; A0A024R8L2: hCG_1987119; NbExp=3; IntAct=EBI-11519926, EBI-14103818;
CC       Q6PI77; P49639: HOXA1; NbExp=3; IntAct=EBI-11519926, EBI-740785;
CC       Q6PI77; Q9C086: INO80B; NbExp=3; IntAct=EBI-11519926, EBI-715611;
CC       Q6PI77; Q8NA54: IQUB; NbExp=3; IntAct=EBI-11519926, EBI-10220600;
CC       Q6PI77; Q2WGJ6: KLHL38; NbExp=3; IntAct=EBI-11519926, EBI-6426443;
CC       Q6PI77; Q969R5: L3MBTL2; NbExp=3; IntAct=EBI-11519926, EBI-739909;
CC       Q6PI77; Q8WVC0: LEO1; NbExp=3; IntAct=EBI-11519926, EBI-932432;
CC       Q6PI77; P25800: LMO1; NbExp=3; IntAct=EBI-11519926, EBI-8639312;
CC       Q6PI77; Q17RB8: LONRF1; NbExp=3; IntAct=EBI-11519926, EBI-2341787;
CC       Q6PI77; P55081: MFAP1; NbExp=3; IntAct=EBI-11519926, EBI-1048159;
CC       Q6PI77; Q8IVT2: MISP; NbExp=3; IntAct=EBI-11519926, EBI-2555085;
CC       Q6PI77; Q00013: MPP1; NbExp=3; IntAct=EBI-11519926, EBI-711788;
CC       Q6PI77; P48552: NRIP1; NbExp=3; IntAct=EBI-11519926, EBI-746484;
CC       Q6PI77; P32242: OTX1; NbExp=3; IntAct=EBI-11519926, EBI-740446;
CC       Q6PI77; Q8N3R9: PALS1; NbExp=3; IntAct=EBI-11519926, EBI-2513978;
CC       Q6PI77; O43189: PHF1; NbExp=5; IntAct=EBI-11519926, EBI-530034;
CC       Q6PI77; Q96PV4: PNMA5; NbExp=3; IntAct=EBI-11519926, EBI-10171633;
CC       Q6PI77; O15160: POLR1C; NbExp=3; IntAct=EBI-11519926, EBI-1055079;
CC       Q6PI77; O43741: PRKAB2; NbExp=3; IntAct=EBI-11519926, EBI-1053424;
CC       Q6PI77; Q8WWY3: PRPF31; NbExp=3; IntAct=EBI-11519926, EBI-1567797;
CC       Q6PI77; Q9P2K3-2: RCOR3; NbExp=3; IntAct=EBI-11519926, EBI-1504830;
CC       Q6PI77; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-11519926, EBI-748391;
CC       Q6PI77; Q96B97: SH3KBP1; NbExp=5; IntAct=EBI-11519926, EBI-346595;
CC       Q6PI77; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-11519926, EBI-358489;
CC       Q6PI77; Q5MJ10: SPANXN2; NbExp=3; IntAct=EBI-11519926, EBI-12023934;
CC       Q6PI77; Q6ZRS2-3: SRCAP; NbExp=3; IntAct=EBI-11519926, EBI-12029182;
CC       Q6PI77; Q5VWN6: TASOR2; NbExp=3; IntAct=EBI-11519926, EBI-745958;
CC       Q6PI77; Q15560: TCEA2; NbExp=3; IntAct=EBI-11519926, EBI-710310;
CC       Q6PI77; Q96N21: TEPSIN; NbExp=3; IntAct=EBI-11519926, EBI-11139477;
CC       Q6PI77; Q96FV9: THOC1; NbExp=3; IntAct=EBI-11519926, EBI-1765605;
CC       Q6PI77; Q9UKI8: TLK1; NbExp=3; IntAct=EBI-11519926, EBI-740492;
CC       Q6PI77; O95985: TOP3B; NbExp=3; IntAct=EBI-11519926, EBI-373403;
CC       Q6PI77; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-11519926, EBI-10241197;
CC       Q6PI77; Q99757: TXN2; NbExp=3; IntAct=EBI-11519926, EBI-2932492;
CC       Q6PI77; O75604: USP2; NbExp=3; IntAct=EBI-11519926, EBI-743272;
CC       Q6PI77; A0A024R8A9: USP20; NbExp=3; IntAct=EBI-11519926, EBI-14096082;
CC       Q6PI77; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-11519926, EBI-740727;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15034937}. Nucleus
CC       {ECO:0000269|PubMed:15034937}. Note=Mainly cytoplasmic, and nuclear at
CC       lower level.
CC   -!- TISSUE SPECIFICITY: Highly expressed in brain. Not expressed in lung or
CC       liver. Down-regulated in brain from patients suffering from Alzheimer
CC       disease. {ECO:0000269|PubMed:15034937}.
CC   -!- INDUCTION: Down-regulated in colon cancer cells, due to CpG
CC       hypermethylation of its promoter. {ECO:0000269|PubMed:18089774}.
CC   -!- SIMILARITY: Belongs to the GPRASP family. {ECO:0000305}.
CC   -!- CAUTION: Despite its name, no basic helix-loop-helix (bHLH) domain is
CC       detected by any prediction tool. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB21792.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AF547055; AAQ12077.1; -; mRNA.
DR   EMBL; AB051488; BAB21792.1; ALT_INIT; mRNA.
DR   EMBL; AL035427; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471190; EAW54726.1; -; Genomic_DNA.
DR   EMBL; BC041409; AAH41409.1; -; mRNA.
DR   RefSeq; NP_001135996.1; NM_001142524.1.
DR   RefSeq; NP_001135997.1; NM_001142525.1.
DR   RefSeq; NP_001135998.1; NM_001142526.1.
DR   RefSeq; NP_001135999.1; NM_001142527.1.
DR   RefSeq; NP_001136000.1; NM_001142528.1.
DR   RefSeq; NP_001136001.1; NM_001142529.1.
DR   RefSeq; NP_001136002.1; NM_001142530.1.
DR   RefSeq; NP_085142.1; NM_030639.2.
DR   AlphaFoldDB; Q6PI77; -.
DR   SMR; Q6PI77; -.
DR   BioGRID; 123320; 60.
DR   IntAct; Q6PI77; 65.
DR   MINT; Q6PI77; -.
DR   STRING; 9606.ENSP00000403226; -.
DR   GlyGen; Q6PI77; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q6PI77; -.
DR   PhosphoSitePlus; Q6PI77; -.
DR   BioMuta; BHLHB9; -.
DR   DMDM; 74749201; -.
DR   EPD; Q6PI77; -.
DR   MassIVE; Q6PI77; -.
DR   PaxDb; 9606-ENSP00000361820; -.
DR   PeptideAtlas; Q6PI77; -.
DR   ProteomicsDB; 67143; -.
DR   Pumba; Q6PI77; -.
DR   Antibodypedia; 28945; 50 antibodies from 13 providers.
DR   DNASU; 80823; -.
DR   Ensembl; ENST00000361229.8; ENSP00000354675.4; ENSG00000198908.12.
DR   Ensembl; ENST00000372735.1; ENSP00000361820.1; ENSG00000198908.12.
DR   Ensembl; ENST00000447531.5; ENSP00000405893.1; ENSG00000198908.12.
DR   Ensembl; ENST00000448867.1; ENSP00000391722.1; ENSG00000198908.12.
DR   Ensembl; ENST00000457056.6; ENSP00000403226.1; ENSG00000198908.12.
DR   GeneID; 80823; -.
DR   KEGG; hsa:80823; -.
DR   MANE-Select; ENST00000457056.6; ENSP00000403226.1; NM_001142524.2; NP_001135996.1.
DR   UCSC; uc004ejo.4; human.
DR   AGR; HGNC:29353; -.
DR   CTD; 80823; -.
DR   DisGeNET; 80823; -.
DR   GeneCards; GPRASP3; -.
DR   HGNC; HGNC:29353; GPRASP3.
DR   HPA; ENSG00000198908; Low tissue specificity.
DR   MIM; 300921; gene.
DR   neXtProt; NX_Q6PI77; -.
DR   OpenTargets; ENSG00000198908; -.
DR   PharmGKB; PA134895992; -.
DR   VEuPathDB; HostDB:ENSG00000198908; -.
DR   eggNOG; ENOG502RU0K; Eukaryota.
DR   GeneTree; ENSGT00940000161990; -.
DR   HOGENOM; CLU_036908_0_0_1; -.
DR   InParanoid; Q6PI77; -.
DR   OMA; TWFWAGE; -.
DR   OrthoDB; 5200088at2759; -.
DR   PhylomeDB; Q6PI77; -.
DR   TreeFam; TF335652; -.
DR   PathwayCommons; Q6PI77; -.
DR   SignaLink; Q6PI77; -.
DR   BioGRID-ORCS; 80823; 18 hits in 781 CRISPR screens.
DR   GenomeRNAi; 80823; -.
DR   Pharos; Q6PI77; Tdark.
DR   PRO; PR:Q6PI77; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; Q6PI77; Protein.
DR   Bgee; ENSG00000198908; Expressed in cortical plate and 110 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:CAFA.
DR   GO; GO:0007611; P:learning or memory; ISS:CAFA.
DR   GO; GO:0043524; P:negative regulation of neuron apoptotic process; ISS:CAFA.
DR   GO; GO:0061003; P:positive regulation of dendritic spine morphogenesis; ISS:CAFA.
DR   GO; GO:0050769; P:positive regulation of neurogenesis; ISS:CAFA.
DR   GO; GO:0051965; P:positive regulation of synapse assembly; ISS:CAFA.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR006911; ARM-rpt_dom.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR043374; GASP1-3.
DR   PANTHER; PTHR46414:SF2; PROTEIN BHLHB9; 1.
DR   PANTHER; PTHR46414; PROTEIN BHLHB9-RELATED; 1.
DR   Pfam; PF04826; Arm_2; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   Genevisible; Q6PI77; HS.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..547
FT                   /note="G protein-coupled receptor associated sorting
FT                   protein 3"
FT                   /id="PRO_0000334662"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          80..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..23
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         132
FT                   /note="S -> G (in dbSNP:rs2179675)"
FT                   /id="VAR_049266"
FT   VARIANT         318
FT                   /note="C -> R (in dbSNP:rs4514179)"
FT                   /id="VAR_049267"
SQ   SEQUENCE   547 AA;  60291 MW;  EC0E8D95CC7CE09D CRC64;
     MAGTKNKTRA QAKTEKKAAI QAKAGAEREA TGVVRPVAKT RAKAKAKTGS KTDAVAEMKA
     VSKNKVVAET KEGALSEPKT LGKAMGDFTP KAGNESTSST CKNEAGTDAW FWAGEEATIN
     SWFWNGEEAG NSFSTKNDKP EIGAQVCAEE LEPAAGADCK PRSGAEEEEE ENVIGNWFWE
     GDDTSFDPNP KPVSRIVKPQ PVYEINEKNR PKDWSEVTIW PNAPAVTPAV LGFRSQAPSE
     ASPPSYIVLA SAEENACSLP VATACRPSRN TRSCSQPIPE CRFDSDPCIQ TIDEIRRQIR
     IREVNGIKPF ACPCKMECYM DSEEFEKLVS LLKSTTDPLI HKIARIAMGV HNVHPFAQEF
     INEVGVVTLI ESLLSFPSPE MRKKTVITLN PPSGDERQRK IELHVKHMCK ETMSFPLNSP
     GQQSGLKILG QLTTDFVHHY IVANYFSELF HLLSSGNCKT RNLVLKLLLN MSENPTAARD
     MINMKALAAL KLIFNQKEAK ANLVSGVAIF INIKEHIRKG SIVVVDHLSY NTLMAIFREV
     KEIIETM
//