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Protein

Leukocyte immunoglobulin-like receptor subfamily A member 6

Gene

LILRA6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May act as receptor for class I MHC antigens.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Adaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte immunoglobulin-like receptor subfamily A member 6
Alternative name(s):
Immunoglobulin-like transcript 8
Short name:
ILT-8
Leukocyte Ig-like receptor
Gene namesi
Name:LILRA6
Synonyms:ILT8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:15495. LILRA6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 447424ExtracellularSequence analysisAdd
BLAST
Transmembranei448 – 46821HelicalSequence analysisAdd
BLAST
Topological domaini469 – 48113CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671548.

Polymorphism and mutation databases

DMDMi152032558.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 481458Leukocyte immunoglobulin-like receptor subfamily A member 6PRO_0000294367Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 98By similarity
Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence analysis
Disulfide bondi144 ↔ 196By similarity
Disulfide bondi245 ↔ 296PROSITE-ProRule annotation
Glycosylationi301 – 3011N-linked (GlcNAc...)Sequence analysis
Glycosylationi340 – 3401N-linked (GlcNAc...)Sequence analysis
Disulfide bondi345 ↔ 396PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ6PI73.
PaxDbiQ6PI73.
PeptideAtlasiQ6PI73.
PRIDEiQ6PI73.

PTM databases

iPTMnetiQ6PI73.

Expressioni

Gene expression databases

BgeeiQ6PI73.
ExpressionAtlasiQ6PI73. baseline and differential.
GenevisibleiQ6PI73. HS.

Interactioni

Protein-protein interaction databases

BioGridi116215. 7 interactions.
STRINGi9606.ENSP00000379651.

Structurei

3D structure databases

ProteinModelPortaliQ6PI73.
SMRiQ6PI73. Positions 28-419.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini225 – 31490Ig-like C2-type 1Add
BLAST
Domaini323 – 40886Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKJD. Eukaryota.
ENOG41116BR. LUCA.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiQ6PI73.
PhylomeDBiQ6PI73.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR016332. A1B_glyco/leuk_Ig-like_rcpt.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 3 hits.
[Graphical view]
PIRSFiPIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PI73-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTPALTALLC LGLSLGPRTR VQAGPFPKPT LWAEPGSVIS WGSPVTIWCQ
60 70 80 90 100
GSLEAQEYQL DKEGSPEPLD RNNPLEPKNK ARFSIPSMTQ HHAGRYRCHY
110 120 130 140 150
YSSAGWSEPS DPLELVMTGF YNKPTLSALP SPVVASGGNM TLRCGSQKGY
160 170 180 190 200
HHFVLMKEGE HQLPRTLDSQ QLHSGGFQAL FPVGPVTPSH RWRFTCYYYY
210 220 230 240 250
TNTPRVWSHP SDPLEILPSG VSRKPSLLTL QGPVLAPGQS LTLQCGSDVG
260 270 280 290 300
YDRFVLYKEG ERDFLQRPGQ QPQAGLSQAN FTLGPVSPSH GGQYRCYGAH
310 320 330 340 350
NLSSEWSAPS DPLNILMAGQ IYDTVSLSAQ PGPTVASGEN VTLLCQSRGY
360 370 380 390 400
FDTFLLTKEG AAHPPLRLRS MYGAHKYQAE FPMSPVTSAH AGTYRCYGSY
410 420 430 440 450
SSNPHLLSFP SEPLELMVSG HSGGSSLPPT GPPSTPASHA KDYTVENLIR
460 470 480
MGMAGLVLVF LGILLFEAQH SQRNPQDAAG R
Note: Gene prediction based on similarity to chimpanzee ortholog.
Length:481
Mass (Da):52,399
Last modified:July 10, 2007 - v2
Checksum:i674640305171201F
GO
Isoform 2 (identifier: Q6PI73-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     192-193: WR → RV
     194-481: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:193
Mass (Da):21,175
Checksum:i6721E1740AC1BDDA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti69 – 691L → W.
Corresponds to variant rs620207 [ dbSNP | Ensembl ].
VAR_033170
Natural varianti149 – 1491G → R.
Corresponds to variant rs1052966 [ dbSNP | Ensembl ].
VAR_033171
Natural varianti288 – 2881P → R.
Corresponds to variant rs1052975 [ dbSNP | Ensembl ].
VAR_033172
Natural varianti400 – 4001Y → H.
Corresponds to variant rs8104206 [ dbSNP | Ensembl ].
VAR_033173

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei192 – 1932WR → RV in isoform 2. 1 PublicationVSP_038149
Alternative sequencei194 – 481288Missing in isoform 2. 1 PublicationVSP_038150Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010492 Genomic DNA. No translation available.
BC041708 mRNA. No translation available.
CCDSiCCDS42610.1. [Q6PI73-1]
RefSeqiXP_006726238.1. XM_006726175.1. [Q6PI73-1]
UniGeneiHs.631592.
Hs.688335.

Genome annotation databases

EnsembliENST00000391735; ENSP00000375615; ENSG00000244482.
ENST00000396365; ENSP00000379651; ENSG00000244482.
ENST00000430421; ENSP00000412929; ENSG00000244482.
ENST00000613333; ENSP00000478128; ENSG00000274148. [Q6PI73-2]
ENST00000614434; ENSP00000484617; ENSG00000275539. [Q6PI73-2]
ENST00000616252; ENSP00000479375; ENSG00000275539. [Q6PI73-2]
ENST00000616466; ENSP00000483909; ENSG00000274148. [Q6PI73-2]
ENST00000616720; ENSP00000478896; ENSG00000274148. [Q6PI73-2]
ENST00000621570; ENSP00000480300; ENSG00000274148. [Q6PI73-1]
GeneIDi11025.
UCSCiuc032ide.2. human. [Q6PI73-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010492 Genomic DNA. No translation available.
BC041708 mRNA. No translation available.
CCDSiCCDS42610.1. [Q6PI73-1]
RefSeqiXP_006726238.1. XM_006726175.1. [Q6PI73-1]
UniGeneiHs.631592.
Hs.688335.

3D structure databases

ProteinModelPortaliQ6PI73.
SMRiQ6PI73. Positions 28-419.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116215. 7 interactions.
STRINGi9606.ENSP00000379651.

PTM databases

iPTMnetiQ6PI73.

Polymorphism and mutation databases

DMDMi152032558.

Proteomic databases

EPDiQ6PI73.
PaxDbiQ6PI73.
PeptideAtlasiQ6PI73.
PRIDEiQ6PI73.

Protocols and materials databases

DNASUi79168.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391735; ENSP00000375615; ENSG00000244482.
ENST00000396365; ENSP00000379651; ENSG00000244482.
ENST00000430421; ENSP00000412929; ENSG00000244482.
ENST00000613333; ENSP00000478128; ENSG00000274148. [Q6PI73-2]
ENST00000614434; ENSP00000484617; ENSG00000275539. [Q6PI73-2]
ENST00000616252; ENSP00000479375; ENSG00000275539. [Q6PI73-2]
ENST00000616466; ENSP00000483909; ENSG00000274148. [Q6PI73-2]
ENST00000616720; ENSP00000478896; ENSG00000274148. [Q6PI73-2]
ENST00000621570; ENSP00000480300; ENSG00000274148. [Q6PI73-1]
GeneIDi11025.
UCSCiuc032ide.2. human. [Q6PI73-1]

Organism-specific databases

CTDi11025.
GeneCardsiLILRA6.
HGNCiHGNC:15495. LILRA6.
neXtProtiNX_Q6PI73.
PharmGKBiPA142671548.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKJD. Eukaryota.
ENOG41116BR. LUCA.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiQ6PI73.
PhylomeDBiQ6PI73.
TreeFamiTF336644.

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

ChiTaRSiLILRA6. human.
GenomeRNAii11025.
PROiQ6PI73.

Gene expression databases

BgeeiQ6PI73.
ExpressionAtlasiQ6PI73. baseline and differential.
GenevisibleiQ6PI73. HS.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR016332. A1B_glyco/leuk_Ig-like_rcpt.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 3 hits.
[Graphical view]
PIRSFiPIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster."
    Wende H., Volz A., Ziegler A.
    Immunogenetics 51:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE LRC.
  4. Erratum
    Wende H., Volz A., Ziegler A.
    Immunogenetics 52:3-4(2001)

Entry informationi

Entry nameiLIRA6_HUMAN
AccessioniPrimary (citable) accession number: Q6PI73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: July 6, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.