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Q6PI62

- GP173_MOUSE

UniProt

Q6PI62 - GP173_MOUSE

Protein

Probable G-protein coupled receptor 173

Gene

Gpr173

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Orphan receptor.

    GO - Molecular functioni

    1. gonadotropin-releasing hormone receptor activity Source: MGI

    GO - Biological processi

    1. cellular response to gonadotropin-releasing hormone Source: GOC
    2. negative regulation of neuron migration Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 173
    Alternative name(s):
    Super conserved receptor expressed in brain 3
    Gene namesi
    Name:Gpr173
    Synonyms:Sreb3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1918021. Gpr173.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 373373Probable G-protein coupled receptor 173PRO_0000069651Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi96 ↔ 174PROSITE-ProRule annotation
    Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ6PI62.

    PTM databases

    PhosphoSiteiQ6PI62.

    Expressioni

    Gene expression databases

    BgeeiQ6PI62.
    CleanExiMM_GPR173.
    GenevestigatoriQ6PI62.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000065533.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PI62.
    SMRiQ6PI62. Positions 14-352.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini48 – 5912CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini81 – 9717ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini119 – 13921CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini161 – 18828ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini210 – 28778CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini309 – 32214ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini344 – 37330CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei60 – 8021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei98 – 11821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei189 – 20921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei288 – 30821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei323 – 34321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG237432.
    GeneTreeiENSGT00750000117696.
    HOGENOMiHOG000231471.
    HOVERGENiHBG051805.
    InParanoidiA2AHI2.
    KOiK04300.
    OMAiKRMTFWT.
    OrthoDBiEOG73NG3K.
    PhylomeDBiQ6PI62.
    TreeFamiTF331163.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6PI62-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANTTGEPEE VSGALSLPSA SAYVKLVLLG LIMCVSLAGN AILSLLVLKE    50
    RALHKAPYYF LLDLCLADGI RSAICFPFVL ASVRHGSSWT FSALSCKIVA 100
    FMAVLFCFHA AFMLFCISVT RYMAIAHHRF YAKRMTLWTC AAVICMAWTL 150
    SVAMAFPPVF DVGTYKFIRE EDQCIFEHRY FKANDTLGFM LMLAVLMAAT 200
    HAVYGKLLLF EYRHRKMKPV QMVPAISQNW TFHGPGATGQ AAANWIAGFG 250
    RGPMPPTLLG IRQNGHAASR RLLGMDEVKG EKQLGRMFYA ITLLFLLLWS 300
    PYIVACYWRV FVKACAVPHR YLATAVWMSF AQAAVNPIVC FLLNKDLKKC 350
    LRTHAPCWGT GGAPAPREPY CVM 373
    Length:373
    Mass (Da):41,511
    Last modified:July 5, 2004 - v1
    Checksum:iC06DEA2F0E88CAF5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL731727 Genomic DNA. Translation: CAM15340.1.
    BC043021 mRNA. Translation: AAH43021.1.
    BC096520 mRNA. Translation: AAH96520.1.
    CCDSiCCDS30475.1.
    RefSeqiNP_081819.2. NM_027543.3.
    XP_006529044.1. XM_006528981.1.
    XP_006529045.1. XM_006528982.1.
    XP_006529046.1. XM_006528983.1.
    UniGeneiMm.158445.

    Genome annotation databases

    EnsembliENSMUST00000070316; ENSMUSP00000065533; ENSMUSG00000056679.
    GeneIDi70771.
    KEGGimmu:70771.
    UCSCiuc009uqh.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL731727 Genomic DNA. Translation: CAM15340.1 .
    BC043021 mRNA. Translation: AAH43021.1 .
    BC096520 mRNA. Translation: AAH96520.1 .
    CCDSi CCDS30475.1.
    RefSeqi NP_081819.2. NM_027543.3.
    XP_006529044.1. XM_006528981.1.
    XP_006529045.1. XM_006528982.1.
    XP_006529046.1. XM_006528983.1.
    UniGenei Mm.158445.

    3D structure databases

    ProteinModelPortali Q6PI62.
    SMRi Q6PI62. Positions 14-352.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000065533.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q6PI62.

    Proteomic databases

    PRIDEi Q6PI62.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000070316 ; ENSMUSP00000065533 ; ENSMUSG00000056679 .
    GeneIDi 70771.
    KEGGi mmu:70771.
    UCSCi uc009uqh.1. mouse.

    Organism-specific databases

    CTDi 54328.
    MGIi MGI:1918021. Gpr173.

    Phylogenomic databases

    eggNOGi NOG237432.
    GeneTreei ENSGT00750000117696.
    HOGENOMi HOG000231471.
    HOVERGENi HBG051805.
    InParanoidi A2AHI2.
    KOi K04300.
    OMAi KRMTFWT.
    OrthoDBi EOG73NG3K.
    PhylomeDBi Q6PI62.
    TreeFami TF331163.

    Miscellaneous databases

    ChiTaRSi GPR173. mouse.
    NextBioi 332225.
    PROi Q6PI62.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6PI62.
    CleanExi MM_GPR173.
    Genevestigatori Q6PI62.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiGP173_MOUSE
    AccessioniPrimary (citable) accession number: Q6PI62
    Secondary accession number(s): A2AHI2, Q4VA66
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3