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Q6PI62

- GP173_MOUSE

UniProt

Q6PI62 - GP173_MOUSE

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Protein

Probable G-protein coupled receptor 173

Gene
Gpr173, Sreb3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. gonadotropin-releasing hormone receptor activity Source: MGI

GO - Biological processi

  1. cellular response to gonadotropin-releasing hormone Source: GOC
  2. negative regulation of neuron migration Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 173
Alternative name(s):
Super conserved receptor expressed in brain 3
Gene namesi
Name:Gpr173
Synonyms:Sreb3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1918021. Gpr173.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Extracellular Reviewed predictionAdd
BLAST
Transmembranei27 – 4721Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini48 – 5912Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei60 – 8021Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini81 – 9717Extracellular Reviewed predictionAdd
BLAST
Transmembranei98 – 11821Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini119 – 13921Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei140 – 16021Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini161 – 18828Extracellular Reviewed predictionAdd
BLAST
Transmembranei189 – 20921Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini210 – 28778Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei288 – 30821Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini309 – 32214Extracellular Reviewed predictionAdd
BLAST
Transmembranei323 – 34321Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini344 – 37330Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 373373Probable G-protein coupled receptor 173PRO_0000069651Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi96 ↔ 174 By similarity
Glycosylationi184 – 1841N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ6PI62.

PTM databases

PhosphoSiteiQ6PI62.

Expressioni

Gene expression databases

BgeeiQ6PI62.
CleanExiMM_GPR173.
GenevestigatoriQ6PI62.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065533.

Structurei

3D structure databases

ProteinModelPortaliQ6PI62.
SMRiQ6PI62. Positions 14-352.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG237432.
GeneTreeiENSGT00750000117696.
HOGENOMiHOG000231471.
HOVERGENiHBG051805.
InParanoidiA2AHI2.
KOiK04300.
OMAiKRMTFWT.
OrthoDBiEOG73NG3K.
PhylomeDBiQ6PI62.
TreeFamiTF331163.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PI62-1 [UniParc]FASTAAdd to Basket

« Hide

MANTTGEPEE VSGALSLPSA SAYVKLVLLG LIMCVSLAGN AILSLLVLKE    50
RALHKAPYYF LLDLCLADGI RSAICFPFVL ASVRHGSSWT FSALSCKIVA 100
FMAVLFCFHA AFMLFCISVT RYMAIAHHRF YAKRMTLWTC AAVICMAWTL 150
SVAMAFPPVF DVGTYKFIRE EDQCIFEHRY FKANDTLGFM LMLAVLMAAT 200
HAVYGKLLLF EYRHRKMKPV QMVPAISQNW TFHGPGATGQ AAANWIAGFG 250
RGPMPPTLLG IRQNGHAASR RLLGMDEVKG EKQLGRMFYA ITLLFLLLWS 300
PYIVACYWRV FVKACAVPHR YLATAVWMSF AQAAVNPIVC FLLNKDLKKC 350
LRTHAPCWGT GGAPAPREPY CVM 373
Length:373
Mass (Da):41,511
Last modified:July 5, 2004 - v1
Checksum:iC06DEA2F0E88CAF5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL731727 Genomic DNA. Translation: CAM15340.1.
BC043021 mRNA. Translation: AAH43021.1.
BC096520 mRNA. Translation: AAH96520.1.
CCDSiCCDS30475.1.
RefSeqiNP_081819.2. NM_027543.3.
XP_006529044.1. XM_006528981.1.
XP_006529045.1. XM_006528982.1.
XP_006529046.1. XM_006528983.1.
UniGeneiMm.158445.

Genome annotation databases

EnsembliENSMUST00000070316; ENSMUSP00000065533; ENSMUSG00000056679.
GeneIDi70771.
KEGGimmu:70771.
UCSCiuc009uqh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL731727 Genomic DNA. Translation: CAM15340.1 .
BC043021 mRNA. Translation: AAH43021.1 .
BC096520 mRNA. Translation: AAH96520.1 .
CCDSi CCDS30475.1.
RefSeqi NP_081819.2. NM_027543.3.
XP_006529044.1. XM_006528981.1.
XP_006529045.1. XM_006528982.1.
XP_006529046.1. XM_006528983.1.
UniGenei Mm.158445.

3D structure databases

ProteinModelPortali Q6PI62.
SMRi Q6PI62. Positions 14-352.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000065533.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q6PI62.

Proteomic databases

PRIDEi Q6PI62.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000070316 ; ENSMUSP00000065533 ; ENSMUSG00000056679 .
GeneIDi 70771.
KEGGi mmu:70771.
UCSCi uc009uqh.1. mouse.

Organism-specific databases

CTDi 54328.
MGIi MGI:1918021. Gpr173.

Phylogenomic databases

eggNOGi NOG237432.
GeneTreei ENSGT00750000117696.
HOGENOMi HOG000231471.
HOVERGENi HBG051805.
InParanoidi A2AHI2.
KOi K04300.
OMAi KRMTFWT.
OrthoDBi EOG73NG3K.
PhylomeDBi Q6PI62.
TreeFami TF331163.

Miscellaneous databases

ChiTaRSi GPR173. mouse.
NextBioi 332225.
PROi Q6PI62.
SOURCEi Search...

Gene expression databases

Bgeei Q6PI62.
CleanExi MM_GPR173.
Genevestigatori Q6PI62.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiGP173_MOUSE
AccessioniPrimary (citable) accession number: Q6PI62
Secondary accession number(s): A2AHI2, Q4VA66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi