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Protein

Probable G-protein coupled receptor 173

Gene

Gpr173

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. gonadotropin-releasing hormone receptor activity Source: MGI

GO - Biological processi

  1. cellular response to gonadotropin-releasing hormone Source: GOC
  2. negative regulation of neuron migration Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 173
Alternative name(s):
Super conserved receptor expressed in brain 3
Gene namesi
Name:Gpr173
Synonyms:Sreb3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1918021. Gpr173.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
BLAST
Transmembranei27 – 4721Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini48 – 5912CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei60 – 8021Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini81 – 9717ExtracellularSequence AnalysisAdd
BLAST
Transmembranei98 – 11821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini119 – 13921CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini161 – 18828ExtracellularSequence AnalysisAdd
BLAST
Transmembranei189 – 20921Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini210 – 28778CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei288 – 30821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini309 – 32214ExtracellularSequence AnalysisAdd
BLAST
Transmembranei323 – 34321Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini344 – 37330CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 373373Probable G-protein coupled receptor 173PRO_0000069651Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi96 ↔ 174PROSITE-ProRule annotation
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ6PI62.

PTM databases

PhosphoSiteiQ6PI62.

Expressioni

Gene expression databases

BgeeiQ6PI62.
CleanExiMM_GPR173.
ExpressionAtlasiQ6PI62. baseline and differential.
GenevestigatoriQ6PI62.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065533.

Structurei

3D structure databases

ProteinModelPortaliQ6PI62.
SMRiQ6PI62. Positions 14-352.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG237432.
GeneTreeiENSGT00780000121897.
HOGENOMiHOG000231471.
HOVERGENiHBG051805.
InParanoidiQ6PI62.
KOiK04300.
OMAiKRMTFWT.
OrthoDBiEOG73NG3K.
PhylomeDBiQ6PI62.
TreeFamiTF331163.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PI62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANTTGEPEE VSGALSLPSA SAYVKLVLLG LIMCVSLAGN AILSLLVLKE
60 70 80 90 100
RALHKAPYYF LLDLCLADGI RSAICFPFVL ASVRHGSSWT FSALSCKIVA
110 120 130 140 150
FMAVLFCFHA AFMLFCISVT RYMAIAHHRF YAKRMTLWTC AAVICMAWTL
160 170 180 190 200
SVAMAFPPVF DVGTYKFIRE EDQCIFEHRY FKANDTLGFM LMLAVLMAAT
210 220 230 240 250
HAVYGKLLLF EYRHRKMKPV QMVPAISQNW TFHGPGATGQ AAANWIAGFG
260 270 280 290 300
RGPMPPTLLG IRQNGHAASR RLLGMDEVKG EKQLGRMFYA ITLLFLLLWS
310 320 330 340 350
PYIVACYWRV FVKACAVPHR YLATAVWMSF AQAAVNPIVC FLLNKDLKKC
360 370
LRTHAPCWGT GGAPAPREPY CVM
Length:373
Mass (Da):41,511
Last modified:July 5, 2004 - v1
Checksum:iC06DEA2F0E88CAF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731727 Genomic DNA. Translation: CAM15340.1.
BC043021 mRNA. Translation: AAH43021.1.
BC096520 mRNA. Translation: AAH96520.1.
CCDSiCCDS30475.1.
RefSeqiNP_081819.2. NM_027543.3.
XP_006529044.1. XM_006528981.2.
XP_006529045.1. XM_006528982.2.
XP_006529046.1. XM_006528983.2.
UniGeneiMm.158445.

Genome annotation databases

EnsembliENSMUST00000070316; ENSMUSP00000065533; ENSMUSG00000056679.
GeneIDi70771.
KEGGimmu:70771.
UCSCiuc009uqh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731727 Genomic DNA. Translation: CAM15340.1.
BC043021 mRNA. Translation: AAH43021.1.
BC096520 mRNA. Translation: AAH96520.1.
CCDSiCCDS30475.1.
RefSeqiNP_081819.2. NM_027543.3.
XP_006529044.1. XM_006528981.2.
XP_006529045.1. XM_006528982.2.
XP_006529046.1. XM_006528983.2.
UniGeneiMm.158445.

3D structure databases

ProteinModelPortaliQ6PI62.
SMRiQ6PI62. Positions 14-352.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065533.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ6PI62.

Proteomic databases

PRIDEiQ6PI62.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070316; ENSMUSP00000065533; ENSMUSG00000056679.
GeneIDi70771.
KEGGimmu:70771.
UCSCiuc009uqh.1. mouse.

Organism-specific databases

CTDi54328.
MGIiMGI:1918021. Gpr173.

Phylogenomic databases

eggNOGiNOG237432.
GeneTreeiENSGT00780000121897.
HOGENOMiHOG000231471.
HOVERGENiHBG051805.
InParanoidiQ6PI62.
KOiK04300.
OMAiKRMTFWT.
OrthoDBiEOG73NG3K.
PhylomeDBiQ6PI62.
TreeFamiTF331163.

Miscellaneous databases

ChiTaRSiGpr173. mouse.
NextBioi332225.
PROiQ6PI62.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PI62.
CleanExiMM_GPR173.
ExpressionAtlasiQ6PI62. baseline and differential.
GenevestigatoriQ6PI62.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiGP173_MOUSE
AccessioniPrimary (citable) accession number: Q6PI62
Secondary accession number(s): A2AHI2, Q4VA66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: July 5, 2004
Last modified: April 1, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.