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Protein
Submitted name:

WT1 protein

Gene

WT1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
WT1 proteinImported
Gene namesi
Name:WT1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 331310Sequence analysisPRO_5004279522Add
BLAST

Proteomic databases

PaxDbiQ6PI38.
PeptideAtlasiQ6PI38.

Expressioni

Gene expression databases

BgeeiQ6PI38.
GenevisibleiQ6PI38. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000331327.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini83 – 331249WT1InterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000230937.
KOiK09234.

Family and domain databases

InterProiIPR017987. Wilms_tumour.
IPR000976. Wilms_tumour_N.
[Graphical view]
PfamiPF02165. WT1. 1 hit.
[Graphical view]
PRINTSiPR00049. WILMSTUMOUR.

Sequencei

Sequence statusi: Fragment.

Q6PI38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GPRRLLAAIL DFLLLQDPAS TCVPEPASQH TLRSGPGCLQ QPEQQGVRDP
60 70 80 90 100
GGIWAKLGAA EASAERLQGR RSRGASGSEP QQMGSDVRDL NALLPAVPSL
110 120 130 140 150
GGGGGCALPV SGAAQWAPVL DFAPPGASAY GSLGGPAPPP APPPPPPPPP
160 170 180 190 200
HSFIKQEPSW GGAEPHEEQC LSAFTVHFSG QFTGTAGACR YGPFGPPPPS
210 220 230 240 250
QASSGQARMF PNAPYLPSCL ESQPAIRNQG YSTVTFDGTP SYGHTPSHHA
260 270 280 290 300
AQFPNHSFKH EDPMGQQGSL GEQQYSVPPP VYGCHTPTDS CTGSQALLLR
310 320 330
TPYSSDNLYQ MTSQLECMTW NQMNLGATLK G
Length:331
Mass (Da):34,592
Last modified:September 5, 2006 - v2
Checksum:iBA8AA8FA79475F68
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC046461 mRNA. Translation: AAH46461.2.
RefSeqiNP_000369.3. NM_000378.4.
NP_001185480.1. NM_001198551.1.
NP_001185481.1. NM_001198552.1.
NP_077742.2. NM_024424.3.
NP_077744.3. NM_024426.4.
UniGeneiHs.591980.

Genome annotation databases

GeneIDi7490.
KEGGihsa:7490.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC046461 mRNA. Translation: AAH46461.2.
RefSeqiNP_000369.3. NM_000378.4.
NP_001185480.1. NM_001198551.1.
NP_001185481.1. NM_001198552.1.
NP_077742.2. NM_024424.3.
NP_077744.3. NM_024426.4.
UniGeneiHs.591980.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000331327.

Proteomic databases

PaxDbiQ6PI38.
PeptideAtlasiQ6PI38.

Protocols and materials databases

DNASUi7490.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi7490.
KEGGihsa:7490.

Organism-specific databases

CTDi7490.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000230937.
KOiK09234.

Miscellaneous databases

ChiTaRSiWT1. human.
GenomeRNAii7490.

Gene expression databases

BgeeiQ6PI38.
GenevisibleiQ6PI38. HS.

Family and domain databases

InterProiIPR017987. Wilms_tumour.
IPR000976. Wilms_tumour_N.
[Graphical view]
PfamiPF02165. WT1. 1 hit.
[Graphical view]
PRINTSiPR00049. WILMSTUMOUR.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.

Entry informationi

Entry nameiQ6PI38_HUMAN
AccessioniPrimary (citable) accession number: Q6PI38
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: September 5, 2006
Last modified: July 6, 2016
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.