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Protein

Protein cornichon homolog 2

Gene

CNIH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors.1 Publication

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-HSA-5694530. Cargo concentration in the ER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein cornichon homolog 2
Short name:
CNIH-2
Alternative name(s):
Cornichon family AMPA receptor auxiliary protein 2
Cornichon-like protein
Gene namesi
Name:CNIH2
Synonyms:CNIL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:28744. CNIH2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence analysis
Transmembranei11 – 3121HelicalSequence analysisAdd
BLAST
Topological domaini32 – 7241LumenalSequence analysisAdd
BLAST
Transmembranei73 – 9321HelicalSequence analysisAdd
BLAST
Topological domaini94 – 13845CytoplasmicSequence analysisAdd
BLAST
Transmembranei139 – 15921HelicalSequence analysisAdd
BLAST
Topological domaini160 – 1601LumenalSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Endoplasmic reticulum, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134887358.

Polymorphism and mutation databases

DMDMi61563951.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 160160Protein cornichon homolog 2PRO_0000122225Add
BLAST

Proteomic databases

PaxDbiQ6PI25.
PeptideAtlasiQ6PI25.
PRIDEiQ6PI25.

PTM databases

PhosphoSiteiQ6PI25.

Expressioni

Tissue specificityi

Expression is up-regulated in dorsolateral prefrontal cortex of patients with schizophrenia (postmortem brain study).1 Publication

Gene expression databases

BgeeiQ6PI25.
CleanExiHS_CNIH2.
ExpressionAtlasiQ6PI25. baseline and differential.
GenevisibleiQ6PI25. HS.

Organism-specific databases

HPAiHPA026976.
HPA038743.

Interactioni

Subunit structurei

Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8 (By similarity). Interacts with CACGN8 (By similarity). Interacts with GRIA1.By similarity1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000310003.

Structurei

3D structure databases

ProteinModelPortaliQ6PI25.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cornichon family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2729. Eukaryota.
ENOG4111MWH. LUCA.
GeneTreeiENSGT00390000015751.
HOGENOMiHOG000214661.
HOVERGENiHBG003814.
InParanoidiQ6PI25.
OMAiIAFDERT.
PhylomeDBiQ6PI25.
TreeFamiTF300083.

Family and domain databases

InterProiIPR003377. Cornichon.
IPR033466. Cornichon_conserved.
[Graphical view]
PfamiPF03311. Cornichon. 1 hit.
[Graphical view]
SMARTiSM01398. Cornichon. 1 hit.
[Graphical view]
PROSITEiPS01340. CORNICHON. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PI25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFTFAAFCY MLTLVLCASL IFFVIWHIIA FDELRTDFKN PIDQGNPARA
60 70 80 90 100
RERLKNIERI CCLLRKLVVP EYSIHGLFCL MFLCAAEWVT LGLNIPLLFY
110 120 130 140 150
HLWRYFHRPA DGSEVMYDAV SIMNADILNY CQKESWCKLA FYLLSFFYYL
160
YSMVYTLVSF
Length:160
Mass (Da):18,931
Last modified:July 5, 2004 - v1
Checksum:i00330E5E609B28BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC047953 mRNA. Translation: AAH47953.1.
CCDSiCCDS8131.1.
RefSeqiNP_872359.1. NM_182553.2.
UniGeneiHs.437072.

Genome annotation databases

EnsembliENST00000311445; ENSP00000310003; ENSG00000174871.
GeneIDi254263.
KEGGihsa:254263.
UCSCiuc001ohi.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC047953 mRNA. Translation: AAH47953.1.
CCDSiCCDS8131.1.
RefSeqiNP_872359.1. NM_182553.2.
UniGeneiHs.437072.

3D structure databases

ProteinModelPortaliQ6PI25.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000310003.

PTM databases

PhosphoSiteiQ6PI25.

Polymorphism and mutation databases

DMDMi61563951.

Proteomic databases

PaxDbiQ6PI25.
PeptideAtlasiQ6PI25.
PRIDEiQ6PI25.

Protocols and materials databases

DNASUi254263.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311445; ENSP00000310003; ENSG00000174871.
GeneIDi254263.
KEGGihsa:254263.
UCSCiuc001ohi.3. human.

Organism-specific databases

CTDi254263.
GeneCardsiCNIH2.
HGNCiHGNC:28744. CNIH2.
HPAiHPA026976.
HPA038743.
MIMi611288. gene.
neXtProtiNX_Q6PI25.
PharmGKBiPA134887358.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2729. Eukaryota.
ENOG4111MWH. LUCA.
GeneTreeiENSGT00390000015751.
HOGENOMiHOG000214661.
HOVERGENiHBG003814.
InParanoidiQ6PI25.
OMAiIAFDERT.
PhylomeDBiQ6PI25.
TreeFamiTF300083.

Enzyme and pathway databases

ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-HSA-5694530. Cargo concentration in the ER.

Miscellaneous databases

ChiTaRSiCNIH2. human.
GenomeRNAii254263.
PROiQ6PI25.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PI25.
CleanExiHS_CNIH2.
ExpressionAtlasiQ6PI25. baseline and differential.
GenevisibleiQ6PI25. HS.

Family and domain databases

InterProiIPR003377. Cornichon.
IPR033466. Cornichon_conserved.
[Graphical view]
PfamiPF03311. Cornichon. 1 hit.
[Graphical view]
SMARTiSM01398. Cornichon. 1 hit.
[Graphical view]
PROSITEiPS01340. CORNICHON. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  2. "Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating."
    Shi Y., Suh Y.H., Milstein A.D., Isozaki K., Schmid S.M., Roche K.W., Nicoll R.A.
    Proc. Natl. Acad. Sci. U.S.A. 107:16315-16319(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH GRIA1.
  3. "Upregulation of cornichon transcripts in the dorsolateral prefrontal cortex in schizophrenia."
    Drummond J.B., Simmons M., Haroutunian V., Meador-Woodruff J.H.
    NeuroReport 23:1031-1034(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiCNIH2_HUMAN
AccessioniPrimary (citable) accession number: Q6PI25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.