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Protein

Putative RNA-binding protein 15B

Gene

Rbm15b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May function in the regulation of alternative or illicit splicing.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing, Transcription, Transcription regulation

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative RNA-binding protein 15B
Alternative name(s):
RNA-binding motif protein 15B
Gene namesi
Name:Rbm15b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1923598. Rbm15b.

Subcellular locationi

  • Nucleusnucleoplasm

  • Note: Localized in the nucleoplasm with a granular staining pattern and excluded from the nucleoli.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 887887Putative RNA-binding protein 15BPRO_0000081779Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei107 – 1071PhosphoserineCombined sources
Modified residuei111 – 1111PhosphoserineCombined sources
Modified residuei261 – 2611PhosphoserineCombined sources
Modified residuei263 – 2631PhosphoserineBy similarity
Modified residuei549 – 5491PhosphoserineBy similarity
Modified residuei559 – 5591PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PHZ5.
MaxQBiQ6PHZ5.
PaxDbiQ6PHZ5.
PRIDEiQ6PHZ5.

PTM databases

PhosphoSiteiQ6PHZ5.

Expressioni

Gene expression databases

BgeeiQ6PHZ5.
CleanExiMM_RBM15B.
ExpressionAtlasiQ6PHZ5. baseline and differential.
GenevisibleiQ6PHZ5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059330.

Structurei

Secondary structure

1
887
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi416 – 4194Combined sources
Helixi427 – 4359Combined sources
Beta strandi440 – 4456Combined sources
Beta strandi447 – 4493Combined sources
Beta strandi452 – 4587Combined sources
Helixi459 – 46911Combined sources
Beta strandi475 – 4784Combined sources
Beta strandi482 – 4854Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WHYNMR-A404-487[»]
ProteinModelPortaliQ6PHZ5.
SMRiQ6PHZ5. Positions 135-214, 314-489, 719-863.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6PHZ5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini136 – 21681RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini333 – 41078RRM 2PROSITE-ProRule annotationAdd
BLAST
Domaini414 – 48875RRM 3PROSITE-ProRule annotationAdd
BLAST
Domaini708 – 886179SPOCPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni719 – 887169Interaction with Epstein-Barr virus BMLF1By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi590 – 5945Nuclear localization signalSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi655 – 67420His-richAdd
BLAST

Sequence similaritiesi

Belongs to the RRM Spen family.Curated
Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation
Contains 1 SPOC domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0112. Eukaryota.
ENOG410XSAC. LUCA.
GeneTreeiENSGT00530000063730.
HOGENOMiHOG000006547.
HOVERGENiHBG058366.
InParanoidiQ6PHZ5.
KOiK13190.
OMAiCEFSQQY.
OrthoDBiEOG7QZG9W.
PhylomeDBiQ6PHZ5.
TreeFamiTF354224.

Family and domain databases

Gene3Di2.40.290.10. 1 hit.
3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR016194. SPOC-like_C_dom.
IPR012921. SPOC_C.
IPR010912. SPOC_met.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
PF07744. SPOC. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF100939. SSF100939. 1 hit.
SSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 3 hits.
PS50917. SPOC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PHZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRQSERDSS PSGRGSSSSA KRPREREREA EAGGRRAAHK ASGGTKHPVP
60 70 80 90 100
ARARDKPRGS GGGGGHRDGR AAGDANHRAS GGRSSGAPGG GGRTGKASGD
110 120 130 140 150
PGAGGASPRA SPLPPPPPPP GAEPAGPGST AAPEYKTLLI SSLSPALPAE
160 170 180 190 200
HLEDRLFHQF KRFGEISLRL SHTPELGRVA YVNFRHPQDA REARQHALAR
210 220 230 240 250
QLLLYDRPLK VEPVYLRGGG SSRRSSSSSA AASTPPPGPP APADPLGYLP
260 270 280 290 300
LHGGYQYKQR SLSPVAAPPL REPRARHAAA AFALDAAAAA AVGLSRERAL
310 320 330 340 350
DYYGLYDDRG RPYGYQAVCE EDLMPEDDQR ATRNLFIGNL DHSVSEVELR
360 370 380 390 400
RAFEKYGIIE EVVIKRPARG QGGAYAFLKF QNLDMAHRAK VAMSGRVIGR
410 420 430 440 450
NPIKIGYGKA NPTTRLWVGG LGPNTSLAAL AREFDRFGSI RTIDHVKGDS
460 470 480 490 500
FAYIQYESLD AAQAACAKMR GFPLGGPDRR LRVDFAKAEE TRYPQQYQPS
510 520 530 540 550
PLPVHYELLT DGYTRHRNLD ADLRVRDRTP PHLLYSDRDR TFLEGDWTSL
560 570 580 590 600
SKSSDRRNSL EGYSRSVRSR SGERWGGDGD RSIAKPWEER RKRRSLSSDR
610 620 630 640 650
GRTTHSPYEE RSRTKGGGQQ SERGSDRTPE RSRKENHSSE GTKESGSNSL
660 670 680 690 700
SNSRHGAEER SHHHHHHEAP DSSHGKKTRE SERNHRTTEA EPKTLEEPKH
710 720 730 740 750
ETKKLKTLSE YAQTLQLGWN GLLVLKNSCF PTSMHILEGD QGVISGLLKD
760 770 780 790 800
HPSGSKLTQL KIAQRLRLDQ PKLDEVTRRI KQGSPNGYAV LLAIQSTPSG
810 820 830 840 850
PGAEGMPVVE PGLQRRLLRN LVSYLKQKQA AGVISLPVGG SKGRDNTGML
860 870 880
YAFPPCDFSQ QYLQSALRTL GKLEEEHMVI VIVRDTA
Length:887
Mass (Da):97,076
Last modified:May 5, 2009 - v2
Checksum:iF9DFCA06595C5DCC
GO

Sequence cautioni

The sequence AAH52180.1 differs from that shown.Aberrant splicing.Curated
The sequence BAC35951.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC147636 Genomic DNA. No translation available.
BC052180 mRNA. Translation: AAH52180.1. Sequence problems.
AK075777 mRNA. Translation: BAC35951.1. Different initiation.
CCDSiCCDS52915.1.
RefSeqiNP_780611.3. NM_175402.4.
UniGeneiMm.431589.
Mm.491186.

Genome annotation databases

EnsembliENSMUST00000055843; ENSMUSP00000059330; ENSMUSG00000074102.
GeneIDi109095.
KEGGimmu:109095.
UCSCiuc012gzz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC147636 Genomic DNA. No translation available.
BC052180 mRNA. Translation: AAH52180.1. Sequence problems.
AK075777 mRNA. Translation: BAC35951.1. Different initiation.
CCDSiCCDS52915.1.
RefSeqiNP_780611.3. NM_175402.4.
UniGeneiMm.431589.
Mm.491186.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WHYNMR-A404-487[»]
ProteinModelPortaliQ6PHZ5.
SMRiQ6PHZ5. Positions 135-214, 314-489, 719-863.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059330.

PTM databases

PhosphoSiteiQ6PHZ5.

Proteomic databases

EPDiQ6PHZ5.
MaxQBiQ6PHZ5.
PaxDbiQ6PHZ5.
PRIDEiQ6PHZ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055843; ENSMUSP00000059330; ENSMUSG00000074102.
GeneIDi109095.
KEGGimmu:109095.
UCSCiuc012gzz.1. mouse.

Organism-specific databases

CTDi29890.
MGIiMGI:1923598. Rbm15b.

Phylogenomic databases

eggNOGiKOG0112. Eukaryota.
ENOG410XSAC. LUCA.
GeneTreeiENSGT00530000063730.
HOGENOMiHOG000006547.
HOVERGENiHBG058366.
InParanoidiQ6PHZ5.
KOiK13190.
OMAiCEFSQQY.
OrthoDBiEOG7QZG9W.
PhylomeDBiQ6PHZ5.
TreeFamiTF354224.

Miscellaneous databases

EvolutionaryTraceiQ6PHZ5.
NextBioi361644.
PROiQ6PHZ5.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PHZ5.
CleanExiMM_RBM15B.
ExpressionAtlasiQ6PHZ5. baseline and differential.
GenevisibleiQ6PHZ5. MM.

Family and domain databases

Gene3Di2.40.290.10. 1 hit.
3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR016194. SPOC-like_C_dom.
IPR012921. SPOC_C.
IPR010912. SPOC_met.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
PF07744. SPOC. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF100939. SSF100939. 1 hit.
SSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 3 hits.
PS50917. SPOC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 311-887.
    Tissue: Embryo.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 343-887.
    Strain: C57BL/6J.
    Tissue: Pancreas.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107; SER-111 AND SER-261, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Kidney, Pancreas, Spleen and Testis.
  5. "Solution structure of the RNA recognition motif from hypothetical RNA binding protein BC052180."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2004) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 404-487.

Entry informationi

Entry nameiRB15B_MOUSE
AccessioniPrimary (citable) accession number: Q6PHZ5
Secondary accession number(s): Q8C6G2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: May 5, 2009
Last modified: May 11, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.