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Protein

Putative RNA-binding protein 15B

Gene

Rbm15b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May function in the regulation of alternative or illicit splicing.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Putative RNA-binding protein 15B
Alternative name(s):
RNA-binding motif protein 15B
Gene namesi
Name:Rbm15b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1923598. Rbm15b.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000817791 – 887Putative RNA-binding protein 15BAdd BLAST887

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei107PhosphoserineCombined sources1
Modified residuei111PhosphoserineCombined sources1
Cross-linki210Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei261PhosphoserineCombined sources1
Modified residuei263PhosphoserineBy similarity1
Modified residuei529PhosphothreonineBy similarity1
Modified residuei549PhosphoserineBy similarity1
Modified residuei553PhosphoserineBy similarity1
Modified residuei559PhosphoserineBy similarity1
Cross-linki699Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ6PHZ5.
MaxQBiQ6PHZ5.
PaxDbiQ6PHZ5.
PeptideAtlasiQ6PHZ5.
PRIDEiQ6PHZ5.

PTM databases

iPTMnetiQ6PHZ5.
PhosphoSitePlusiQ6PHZ5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000074102.
CleanExiMM_RBM15B.
ExpressionAtlasiQ6PHZ5. baseline and differential.
GenevisibleiQ6PHZ5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059330.

Structurei

Secondary structure

1887
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi416 – 419Combined sources4
Helixi427 – 435Combined sources9
Beta strandi440 – 445Combined sources6
Beta strandi447 – 449Combined sources3
Beta strandi452 – 458Combined sources7
Helixi459 – 469Combined sources11
Beta strandi475 – 478Combined sources4
Beta strandi482 – 485Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WHYNMR-A404-487[»]
ProteinModelPortaliQ6PHZ5.
SMRiQ6PHZ5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6PHZ5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini136 – 216RRM 1PROSITE-ProRule annotationAdd BLAST81
Domaini333 – 410RRM 2PROSITE-ProRule annotationAdd BLAST78
Domaini414 – 488RRM 3PROSITE-ProRule annotationAdd BLAST75
Domaini708 – 886SPOCPROSITE-ProRule annotationAdd BLAST179

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni719 – 887Interaction with Epstein-Barr virus BMLF1By similarityAdd BLAST169

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi590 – 594Nuclear localization signalSequence analysis5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi655 – 674His-richAdd BLAST20

Sequence similaritiesi

Belongs to the RRM Spen family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0112. Eukaryota.
ENOG410XSAC. LUCA.
GeneTreeiENSGT00530000063730.
HOGENOMiHOG000006547.
HOVERGENiHBG058366.
InParanoidiQ6PHZ5.
KOiK13190.
OMAiCEFSQQY.
OrthoDBiEOG091G0615.
PhylomeDBiQ6PHZ5.
TreeFamiTF354224.

Family and domain databases

CDDicd12554. RRM1_RBM15B. 1 hit.
cd12556. RRM2_RBM15B. 1 hit.
cd12558. RRM3_RBM15B. 1 hit.
Gene3Di2.40.290.10. 1 hit.
InterProiView protein in InterPro
IPR034475. RBM15B_RRM1.
IPR034535. RBM15B_RRM2.
IPR034536. RBM15B_RRM3.
IPR000504. RRM_dom.
IPR016194. SPOC-like_C_dom.
IPR012921. SPOC_C.
IPR010912. SPOC_met.
PfamiView protein in Pfam
PF00076. RRM_1. 2 hits.
PF07744. SPOC. 1 hit.
SMARTiView protein in SMART
SM00360. RRM. 3 hits.
SUPFAMiSSF100939. SSF100939. 1 hit.
SSF54928. SSF54928. 2 hits.
PROSITEiView protein in PROSITE
PS50102. RRM. 3 hits.
PS50917. SPOC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6PHZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRQSERDSS PSGRGSSSSA KRPREREREA EAGGRRAAHK ASGGTKHPVP
60 70 80 90 100
ARARDKPRGS GGGGGHRDGR AAGDANHRAS GGRSSGAPGG GGRTGKASGD
110 120 130 140 150
PGAGGASPRA SPLPPPPPPP GAEPAGPGST AAPEYKTLLI SSLSPALPAE
160 170 180 190 200
HLEDRLFHQF KRFGEISLRL SHTPELGRVA YVNFRHPQDA REARQHALAR
210 220 230 240 250
QLLLYDRPLK VEPVYLRGGG SSRRSSSSSA AASTPPPGPP APADPLGYLP
260 270 280 290 300
LHGGYQYKQR SLSPVAAPPL REPRARHAAA AFALDAAAAA AVGLSRERAL
310 320 330 340 350
DYYGLYDDRG RPYGYQAVCE EDLMPEDDQR ATRNLFIGNL DHSVSEVELR
360 370 380 390 400
RAFEKYGIIE EVVIKRPARG QGGAYAFLKF QNLDMAHRAK VAMSGRVIGR
410 420 430 440 450
NPIKIGYGKA NPTTRLWVGG LGPNTSLAAL AREFDRFGSI RTIDHVKGDS
460 470 480 490 500
FAYIQYESLD AAQAACAKMR GFPLGGPDRR LRVDFAKAEE TRYPQQYQPS
510 520 530 540 550
PLPVHYELLT DGYTRHRNLD ADLRVRDRTP PHLLYSDRDR TFLEGDWTSL
560 570 580 590 600
SKSSDRRNSL EGYSRSVRSR SGERWGGDGD RSIAKPWEER RKRRSLSSDR
610 620 630 640 650
GRTTHSPYEE RSRTKGGGQQ SERGSDRTPE RSRKENHSSE GTKESGSNSL
660 670 680 690 700
SNSRHGAEER SHHHHHHEAP DSSHGKKTRE SERNHRTTEA EPKTLEEPKH
710 720 730 740 750
ETKKLKTLSE YAQTLQLGWN GLLVLKNSCF PTSMHILEGD QGVISGLLKD
760 770 780 790 800
HPSGSKLTQL KIAQRLRLDQ PKLDEVTRRI KQGSPNGYAV LLAIQSTPSG
810 820 830 840 850
PGAEGMPVVE PGLQRRLLRN LVSYLKQKQA AGVISLPVGG SKGRDNTGML
860 870 880
YAFPPCDFSQ QYLQSALRTL GKLEEEHMVI VIVRDTA
Length:887
Mass (Da):97,076
Last modified:May 5, 2009 - v2
Checksum:iF9DFCA06595C5DCC
GO

Sequence cautioni

The sequence AAH52180 differs from that shown. Aberrant splicing.Curated
The sequence BAC35951 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC147636 Genomic DNA. No translation available.
BC052180 mRNA. Translation: AAH52180.1. Sequence problems.
AK075777 mRNA. Translation: BAC35951.1. Different initiation.
CCDSiCCDS52915.1.
RefSeqiNP_780611.3. NM_175402.4.
UniGeneiMm.431589.
Mm.491186.

Genome annotation databases

EnsembliENSMUST00000055843; ENSMUSP00000059330; ENSMUSG00000074102.
GeneIDi109095.
KEGGimmu:109095.
UCSCiuc012gzz.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiRB15B_MOUSE
AccessioniPrimary (citable) accession number: Q6PHZ5
Secondary accession number(s): Q8C6G2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: May 5, 2009
Last modified: August 30, 2017
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families