SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6PHW0

- IYD1_HUMAN

UniProt

Q6PHW0 - IYD1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Iodotyrosine dehalogenase 1
Gene
IYD, C6orf71, DEHAL1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine.1 Publication

Catalytic activityi

L-tyrosine + 2 NADP+ + 2 I- = 3,5-diiodo-L-tyrosine + 2 NADPH.

Cofactori

FMN Inferred.

Kineticsi

  1. KM=2.67 µM for L-DIT1 Publication
  2. KM=1.35 µM for L-MIT

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei104 – 1041Substrate By similarity
Binding sitei161 – 1611Substrate By similarity
Binding sitei182 – 1821Substrate By similarity
Binding sitei279 – 2791FMN By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi100 – 1045FMN By similarity
Nucleotide bindingi127 – 1293FMN By similarity
Nucleotide bindingi236 – 2394FMN By similarity

GO - Molecular functioni

  1. iodide peroxidase activity Source: Ensembl
  2. oxidoreductase activity Source: Reactome
Complete GO annotation...

GO - Biological processi

  1. cellular nitrogen compound metabolic process Source: Reactome
  2. small molecule metabolic process Source: Reactome
  3. thyroid hormone generation Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Flavoprotein, FMN, NADP

Enzyme and pathway databases

ReactomeiREACT_15292. Thyroxine biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Iodotyrosine dehalogenase 1 (EC:1.22.1.1)
Short name:
IYD-1
Gene namesi
Name:IYD
Synonyms:C6orf71, DEHAL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:21071. IYD.

Subcellular locationi

Cell membrane; Single-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 214191Extracellular Reviewed prediction
Add
BLAST
Transmembranei215 – 23521Helical; Reviewed prediction
Add
BLAST
Topological domaini236 – 28954Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Thyroid dyshormonogenesis 4 (TDH4) [MIM:274800]: A disorder due to thyroid dyshormonogenesis, causing severe hypothyroidism, goiter, excessive levels of iodotyrosine in serum and urine, and variable mental deficits derived from unrecognized and untreated hypothyroidism.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti101 – 1011R → W in TDH4; strongly reduces activity; does not respond to the increase of flavin mononucleotide concentration. 1 Publication
VAR_045963
Natural varianti105 – 1062FI → L in TDH4; strongly reduces activity; does not respond to the increase of flavin mononucleotide concentration.
VAR_045964
Natural varianti116 – 1161I → T in TDH4; strongly reduces activity; marginally respond to the increase of flavin mononucleotide concentration; reduces protein stability. 1 Publication
VAR_045965

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi101 – 1011R → A: Strongly reduces activity. 1 Publication
Mutagenesisi101 – 1011R → H: Reduces activity. 1 Publication
Mutagenesisi105 – 1051F → A: Activity as the wild type. 1 Publication
Mutagenesisi105 – 1051F → Y: Activity as the wild type. 1 Publication
Mutagenesisi116 – 1161I → V: Activity as the wild type. 1 Publication

Keywords - Diseasei

Congenital hypothyroidism, Disease mutation

Organism-specific databases

MIMi274800. phenotype.
Orphaneti95716. Familial thyroid dyshormonogenesis.
PharmGKBiPA162392352.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 289266Iodotyrosine dehalogenase 1
PRO_0000230278Add
BLAST

Proteomic databases

PaxDbiQ6PHW0.
PRIDEiQ6PHW0.

PTM databases

PhosphoSiteiQ6PHW0.

Expressioni

Tissue specificityi

Expressed at a high level in thyroid gland and at lower level in kidney and trachea.1 Publication

Gene expression databases

BgeeiQ6PHW0.
GenevestigatoriQ6PHW0.

Organism-specific databases

HPAiHPA059627.

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ6PHW0.
SMRiQ6PHW0. Positions 70-289.

Family & Domainsi

Sequence similaritiesi

Belongs to the nitroreductase family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0778.
HOVERGENiHBG055004.
KOiK17231.
OMAiQTARHRH.
OrthoDBiEOG7HMS24.
PhylomeDBiQ6PHW0.
TreeFamiTF313415.

Family and domain databases

Gene3Di3.40.109.10. 1 hit.
InterProiIPR029479. Nitroreductase.
IPR000415. Nitroreductase-like.
[Graphical view]
PfamiPF00881. Nitroreductase. 1 hit.
[Graphical view]
SUPFAMiSSF55469. SSF55469. 1 hit.

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6PHW0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MYFLTPILVA ILCILVVWIF KNADRSMEKK KGEPRTRAEA RPWVDEDLKD    50
SSDLHQAEED ADEWQESEEN VEHIPFSHNH YPEKEMVKRS QEFYELLNKR 100
RSVRFISNEQ VPMEVIDNVI RTAGTAPSGA HTEPWTFVVV KDPDVKHKIR 150
KIIEEEEEIN YMKRMGHRWV TDLKKLRTNW IKEYLDTAPI LILIFKQVHG 200
FAANGKKKVH YYNEISVSIA CGILLAALQN AGLVTVTTTP LNCGPRLRVL 250
LGRPAHEKLL MLLPVGYPSK EATVPDLKRK PLDQIMVTV 289
Length:289
Mass (Da):33,360
Last modified:April 4, 2006 - v2
Checksum:iB73560A682BF6045
GO
Isoform 3 (identifier: Q6PHW0-3) [UniParc]FASTAAdd to Basket

Also known as: E

The sequence of this isoform differs from the canonical sequence as follows:
     230-248: NAGLVTVTTTPLNCGPRLR → VFGKIILKELALISFLNL
     249-289: Missing.

Show »
Length:247
Mass (Da):28,858
Checksum:i256CCEE175E985A1
GO
Isoform 4 (identifier: Q6PHW0-4) [UniParc]FASTAAdd to Basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     230-289: NAGLVTVTTT...KPLDQIMVTV → VNNGITMRHQ...TEGAPGPPRT

Show »
Length:293
Mass (Da):33,781
Checksum:i2DEF1D502CC9F28E
GO
Isoform 5 (identifier: Q6PHW0-5) [UniParc]FASTAAdd to Basket

Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     230-284: NAGLVTVTTT...PDLKRKPLDQ → VNNGITMRHQ...FHFAIEFAAP
     285-289: Missing.

Show »
Length:284
Mass (Da):32,642
Checksum:i2C8639AEB123CF4F
GO
Isoform 6 (identifier: Q6PHW0-6) [UniParc]FASTAAdd to Basket

Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     230-270: NAGLVTVTTT...MLLPVGYPSK → VNNGITMRHQ...SSQGRPGFYC
     271-289: Missing.

Show »
Length:270
Mass (Da):31,367
Checksum:i501B6AC58642354A
GO
Isoform 7 (identifier: Q6PHW0-7) [UniParc]FASTAAdd to Basket

Also known as: F

The sequence of this isoform differs from the canonical sequence as follows:
     1-55: Missing.
     56-61: QAEEDA → MKEADV
     230-248: NAGLVTVTTTPLNCGPRLR → VFGKIILKELALISFLNL
     249-289: Missing.

Show »
Length:192
Mass (Da):22,460
Checksum:i5EFAEB7D3AF9FFBC
GO

Sequence cautioni

The sequence BAC85255.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti101 – 1011R → W in TDH4; strongly reduces activity; does not respond to the increase of flavin mononucleotide concentration. 1 Publication
VAR_045963
Natural varianti105 – 1062FI → L in TDH4; strongly reduces activity; does not respond to the increase of flavin mononucleotide concentration.
VAR_045964
Natural varianti116 – 1161I → T in TDH4; strongly reduces activity; marginally respond to the increase of flavin mononucleotide concentration; reduces protein stability. 1 Publication
VAR_045965
Natural varianti260 – 2601L → P.1 Publication
Corresponds to variant rs17854906 [ dbSNP | Ensembl ].
VAR_025785
Natural varianti271 – 2711E → K.
Corresponds to variant rs36063028 [ dbSNP | Ensembl ].
VAR_045966

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5555Missing in isoform 7.
VSP_017802Add
BLAST
Alternative sequencei56 – 616QAEEDA → MKEADV in isoform 7.
VSP_017803
Alternative sequencei230 – 28960NAGLV…IMVTV → VNNGITMRHQTARHRHLIEG PGRSSEACSKLSSQGCPECR SGDCHYHSSQLWPSTEGAPG PPRT in isoform 4.
VSP_017805Add
BLAST
Alternative sequencei230 – 28455NAGLV…KPLDQ → VNNGITMRHQTARHRHLIEG PGRSSEACSKLSSQGRPGAS AAGSLFHFAIEFAAP in isoform 5.
VSP_017806Add
BLAST
Alternative sequencei230 – 27041NAGLV…GYPSK → VNNGITMRHQTARHRHLIEG PGRSSEACSKLSSQGRPGFY C in isoform 6.
VSP_017807Add
BLAST
Alternative sequencei230 – 24819NAGLV…GPRLR → VFGKIILKELALISFLNL in isoform 3 and isoform 7.
VSP_017809Add
BLAST
Alternative sequencei249 – 28941Missing in isoform 3 and isoform 7.
VSP_017810Add
BLAST
Alternative sequencei271 – 28919Missing in isoform 6.
VSP_017812Add
BLAST
Alternative sequencei285 – 2895Missing in isoform 5.
VSP_017813

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Isoform 4 (identifier: Q6PHW0-4)
Sequence conflicti265 – 2651C → R in AAP22073. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY259176 mRNA. Translation: AAP22072.1.
AY259177 mRNA. Translation: AAP22073.1.
AY424901 mRNA. Translation: AAR84259.1.
AY424902 mRNA. Translation: AAR84260.1.
AY957659 mRNA. Translation: AAY41465.1.
AY957660 mRNA. Translation: AAY41466.1.
AY957661 mRNA. Translation: AAY41467.1. Sequence problems.
AL031010 Genomic DNA. No translation available.
BC056253 mRNA. Translation: AAH56253.1.
AK129950 mRNA. Translation: BAC85255.1. Different initiation.
CCDSiCCDS5227.1. [Q6PHW0-1]
CCDS55066.1. [Q6PHW0-3]
CCDS55067.1. [Q6PHW0-4]
RefSeqiNP_001158166.1. NM_001164694.1. [Q6PHW0-4]
NP_001158167.1. NM_001164695.1. [Q6PHW0-3]
NP_981932.1. NM_203395.2. [Q6PHW0-1]
UniGeneiHs.310225.

Genome annotation databases

EnsembliENST00000229447; ENSP00000229447; ENSG00000009765. [Q6PHW0-4]
ENST00000344419; ENSP00000343763; ENSG00000009765. [Q6PHW0-1]
ENST00000367335; ENSP00000356304; ENSG00000009765. [Q6PHW0-3]
ENST00000392256; ENSP00000376085; ENSG00000009765. [Q6PHW0-3]
GeneIDi389434.
KEGGihsa:389434.
UCSCiuc003qnu.2. human. [Q6PHW0-1]
uc003qnv.2. human. [Q6PHW0-3]

Polymorphism databases

DMDMi91207083.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY259176 mRNA. Translation: AAP22072.1 .
AY259177 mRNA. Translation: AAP22073.1 .
AY424901 mRNA. Translation: AAR84259.1 .
AY424902 mRNA. Translation: AAR84260.1 .
AY957659 mRNA. Translation: AAY41465.1 .
AY957660 mRNA. Translation: AAY41466.1 .
AY957661 mRNA. Translation: AAY41467.1 . Sequence problems.
AL031010 Genomic DNA. No translation available.
BC056253 mRNA. Translation: AAH56253.1 .
AK129950 mRNA. Translation: BAC85255.1 . Different initiation.
CCDSi CCDS5227.1. [Q6PHW0-1 ]
CCDS55066.1. [Q6PHW0-3 ]
CCDS55067.1. [Q6PHW0-4 ]
RefSeqi NP_001158166.1. NM_001164694.1. [Q6PHW0-4 ]
NP_001158167.1. NM_001164695.1. [Q6PHW0-3 ]
NP_981932.1. NM_203395.2. [Q6PHW0-1 ]
UniGenei Hs.310225.

3D structure databases

ProteinModelPortali Q6PHW0.
SMRi Q6PHW0. Positions 70-289.
ModBasei Search...

PTM databases

PhosphoSitei Q6PHW0.

Polymorphism databases

DMDMi 91207083.

Proteomic databases

PaxDbi Q6PHW0.
PRIDEi Q6PHW0.

Protocols and materials databases

DNASUi 389434.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000229447 ; ENSP00000229447 ; ENSG00000009765 . [Q6PHW0-4 ]
ENST00000344419 ; ENSP00000343763 ; ENSG00000009765 . [Q6PHW0-1 ]
ENST00000367335 ; ENSP00000356304 ; ENSG00000009765 . [Q6PHW0-3 ]
ENST00000392256 ; ENSP00000376085 ; ENSG00000009765 . [Q6PHW0-3 ]
GeneIDi 389434.
KEGGi hsa:389434.
UCSCi uc003qnu.2. human. [Q6PHW0-1 ]
uc003qnv.2. human. [Q6PHW0-3 ]

Organism-specific databases

CTDi 389434.
GeneCardsi GC06P150731.
H-InvDBi HIX0025059.
HGNCi HGNC:21071. IYD.
HPAi HPA059627.
MIMi 274800. phenotype.
612025. gene.
neXtProti NX_Q6PHW0.
Orphaneti 95716. Familial thyroid dyshormonogenesis.
PharmGKBi PA162392352.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0778.
HOVERGENi HBG055004.
KOi K17231.
OMAi QTARHRH.
OrthoDBi EOG7HMS24.
PhylomeDBi Q6PHW0.
TreeFami TF313415.

Enzyme and pathway databases

Reactomei REACT_15292. Thyroxine biosynthesis.

Miscellaneous databases

GeneWikii Iodotyrosine_deiodinase.
GenomeRNAii 389434.
NextBioi 102878.
PROi Q6PHW0.
SOURCEi Search...

Gene expression databases

Bgeei Q6PHW0.
Genevestigatori Q6PHW0.

Family and domain databases

Gene3Di 3.40.109.10. 1 hit.
InterProi IPR029479. Nitroreductase.
IPR000415. Nitroreductase-like.
[Graphical view ]
Pfami PF00881. Nitroreductase. 1 hit.
[Graphical view ]
SUPFAMi SSF55469. SSF55469. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel thyroidal gene encoding proteins with a conserved nitroreductase domain."
    Moreno J.C., Keijser R., Aarraas S., De Vijlder J.J.M., Ris-Stalpers C.
    J. Endocrinol. Invest. 25 Suppl. 7:S23-S23(2002)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 4 AND 5).
    Tissue: Thyroid.
  2. "Cloning and characterization of the human iodotyrosine dehalogenase isoform 1C."
    Gnidehou S., Ohayon R., Kaniewski J., Morand S., Noel-Hudson M.-S., Virion A., Dupuy C.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6).
    Tissue: Thyroid.
  3. "New transcript variants of the human iodotyrosine dehalogenase gene."
    Rodrigues-Serpa A.R., Laires R.S., Monteiro C.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 7).
    Tissue: Thyroid.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT PRO-260.
    Tissue: Kidney.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 11-289 (ISOFORM 1).
    Tissue: Kidney.
  7. "Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide close to the thyroglobulin iodination site."
    Gnidehou S., Caillou B., Talbot M., Ohayon R., Kaniewski J., Noel-Hudson M.-S., Morand S., Agnangji D., Sezan A., Courtin F., Virion A., Dupuy C.
    FASEB J. 18:1574-1576(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  8. Cited for: VARIANTS TDH4 TRP-101; 105-PHE-ISO-106 DELINS LEU AND THR-116, CHARACTERIZATION OF VARIANTS TDH4 TRP-101; 105-PHE-ISO-106 DELINS LEU AND THR-116, MUTAGENESIS OF ARG-101; PHE-105 AND ILE-116.

Entry informationi

Entry nameiIYD1_HUMAN
AccessioniPrimary (citable) accession number: Q6PHW0
Secondary accession number(s): C9JFW2
, Q2VPW0, Q2VPW1, Q5F1L5, Q5F1L6, Q5THM4, Q6ZP69, Q7Z7D7, Q7Z7D8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: September 3, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi