Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Iodotyrosine dehalogenase 1

Gene

IYD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine.1 Publication

Catalytic activityi

L-tyrosine + 2 NADP+ + 2 I- = 3,5-diiodo-L-tyrosine + 2 NADPH.

Cofactori

FMNCurated

Kineticsi

  1. KM=2.67 µM for L-DIT1 Publication
  2. KM=1.35 µM for L-MIT1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei104 – 1041SubstrateBy similarity
    Binding sitei161 – 1611SubstrateBy similarity
    Binding sitei182 – 1821SubstrateBy similarity
    Binding sitei279 – 2791FMNBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi100 – 1045FMNBy similarity
    Nucleotide bindingi127 – 1293FMNBy similarity
    Nucleotide bindingi236 – 2394FMNBy similarity

    GO - Molecular functioni

    GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Flavoprotein, FMN, NADP

    Enzyme and pathway databases

    BRENDAi1.22.1.1. 2681.
    ReactomeiREACT_15292. Thyroxine biosynthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Iodotyrosine dehalogenase 1 (EC:1.22.1.1)
    Short name:
    IYD-1
    Gene namesi
    Name:IYD
    Synonyms:C6orf71, DEHAL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640 Componenti: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:21071. IYD.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 214191ExtracellularSequence AnalysisAdd
    BLAST
    Transmembranei215 – 23521HelicalSequence AnalysisAdd
    BLAST
    Topological domaini236 – 28954CytoplasmicSequence AnalysisAdd
    BLAST

    GO - Cellular componenti

    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Thyroid dyshormonogenesis 4 (TDH4)1 Publication

    The disease is caused by mutations affecting the gene represented in this entry.

    Disease descriptionA disorder due to thyroid dyshormonogenesis, causing severe hypothyroidism, goiter, excessive levels of iodotyrosine in serum and urine, and variable mental deficits derived from unrecognized and untreated hypothyroidism.

    See also OMIM:274800
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti101 – 1011R → W in TDH4; strongly reduces activity; does not respond to the increase of flavin mononucleotide concentration. 1 Publication
    VAR_045963
    Natural varianti105 – 1062FI → L in TDH4; strongly reduces activity; does not respond to the increase of flavin mononucleotide concentration.
    VAR_045964
    Natural varianti116 – 1161I → T in TDH4; strongly reduces activity; marginally respond to the increase of flavin mononucleotide concentration; reduces protein stability. 1 Publication
    VAR_045965

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi101 – 1011R → A: Strongly reduces activity. 1 Publication
    Mutagenesisi101 – 1011R → H: Reduces activity. 1 Publication
    Mutagenesisi105 – 1051F → A: Activity as the wild type. 1 Publication
    Mutagenesisi105 – 1051F → Y: Activity as the wild type. 1 Publication
    Mutagenesisi116 – 1161I → V: Activity as the wild type. 1 Publication

    Keywords - Diseasei

    Congenital hypothyroidism, Disease mutation

    Organism-specific databases

    MIMi274800. phenotype.
    Orphaneti95716. Familial thyroid dyshormonogenesis.
    PharmGKBiPA162392352.

    Polymorphism and mutation databases

    BioMutaiIYD.
    DMDMi91207083.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 289266Iodotyrosine dehalogenase 1PRO_0000230278Add
    BLAST

    Proteomic databases

    PaxDbiQ6PHW0.
    PRIDEiQ6PHW0.

    PTM databases

    PhosphoSiteiQ6PHW0.

    Expressioni

    Tissue specificityi

    Expressed at a high level in thyroid gland and at lower level in kidney and trachea.1 Publication

    Gene expression databases

    BgeeiQ6PHW0.
    ExpressionAtlasiQ6PHW0. baseline and differential.
    GenevisibleiQ6PHW0. HS.

    Organism-specific databases

    HPAiHPA059627.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TRIM69Q86WT63EBI-10253668,EBI-749955

    Protein-protein interaction databases

    BioGridi133150. 3 interactions.
    IntActiQ6PHW0. 1 interaction.
    STRINGi9606.ENSP00000229447.

    Structurei

    Secondary structure

    1
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi73 – 753Combined sources
    Beta strandi77 – 793Combined sources
    Helixi83 – 9816Combined sources
    Helixi113 – 12311Combined sources
    Helixi129 – 1313Combined sources
    Beta strandi135 – 1406Combined sources
    Helixi143 – 15715Combined sources
    Helixi167 – 1726Combined sources
    Helixi174 – 1763Combined sources
    Helixi184 – 1874Combined sources
    Beta strandi188 – 19710Combined sources
    Beta strandi207 – 2093Combined sources
    Helixi213 – 23119Combined sources
    Helixi244 – 2507Combined sources
    Beta strandi255 – 26612Combined sources
    Beta strandi273 – 2753Combined sources
    Helixi282 – 2843Combined sources
    Beta strandi286 – 2894Combined sources

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4TTBX-ray2.45A/B32-289[»]
    4TTCX-ray2.65A/B/C/D/E/F32-289[»]
    ProteinModelPortaliQ6PHW0.
    SMRiQ6PHW0. Positions 71-289.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the nitroreductase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0778.
    GeneTreeiENSGT00390000004348.
    HOGENOMiHOG000146731.
    HOVERGENiHBG055004.
    InParanoidiQ6PHW0.
    KOiK17231.
    OMAiVHESVGI.
    OrthoDBiEOG7HMS24.
    PhylomeDBiQ6PHW0.
    TreeFamiTF313415.

    Family and domain databases

    Gene3Di3.40.109.10. 1 hit.
    InterProiIPR029479. Nitroreductase.
    IPR000415. Nitroreductase-like.
    [Graphical view]
    PfamiPF00881. Nitroreductase. 1 hit.
    [Graphical view]
    SUPFAMiSSF55469. SSF55469. 1 hit.

    Sequences (6)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

    Isoform 1 (identifier: Q6PHW0-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MYFLTPILVA ILCILVVWIF KNADRSMEKK KGEPRTRAEA RPWVDEDLKD
    60 70 80 90 100
    SSDLHQAEED ADEWQESEEN VEHIPFSHNH YPEKEMVKRS QEFYELLNKR
    110 120 130 140 150
    RSVRFISNEQ VPMEVIDNVI RTAGTAPSGA HTEPWTFVVV KDPDVKHKIR
    160 170 180 190 200
    KIIEEEEEIN YMKRMGHRWV TDLKKLRTNW IKEYLDTAPI LILIFKQVHG
    210 220 230 240 250
    FAANGKKKVH YYNEISVSIA CGILLAALQN AGLVTVTTTP LNCGPRLRVL
    260 270 280
    LGRPAHEKLL MLLPVGYPSK EATVPDLKRK PLDQIMVTV
    Length:289
    Mass (Da):33,360
    Last modified:April 4, 2006 - v2
    Checksum:iB73560A682BF6045
    GO
    Isoform 3 (identifier: Q6PHW0-3) [UniParc]FASTAAdd to basket

    Also known as: E

    The sequence of this isoform differs from the canonical sequence as follows:
         230-248: NAGLVTVTTTPLNCGPRLR → VFGKIILKELALISFLNL
         249-289: Missing.

    Show »
    Length:247
    Mass (Da):28,858
    Checksum:i256CCEE175E985A1
    GO
    Isoform 4 (identifier: Q6PHW0-4) [UniParc]FASTAAdd to basket

    Also known as: B

    The sequence of this isoform differs from the canonical sequence as follows:
         230-289: NAGLVTVTTT...KPLDQIMVTV → VNNGITMRHQ...TEGAPGPPRT

    Show »
    Length:293
    Mass (Da):33,781
    Checksum:i2DEF1D502CC9F28E
    GO
    Isoform 5 (identifier: Q6PHW0-5) [UniParc]FASTAAdd to basket

    Also known as: C

    The sequence of this isoform differs from the canonical sequence as follows:
         230-284: NAGLVTVTTT...PDLKRKPLDQ → VNNGITMRHQ...FHFAIEFAAP
         285-289: Missing.

    Show »
    Length:284
    Mass (Da):32,642
    Checksum:i2C8639AEB123CF4F
    GO
    Isoform 6 (identifier: Q6PHW0-6) [UniParc]FASTAAdd to basket

    Also known as: D

    The sequence of this isoform differs from the canonical sequence as follows:
         230-270: NAGLVTVTTT...MLLPVGYPSK → VNNGITMRHQ...SSQGRPGFYC
         271-289: Missing.

    Show »
    Length:270
    Mass (Da):31,367
    Checksum:i501B6AC58642354A
    GO
    Isoform 7 (identifier: Q6PHW0-7) [UniParc]FASTAAdd to basket

    Also known as: F

    The sequence of this isoform differs from the canonical sequence as follows:
         1-55: Missing.
         56-61: QAEEDA → MKEADV
         230-248: NAGLVTVTTTPLNCGPRLR → VFGKIILKELALISFLNL
         249-289: Missing.

    Show »
    Length:192
    Mass (Da):22,460
    Checksum:i5EFAEB7D3AF9FFBC
    GO

    Sequence cautioni

    The sequence AAY41467.1 differs from that shown. Reason: Erroneous translation. Curated
    The sequence BAC85255.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Isoform 4 (identifier: Q6PHW0-4)
    Sequence conflicti265 – 2651C → R in AAP22073 (Ref. 1) Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti101 – 1011R → W in TDH4; strongly reduces activity; does not respond to the increase of flavin mononucleotide concentration. 1 Publication
    VAR_045963
    Natural varianti105 – 1062FI → L in TDH4; strongly reduces activity; does not respond to the increase of flavin mononucleotide concentration.
    VAR_045964
    Natural varianti116 – 1161I → T in TDH4; strongly reduces activity; marginally respond to the increase of flavin mononucleotide concentration; reduces protein stability. 1 Publication
    VAR_045965
    Natural varianti260 – 2601L → P.1 Publication
    Corresponds to variant rs17854906 [ dbSNP | Ensembl ].
    VAR_025785
    Natural varianti271 – 2711E → K.
    Corresponds to variant rs36063028 [ dbSNP | Ensembl ].
    VAR_045966

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5555Missing in isoform 7. 1 PublicationVSP_017802Add
    BLAST
    Alternative sequencei56 – 616QAEEDA → MKEADV in isoform 7. 1 PublicationVSP_017803
    Alternative sequencei230 – 28960NAGLV…IMVTV → VNNGITMRHQTARHRHLIEG PGRSSEACSKLSSQGCPECR SGDCHYHSSQLWPSTEGAPG PPRT in isoform 4. 1 PublicationVSP_017805Add
    BLAST
    Alternative sequencei230 – 28455NAGLV…KPLDQ → VNNGITMRHQTARHRHLIEG PGRSSEACSKLSSQGRPGAS AAGSLFHFAIEFAAP in isoform 5. 1 PublicationVSP_017806Add
    BLAST
    Alternative sequencei230 – 27041NAGLV…GYPSK → VNNGITMRHQTARHRHLIEG PGRSSEACSKLSSQGRPGFY C in isoform 6. 1 PublicationVSP_017807Add
    BLAST
    Alternative sequencei230 – 24819NAGLV…GPRLR → VFGKIILKELALISFLNL in isoform 3 and isoform 7. 1 PublicationVSP_017809Add
    BLAST
    Alternative sequencei249 – 28941Missing in isoform 3 and isoform 7. 1 PublicationVSP_017810Add
    BLAST
    Alternative sequencei271 – 28919Missing in isoform 6. 1 PublicationVSP_017812Add
    BLAST
    Alternative sequencei285 – 2895Missing in isoform 5. 1 PublicationVSP_017813

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AY259176 mRNA. Translation: AAP22072.1.
    AY259177 mRNA. Translation: AAP22073.1.
    AY424901 mRNA. Translation: AAR84259.1.
    AY424902 mRNA. Translation: AAR84260.1.
    AY957659 mRNA. Translation: AAY41465.1.
    AY957660 mRNA. Translation: AAY41466.1.
    AY957661 mRNA. Translation: AAY41467.1. Sequence problems.
    AL031010 Genomic DNA. No translation available.
    BC056253 mRNA. Translation: AAH56253.1.
    AK129950 mRNA. Translation: BAC85255.1. Different initiation.
    CCDSiCCDS5227.1. [Q6PHW0-1]
    CCDS55066.1. [Q6PHW0-3]
    CCDS55067.1. [Q6PHW0-4]
    RefSeqiNP_001158166.1. NM_001164694.1. [Q6PHW0-4]
    NP_001158167.1. NM_001164695.1. [Q6PHW0-3]
    NP_981932.1. NM_203395.2. [Q6PHW0-1]
    UniGeneiHs.310225.

    Genome annotation databases

    EnsembliENST00000229447; ENSP00000229447; ENSG00000009765. [Q6PHW0-4]
    ENST00000344419; ENSP00000343763; ENSG00000009765.
    ENST00000367335; ENSP00000356304; ENSG00000009765. [Q6PHW0-3]
    ENST00000392256; ENSP00000376085; ENSG00000009765. [Q6PHW0-3]
    GeneIDi389434.
    KEGGihsa:389434.
    UCSCiuc003qnu.2. human. [Q6PHW0-1]
    uc003qnv.2. human. [Q6PHW0-3]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AY259176 mRNA. Translation: AAP22072.1.
    AY259177 mRNA. Translation: AAP22073.1.
    AY424901 mRNA. Translation: AAR84259.1.
    AY424902 mRNA. Translation: AAR84260.1.
    AY957659 mRNA. Translation: AAY41465.1.
    AY957660 mRNA. Translation: AAY41466.1.
    AY957661 mRNA. Translation: AAY41467.1. Sequence problems.
    AL031010 Genomic DNA. No translation available.
    BC056253 mRNA. Translation: AAH56253.1.
    AK129950 mRNA. Translation: BAC85255.1. Different initiation.
    CCDSiCCDS5227.1. [Q6PHW0-1]
    CCDS55066.1. [Q6PHW0-3]
    CCDS55067.1. [Q6PHW0-4]
    RefSeqiNP_001158166.1. NM_001164694.1. [Q6PHW0-4]
    NP_001158167.1. NM_001164695.1. [Q6PHW0-3]
    NP_981932.1. NM_203395.2. [Q6PHW0-1]
    UniGeneiHs.310225.

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4TTBX-ray2.45A/B32-289[»]
    4TTCX-ray2.65A/B/C/D/E/F32-289[»]
    ProteinModelPortaliQ6PHW0.
    SMRiQ6PHW0. Positions 71-289.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi133150. 3 interactions.
    IntActiQ6PHW0. 1 interaction.
    STRINGi9606.ENSP00000229447.

    PTM databases

    PhosphoSiteiQ6PHW0.

    Polymorphism and mutation databases

    BioMutaiIYD.
    DMDMi91207083.

    Proteomic databases

    PaxDbiQ6PHW0.
    PRIDEiQ6PHW0.

    Protocols and materials databases

    DNASUi389434.
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000229447; ENSP00000229447; ENSG00000009765. [Q6PHW0-4]
    ENST00000344419; ENSP00000343763; ENSG00000009765.
    ENST00000367335; ENSP00000356304; ENSG00000009765. [Q6PHW0-3]
    ENST00000392256; ENSP00000376085; ENSG00000009765. [Q6PHW0-3]
    GeneIDi389434.
    KEGGihsa:389434.
    UCSCiuc003qnu.2. human. [Q6PHW0-1]
    uc003qnv.2. human. [Q6PHW0-3]

    Organism-specific databases

    CTDi389434.
    GeneCardsiGC06P150731.
    H-InvDBHIX0025059.
    HGNCiHGNC:21071. IYD.
    HPAiHPA059627.
    MIMi274800. phenotype.
    612025. gene.
    neXtProtiNX_Q6PHW0.
    Orphaneti95716. Familial thyroid dyshormonogenesis.
    PharmGKBiPA162392352.
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiCOG0778.
    GeneTreeiENSGT00390000004348.
    HOGENOMiHOG000146731.
    HOVERGENiHBG055004.
    InParanoidiQ6PHW0.
    KOiK17231.
    OMAiVHESVGI.
    OrthoDBiEOG7HMS24.
    PhylomeDBiQ6PHW0.
    TreeFamiTF313415.

    Enzyme and pathway databases

    BRENDAi1.22.1.1. 2681.
    ReactomeiREACT_15292. Thyroxine biosynthesis.

    Miscellaneous databases

    ChiTaRSiIYD. human.
    GeneWikiiIodotyrosine_deiodinase.
    GenomeRNAii389434.
    NextBioi102878.
    PROiQ6PHW0.
    SOURCEiSearch...

    Gene expression databases

    BgeeiQ6PHW0.
    ExpressionAtlasiQ6PHW0. baseline and differential.
    GenevisibleiQ6PHW0. HS.

    Family and domain databases

    Gene3Di3.40.109.10. 1 hit.
    InterProiIPR029479. Nitroreductase.
    IPR000415. Nitroreductase-like.
    [Graphical view]
    PfamiPF00881. Nitroreductase. 1 hit.
    [Graphical view]
    SUPFAMiSSF55469. SSF55469. 1 hit.
    ProtoNetiSearch...

    Publicationsi

    « Hide 'large scale' publications
    1. "Cloning and characterization of a novel thyroidal gene encoding proteins with a conserved nitroreductase domain."
      Moreno J.C., Keijser R., Aarraas S., De Vijlder J.J.M., Ris-Stalpers C.
      J. Endocrinol. Invest. 25 Suppl. 7:S23-S23(2002)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 4 AND 5).
      Tissue: Thyroid.
    2. "Cloning and characterization of the human iodotyrosine dehalogenase isoform 1C."
      Gnidehou S., Ohayon R., Kaniewski J., Morand S., Noel-Hudson M.-S., Virion A., Dupuy C.
      Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6).
      Tissue: Thyroid.
    3. "New transcript variants of the human iodotyrosine dehalogenase gene."
      Rodrigues-Serpa A.R., Laires R.S., Monteiro C.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 7).
      Tissue: Thyroid.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT PRO-260.
      Tissue: Kidney.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 11-289 (ISOFORM 1).
      Tissue: Kidney.
    7. "Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide close to the thyroglobulin iodination site."
      Gnidehou S., Caillou B., Talbot M., Ohayon R., Kaniewski J., Noel-Hudson M.-S., Morand S., Agnangji D., Sezan A., Courtin F., Virion A., Dupuy C.
      FASEB J. 18:1574-1576(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
      Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
      J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    9. Cited for: VARIANTS TDH4 TRP-101; 105-PHE-ISO-106 DELINS LEU AND THR-116, CHARACTERIZATION OF VARIANTS TDH4 TRP-101; 105-PHE-ISO-106 DELINS LEU AND THR-116, MUTAGENESIS OF ARG-101; PHE-105 AND ILE-116.

    Entry informationi

    Entry nameiIYD1_HUMAN
    AccessioniPrimary (citable) accession number: Q6PHW0
    Secondary accession number(s): C9JFW2
    , Q2VPW0, Q2VPW1, Q5F1L5, Q5F1L6, Q5THM4, Q6ZP69, Q7Z7D7, Q7Z7D8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: April 4, 2006
    Last modified: July 22, 2015
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.