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Q6PHW0

- IYD1_HUMAN

UniProt

Q6PHW0 - IYD1_HUMAN

Protein

Iodotyrosine dehalogenase 1

Gene

IYD

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (04 Apr 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine.1 Publication

    Catalytic activityi

    L-tyrosine + 2 NADP+ + 2 I- = 3,5-diiodo-L-tyrosine + 2 NADPH.

    Cofactori

    FMN.Curated

    Kineticsi

    1. KM=2.67 µM for L-DIT1 Publication
    2. KM=1.35 µM for L-MIT1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei104 – 1041SubstrateBy similarity
    Binding sitei161 – 1611SubstrateBy similarity
    Binding sitei182 – 1821SubstrateBy similarity
    Binding sitei279 – 2791FMNBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi100 – 1045FMNBy similarity
    Nucleotide bindingi127 – 1293FMNBy similarity
    Nucleotide bindingi236 – 2394FMNBy similarity

    GO - Molecular functioni

    1. iodide peroxidase activity Source: Ensembl
    2. oxidoreductase activity Source: Reactome

    GO - Biological processi

    1. cellular nitrogen compound metabolic process Source: Reactome
    2. small molecule metabolic process Source: Reactome
    3. thyroid hormone generation Source: Reactome

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Flavoprotein, FMN, NADP

    Enzyme and pathway databases

    ReactomeiREACT_15292. Thyroxine biosynthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Iodotyrosine dehalogenase 1 (EC:1.22.1.1)
    Short name:
    IYD-1
    Gene namesi
    Name:IYD
    Synonyms:C6orf71, DEHAL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:21071. IYD.

    Subcellular locationi

    Cell membrane 1 Publication; Single-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Thyroid dyshormonogenesis 4 (TDH4) [MIM:274800]: A disorder due to thyroid dyshormonogenesis, causing severe hypothyroidism, goiter, excessive levels of iodotyrosine in serum and urine, and variable mental deficits derived from unrecognized and untreated hypothyroidism.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti101 – 1011R → W in TDH4; strongly reduces activity; does not respond to the increase of flavin mononucleotide concentration. 1 Publication
    VAR_045963
    Natural varianti105 – 1062FI → L in TDH4; strongly reduces activity; does not respond to the increase of flavin mononucleotide concentration.
    VAR_045964
    Natural varianti116 – 1161I → T in TDH4; strongly reduces activity; marginally respond to the increase of flavin mononucleotide concentration; reduces protein stability. 1 Publication
    VAR_045965

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi101 – 1011R → A: Strongly reduces activity. 1 Publication
    Mutagenesisi101 – 1011R → H: Reduces activity. 1 Publication
    Mutagenesisi105 – 1051F → A: Activity as the wild type. 1 Publication
    Mutagenesisi105 – 1051F → Y: Activity as the wild type. 1 Publication
    Mutagenesisi116 – 1161I → V: Activity as the wild type. 1 Publication

    Keywords - Diseasei

    Congenital hypothyroidism, Disease mutation

    Organism-specific databases

    MIMi274800. phenotype.
    Orphaneti95716. Familial thyroid dyshormonogenesis.
    PharmGKBiPA162392352.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 289266Iodotyrosine dehalogenase 1PRO_0000230278Add
    BLAST

    Proteomic databases

    PaxDbiQ6PHW0.
    PRIDEiQ6PHW0.

    PTM databases

    PhosphoSiteiQ6PHW0.

    Expressioni

    Tissue specificityi

    Expressed at a high level in thyroid gland and at lower level in kidney and trachea.1 Publication

    Gene expression databases

    BgeeiQ6PHW0.
    GenevestigatoriQ6PHW0.

    Organism-specific databases

    HPAiHPA059627.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PHW0.
    SMRiQ6PHW0. Positions 70-289.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 214191ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini236 – 28954CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei215 – 23521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the nitroreductase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0778.
    HOVERGENiHBG055004.
    KOiK17231.
    OMAiQTARHRH.
    OrthoDBiEOG7HMS24.
    PhylomeDBiQ6PHW0.
    TreeFamiTF313415.

    Family and domain databases

    Gene3Di3.40.109.10. 1 hit.
    InterProiIPR029479. Nitroreductase.
    IPR000415. Nitroreductase-like.
    [Graphical view]
    PfamiPF00881. Nitroreductase. 1 hit.
    [Graphical view]
    SUPFAMiSSF55469. SSF55469. 1 hit.

    Sequences (6)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6PHW0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MYFLTPILVA ILCILVVWIF KNADRSMEKK KGEPRTRAEA RPWVDEDLKD    50
    SSDLHQAEED ADEWQESEEN VEHIPFSHNH YPEKEMVKRS QEFYELLNKR 100
    RSVRFISNEQ VPMEVIDNVI RTAGTAPSGA HTEPWTFVVV KDPDVKHKIR 150
    KIIEEEEEIN YMKRMGHRWV TDLKKLRTNW IKEYLDTAPI LILIFKQVHG 200
    FAANGKKKVH YYNEISVSIA CGILLAALQN AGLVTVTTTP LNCGPRLRVL 250
    LGRPAHEKLL MLLPVGYPSK EATVPDLKRK PLDQIMVTV 289
    Length:289
    Mass (Da):33,360
    Last modified:April 4, 2006 - v2
    Checksum:iB73560A682BF6045
    GO
    Isoform 3 (identifier: Q6PHW0-3) [UniParc]FASTAAdd to Basket

    Also known as: E

    The sequence of this isoform differs from the canonical sequence as follows:
         230-248: NAGLVTVTTTPLNCGPRLR → VFGKIILKELALISFLNL
         249-289: Missing.

    Show »
    Length:247
    Mass (Da):28,858
    Checksum:i256CCEE175E985A1
    GO
    Isoform 4 (identifier: Q6PHW0-4) [UniParc]FASTAAdd to Basket

    Also known as: B

    The sequence of this isoform differs from the canonical sequence as follows:
         230-289: NAGLVTVTTT...KPLDQIMVTV → VNNGITMRHQ...TEGAPGPPRT

    Show »
    Length:293
    Mass (Da):33,781
    Checksum:i2DEF1D502CC9F28E
    GO
    Isoform 5 (identifier: Q6PHW0-5) [UniParc]FASTAAdd to Basket

    Also known as: C

    The sequence of this isoform differs from the canonical sequence as follows:
         230-284: NAGLVTVTTT...PDLKRKPLDQ → VNNGITMRHQ...FHFAIEFAAP
         285-289: Missing.

    Show »
    Length:284
    Mass (Da):32,642
    Checksum:i2C8639AEB123CF4F
    GO
    Isoform 6 (identifier: Q6PHW0-6) [UniParc]FASTAAdd to Basket

    Also known as: D

    The sequence of this isoform differs from the canonical sequence as follows:
         230-270: NAGLVTVTTT...MLLPVGYPSK → VNNGITMRHQ...SSQGRPGFYC
         271-289: Missing.

    Show »
    Length:270
    Mass (Da):31,367
    Checksum:i501B6AC58642354A
    GO
    Isoform 7 (identifier: Q6PHW0-7) [UniParc]FASTAAdd to Basket

    Also known as: F

    The sequence of this isoform differs from the canonical sequence as follows:
         1-55: Missing.
         56-61: QAEEDA → MKEADV
         230-248: NAGLVTVTTTPLNCGPRLR → VFGKIILKELALISFLNL
         249-289: Missing.

    Show »
    Length:192
    Mass (Da):22,460
    Checksum:i5EFAEB7D3AF9FFBC
    GO

    Sequence cautioni

    The sequence BAC85255.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Isoform 4 (identifier: Q6PHW0-4)
    Sequence conflicti265 – 2651C → R in AAP22073. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti101 – 1011R → W in TDH4; strongly reduces activity; does not respond to the increase of flavin mononucleotide concentration. 1 Publication
    VAR_045963
    Natural varianti105 – 1062FI → L in TDH4; strongly reduces activity; does not respond to the increase of flavin mononucleotide concentration.
    VAR_045964
    Natural varianti116 – 1161I → T in TDH4; strongly reduces activity; marginally respond to the increase of flavin mononucleotide concentration; reduces protein stability. 1 Publication
    VAR_045965
    Natural varianti260 – 2601L → P.1 Publication
    Corresponds to variant rs17854906 [ dbSNP | Ensembl ].
    VAR_025785
    Natural varianti271 – 2711E → K.
    Corresponds to variant rs36063028 [ dbSNP | Ensembl ].
    VAR_045966

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5555Missing in isoform 7. 1 PublicationVSP_017802Add
    BLAST
    Alternative sequencei56 – 616QAEEDA → MKEADV in isoform 7. 1 PublicationVSP_017803
    Alternative sequencei230 – 28960NAGLV…IMVTV → VNNGITMRHQTARHRHLIEG PGRSSEACSKLSSQGCPECR SGDCHYHSSQLWPSTEGAPG PPRT in isoform 4. 1 PublicationVSP_017805Add
    BLAST
    Alternative sequencei230 – 28455NAGLV…KPLDQ → VNNGITMRHQTARHRHLIEG PGRSSEACSKLSSQGRPGAS AAGSLFHFAIEFAAP in isoform 5. 1 PublicationVSP_017806Add
    BLAST
    Alternative sequencei230 – 27041NAGLV…GYPSK → VNNGITMRHQTARHRHLIEG PGRSSEACSKLSSQGRPGFY C in isoform 6. 1 PublicationVSP_017807Add
    BLAST
    Alternative sequencei230 – 24819NAGLV…GPRLR → VFGKIILKELALISFLNL in isoform 3 and isoform 7. 1 PublicationVSP_017809Add
    BLAST
    Alternative sequencei249 – 28941Missing in isoform 3 and isoform 7. 1 PublicationVSP_017810Add
    BLAST
    Alternative sequencei271 – 28919Missing in isoform 6. 1 PublicationVSP_017812Add
    BLAST
    Alternative sequencei285 – 2895Missing in isoform 5. 1 PublicationVSP_017813

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY259176 mRNA. Translation: AAP22072.1.
    AY259177 mRNA. Translation: AAP22073.1.
    AY424901 mRNA. Translation: AAR84259.1.
    AY424902 mRNA. Translation: AAR84260.1.
    AY957659 mRNA. Translation: AAY41465.1.
    AY957660 mRNA. Translation: AAY41466.1.
    AY957661 mRNA. Translation: AAY41467.1. Sequence problems.
    AL031010 Genomic DNA. No translation available.
    BC056253 mRNA. Translation: AAH56253.1.
    AK129950 mRNA. Translation: BAC85255.1. Different initiation.
    CCDSiCCDS5227.1. [Q6PHW0-1]
    CCDS55066.1. [Q6PHW0-3]
    CCDS55067.1. [Q6PHW0-4]
    RefSeqiNP_001158166.1. NM_001164694.1. [Q6PHW0-4]
    NP_001158167.1. NM_001164695.1. [Q6PHW0-3]
    NP_981932.1. NM_203395.2. [Q6PHW0-1]
    UniGeneiHs.310225.

    Genome annotation databases

    EnsembliENST00000229447; ENSP00000229447; ENSG00000009765. [Q6PHW0-4]
    ENST00000344419; ENSP00000343763; ENSG00000009765. [Q6PHW0-1]
    ENST00000367335; ENSP00000356304; ENSG00000009765. [Q6PHW0-3]
    ENST00000392256; ENSP00000376085; ENSG00000009765. [Q6PHW0-3]
    GeneIDi389434.
    KEGGihsa:389434.
    UCSCiuc003qnu.2. human. [Q6PHW0-1]
    uc003qnv.2. human. [Q6PHW0-3]

    Polymorphism databases

    DMDMi91207083.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY259176 mRNA. Translation: AAP22072.1 .
    AY259177 mRNA. Translation: AAP22073.1 .
    AY424901 mRNA. Translation: AAR84259.1 .
    AY424902 mRNA. Translation: AAR84260.1 .
    AY957659 mRNA. Translation: AAY41465.1 .
    AY957660 mRNA. Translation: AAY41466.1 .
    AY957661 mRNA. Translation: AAY41467.1 . Sequence problems.
    AL031010 Genomic DNA. No translation available.
    BC056253 mRNA. Translation: AAH56253.1 .
    AK129950 mRNA. Translation: BAC85255.1 . Different initiation.
    CCDSi CCDS5227.1. [Q6PHW0-1 ]
    CCDS55066.1. [Q6PHW0-3 ]
    CCDS55067.1. [Q6PHW0-4 ]
    RefSeqi NP_001158166.1. NM_001164694.1. [Q6PHW0-4 ]
    NP_001158167.1. NM_001164695.1. [Q6PHW0-3 ]
    NP_981932.1. NM_203395.2. [Q6PHW0-1 ]
    UniGenei Hs.310225.

    3D structure databases

    ProteinModelPortali Q6PHW0.
    SMRi Q6PHW0. Positions 70-289.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q6PHW0.

    Polymorphism databases

    DMDMi 91207083.

    Proteomic databases

    PaxDbi Q6PHW0.
    PRIDEi Q6PHW0.

    Protocols and materials databases

    DNASUi 389434.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000229447 ; ENSP00000229447 ; ENSG00000009765 . [Q6PHW0-4 ]
    ENST00000344419 ; ENSP00000343763 ; ENSG00000009765 . [Q6PHW0-1 ]
    ENST00000367335 ; ENSP00000356304 ; ENSG00000009765 . [Q6PHW0-3 ]
    ENST00000392256 ; ENSP00000376085 ; ENSG00000009765 . [Q6PHW0-3 ]
    GeneIDi 389434.
    KEGGi hsa:389434.
    UCSCi uc003qnu.2. human. [Q6PHW0-1 ]
    uc003qnv.2. human. [Q6PHW0-3 ]

    Organism-specific databases

    CTDi 389434.
    GeneCardsi GC06P150731.
    H-InvDB HIX0025059.
    HGNCi HGNC:21071. IYD.
    HPAi HPA059627.
    MIMi 274800. phenotype.
    612025. gene.
    neXtProti NX_Q6PHW0.
    Orphaneti 95716. Familial thyroid dyshormonogenesis.
    PharmGKBi PA162392352.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0778.
    HOVERGENi HBG055004.
    KOi K17231.
    OMAi QTARHRH.
    OrthoDBi EOG7HMS24.
    PhylomeDBi Q6PHW0.
    TreeFami TF313415.

    Enzyme and pathway databases

    Reactomei REACT_15292. Thyroxine biosynthesis.

    Miscellaneous databases

    GeneWikii Iodotyrosine_deiodinase.
    GenomeRNAii 389434.
    NextBioi 102878.
    PROi Q6PHW0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6PHW0.
    Genevestigatori Q6PHW0.

    Family and domain databases

    Gene3Di 3.40.109.10. 1 hit.
    InterProi IPR029479. Nitroreductase.
    IPR000415. Nitroreductase-like.
    [Graphical view ]
    Pfami PF00881. Nitroreductase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55469. SSF55469. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a novel thyroidal gene encoding proteins with a conserved nitroreductase domain."
      Moreno J.C., Keijser R., Aarraas S., De Vijlder J.J.M., Ris-Stalpers C.
      J. Endocrinol. Invest. 25 Suppl. 7:S23-S23(2002)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 4 AND 5).
      Tissue: Thyroid.
    2. "Cloning and characterization of the human iodotyrosine dehalogenase isoform 1C."
      Gnidehou S., Ohayon R., Kaniewski J., Morand S., Noel-Hudson M.-S., Virion A., Dupuy C.
      Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6).
      Tissue: Thyroid.
    3. "New transcript variants of the human iodotyrosine dehalogenase gene."
      Rodrigues-Serpa A.R., Laires R.S., Monteiro C.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 7).
      Tissue: Thyroid.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT PRO-260.
      Tissue: Kidney.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 11-289 (ISOFORM 1).
      Tissue: Kidney.
    7. "Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide close to the thyroglobulin iodination site."
      Gnidehou S., Caillou B., Talbot M., Ohayon R., Kaniewski J., Noel-Hudson M.-S., Morand S., Agnangji D., Sezan A., Courtin F., Virion A., Dupuy C.
      FASEB J. 18:1574-1576(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    8. Cited for: VARIANTS TDH4 TRP-101; 105-PHE-ISO-106 DELINS LEU AND THR-116, CHARACTERIZATION OF VARIANTS TDH4 TRP-101; 105-PHE-ISO-106 DELINS LEU AND THR-116, MUTAGENESIS OF ARG-101; PHE-105 AND ILE-116.

    Entry informationi

    Entry nameiIYD1_HUMAN
    AccessioniPrimary (citable) accession number: Q6PHW0
    Secondary accession number(s): C9JFW2
    , Q2VPW0, Q2VPW1, Q5F1L5, Q5F1L6, Q5THM4, Q6ZP69, Q7Z7D7, Q7Z7D8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3