Q6PHW0 (IYD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Iodotyrosine dehalogenase 1
Short name=IYD-1
EC=1.22.1.1

Gene names

Name:	IYD
Synonyms:	C6orf71, DEHAL1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	289 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine. Ref.7
Catalytic activity	L-tyrosine + 2 NADP+ + 2 I- = 3,5-diiodo-L-tyrosine + 2 NADPH.
Cofactor	FMN Probable.
Subunit structure	Homodimer By similarity.
Subcellular location	Cell membrane; Single-pass membrane protein Ref.7.
Tissue specificity	Expressed at a high level in thyroid gland and at lower level in kidney and trachea. Ref.7
Involvement in disease	Thyroid dyshormonogenesis 4 (TDH4) [MIM:274800]: A disorder due to thyroid dyshormonogenesis, causing severe hypothyroidism, goiter, excessive levels of iodotyrosine in serum and urine, and variable mental deficits derived from unrecognized and untreated hypothyroidism. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.8
Sequence similarities	Belongs to the nitroreductase family.
Biophysicochemical properties	Kinetic parameters: KM=2.67 µM for L-DIT Ref.7 KM=1.35 µM for L-MIT
Sequence caution	The sequence AAY41467.1 differs from that shown. Reason: Erroneous translation. The sequence BAC85255.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAI20537.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Congenital hypothyroidism Disease mutation
Domain	Signal Transmembrane Transmembrane helix
Ligand	FMN Flavoprotein NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular nitrogen compound metabolic process Traceable author statement. Source: Reactome thyroid hormone generation Traceable author statement. Source: Reactome
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6PHW0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 3 (identifier: Q6PHW0-3)

Also known as: E;

The sequence of this isoform differs from the canonical sequence as follows:
     230-248: NAGLVTVTTTPLNCGPRLR → VFGKIILKELALISFLNL
     249-289: Missing.

Isoform 4 (identifier: Q6PHW0-4)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     230-289: NAGLVTVTTT...KPLDQIMVTV → VNNGITMRHQ...TEGAPGPPRT

Isoform 5 (identifier: Q6PHW0-5)

Also known as: C;

The sequence of this isoform differs from the canonical sequence as follows:
     230-284: NAGLVTVTTT...PDLKRKPLDQ → VNNGITMRHQ...FHFAIEFAAP
     285-289: Missing.

Isoform 6 (identifier: Q6PHW0-6)

Also known as: D;

The sequence of this isoform differs from the canonical sequence as follows:
     230-270: NAGLVTVTTT...MLLPVGYPSK → VNNGITMRHQ...SSQGRPGFYC
     271-289: Missing.

Isoform 7 (identifier: Q6PHW0-7)

Also known as: F;

The sequence of this isoform differs from the canonical sequence as follows:
     1-55: Missing.
     56-61: QAEEDA → MKEADV
     230-248: NAGLVTVTTTPLNCGPRLR → VFGKIILKELALISFLNL
     249-289: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 289	266	Iodotyrosine dehalogenase 1		PRO_0000230278
Regions
	Topological domain	24 – 214	191	Extracellular Potential
	Transmembrane	215 – 235	21	Helical; Potential
	Topological domain	236 – 289	54	Cytoplasmic Potential
	Nucleotide binding	100 – 104	5	FMN By similarity
	Nucleotide binding	127 – 129	3	FMN By similarity
	Nucleotide binding	236 – 239	4	FMN By similarity
Sites
	Binding site	104	1	Substrate By similarity
	Binding site	161	1	Substrate By similarity
	Binding site	182	1	Substrate By similarity
	Binding site	279	1	FMN By similarity
Natural variations
	Alternative sequence	1 – 55	55	Missing in isoform 7.		VSP_017802
	Alternative sequence	56 – 61	6	QAEEDA → MKEADV in isoform 7.		VSP_017803
	Alternative sequence	230 – 289	60	NAGLV…IMVTV → VNNGITMRHQTARHRHLIEG PGRSSEACSKLSSQGRPECR SGDCHYHSSQLWPSTEGAPG PPRT in isoform 4.		VSP_017805
	Alternative sequence	230 – 284	55	NAGLV…KPLDQ → VNNGITMRHQTARHRHLIEG PGRSSEACSKLSSQGRPGAS AAGSLFHFAIEFAAP in isoform 5.		VSP_017806
	Alternative sequence	230 – 270	41	NAGLV…GYPSK → VNNGITMRHQTARHRHLIEG PGRSSEACSKLSSQGRPGFY C in isoform 6.		VSP_017807
	Alternative sequence	230 – 248	19	NAGLV…GPRLR → VFGKIILKELALISFLNL in isoform 3 and isoform 7.		VSP_017809
	Alternative sequence	249 – 289	41	Missing in isoform 3 and isoform 7.		VSP_017810
	Alternative sequence	271 – 289	19	Missing in isoform 6.		VSP_017812
	Alternative sequence	285 – 289	5	Missing in isoform 5.		VSP_017813
	Natural variant	101	1	R → W in TDH4; strongly reduces activity; does not respond to the increase of flavin mononucleotide concentration. Ref.8		VAR_045963
	Natural variant	105 – 106	2	FI → L in TDH4; strongly reduces activity; does not respond to the increase of flavin mononucleotide concentration.		VAR_045964
	Natural variant	116	1	I → T in TDH4; strongly reduces activity; marginally respond to the increase of flavin mononucleotide concentration; reduces protein stability. Ref.8		VAR_045965
	Natural variant	260	1	L → P. Ref.5 Corresponds to variant rs17854906 [ dbSNP | Ensembl ].		VAR_025785
	Natural variant	271	1	E → K. Corresponds to variant rs36063028 [ dbSNP | Ensembl ].		VAR_045966
Experimental info
	Mutagenesis	101	1	R → A: Strongly reduces activity. Ref.8
	Mutagenesis	101	1	R → H: Reduces activity. Ref.8
	Mutagenesis	105	1	F → A: Activity as the wild type. Ref.8
	Mutagenesis	105	1	F → Y: Activity as the wild type. Ref.8
	Mutagenesis	116	1	I → V: Activity as the wild type. Ref.8

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 4, 2006. Version 2. Checksum: B73560A682BF6045	FASTA	289	33,360
	10 20 30 40 50 60 MYFLTPILVA ILCILVVWIF KNADRSMEKK KGEPRTRAEA RPWVDEDLKD SSDLHQAEED 70 80 90 100 110 120 ADEWQESEEN VEHIPFSHNH YPEKEMVKRS QEFYELLNKR RSVRFISNEQ VPMEVIDNVI 130 140 150 160 170 180 RTAGTAPSGA HTEPWTFVVV KDPDVKHKIR KIIEEEEEIN YMKRMGHRWV TDLKKLRTNW 190 200 210 220 230 240 IKEYLDTAPI LILIFKQVHG FAANGKKKVH YYNEISVSIA CGILLAALQN AGLVTVTTTP 250 260 270 280 LNCGPRLRVL LGRPAHEKLL MLLPVGYPSK EATVPDLKRK PLDQIMVTV
	Isoform 3 (E) [UniParc]. Checksum: 256CCEE175E985A1	FASTA	247	28,858
	10 20 30 40 50 60 MYFLTPILVA ILCILVVWIF KNADRSMEKK KGEPRTRAEA RPWVDEDLKD SSDLHQAEED 70 80 90 100 110 120 ADEWQESEEN VEHIPFSHNH YPEKEMVKRS QEFYELLNKR RSVRFISNEQ VPMEVIDNVI 130 140 150 160 170 180 RTAGTAPSGA HTEPWTFVVV KDPDVKHKIR KIIEEEEEIN YMKRMGHRWV TDLKKLRTNW 190 200 210 220 230 240 IKEYLDTAPI LILIFKQVHG FAANGKKKVH YYNEISVSIA CGILLAALQV FGKIILKELA LISFLNL
	Isoform 4 (B) [UniParc]. Checksum: 2DEF1D503CD8F38E	FASTA	293	33,835
	10 20 30 40 50 60 MYFLTPILVA ILCILVVWIF KNADRSMEKK KGEPRTRAEA RPWVDEDLKD SSDLHQAEED 70 80 90 100 110 120 ADEWQESEEN VEHIPFSHNH YPEKEMVKRS QEFYELLNKR RSVRFISNEQ VPMEVIDNVI 130 140 150 160 170 180 RTAGTAPSGA HTEPWTFVVV KDPDVKHKIR KIIEEEEEIN YMKRMGHRWV TDLKKLRTNW 190 200 210 220 230 240 IKEYLDTAPI LILIFKQVHG FAANGKKKVH YYNEISVSIA CGILLAALQV NNGITMRHQT 250 260 270 280 290 ARHRHLIEGP GRSSEACSKL SSQGRPECRS GDCHYHSSQL WPSTEGAPGP PRT
	Isoform 5 (C) [UniParc]. Checksum: 2C8639AEB123CF4F	FASTA	284	32,642
	10 20 30 40 50 60 MYFLTPILVA ILCILVVWIF KNADRSMEKK KGEPRTRAEA RPWVDEDLKD SSDLHQAEED 70 80 90 100 110 120 ADEWQESEEN VEHIPFSHNH YPEKEMVKRS QEFYELLNKR RSVRFISNEQ VPMEVIDNVI 130 140 150 160 170 180 RTAGTAPSGA HTEPWTFVVV KDPDVKHKIR KIIEEEEEIN YMKRMGHRWV TDLKKLRTNW 190 200 210 220 230 240 IKEYLDTAPI LILIFKQVHG FAANGKKKVH YYNEISVSIA CGILLAALQV NNGITMRHQT 250 260 270 280 ARHRHLIEGP GRSSEACSKL SSQGRPGASA AGSLFHFAIE FAAP
	Isoform 6 (D) [UniParc]. Checksum: 501B6AC58642354A	FASTA	270	31,367
	10 20 30 40 50 60 MYFLTPILVA ILCILVVWIF KNADRSMEKK KGEPRTRAEA RPWVDEDLKD SSDLHQAEED 70 80 90 100 110 120 ADEWQESEEN VEHIPFSHNH YPEKEMVKRS QEFYELLNKR RSVRFISNEQ VPMEVIDNVI 130 140 150 160 170 180 RTAGTAPSGA HTEPWTFVVV KDPDVKHKIR KIIEEEEEIN YMKRMGHRWV TDLKKLRTNW 190 200 210 220 230 240 IKEYLDTAPI LILIFKQVHG FAANGKKKVH YYNEISVSIA CGILLAALQV NNGITMRHQT 250 260 270 ARHRHLIEGP GRSSEACSKL SSQGRPGFYC
	Isoform 7 (F) [UniParc]. Checksum: 5EFAEB7D3AF9FFBC	FASTA	192	22,460
	10 20 30 40 50 60 MKEADVDEWQ ESEENVEHIP FSHNHYPEKE MVKRSQEFYE LLNKRRSVRF ISNEQVPMEV 70 80 90 100 110 120 IDNVIRTAGT APSGAHTEPW TFVVVKDPDV KHKIRKIIEE EEEINYMKRM GHRWVTDLKK 130 140 150 160 170 180 LRTNWIKEYL DTAPILILIF KQVHGFAANG KKKVHYYNEI SVSIACGILL AALQVFGKII 190 LKELALISFL NL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of a novel thyroidal gene encoding proteins with a conserved nitroreductase domain." Moreno J.C., Keijser R., Aarraas S., De Vijlder J.J.M., Ris-Stalpers C. J. Endocrinol. Invest. 25 Suppl. 7:S23-S23(2002) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Thyroid.
[2]	"Cloning and characterization of the human iodotyrosine dehalogenase isoform 1C." Gnidehou S., Ohayon R., Kaniewski J., Morand S., Noel-Hudson M.-S., Virion A., Dupuy C. Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5 AND 6). Tissue: Thyroid.
[3]	"New transcript variants of the human iodotyrosine dehalogenase gene." Rodrigues-Serpa A.R., Laires R.S., Monteiro C. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 4 AND 7). Tissue: Thyroid.
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT PRO-260. Tissue: Kidney.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 11-289 (ISOFORM 1). Tissue: Kidney.
[7]	"Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide close to the thyroglobulin iodination site." Gnidehou S., Caillou B., Talbot M., Ohayon R., Kaniewski J., Noel-Hudson M.-S., Morand S., Agnangji D., Sezan A., Courtin F., Virion A., Dupuy C. FASEB J. 18:1574-1576(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[8]	"Mutations in the iodotyrosine deiodinase gene and hypothyroidism." Moreno J.C., Klootwijk W., van Toor H., Pinto G., D'Alessandro M., Leger A., Goudie D., Polak M., Grueters A., Visser T.J. N. Engl. J. Med. 358:1811-1818(2008) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS TDH4 TRP-101; 105-PHE-ISO-106 DELINS LEU AND THR-116, CHARACTERIZATION OF VARIANTS TDH4 TRP-101; 105-PHE-ISO-106 DELINS LEU AND THR-116, MUTAGENESIS OF ARG-101; PHE-105 AND ILE-116.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY259176 mRNA. Translation: AAP22072.1. AY259177 mRNA. Translation: AAP22073.1. AY424901 mRNA. Translation: AAR84259.1. AY424902 mRNA. Translation: AAR84260.1. AY957659 mRNA. Translation: AAY41465.1. AY957660 mRNA. Translation: AAY41466.1. AY957661 mRNA. Translation: AAY41467.1. Sequence problems. AL031010 Genomic DNA. Translation: CAI20537.1. Sequence problems. BC056253 mRNA. Translation: AAH56253.1. AK129950 mRNA. Translation: BAC85255.1. Different initiation.
IPI	IPI00385533. IPI00465267. IPI00736489. IPI00737829. IPI00738915. IPI00940869.
RefSeq	NP_001158166.1. NM_001164694.1. NP_001158167.1. NM_001164695.1. NP_981932.1. NM_203395.2.
UniGene	Hs.310225.
3D structure databases
ProteinModelPortal	Q6PHW0.
ModBase	Search...
PTM databases
PhosphoSite	Q6PHW0.
Polymorphism databases
DMDM	91207083.
Proteomic databases
PaxDb	Q6PHW0.
PRIDE	Q6PHW0.
Protocols and materials databases
DNASU	389434.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000344419; ENSP00000343763; ENSG00000009765. ENST00000367335; ENSP00000356304; ENSG00000009765. ENST00000392256; ENSP00000376085; ENSG00000009765.
GeneID	389434.
KEGG	hsa:389434.
UCSC	uc003qnu.2. human. uc003qnv.2. human.
Organism-specific databases
CTD	389434.
GeneCards	GC06P150731.
H-InvDB	HIX0025059.
HGNC	HGNC:21071. IYD.
MIM	274800. phenotype. 612025. gene.
neXtProt	NX_Q6PHW0.
Orphanet	95716. Familial thyroid dyshormonogenesis.
PharmGKB	PA162392352.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0778.
HOVERGEN	HBG055004.
OMA	HQPWHFV.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism.
Gene expression databases
ArrayExpress	Q6PHW0.
Bgee	Q6PHW0.
Genevestigator	Q6PHW0.
GermOnline	ENSG00000009765. Homo sapiens.
Family and domain databases
Gene3D	3.40.109.10. 1 hit.
InterPro	IPR000415. Nitroreductase-like. [Graphical view]
Pfam	PF00881. Nitroreductase. 1 hit. [Graphical view]
SUPFAM	SSF55469. Nitroreductase. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	389434.
NextBio	102878.
SOURCE	Search...

Entry information

Entry name

IYD1_HUMAN

Accession

Primary (citable) accession number: Q6PHW0
Secondary accession number(s): Q2VPW0 , Q2VPW1, Q5F1L5, Q5F1L6, Q5THM4, Q6ZP69, Q7Z7D7, Q7Z7D8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	April 4, 2006
Last modified:	May 1, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.