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Protein

Sorting nexin-13

Gene

Snx13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in several stages of intracellular trafficking. Acts as a GAP for Galphas (By similarity). May play a role in endosome homeostasis.By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei601Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei603Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei628Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei642Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor
Biological processProtein transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-13
Gene namesi
Name:Snx13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2661416 Snx13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Disruption phenotypei

Embryonic lethal. After 8.5 dpc, embryos are smaller, show failure of neural tube closure and abnormal cephalic vascularization. None survive after 14.5 dpc. Visceral yolk sac endoderm cells contain large autophagic vacuoles.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002362001 – 957Sorting nexin-13Add BLAST957

Proteomic databases

MaxQBiQ6PHS6
PaxDbiQ6PHS6
PRIDEiQ6PHS6

PTM databases

iPTMnetiQ6PHS6
PhosphoSitePlusiQ6PHS6

Expressioni

Gene expression databases

CleanExiMM_SNX13

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038430

Structurei

3D structure databases

ProteinModelPortaliQ6PHS6
SMRiQ6PHS6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini97 – 284PXAPROSITE-ProRule annotationAdd BLAST188
Domaini373 – 511RGSPROSITE-ProRule annotationAdd BLAST139
Domaini559 – 680PXPROSITE-ProRule annotationAdd BLAST122

Domaini

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Phylogenomic databases

eggNOGiENOG410IMHZ Eukaryota
ENOG410XRJ0 LUCA
HOGENOMiHOG000059640
HOVERGENiHBG060026
InParanoidiQ6PHS6
KOiK17925
OMAiPIKIDRR
PhylomeDBiQ6PHS6

Family and domain databases

CDDicd06873 PX_SNX13, 1 hit
cd08719 RGS_SNX13, 1 hit
Gene3Di3.30.1520.101 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR003114 Phox_assoc
IPR036871 PX_dom_sf
IPR016137 RGS
IPR036305 RGS_sf
IPR037437 SNX13_PX
IPR037896 SNX13_RGS
IPR013937 Sorting_nexin_C
PfamiView protein in Pfam
PF08628 Nexin_C, 1 hit
PF00787 PX, 1 hit
PF02194 PXA, 1 hit
PF00615 RGS, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SM00313 PXA, 1 hit
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit
PS51207 PXA, 1 hit
PS50132 RGS, 1 hit

Sequencei

Sequence statusi: Complete.

Q6PHS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTEASLSIW GWGSLGIVLF LITFGPFVIF YLAFYILCFV GGGLVVTLLY
60 70 80 90 100
GKTNSEKYLE QCEHSFLPPT SSGVPKCLEE MKREARTIKI DRRLTGANII
110 120 130 140 150
DEPLQQVIQF SLRDYVQYWY YTLSDDESFL LEIRQTLQNA LIQFATRSKE
160 170 180 190 200
IDWQPYFTTR IVDDFGTHLR VFRKAQQRVT EKDDQVKGTA EDLVETFFEV
210 220 230 240 250
EVEMEKDVCR DLVCTSPKDE EGFLRDLCEV LLYLLLPPGD FQSKIMRYFV
260 270 280 290 300
REILARGILL PLINQLSDPD YINQYVIWMI RDSNCNYEAF MNIIKLSDNI
310 320 330 340 350
GELEAVRDKA AEELQYLRSL DTAGDDINTI KNQINSLLFV KKVCDSRIQR
360 370 380 390 400
LQSGKEINTV KLAANFGKLC TVPLDSILVD NVALQFFMDY MQQTGGQAHL
410 420 430 440 450
FFWMTVEGYR VTAQQQLEVL SGRQRDGKQQ TNQTKGLLRA AAVGIYEQYL
460 470 480 490 500
SEKASPRVTV DDYLVAKLAD TLNHEDPTPE IFDDIQRKVY ELMLRDERFY
510 520 530 540 550
PSFRQNALYV RMLAELDMLK DPSFRGSDDG DGESFNGSPT GSINLSLDDL
560 570 580 590 600
SSVTSDDSVQ LHAYISDTGV CNDHGKTYAL YAITVHRRNL NTEEMWKTYR
610 620 630 640 650
RYSDFHDFHM RITEQFENLS SILKLPGKKT FNNMDRDFLE KRKKDLNAYL
660 670 680 690 700
QLLLTPEMMK ASPALAHCVY DFLENKAYSK GKGDFARKMD TFVNPLRNSM
710 720 730 740 750
RNVSNAVKSL PDSLAEGVTK MSDNVGRMSE RLGQDIKQSF FKVPPLITKT
760 770 780 790 800
DSDPEHCRVS AQLDDNVDDN IPLRVMLLLM DEVFDLKERN QWLRRNIKNL
810 820 830 840 850
LQQLIRATYG DTINRKIVDH VDWMTSPEQV ADSVKRFRDA FWPNGILAET
860 870 880 890 900
VPCRDKAIRM RTRIAGKTKL FAIMPDELKH IIGAETTRKG ILRVFEMFQH
910 920 930 940 950
NQLNRRMVYV FLEGFLETLF PQYKFRELFN KLHSRSKQMQ KYKQKLQSTQ

APSLQKR
Length:957
Mass (Da):110,819
Last modified:July 5, 2004 - v1
Checksum:i45621C3D6F9C1DF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC056394 mRNA Translation: AAH56394.1
RefSeqiNP_001014973.2, NM_001014973.2
UniGeneiMm.213991

Genome annotation databases

GeneIDi217463
KEGGimmu:217463
UCSCiuc011yli.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSNX13_MOUSE
AccessioniPrimary (citable) accession number: Q6PHS6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: July 5, 2004
Last modified: February 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome