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Q6PHS6

- SNX13_MOUSE

UniProt

Q6PHS6 - SNX13_MOUSE

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Protein

Sorting nexin-13

Gene

Snx13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in several stages of intracellular trafficking. Acts as a GAP for Galphas (By similarity). May play a role in endosome homeostasis.By similarity1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei601 – 6011Phosphatidylinositol 3-phosphateBy similarity
Binding sitei603 – 6031Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei628 – 6281Phosphatidylinositol 3-phosphateBy similarity
Binding sitei642 – 6421Phosphatidylinositol 3-phosphateBy similarity

GO - Molecular functioni

  1. phosphatidylinositol binding Source: Ensembl

GO - Biological processi

  1. intracellular protein transport Source: Ensembl
  2. positive regulation of GTPase activity Source: Ensembl
  3. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-13
Gene namesi
Name:Snx13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:2661416. Snx13.

Subcellular locationi

Early endosome membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

GO - Cellular componenti

  1. early endosome Source: Ensembl
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Disruption phenotypei

Embryonic lethal. After 8.5 dpc, embryos are smaller, show failure of neural tube closure and abnormal cephalic vascularization. None survive after 14.5 dpc. Visceral yolk sac endoderm cells contain large autophagic vacuoles.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 957957Sorting nexin-13PRO_0000236200Add
BLAST

Proteomic databases

MaxQBiQ6PHS6.
PaxDbiQ6PHS6.
PRIDEiQ6PHS6.

PTM databases

PhosphoSiteiQ6PHS6.

Expressioni

Gene expression databases

BgeeiQ6PHS6.
CleanExiMM_SNX13.
ExpressionAtlasiQ6PHS6. baseline and differential.
GenevestigatoriQ6PHS6.

Structurei

3D structure databases

ProteinModelPortaliQ6PHS6.
SMRiQ6PHS6. Positions 577-670.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini97 – 284188PXAPROSITE-ProRule annotationAdd
BLAST
Domaini373 – 511139RGSPROSITE-ProRule annotationAdd
BLAST
Domaini559 – 680122PXPROSITE-ProRule annotationAdd
BLAST

Domaini

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation
Contains 1 PXA domain.PROSITE-ProRule annotation
Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG313668.
HOGENOMiHOG000059640.
HOVERGENiHBG060026.
InParanoidiQ6PHS6.
KOiK17925.
OMAiGPFAIFY.
PhylomeDBiQ6PHS6.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR003114. Phox_assoc.
IPR013996. PX_assoc_Snx13.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR013937. Sorting_nexin_C.
[Graphical view]
PfamiPF08628. Nexin_C. 1 hit.
PF00787. PX. 1 hit.
PF02194. PXA. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
SM00313. PXA. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
PS51207. PXA. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PHS6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLTEASLSIW GWGSLGIVLF LITFGPFVIF YLAFYILCFV GGGLVVTLLY
60 70 80 90 100
GKTNSEKYLE QCEHSFLPPT SSGVPKCLEE MKREARTIKI DRRLTGANII
110 120 130 140 150
DEPLQQVIQF SLRDYVQYWY YTLSDDESFL LEIRQTLQNA LIQFATRSKE
160 170 180 190 200
IDWQPYFTTR IVDDFGTHLR VFRKAQQRVT EKDDQVKGTA EDLVETFFEV
210 220 230 240 250
EVEMEKDVCR DLVCTSPKDE EGFLRDLCEV LLYLLLPPGD FQSKIMRYFV
260 270 280 290 300
REILARGILL PLINQLSDPD YINQYVIWMI RDSNCNYEAF MNIIKLSDNI
310 320 330 340 350
GELEAVRDKA AEELQYLRSL DTAGDDINTI KNQINSLLFV KKVCDSRIQR
360 370 380 390 400
LQSGKEINTV KLAANFGKLC TVPLDSILVD NVALQFFMDY MQQTGGQAHL
410 420 430 440 450
FFWMTVEGYR VTAQQQLEVL SGRQRDGKQQ TNQTKGLLRA AAVGIYEQYL
460 470 480 490 500
SEKASPRVTV DDYLVAKLAD TLNHEDPTPE IFDDIQRKVY ELMLRDERFY
510 520 530 540 550
PSFRQNALYV RMLAELDMLK DPSFRGSDDG DGESFNGSPT GSINLSLDDL
560 570 580 590 600
SSVTSDDSVQ LHAYISDTGV CNDHGKTYAL YAITVHRRNL NTEEMWKTYR
610 620 630 640 650
RYSDFHDFHM RITEQFENLS SILKLPGKKT FNNMDRDFLE KRKKDLNAYL
660 670 680 690 700
QLLLTPEMMK ASPALAHCVY DFLENKAYSK GKGDFARKMD TFVNPLRNSM
710 720 730 740 750
RNVSNAVKSL PDSLAEGVTK MSDNVGRMSE RLGQDIKQSF FKVPPLITKT
760 770 780 790 800
DSDPEHCRVS AQLDDNVDDN IPLRVMLLLM DEVFDLKERN QWLRRNIKNL
810 820 830 840 850
LQQLIRATYG DTINRKIVDH VDWMTSPEQV ADSVKRFRDA FWPNGILAET
860 870 880 890 900
VPCRDKAIRM RTRIAGKTKL FAIMPDELKH IIGAETTRKG ILRVFEMFQH
910 920 930 940 950
NQLNRRMVYV FLEGFLETLF PQYKFRELFN KLHSRSKQMQ KYKQKLQSTQ

APSLQKR
Length:957
Mass (Da):110,819
Last modified:July 5, 2004 - v1
Checksum:i45621C3D6F9C1DF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC056394 mRNA. Translation: AAH56394.1.
RefSeqiNP_001014973.2. NM_001014973.2.
UniGeneiMm.213991.

Genome annotation databases

GeneIDi217463.
KEGGimmu:217463.
UCSCiuc007njg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC056394 mRNA. Translation: AAH56394.1 .
RefSeqi NP_001014973.2. NM_001014973.2.
UniGenei Mm.213991.

3D structure databases

ProteinModelPortali Q6PHS6.
SMRi Q6PHS6. Positions 577-670.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q6PHS6.

Proteomic databases

MaxQBi Q6PHS6.
PaxDbi Q6PHS6.
PRIDEi Q6PHS6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 217463.
KEGGi mmu:217463.
UCSCi uc007njg.2. mouse.

Organism-specific databases

CTDi 23161.
MGIi MGI:2661416. Snx13.

Phylogenomic databases

eggNOGi NOG313668.
HOGENOMi HOG000059640.
HOVERGENi HBG060026.
InParanoidi Q6PHS6.
KOi K17925.
OMAi GPFAIFY.
PhylomeDBi Q6PHS6.

Miscellaneous databases

NextBioi 375865.
PROi Q6PHS6.
SOURCEi Search...

Gene expression databases

Bgeei Q6PHS6.
CleanExi MM_SNX13.
ExpressionAtlasi Q6PHS6. baseline and differential.
Genevestigatori Q6PHS6.

Family and domain databases

Gene3Di 3.30.1520.10. 1 hit.
InterProi IPR001683. Phox.
IPR003114. Phox_assoc.
IPR013996. PX_assoc_Snx13.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR013937. Sorting_nexin_C.
[Graphical view ]
Pfami PF08628. Nexin_C. 1 hit.
PF00787. PX. 1 hit.
PF02194. PXA. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view ]
SMARTi SM00312. PX. 1 hit.
SM00313. PXA. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEi PS50195. PX. 1 hit.
PS51207. PXA. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  2. "Essential role of RGS-PX1/sorting nexin 13 in mouse development and regulation of endocytosis dynamics."
    Zheng B., Tang T., Tang N., Kudlicka K., Ohtsubo K., Ma P., Marth J.D., Farquhar M.G., Lehtonen E.
    Proc. Natl. Acad. Sci. U.S.A. 103:16776-16781(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiSNX13_MOUSE
AccessioniPrimary (citable) accession number: Q6PHS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3