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Q6PHS6 (SNX13_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sorting nexin-13
Gene names
Name:Snx13
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length957 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in several stages of intracellular trafficking. Acts as a GAP for Galphas By similarity. May play a role in endosome homeostasis. Ref.2

Subcellular location

Early endosome membrane; Peripheral membrane protein; Cytoplasmic side By similarity.

Domain

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate By similarity.

Disruption phenotype

Embryonic lethal. After 8.5 dpc, embryos are smaller, show failure of neural tube closure and abnormal cephalic vascularization. None survive after 14.5 dpc. Visceral yolk sac endoderm cells contain large autophagic vacuoles. Ref.2

Sequence similarities

Belongs to the sorting nexin family.

Contains 1 PX (phox homology) domain.

Contains 1 PXA domain.

Contains 1 RGS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 957957Sorting nexin-13
PRO_0000236200

Regions

Domain97 – 284188PXA
Domain373 – 511139RGS
Domain559 – 680122PX

Sites

Binding site6011Phosphatidylinositol 3-phosphate By similarity
Binding site6031Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygen By similarity
Binding site6281Phosphatidylinositol 3-phosphate By similarity
Binding site6421Phosphatidylinositol 3-phosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6PHS6 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 45621C3D6F9C1DF3

FASTA957110,819
        10         20         30         40         50         60 
MLTEASLSIW GWGSLGIVLF LITFGPFVIF YLAFYILCFV GGGLVVTLLY GKTNSEKYLE 

        70         80         90        100        110        120 
QCEHSFLPPT SSGVPKCLEE MKREARTIKI DRRLTGANII DEPLQQVIQF SLRDYVQYWY 

       130        140        150        160        170        180 
YTLSDDESFL LEIRQTLQNA LIQFATRSKE IDWQPYFTTR IVDDFGTHLR VFRKAQQRVT 

       190        200        210        220        230        240 
EKDDQVKGTA EDLVETFFEV EVEMEKDVCR DLVCTSPKDE EGFLRDLCEV LLYLLLPPGD 

       250        260        270        280        290        300 
FQSKIMRYFV REILARGILL PLINQLSDPD YINQYVIWMI RDSNCNYEAF MNIIKLSDNI 

       310        320        330        340        350        360 
GELEAVRDKA AEELQYLRSL DTAGDDINTI KNQINSLLFV KKVCDSRIQR LQSGKEINTV 

       370        380        390        400        410        420 
KLAANFGKLC TVPLDSILVD NVALQFFMDY MQQTGGQAHL FFWMTVEGYR VTAQQQLEVL 

       430        440        450        460        470        480 
SGRQRDGKQQ TNQTKGLLRA AAVGIYEQYL SEKASPRVTV DDYLVAKLAD TLNHEDPTPE 

       490        500        510        520        530        540 
IFDDIQRKVY ELMLRDERFY PSFRQNALYV RMLAELDMLK DPSFRGSDDG DGESFNGSPT 

       550        560        570        580        590        600 
GSINLSLDDL SSVTSDDSVQ LHAYISDTGV CNDHGKTYAL YAITVHRRNL NTEEMWKTYR 

       610        620        630        640        650        660 
RYSDFHDFHM RITEQFENLS SILKLPGKKT FNNMDRDFLE KRKKDLNAYL QLLLTPEMMK 

       670        680        690        700        710        720 
ASPALAHCVY DFLENKAYSK GKGDFARKMD TFVNPLRNSM RNVSNAVKSL PDSLAEGVTK 

       730        740        750        760        770        780 
MSDNVGRMSE RLGQDIKQSF FKVPPLITKT DSDPEHCRVS AQLDDNVDDN IPLRVMLLLM 

       790        800        810        820        830        840 
DEVFDLKERN QWLRRNIKNL LQQLIRATYG DTINRKIVDH VDWMTSPEQV ADSVKRFRDA 

       850        860        870        880        890        900 
FWPNGILAET VPCRDKAIRM RTRIAGKTKL FAIMPDELKH IIGAETTRKG ILRVFEMFQH 

       910        920        930        940        950 
NQLNRRMVYV FLEGFLETLF PQYKFRELFN KLHSRSKQMQ KYKQKLQSTQ APSLQKR 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[2]"Essential role of RGS-PX1/sorting nexin 13 in mouse development and regulation of endocytosis dynamics."
Zheng B., Tang T., Tang N., Kudlicka K., Ohtsubo K., Ma P., Marth J.D., Farquhar M.G., Lehtonen E.
Proc. Natl. Acad. Sci. U.S.A. 103:16776-16781(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC056394 mRNA. Translation: AAH56394.1.
RefSeqNP_001014973.2. NM_001014973.2.
UniGeneMm.213991.

3D structure databases

ProteinModelPortalQ6PHS6.
SMRQ6PHS6. Positions 577-670.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ6PHS6.

Proteomic databases

PaxDbQ6PHS6.
PRIDEQ6PHS6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID217463.
KEGGmmu:217463.
UCSCuc007njg.2. mouse.

Organism-specific databases

CTD23161.
MGIMGI:2661416. Snx13.

Phylogenomic databases

eggNOGNOG313668.
HOGENOMHOG000059640.
HOVERGENHBG060026.
InParanoidQ6PHS6.
KOK17925.
OMAGPFAIFY.
PhylomeDBQ6PHS6.

Gene expression databases

ArrayExpressQ6PHS6.
BgeeQ6PHS6.
CleanExMM_SNX13.
GenevestigatorQ6PHS6.

Family and domain databases

Gene3D3.30.1520.10. 1 hit.
InterProIPR001683. Phox.
IPR003114. Phox_assoc.
IPR013996. PX_assoc_Snx13.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR013937. Sorting_nexin_C.
[Graphical view]
PfamPF08628. Nexin_C. 1 hit.
PF00787. PX. 1 hit.
PF02194. PXA. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
SMARTSM00312. PX. 1 hit.
SM00313. PXA. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMSSF48097. SSF48097. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEPS50195. PX. 1 hit.
PS51207. PXA. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio375865.
PROQ6PHS6.
SOURCESearch...

Entry information

Entry nameSNX13_MOUSE
AccessionPrimary (citable) accession number: Q6PHS6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot