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Q6PHS6

- SNX13_MOUSE

UniProt

Q6PHS6 - SNX13_MOUSE

Protein

Sorting nexin-13

Gene

Snx13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    May be involved in several stages of intracellular trafficking. Acts as a GAP for Galphas By similarity. May play a role in endosome homeostasis.By similarity1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei601 – 6011Phosphatidylinositol 3-phosphateBy similarity
    Binding sitei603 – 6031Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei628 – 6281Phosphatidylinositol 3-phosphateBy similarity
    Binding sitei642 – 6421Phosphatidylinositol 3-phosphateBy similarity

    GO - Molecular functioni

    1. phosphatidylinositol binding Source: Ensembl

    GO - Biological processi

    1. intracellular protein transport Source: Ensembl
    2. positive regulation of GTPase activity Source: Ensembl
    3. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sorting nexin-13
    Gene namesi
    Name:Snx13
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:2661416. Snx13.

    Subcellular locationi

    Early endosome membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

    GO - Cellular componenti

    1. early endosome membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endosome, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Embryonic lethal. After 8.5 dpc, embryos are smaller, show failure of neural tube closure and abnormal cephalic vascularization. None survive after 14.5 dpc. Visceral yolk sac endoderm cells contain large autophagic vacuoles.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 957957Sorting nexin-13PRO_0000236200Add
    BLAST

    Proteomic databases

    PaxDbiQ6PHS6.
    PRIDEiQ6PHS6.

    PTM databases

    PhosphoSiteiQ6PHS6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6PHS6.
    BgeeiQ6PHS6.
    CleanExiMM_SNX13.
    GenevestigatoriQ6PHS6.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PHS6.
    SMRiQ6PHS6. Positions 577-670.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini97 – 284188PXAPROSITE-ProRule annotationAdd
    BLAST
    Domaini373 – 511139RGSPROSITE-ProRule annotationAdd
    BLAST
    Domaini559 – 680122PXPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.By similarity

    Sequence similaritiesi

    Belongs to the sorting nexin family.Curated
    Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation
    Contains 1 PXA domain.PROSITE-ProRule annotation
    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG313668.
    HOGENOMiHOG000059640.
    HOVERGENiHBG060026.
    InParanoidiQ6PHS6.
    KOiK17925.
    OMAiGPFAIFY.
    PhylomeDBiQ6PHS6.

    Family and domain databases

    Gene3Di3.30.1520.10. 1 hit.
    InterProiIPR001683. Phox.
    IPR003114. Phox_assoc.
    IPR013996. PX_assoc_Snx13.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR013937. Sorting_nexin_C.
    [Graphical view]
    PfamiPF08628. Nexin_C. 1 hit.
    PF00787. PX. 1 hit.
    PF02194. PXA. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view]
    SMARTiSM00312. PX. 1 hit.
    SM00313. PXA. 1 hit.
    SM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    SSF64268. SSF64268. 1 hit.
    PROSITEiPS50195. PX. 1 hit.
    PS51207. PXA. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6PHS6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLTEASLSIW GWGSLGIVLF LITFGPFVIF YLAFYILCFV GGGLVVTLLY    50
    GKTNSEKYLE QCEHSFLPPT SSGVPKCLEE MKREARTIKI DRRLTGANII 100
    DEPLQQVIQF SLRDYVQYWY YTLSDDESFL LEIRQTLQNA LIQFATRSKE 150
    IDWQPYFTTR IVDDFGTHLR VFRKAQQRVT EKDDQVKGTA EDLVETFFEV 200
    EVEMEKDVCR DLVCTSPKDE EGFLRDLCEV LLYLLLPPGD FQSKIMRYFV 250
    REILARGILL PLINQLSDPD YINQYVIWMI RDSNCNYEAF MNIIKLSDNI 300
    GELEAVRDKA AEELQYLRSL DTAGDDINTI KNQINSLLFV KKVCDSRIQR 350
    LQSGKEINTV KLAANFGKLC TVPLDSILVD NVALQFFMDY MQQTGGQAHL 400
    FFWMTVEGYR VTAQQQLEVL SGRQRDGKQQ TNQTKGLLRA AAVGIYEQYL 450
    SEKASPRVTV DDYLVAKLAD TLNHEDPTPE IFDDIQRKVY ELMLRDERFY 500
    PSFRQNALYV RMLAELDMLK DPSFRGSDDG DGESFNGSPT GSINLSLDDL 550
    SSVTSDDSVQ LHAYISDTGV CNDHGKTYAL YAITVHRRNL NTEEMWKTYR 600
    RYSDFHDFHM RITEQFENLS SILKLPGKKT FNNMDRDFLE KRKKDLNAYL 650
    QLLLTPEMMK ASPALAHCVY DFLENKAYSK GKGDFARKMD TFVNPLRNSM 700
    RNVSNAVKSL PDSLAEGVTK MSDNVGRMSE RLGQDIKQSF FKVPPLITKT 750
    DSDPEHCRVS AQLDDNVDDN IPLRVMLLLM DEVFDLKERN QWLRRNIKNL 800
    LQQLIRATYG DTINRKIVDH VDWMTSPEQV ADSVKRFRDA FWPNGILAET 850
    VPCRDKAIRM RTRIAGKTKL FAIMPDELKH IIGAETTRKG ILRVFEMFQH 900
    NQLNRRMVYV FLEGFLETLF PQYKFRELFN KLHSRSKQMQ KYKQKLQSTQ 950
    APSLQKR 957
    Length:957
    Mass (Da):110,819
    Last modified:July 5, 2004 - v1
    Checksum:i45621C3D6F9C1DF3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC056394 mRNA. Translation: AAH56394.1.
    RefSeqiNP_001014973.2. NM_001014973.2.
    UniGeneiMm.213991.

    Genome annotation databases

    GeneIDi217463.
    KEGGimmu:217463.
    UCSCiuc007njg.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC056394 mRNA. Translation: AAH56394.1 .
    RefSeqi NP_001014973.2. NM_001014973.2.
    UniGenei Mm.213991.

    3D structure databases

    ProteinModelPortali Q6PHS6.
    SMRi Q6PHS6. Positions 577-670.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q6PHS6.

    Proteomic databases

    PaxDbi Q6PHS6.
    PRIDEi Q6PHS6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 217463.
    KEGGi mmu:217463.
    UCSCi uc007njg.2. mouse.

    Organism-specific databases

    CTDi 23161.
    MGIi MGI:2661416. Snx13.

    Phylogenomic databases

    eggNOGi NOG313668.
    HOGENOMi HOG000059640.
    HOVERGENi HBG060026.
    InParanoidi Q6PHS6.
    KOi K17925.
    OMAi GPFAIFY.
    PhylomeDBi Q6PHS6.

    Miscellaneous databases

    NextBioi 375865.
    PROi Q6PHS6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6PHS6.
    Bgeei Q6PHS6.
    CleanExi MM_SNX13.
    Genevestigatori Q6PHS6.

    Family and domain databases

    Gene3Di 3.30.1520.10. 1 hit.
    InterProi IPR001683. Phox.
    IPR003114. Phox_assoc.
    IPR013996. PX_assoc_Snx13.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR013937. Sorting_nexin_C.
    [Graphical view ]
    Pfami PF08628. Nexin_C. 1 hit.
    PF00787. PX. 1 hit.
    PF02194. PXA. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view ]
    SMARTi SM00312. PX. 1 hit.
    SM00313. PXA. 1 hit.
    SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    SSF64268. SSF64268. 1 hit.
    PROSITEi PS50195. PX. 1 hit.
    PS51207. PXA. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    2. "Essential role of RGS-PX1/sorting nexin 13 in mouse development and regulation of endocytosis dynamics."
      Zheng B., Tang T., Tang N., Kudlicka K., Ohtsubo K., Ma P., Marth J.D., Farquhar M.G., Lehtonen E.
      Proc. Natl. Acad. Sci. U.S.A. 103:16776-16781(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiSNX13_MOUSE
    AccessioniPrimary (citable) accession number: Q6PHS6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3