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Protein

Polyadenylate-binding protein

Gene

Pabpc4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds the poly(A) tail of mRNA.UniRule annotation

GO - Molecular functioni

  • mRNA binding Source: MGI
  • poly(A) binding Source: MGI
  • poly(U) RNA binding Source: MGI

GO - Biological processi

  • myeloid cell development Source: MGI
  • regulation of mRNA stability Source: MGI

Keywordsi

Molecular functionRNA-bindingPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Polyadenylate-binding proteinUniRule annotation
Short name:
PABPUniRule annotation
Gene namesi
Name:Pabpc4Imported
ORF Names:mCG_5546Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2385206 Pabpc4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000011257

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079070

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 89RRMInterPro annotationAdd BLAST79
Domaini99 – 175RRMInterPro annotationAdd BLAST77
Domaini191 – 268RRMInterPro annotationAdd BLAST78
Domaini294 – 370RRMInterPro annotationAdd BLAST77
Domaini567 – 644PABCInterPro annotationAdd BLAST78

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili266 – 286Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the polyadenylate-binding protein type-1 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG0123 Eukaryota
ENOG410XR5X LUCA
GeneTreeiENSGT00760000118913
HOGENOMiHOG000217922
HOVERGENiHBG002295
OMAiKKVYVGH
OrthoDBiEOG091G03ZE
TreeFamiTF300458

Family and domain databases

Gene3Di3.30.70.330, 4 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR036053 PABP-dom
IPR006515 PABP_1234
IPR002004 PABP_HYD
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR003954 RRM_dom_euk
PfamiView protein in Pfam
PF00658 PABP, 1 hit
PF00076 RRM_1, 4 hits
SMARTiView protein in SMART
SM00517 PolyA, 1 hit
SM00360 RRM, 4 hits
SM00361 RRM_1, 3 hits
SUPFAMiSSF54928 SSF54928, 2 hits
SSF63570 SSF63570, 1 hit
TIGRFAMsiTIGR01628 PABP-1234, 1 hit
PROSITEiView protein in PROSITE
PS51309 PABC, 1 hit
PS50102 RRM, 4 hits

Sequencei

Sequence statusi: Complete.

Q6PHQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAAASSYPM ASLYVGDLHS DVTEAMLYEK FSPAGPVLSI RVCRDMITRR
60 70 80 90 100
SLGYAYVNFQ QPADAERALD TMNFDVMKGK PIRIMWSQRD PSLRKSGVGN
110 120 130 140 150
VFIKNLDKSI DNKALYDTFS AFGNILSCKV VCDENGSKGY AFVHFETQEA
160 170 180 190 200
ADKAIEKMNG MLLNDRKVFV GRFKSRKERE AELGAKAKEF TNVYIKNFGE
210 220 230 240 250
EVDDGNLKEL FSQFGKTLSV KVMRDSSGKS KGFGFVSYEK HEDANKAVEE
260 270 280 290 300
MNGKEMSGKA IFVGRAQKKV ERQAELKRKF EQLKQERISR YQGVNLYIKN
310 320 330 340 350
LDDTIDDEKL RREFSPFGSI TSAKVMLEDG RSKGFGFVCF SSPEEATKAV
360 370 380 390 400
TEMNGRIVGS KPLYVALAQR KEERKAHLTN QYMQRVAGMR ALPASAILNQ
410 420 430 440 450
FQPAAGGYFV PAVPQAQGRP PYYTPNQLAQ MRPNPRWQQG GRPQGFQGMP
460 470 480 490 500
SALRQSGPRP ALRHLAPTGN APASRGLPTT AQRVGSECPD RLAMDFGGAG
510 520 530 540 550
AAQQGLTDSC QSGGVPTAVP NLAPRAAVAA AAPRAVAPYK YASSVRSPHP
560 570 580 590 600
AIQPLQAPQP AVHVQGQEPL TASMLAAAPP QEQKQMLGER LFPLIQTMHS
610 620 630 640 650
NLAGKITGML LEIDNSELLH MLESPESLRS KVDEAVAVLQ AHHAKKEAAQ
660
KVGTVAAATS
Length:660
Mass (Da):72,242
Last modified:July 5, 2004 - v1
Checksum:iAA44BB03BC794B7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606917 Genomic DNA No translation available.
AL606934 Genomic DNA No translation available.
BC056432 mRNA Translation: AAH56432.1
CH466552 Genomic DNA Translation: EDL30384.1
RefSeqiNP_570951.2, NM_130881.2
UniGeneiMm.277091

Genome annotation databases

EnsembliENSMUST00000080178; ENSMUSP00000079070; ENSMUSG00000011257
GeneIDi230721
UCSCiuc008upa.2 mouse

Similar proteinsi

Entry informationi

Entry nameiQ6PHQ9_MOUSE
AccessioniPrimary (citable) accession number: Q6PHQ9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 25, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health