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Protein

N-alpha-acetyltransferase 35, NatC auxiliary subunit

Gene

Naa35

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.1 Publication

GO - Biological processi

  • negative regulation of apoptotic process Source: UniProtKB
  • smooth muscle cell proliferation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
N-alpha-acetyltransferase 35, NatC auxiliary subunit
Alternative name(s):
Embryonic growth-associated protein
Protein MAK10 homolog
Gene namesi
Name:Naa35
Synonyms:Egap, Mak10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1925939. Naa35.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • NatC complex Source: UniProtKB
  • polysome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 725725N-alpha-acetyltransferase 35, NatC auxiliary subunitPRO_0000308616Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei187 – 1871PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PHQ8.
MaxQBiQ6PHQ8.
PaxDbiQ6PHQ8.
PeptideAtlasiQ6PHQ8.
PRIDEiQ6PHQ8.

PTM databases

iPTMnetiQ6PHQ8.
PhosphoSiteiQ6PHQ8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021555.
ExpressionAtlasiQ6PHQ8. baseline and differential.
GenevisibleiQ6PHQ8. MM.

Interactioni

Subunit structurei

Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022038.

Structurei

3D structure databases

ProteinModelPortaliQ6PHQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MAK10 family.Curated

Phylogenomic databases

eggNOGiKOG2343. Eukaryota.
ENOG410XS3T. LUCA.
GeneTreeiENSGT00390000002445.
HOGENOMiHOG000068098.
HOVERGENiHBG099871.
InParanoidiQ6PHQ8.
OMAiNHQAKDY.
OrthoDBiEOG091G06Y3.
PhylomeDBiQ6PHQ8.
TreeFamiTF320627.

Family and domain databases

InterProiIPR007244. NatC_AcTrfase_Mak10.
[Graphical view]
PfamiPF04112. Mak10. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PHQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVMKATVDDD ASGWELGVPE KMEKSSTSWV DITQDFEDAC RELKLGELLH
60 70 80 90 100
DKLFGLFEAM SAIEMMDPKM DAGMIGNQVN RKVLNFEQAI KDGTIKIKDL
110 120 130 140 150
SLPELIGIMD TCFCCLITWL EGHSLAQTVF TCLYIHNPDF IEDPAMKAFA
160 170 180 190 200
LGILKICDIA REKVNKAAVF EEEDFQSMTY GFKMANSVTD LRVTGMLKDV
210 220 230 240 250
EDDLQRRVKS TRSRQGEERD PEVELEHQQC LAAFSRVKFT RVLLTVLIAF
260 270 280 290 300
TKKETSAVAE AQKLMVQAAD LLSAIHTSLH HGIQAQNGTT KGDHPIMMGF
310 320 330 340 350
EPLVNQRLLP PTFPRYAKII KREEMVNYFS RLIDRIKTVC EVVNLPNLHC
360 370 380 390 400
ILDFFCEFSE QSPCVLSRSL LQTTFLVDNK KVFGTHLMQD MVKDALRSFV
410 420 430 440 450
SPPVLSPKCC LYNNHQAKDC IDSFVTHCVR PFCSLVQIHG HNRARQRDKL
460 470 480 490 500
GHILEEFATL QDEAEKVDAA LHTMLLKQEP QRQHLACLGT WVLYHNLRIM
510 520 530 540 550
IQYLLSGFEL ELYSMHEYYY IYWYLSEFLY AWLMSTLSRA DGSQMAEERI
560 570 580 590 600
MEEQQKGRSS KKTKKKKKVR PLSREITMSQ AYQNMCAGMF KTMVAFDMDG
610 620 630 640 650
KVRKPKFELD SEQVRYEHRF APFNSVMTPP PVHYLQFKEM SDLNKYSPPP
660 670 680 690 700
QSPELYVAAS KHFQQAKMIL ENIPNPDREV SRILKVAKPN FVVMKLLAGG
710 720
HKKESKVPPE FDFSVHKYFP VVKLV
Length:725
Mass (Da):83,306
Last modified:July 5, 2004 - v1
Checksum:i5362E77747B5F248
GO

Sequence cautioni

The sequence AAH27201 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti246 – 2461V → L in AAM52342 (PubMed:16484612).Curated
Sequence conflicti608 – 6081E → G in BAC30316 (PubMed:16141072).Curated
Sequence conflicti666 – 6661A → T in AAM52342 (PubMed:16484612).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY102701 mRNA. Translation: AAM52342.1.
AK039316 mRNA. Translation: BAC30316.1.
BC027201 mRNA. Translation: AAH27201.1. Sequence problems.
BC056435 mRNA. Translation: AAH56435.1.
CCDSiCCDS26575.1.
RefSeqiNP_084429.2. NM_030153.2.
XP_006517522.1. XM_006517459.2.
UniGeneiMm.253902.

Genome annotation databases

EnsembliENSMUST00000022038; ENSMUSP00000022038; ENSMUSG00000021555.
GeneIDi78689.
KEGGimmu:78689.
UCSCiuc007quu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY102701 mRNA. Translation: AAM52342.1.
AK039316 mRNA. Translation: BAC30316.1.
BC027201 mRNA. Translation: AAH27201.1. Sequence problems.
BC056435 mRNA. Translation: AAH56435.1.
CCDSiCCDS26575.1.
RefSeqiNP_084429.2. NM_030153.2.
XP_006517522.1. XM_006517459.2.
UniGeneiMm.253902.

3D structure databases

ProteinModelPortaliQ6PHQ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022038.

PTM databases

iPTMnetiQ6PHQ8.
PhosphoSiteiQ6PHQ8.

Proteomic databases

EPDiQ6PHQ8.
MaxQBiQ6PHQ8.
PaxDbiQ6PHQ8.
PeptideAtlasiQ6PHQ8.
PRIDEiQ6PHQ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022038; ENSMUSP00000022038; ENSMUSG00000021555.
GeneIDi78689.
KEGGimmu:78689.
UCSCiuc007quu.2. mouse.

Organism-specific databases

CTDi60560.
MGIiMGI:1925939. Naa35.

Phylogenomic databases

eggNOGiKOG2343. Eukaryota.
ENOG410XS3T. LUCA.
GeneTreeiENSGT00390000002445.
HOGENOMiHOG000068098.
HOVERGENiHBG099871.
InParanoidiQ6PHQ8.
OMAiNHQAKDY.
OrthoDBiEOG091G06Y3.
PhylomeDBiQ6PHQ8.
TreeFamiTF320627.

Miscellaneous databases

ChiTaRSiNaa35. mouse.
PROiQ6PHQ8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021555.
ExpressionAtlasiQ6PHQ8. baseline and differential.
GenevisibleiQ6PHQ8. MM.

Family and domain databases

InterProiIPR007244. NatC_AcTrfase_Mak10.
[Graphical view]
PfamiPF04112. Mak10. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNAA35_MOUSE
AccessioniPrimary (citable) accession number: Q6PHQ8
Secondary accession number(s): Q05CD3, Q8BYJ9, Q8K3H2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

PubMed:16484612 decribes a Naa35/Egap-containing complex as evolutionary conserved NatC complex; however, the mMak3 protein investigated in this context corresponds to mammalian NAA50 and not NAA30 and its interaction with NAA35 is ambiguous.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.