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Protein

Ras-related protein Rab-4A

Gene

rab4a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 23GTPBy similarity9
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi121 – 124GTPBy similarity4
Nucleotide bindingi151 – 153GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

  • protein transport Source: UniProtKB-KW
  • regulation of endocytosis Source: GO_Central
  • small GTPase mediated signal transduction Source: InterPro
  • vasculature development Source: ZFIN
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DRE-1660499. Synthesis of PIPs at the plasma membrane.
R-DRE-8875656. MET receptor recycling.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-4A
Gene namesi
Name:rab4a
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 13

Organism-specific databases

ZFINiZDB-GENE-040525-1. rab4a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001210961 – 213Ras-related protein Rab-4AAdd BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi211S-geranylgeranyl cysteineBy similarity1
Modified residuei213Cysteine methyl esterBy similarity1
Lipidationi213S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ6PHI9.
PRIDEiQ6PHI9.

Expressioni

Gene expression databases

BgeeiENSDARG00000019144.
ExpressionAtlasiQ6PHI9. differential.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000012097.

Structurei

3D structure databases

ProteinModelPortaliQ6PHI9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi37 – 45Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0086. Eukaryota.
ENOG410XQ9X. LUCA.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ6PHI9.
KOiK07879.
OMAiMVKLQIW.
OrthoDBiEOG091G0QOB.
PhylomeDBiQ6PHI9.
TreeFamiTF300032.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PHI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSETYDFLFK FLVIGNAGTG KSCLLHQFIE KRFKDDSNHT IGVEFGSKII
60 70 80 90 100
SVVNKFVKLQ IWDTAGQERF RSVTRSYYRG AAGALLVYDI TSRETYNALT
110 120 130 140 150
NWLTDARMLA SQNIVIILCG NKKDLDADRE VTFLEASRFA QENELMFLET
160 170 180 190 200
SALTGENVEE AFVQCARKIL NKIESGELDP ERMGSGIQYG DAALRQLRSP
210
RRAQAESIQE CGC
Length:213
Mass (Da):24,002
Last modified:April 26, 2005 - v2
Checksum:i26C34E6CCD62C95B
GO

Sequence cautioni

The sequence AAH56535 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC056535 mRNA. Translation: AAH56535.1. Different initiation.
RefSeqiNP_001119853.1. NM_001126381.1.
UniGeneiDr.159894.

Genome annotation databases

EnsembliENSDART00000004420; ENSDARP00000012097; ENSDARG00000019144.
GeneIDi403031.
KEGGidre:403031.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC056535 mRNA. Translation: AAH56535.1. Different initiation.
RefSeqiNP_001119853.1. NM_001126381.1.
UniGeneiDr.159894.

3D structure databases

ProteinModelPortaliQ6PHI9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000012097.

Proteomic databases

PaxDbiQ6PHI9.
PRIDEiQ6PHI9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000004420; ENSDARP00000012097; ENSDARG00000019144.
GeneIDi403031.
KEGGidre:403031.

Organism-specific databases

CTDi5867.
ZFINiZDB-GENE-040525-1. rab4a.

Phylogenomic databases

eggNOGiKOG0086. Eukaryota.
ENOG410XQ9X. LUCA.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ6PHI9.
KOiK07879.
OMAiMVKLQIW.
OrthoDBiEOG091G0QOB.
PhylomeDBiQ6PHI9.
TreeFamiTF300032.

Enzyme and pathway databases

ReactomeiR-DRE-1660499. Synthesis of PIPs at the plasma membrane.
R-DRE-8875656. MET receptor recycling.

Miscellaneous databases

PROiQ6PHI9.

Gene expression databases

BgeeiENSDARG00000019144.
ExpressionAtlasiQ6PHI9. differential.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB4A_DANRE
AccessioniPrimary (citable) accession number: Q6PHI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: November 30, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.