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Protein

Ras-related protein Rab-4A

Gene

rab4a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 23GTPBy similarity9
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi121 – 124GTPBy similarity4
Nucleotide bindingi151 – 153GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

  • protein transport Source: UniProtKB-KW
  • regulation of endocytosis Source: GO_Central
  • vasculature development Source: ZFIN

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DRE-8854214 TBC/RABGAPs
R-DRE-8873719 RAB geranylgeranylation
R-DRE-8875656 MET receptor recycling

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-4A
Gene namesi
Name:rab4a
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 13

Organism-specific databases

ZFINiZDB-GENE-040525-1 rab4a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001210961 – 213Ras-related protein Rab-4AAdd BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi211S-geranylgeranyl cysteineBy similarity1
Modified residuei213Cysteine methyl esterBy similarity1
Lipidationi213S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ6PHI9
PRIDEiQ6PHI9

Expressioni

Gene expression databases

BgeeiENSDARG00000019144
ExpressionAtlasiQ6PHI9 baseline

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000012097

Structurei

3D structure databases

ProteinModelPortaliQ6PHI9
SMRiQ6PHI9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi37 – 45Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0086 Eukaryota
ENOG410XQ9X LUCA
GeneTreeiENSGT00760000118841
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ6PHI9
KOiK07879
OMAiGTQECGC
OrthoDBiEOG091G0QOB
PhylomeDBiQ6PHI9
TreeFamiTF300032

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Q6PHI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSETYDFLFK FLVIGNAGTG KSCLLHQFIE KRFKDDSNHT IGVEFGSKII
60 70 80 90 100
SVVNKFVKLQ IWDTAGQERF RSVTRSYYRG AAGALLVYDI TSRETYNALT
110 120 130 140 150
NWLTDARMLA SQNIVIILCG NKKDLDADRE VTFLEASRFA QENELMFLET
160 170 180 190 200
SALTGENVEE AFVQCARKIL NKIESGELDP ERMGSGIQYG DAALRQLRSP
210
RRAQAESIQE CGC
Length:213
Mass (Da):24,002
Last modified:April 26, 2005 - v2
Checksum:i26C34E6CCD62C95B
GO

Sequence cautioni

The sequence AAH56535 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC056535 mRNA Translation: AAH56535.1 Different initiation.
RefSeqiNP_001119853.1, NM_001126381.1
UniGeneiDr.159894

Genome annotation databases

EnsembliENSDART00000004420; ENSDARP00000012097; ENSDARG00000019144
GeneIDi403031
KEGGidre:403031

Similar proteinsi

Entry informationi

Entry nameiRAB4A_DANRE
AccessioniPrimary (citable) accession number: Q6PHI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: March 28, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health