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Protein

Charged multivesicular body protein 1a

Gene

chmp1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity).By similarity

GO - Biological processi

  • cerebellum development Source: ZFIN
  • mitotic chromosome condensation Source: InterPro
  • protein transport Source: UniProtKB-KW
  • vacuolar transport Source: InterPro
  • vesicle-mediated transport Source: InterPro

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Charged multivesicular body protein 1a
Alternative name(s):
Chromatin-modifying protein 1a
Short name:
CHMP1a
Gene namesi
Name:chmp1a
Synonyms:km0004, pcoln3
ORF Names:zgc:65914, zgc:85863
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040426-1474. chmp1a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

Pathology & Biotechi

Disruption phenotypei

Reduced cerebellar and forebrain volume. The phenotype of these animals resemble that seen in those after bmi1 knockdown, supporting a link between chmp1a and bmi1. In chmp1a knockdown models, the internal granule and molecular layers were more severely affected than the Purkinje cells, which are consistent with the relatively preserved folia observed in humans with CHMP1A mutations.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002114511 – 198Charged multivesicular body protein 1aAdd BLAST198

Proteomic databases

PaxDbiQ6PHF0.
PRIDEiQ6PHF0.

Interactioni

Subunit structurei

Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III).By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000076077.

Structurei

3D structure databases

ProteinModelPortaliQ6PHF0.
SMRiQ6PHF0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili7 – 41Sequence analysisAdd BLAST35
Coiled coili176 – 198Sequence analysisAdd BLAST23

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi187 – 197MIT-interacting motifAdd BLAST11

Sequence similaritiesi

Belongs to the SNF7 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3232. Eukaryota.
COG5491. LUCA.
HOGENOMiHOG000241980.
HOVERGENiHBG080200.
InParanoidiQ6PHF0.
KOiK12197.
PhylomeDBiQ6PHF0.

Family and domain databases

InterProiView protein in InterPro
IPR029888. CHMP1A.
IPR005024. Snf7_fam.
PANTHERiPTHR10476:SF17. PTHR10476:SF17. 1 hit.
PfamiView protein in Pfam
PF03357. Snf7. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6PHF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDTLFQLKF TSKQLERLAK KAEKDSKSEQ AKVKKALQQK NVECARVYAE
60 70 80 90 100
NAIRKKNEGL NWLRMASRVD AVASKVQTAL TMKGVAKNMT QVTKALDKAL
110 120 130 140 150
SSMDLQKVSA VMDKFETQVQ NLDVHTSVME DSMSSATTLS TPQQQVDDLI
160 170 180 190
LQIAEESGLE VEDQLSQLPA GASALGETSA RAQEKEDQLS RRLAALRN
Length:198
Mass (Da):21,888
Last modified:July 5, 2004 - v1
Checksum:i98DF939479197663
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54R → C in AAH67665 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY398372 mRNA. Translation: AAQ97805.1.
BC056577 mRNA. Translation: AAH56577.1.
BC067665 mRNA. Translation: AAH67665.1.
RefSeqiNP_956857.1. NM_200563.2.
XP_009296498.1. XM_009298223.2.
UniGeneiDr.10291.

Genome annotation databases

GeneIDi393535.
KEGGidre:393535.

Similar proteinsi

Entry informationi

Entry nameiCHM1A_DANRE
AccessioniPrimary (citable) accession number: Q6PHF0
Secondary accession number(s): Q6NWA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families