ID   I20RA_MOUSE             Reviewed;         546 AA.
AC   Q6PHB0; Q8BW64;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   31-AUG-2004, sequence version 2.
DT   24-JAN-2024, entry version 136.
DE   RecName: Full=Interleukin-20 receptor subunit alpha;
DE            Short=IL-20 receptor subunit alpha;
DE            Short=IL-20R-alpha;
DE            Short=IL-20RA;
DE   AltName: Full=IL-20R1;
DE   Flags: Precursor;
GN   Name=Il20ra;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Oviduct;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=129; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and
CC       IL24. The IL20RA/IL10RB dimer is a receptor for IL26 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer with IL20RB and heterodimer with IL10RB.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the type II cytokine receptor family.
CC       {ECO:0000305}.
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DR   EMBL; AK054215; BAC35695.1; -; mRNA.
DR   EMBL; BC056628; AAH56628.1; -; mRNA.
DR   CCDS; CCDS23718.1; -.
DR   RefSeq; NP_766374.1; NM_172786.2.
DR   RefSeq; XP_006512789.1; XM_006512726.1.
DR   AlphaFoldDB; Q6PHB0; -.
DR   SMR; Q6PHB0; -.
DR   STRING; 10090.ENSMUSP00000020185; -.
DR   GlyCosmos; Q6PHB0; 5 sites, No reported glycans.
DR   GlyGen; Q6PHB0; 5 sites.
DR   PaxDb; 10090-ENSMUSP00000020185; -.
DR   Antibodypedia; 33022; 448 antibodies from 30 providers.
DR   DNASU; 237313; -.
DR   Ensembl; ENSMUST00000020185.5; ENSMUSP00000020185.4; ENSMUSG00000020007.5.
DR   GeneID; 237313; -.
DR   KEGG; mmu:237313; -.
DR   UCSC; uc007eni.1; mouse.
DR   AGR; MGI:3605069; -.
DR   CTD; 53832; -.
DR   MGI; MGI:3605069; Il20ra.
DR   VEuPathDB; HostDB:ENSMUSG00000020007; -.
DR   eggNOG; ENOG502RPFC; Eukaryota.
DR   GeneTree; ENSGT00940000157314; -.
DR   HOGENOM; CLU_527430_0_0_1; -.
DR   InParanoid; Q6PHB0; -.
DR   OMA; MINFITL; -.
DR   OrthoDB; 5307423at2759; -.
DR   PhylomeDB; Q6PHB0; -.
DR   TreeFam; TF334107; -.
DR   Reactome; R-MMU-8854691; Interleukin-20 family signaling.
DR   BioGRID-ORCS; 237313; 3 hits in 76 CRISPR screens.
DR   PRO; PR:Q6PHB0; -.
DR   Proteomes; UP000000589; Chromosome 10.
DR   RNAct; Q6PHB0; Protein.
DR   Bgee; ENSMUSG00000020007; Expressed in mesodermal cell in embryo and 26 other cell types or tissues.
DR   ExpressionAtlas; Q6PHB0; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central.
DR   GO; GO:0042015; F:interleukin-20 binding; IPI:MGI.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IMP:MGI.
DR   GO; GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IGI:MGI.
DR   GO; GO:0045124; P:regulation of bone resorption; IMP:MGI.
DR   CDD; cd00063; FN3; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR015373; Interferon/interleukin_rcp_dom.
DR   PANTHER; PTHR20859; INTERFERON/INTERLEUKIN RECEPTOR; 1.
DR   PANTHER; PTHR20859:SF86; INTERLEUKIN-20 RECEPTOR SUBUNIT ALPHA; 1.
DR   Pfam; PF09294; Interfer-bind; 1.
DR   Pfam; PF01108; Tissue_fac; 1.
DR   SUPFAM; SSF49265; Fibronectin type III; 2.
DR   PROSITE; PS50853; FN3; 2.
DR   Genevisible; Q6PHB0; MM.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Membrane; Receptor; Reference proteome;
KW   Repeat; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000255"
FT   CHAIN           33..546
FT                   /note="Interleukin-20 receptor subunit alpha"
FT                   /id="PRO_0000011037"
FT   TOPO_DOM        33..253
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        254..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        275..546
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          42..138
FT                   /note="Fibronectin type-III 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   DOMAIN          139..245
FT                   /note="Fibronectin type-III 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   CARBOHYD        45
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        86
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        94
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        185
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        203
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        90..98
FT                   /evidence="ECO:0000250"
FT   DISULFID        218..239
FT                   /evidence="ECO:0000250"
FT   CONFLICT        145
FT                   /note="V -> I (in Ref. 2; AAH56628)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   546 AA;  61978 MW;  E7EC07DA2D49AF7F CRC64;
     MHTPGTPAPG HPDPPPLLLL TLLLLLAASG RAVPCVFCGL PKPTNITFLS INMKNVLHWN
     PPESLHGVEV TYTVQYFIYG QKKWLNASKC GSINRTYCDL SVETSDYEHQ FYAKVKAIWE
     ARCSEWAETE RFYPFLETQV SPPEVALTTG EKSISIALTA PEKWKRNPQD HTVSMQQIYP
     NLKYNVSVYN TKSRRTWSQC VTNSTLVLSW LEPNTLYCVH VESLVPGPPR LPMPSQKQCI
     STLEVQTSAW KAKVIFWYVF LTSVIVFLFS AIGYLVYRYI HVGKEKHPAN LVLIYRNEIG
     TRVFEPTETI TLNFITFSML DDTKISPKDM NLLDKSSDDI SVNDPEHNEA WEPHWEEVEG
     QHLGCSSHLM DAVCGAEQRD GDTSLTQHGW LNSTIPTGET DTEPQYKVLS DFYGEGEIQL
     SCEPEEAART EKISEPLVTS ANLDPQLEDL HHLGQEHTVS EDGPEEETSI TVVDWDPQTG
     RLCIPSLPIF GRDPENYGHY ERDQLLEGGL LSRLYENQAP DKPEKENENC LTRFMEEWGL
     HVQMES
//