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Q6PHB0

- I20RA_MOUSE

UniProt

Q6PHB0 - I20RA_MOUSE

Protein

Interleukin-20 receptor subunit alpha

Gene

Il20ra

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (31 Aug 2004)
      Previous versions | rss
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    Functioni

    The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26 By similarity.By similarity

    GO - Molecular functioni

    1. interleukin-20 binding Source: MGI

    GO - Biological processi

    1. cytokine-mediated signaling pathway Source: MGI
    2. positive regulation of intrinsic apoptotic signaling pathway Source: MGI
    3. regulation of bone resorption Source: MGI

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-20 receptor subunit alpha
    Short name:
    IL-20 receptor subunit alpha
    Short name:
    IL-20R-alpha
    Short name:
    IL-20RA
    Alternative name(s):
    IL-20R1
    Gene namesi
    Name:Il20ra
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:3605069. Il20ra.

    Subcellular locationi

    Membrane By similarity; Single-pass type I membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3232Sequence AnalysisAdd
    BLAST
    Chaini33 – 546514Interleukin-20 receptor subunit alphaPRO_0000011037Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi45 – 451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi90 ↔ 98By similarity
    Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi203 – 2031N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi218 ↔ 239By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ6PHB0.

    PTM databases

    PhosphoSiteiQ6PHB0.

    Expressioni

    Gene expression databases

    BgeeiQ6PHB0.
    CleanExiMM_IL20RA.
    GenevestigatoriQ6PHB0.

    Interactioni

    Subunit structurei

    Heterodimer with IL20RB and heterodimer with IL10RB.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000020185.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PHB0.
    SMRiQ6PHB0. Positions 42-244.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini33 – 253221ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini275 – 546272CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei254 – 27421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini42 – 13897Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini139 – 245107Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the type II cytokine receptor family.Curated
    Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG25594.
    GeneTreeiENSGT00530000063352.
    HOGENOMiHOG000112987.
    HOVERGENiHBG052065.
    InParanoidiQ6PHB0.
    KOiK05136.
    OMAiQFMEEWG.
    OrthoDBiEOG7C2R12.
    PhylomeDBiQ6PHB0.
    TreeFamiTF334107.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR015713. IL-20_rcpt_alpha.
    IPR015373. Interferon_alpha/beta_rcpt_bsu.
    [Graphical view]
    PANTHERiPTHR20859:SF21. PTHR20859:SF21. 1 hit.
    PfamiPF09294. Interfer-bind. 1 hit.
    PF01108. Tissue_fac. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    PROSITEiPS50853. FN3. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6PHB0-1 [UniParc]FASTAAdd to Basket

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    MHTPGTPAPG HPDPPPLLLL TLLLLLAASG RAVPCVFCGL PKPTNITFLS    50
    INMKNVLHWN PPESLHGVEV TYTVQYFIYG QKKWLNASKC GSINRTYCDL 100
    SVETSDYEHQ FYAKVKAIWE ARCSEWAETE RFYPFLETQV SPPEVALTTG 150
    EKSISIALTA PEKWKRNPQD HTVSMQQIYP NLKYNVSVYN TKSRRTWSQC 200
    VTNSTLVLSW LEPNTLYCVH VESLVPGPPR LPMPSQKQCI STLEVQTSAW 250
    KAKVIFWYVF LTSVIVFLFS AIGYLVYRYI HVGKEKHPAN LVLIYRNEIG 300
    TRVFEPTETI TLNFITFSML DDTKISPKDM NLLDKSSDDI SVNDPEHNEA 350
    WEPHWEEVEG QHLGCSSHLM DAVCGAEQRD GDTSLTQHGW LNSTIPTGET 400
    DTEPQYKVLS DFYGEGEIQL SCEPEEAART EKISEPLVTS ANLDPQLEDL 450
    HHLGQEHTVS EDGPEEETSI TVVDWDPQTG RLCIPSLPIF GRDPENYGHY 500
    ERDQLLEGGL LSRLYENQAP DKPEKENENC LTRFMEEWGL HVQMES 546
    Length:546
    Mass (Da):61,978
    Last modified:August 31, 2004 - v2
    Checksum:iE7EC07DA2D49AF7F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti145 – 1451V → I in AAH56628. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK054215 mRNA. Translation: BAC35695.1.
    BC056628 mRNA. Translation: AAH56628.1.
    CCDSiCCDS23718.1.
    RefSeqiNP_766374.1. NM_172786.2.
    XP_006512789.1. XM_006512726.1.
    XP_006512790.1. XM_006512727.1.
    UniGeneiMm.234667.

    Genome annotation databases

    EnsembliENSMUST00000020185; ENSMUSP00000020185; ENSMUSG00000020007.
    GeneIDi237313.
    KEGGimmu:237313.
    UCSCiuc007eni.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK054215 mRNA. Translation: BAC35695.1 .
    BC056628 mRNA. Translation: AAH56628.1 .
    CCDSi CCDS23718.1.
    RefSeqi NP_766374.1. NM_172786.2.
    XP_006512789.1. XM_006512726.1.
    XP_006512790.1. XM_006512727.1.
    UniGenei Mm.234667.

    3D structure databases

    ProteinModelPortali Q6PHB0.
    SMRi Q6PHB0. Positions 42-244.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000020185.

    PTM databases

    PhosphoSitei Q6PHB0.

    Proteomic databases

    PRIDEi Q6PHB0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020185 ; ENSMUSP00000020185 ; ENSMUSG00000020007 .
    GeneIDi 237313.
    KEGGi mmu:237313.
    UCSCi uc007eni.1. mouse.

    Organism-specific databases

    CTDi 53832.
    MGIi MGI:3605069. Il20ra.

    Phylogenomic databases

    eggNOGi NOG25594.
    GeneTreei ENSGT00530000063352.
    HOGENOMi HOG000112987.
    HOVERGENi HBG052065.
    InParanoidi Q6PHB0.
    KOi K05136.
    OMAi QFMEEWG.
    OrthoDBi EOG7C2R12.
    PhylomeDBi Q6PHB0.
    TreeFami TF334107.

    Miscellaneous databases

    NextBioi 383294.
    PROi Q6PHB0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6PHB0.
    CleanExi MM_IL20RA.
    Genevestigatori Q6PHB0.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR015713. IL-20_rcpt_alpha.
    IPR015373. Interferon_alpha/beta_rcpt_bsu.
    [Graphical view ]
    PANTHERi PTHR20859:SF21. PTHR20859:SF21. 1 hit.
    Pfami PF09294. Interfer-bind. 1 hit.
    PF01108. Tissue_fac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    PROSITEi PS50853. FN3. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Oviduct.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: 129.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiI20RA_MOUSE
    AccessioniPrimary (citable) accession number: Q6PHB0
    Secondary accession number(s): Q8BW64
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: August 31, 2004
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3