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Q6PHB0

- I20RA_MOUSE

UniProt

Q6PHB0 - I20RA_MOUSE

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Protein
Interleukin-20 receptor subunit alpha
Gene
Il20ra
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26 By similarity.

GO - Molecular functioni

  1. interleukin-20 binding Source: MGI

GO - Biological processi

  1. cytokine-mediated signaling pathway Source: MGI
  2. positive regulation of intrinsic apoptotic signaling pathway Source: MGI
  3. regulation of bone resorption Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-20 receptor subunit alpha
Short name:
IL-20 receptor subunit alpha
Short name:
IL-20R-alpha
Short name:
IL-20RA
Alternative name(s):
IL-20R1
Gene namesi
Name:Il20ra
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:3605069. Il20ra.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini33 – 253221Extracellular Reviewed prediction
Add
BLAST
Transmembranei254 – 27421Helical; Reviewed prediction
Add
BLAST
Topological domaini275 – 546272Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232 Reviewed prediction
Add
BLAST
Chaini33 – 546514Interleukin-20 receptor subunit alpha
PRO_0000011037Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi45 – 451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi86 – 861N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi90 ↔ 98 By similarity
Glycosylationi94 – 941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi185 – 1851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi203 – 2031N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi218 ↔ 239 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ6PHB0.

PTM databases

PhosphoSiteiQ6PHB0.

Expressioni

Gene expression databases

BgeeiQ6PHB0.
CleanExiMM_IL20RA.
GenevestigatoriQ6PHB0.

Interactioni

Subunit structurei

Heterodimer with IL20RB and heterodimer with IL10RB By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020185.

Structurei

3D structure databases

ProteinModelPortaliQ6PHB0.
SMRiQ6PHB0. Positions 42-244.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 13897Fibronectin type-III 1
Add
BLAST
Domaini139 – 245107Fibronectin type-III 2
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG25594.
GeneTreeiENSGT00530000063352.
HOGENOMiHOG000112987.
HOVERGENiHBG052065.
InParanoidiQ6PHB0.
KOiK05136.
OMAiQFMEEWG.
OrthoDBiEOG7C2R12.
PhylomeDBiQ6PHB0.
TreeFamiTF334107.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR015713. IL-20_rcpt_alpha.
IPR015373. Interferon_alpha/beta_rcpt_bsu.
[Graphical view]
PANTHERiPTHR20859:SF21. PTHR20859:SF21. 1 hit.
PfamiPF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6PHB0-1 [UniParc]FASTAAdd to Basket

« Hide

MHTPGTPAPG HPDPPPLLLL TLLLLLAASG RAVPCVFCGL PKPTNITFLS    50
INMKNVLHWN PPESLHGVEV TYTVQYFIYG QKKWLNASKC GSINRTYCDL 100
SVETSDYEHQ FYAKVKAIWE ARCSEWAETE RFYPFLETQV SPPEVALTTG 150
EKSISIALTA PEKWKRNPQD HTVSMQQIYP NLKYNVSVYN TKSRRTWSQC 200
VTNSTLVLSW LEPNTLYCVH VESLVPGPPR LPMPSQKQCI STLEVQTSAW 250
KAKVIFWYVF LTSVIVFLFS AIGYLVYRYI HVGKEKHPAN LVLIYRNEIG 300
TRVFEPTETI TLNFITFSML DDTKISPKDM NLLDKSSDDI SVNDPEHNEA 350
WEPHWEEVEG QHLGCSSHLM DAVCGAEQRD GDTSLTQHGW LNSTIPTGET 400
DTEPQYKVLS DFYGEGEIQL SCEPEEAART EKISEPLVTS ANLDPQLEDL 450
HHLGQEHTVS EDGPEEETSI TVVDWDPQTG RLCIPSLPIF GRDPENYGHY 500
ERDQLLEGGL LSRLYENQAP DKPEKENENC LTRFMEEWGL HVQMES 546
Length:546
Mass (Da):61,978
Last modified:August 31, 2004 - v2
Checksum:iE7EC07DA2D49AF7F
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti145 – 1451V → I in AAH56628. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK054215 mRNA. Translation: BAC35695.1.
BC056628 mRNA. Translation: AAH56628.1.
CCDSiCCDS23718.1.
RefSeqiNP_766374.1. NM_172786.2.
XP_006512789.1. XM_006512726.1.
XP_006512790.1. XM_006512727.1.
UniGeneiMm.234667.

Genome annotation databases

EnsembliENSMUST00000020185; ENSMUSP00000020185; ENSMUSG00000020007.
GeneIDi237313.
KEGGimmu:237313.
UCSCiuc007eni.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK054215 mRNA. Translation: BAC35695.1 .
BC056628 mRNA. Translation: AAH56628.1 .
CCDSi CCDS23718.1.
RefSeqi NP_766374.1. NM_172786.2.
XP_006512789.1. XM_006512726.1.
XP_006512790.1. XM_006512727.1.
UniGenei Mm.234667.

3D structure databases

ProteinModelPortali Q6PHB0.
SMRi Q6PHB0. Positions 42-244.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000020185.

PTM databases

PhosphoSitei Q6PHB0.

Proteomic databases

PRIDEi Q6PHB0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020185 ; ENSMUSP00000020185 ; ENSMUSG00000020007 .
GeneIDi 237313.
KEGGi mmu:237313.
UCSCi uc007eni.1. mouse.

Organism-specific databases

CTDi 53832.
MGIi MGI:3605069. Il20ra.

Phylogenomic databases

eggNOGi NOG25594.
GeneTreei ENSGT00530000063352.
HOGENOMi HOG000112987.
HOVERGENi HBG052065.
InParanoidi Q6PHB0.
KOi K05136.
OMAi QFMEEWG.
OrthoDBi EOG7C2R12.
PhylomeDBi Q6PHB0.
TreeFami TF334107.

Miscellaneous databases

NextBioi 383294.
PROi Q6PHB0.
SOURCEi Search...

Gene expression databases

Bgeei Q6PHB0.
CleanExi MM_IL20RA.
Genevestigatori Q6PHB0.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR015713. IL-20_rcpt_alpha.
IPR015373. Interferon_alpha/beta_rcpt_bsu.
[Graphical view ]
PANTHERi PTHR20859:SF21. PTHR20859:SF21. 1 hit.
Pfami PF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
PROSITEi PS50853. FN3. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Oviduct.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: 129.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiI20RA_MOUSE
AccessioniPrimary (citable) accession number: Q6PHB0
Secondary accession number(s): Q8BW64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: July 9, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi