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Protein

DCN1-like protein 2

Gene

DCUN1D2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Potently stimulates the neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes from the NEDD8-conjugating E2 enzyme UBC12. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
DCN1-like protein 2
Alternative name(s):
DCUN1 domain-containing protein 2
Defective in cullin neddylation protein 1-like protein 2
Gene namesi
Name:DCUN1D2
Synonyms:C13orf17, DCUN1L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:20328. DCUN1D2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000150401.
PharmGKBiPA134941036.

Polymorphism and mutation databases

BioMutaiDCUN1D2.
DMDMi73919224.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001295011 – 259DCN1-like protein 2Add BLAST259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei55PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PH85.
MaxQBiQ6PH85.
PaxDbiQ6PH85.
PeptideAtlasiQ6PH85.
PRIDEiQ6PH85.

PTM databases

iPTMnetiQ6PH85.
PhosphoSitePlusiQ6PH85.

Expressioni

Gene expression databases

BgeeiENSG00000150401.
CleanExiHS_DCUN1D2.
ExpressionAtlasiQ6PH85. baseline and differential.
GenevisibleiQ6PH85. HS.

Organism-specific databases

HPAiHPA039349.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120504. 15 interactors.
DIPiDIP-60768N.
IntActiQ6PH85. 4 interactors.
STRINGi9606.ENSP00000417706.

Structurei

Secondary structure

1259
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi62 – 70Combined sources9
Beta strandi77 – 81Combined sources5
Helixi83 – 92Combined sources10
Helixi100 – 109Combined sources10
Helixi119 – 128Combined sources10
Helixi134 – 146Combined sources13
Helixi147 – 149Combined sources3
Helixi151 – 165Combined sources15
Beta strandi171 – 174Combined sources4
Helixi175 – 185Combined sources11
Turni187 – 189Combined sources3
Helixi193 – 202Combined sources10
Helixi210 – 222Combined sources13
Helixi238 – 247Combined sources10
Helixi249 – 251Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GAOX-ray3.28A/B/D/G62-259[»]
ProteinModelPortaliQ6PH85.
SMRiQ6PH85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 45UBA-likeAdd BLAST38
Domaini60 – 248DCUN1PROSITE-ProRule annotationAdd BLAST189

Domaini

The DCUN1 domain, also known as PONY domain mediates recognition of the N-terminally acetylated NEDD8-conjugating E2 enzyme.1 Publication

Sequence similaritiesi

Contains 1 DCUN1 domain.PROSITE-ProRule annotation
Contains 1 UBA-like domain.Curated

Phylogenomic databases

eggNOGiKOG3077. Eukaryota.
ENOG410XTIJ. LUCA.
GeneTreeiENSGT00550000074529.
HOGENOMiHOG000241761.
HOVERGENiHBG055256.
InParanoidiQ6PH85.
KOiK17822.
OMAiSFHRESM.
OrthoDBiEOG091G0HHH.
PhylomeDBiQ6PH85.
TreeFamiTF313332.

Family and domain databases

InterProiIPR014764. DCN-prot.
IPR005176. PONY_dom.
IPR009060. UBA-like.
[Graphical view]
PANTHERiPTHR12281. PTHR12281. 1 hit.
PfamiPF03556. Cullin_binding. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
PROSITEiPS51229. DCUN1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PH85-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHKLKSSQKD KVRQFMACTQ AGERTAIYCL TQNEWRLDEA TDSFFQNPDS
60 70 80 90 100
LHRESMRNAV DKKKLERLYG RYKDPQDENK IGVDGIQQFC DDLSLDPASI
110 120 130 140 150
SVLVIAWKFR AATQCEFSRK EFLDGMTELG CDSMEKLKAL LPRLEQELKD
160 170 180 190 200
TAKFKDFYQF TFTFAKNPGQ KGLDLEMAVA YWKLVLSGRF KFLDLWNTFL
210 220 230 240 250
MEHHKRSIPR DTWNLLLDFG NMIADDMSNY DEEGAWPVLI DDFVEYARPV

VTGGKRSLF
Length:259
Mass (Da):30,179
Last modified:July 5, 2004 - v1
Checksum:iB12A33F80D419A28
GO
Isoform 2 (identifier: Q6PH85-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     174-186: DLEMAVAYWKLVL → GSPPFLNVKALHH
     187-259: Missing.

Note: No experimental confirmation available.
Show »
Length:186
Mass (Da):21,467
Checksum:iBDFE4F388A59A041
GO

Sequence cautioni

The sequence BAA90944 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI39428 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI39429 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI39777 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI39778 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI39779 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015315174 – 186DLEMA…WKLVL → GSPPFLNVKALHH in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_015316187 – 259Missing in isoform 2. 1 PublicationAdd BLAST73

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000099 mRNA. Translation: BAA90944.1. Different initiation.
AK001566 mRNA. Translation: BAA91760.1.
AL160251, AL442125 Genomic DNA. Translation: CAI39428.1. Sequence problems.
AL160251, AL442125 Genomic DNA. Translation: CAI39429.1. Sequence problems.
AL442125, AL160251 Genomic DNA. Translation: CAI39777.1. Sequence problems.
AL442125 Genomic DNA. Translation: CAI39778.1. Sequence problems.
AL442125, AL160251 Genomic DNA. Translation: CAI39779.1. Sequence problems.
BC056669 mRNA. Translation: AAH56669.1.
CCDSiCCDS32013.1. [Q6PH85-1]
RefSeqiNP_001014305.1. NM_001014283.1. [Q6PH85-1]
UniGeneiHs.682987.

Genome annotation databases

EnsembliENST00000375403; ENSP00000364552; ENSG00000150401. [Q6PH85-2]
ENST00000478244; ENSP00000417706; ENSG00000150401. [Q6PH85-1]
GeneIDi55208.
KEGGihsa:55208.
UCSCiuc001vtr.2. human. [Q6PH85-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000099 mRNA. Translation: BAA90944.1. Different initiation.
AK001566 mRNA. Translation: BAA91760.1.
AL160251, AL442125 Genomic DNA. Translation: CAI39428.1. Sequence problems.
AL160251, AL442125 Genomic DNA. Translation: CAI39429.1. Sequence problems.
AL442125, AL160251 Genomic DNA. Translation: CAI39777.1. Sequence problems.
AL442125 Genomic DNA. Translation: CAI39778.1. Sequence problems.
AL442125, AL160251 Genomic DNA. Translation: CAI39779.1. Sequence problems.
BC056669 mRNA. Translation: AAH56669.1.
CCDSiCCDS32013.1. [Q6PH85-1]
RefSeqiNP_001014305.1. NM_001014283.1. [Q6PH85-1]
UniGeneiHs.682987.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GAOX-ray3.28A/B/D/G62-259[»]
ProteinModelPortaliQ6PH85.
SMRiQ6PH85.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120504. 15 interactors.
DIPiDIP-60768N.
IntActiQ6PH85. 4 interactors.
STRINGi9606.ENSP00000417706.

PTM databases

iPTMnetiQ6PH85.
PhosphoSitePlusiQ6PH85.

Polymorphism and mutation databases

BioMutaiDCUN1D2.
DMDMi73919224.

Proteomic databases

EPDiQ6PH85.
MaxQBiQ6PH85.
PaxDbiQ6PH85.
PeptideAtlasiQ6PH85.
PRIDEiQ6PH85.

Protocols and materials databases

DNASUi55208.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375403; ENSP00000364552; ENSG00000150401. [Q6PH85-2]
ENST00000478244; ENSP00000417706; ENSG00000150401. [Q6PH85-1]
GeneIDi55208.
KEGGihsa:55208.
UCSCiuc001vtr.2. human. [Q6PH85-1]

Organism-specific databases

CTDi55208.
GeneCardsiDCUN1D2.
HGNCiHGNC:20328. DCUN1D2.
HPAiHPA039349.
neXtProtiNX_Q6PH85.
OpenTargetsiENSG00000150401.
PharmGKBiPA134941036.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3077. Eukaryota.
ENOG410XTIJ. LUCA.
GeneTreeiENSGT00550000074529.
HOGENOMiHOG000241761.
HOVERGENiHBG055256.
InParanoidiQ6PH85.
KOiK17822.
OMAiSFHRESM.
OrthoDBiEOG091G0HHH.
PhylomeDBiQ6PH85.
TreeFamiTF313332.

Miscellaneous databases

ChiTaRSiDCUN1D2. human.
GenomeRNAii55208.
PROiQ6PH85.

Gene expression databases

BgeeiENSG00000150401.
CleanExiHS_DCUN1D2.
ExpressionAtlasiQ6PH85. baseline and differential.
GenevisibleiQ6PH85. HS.

Family and domain databases

InterProiIPR014764. DCN-prot.
IPR005176. PONY_dom.
IPR009060. UBA-like.
[Graphical view]
PANTHERiPTHR12281. PTHR12281. 1 hit.
PfamiPF03556. Cullin_binding. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
PROSITEiPS51229. DCUN1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCNL2_HUMAN
AccessioniPrimary (citable) accession number: Q6PH85
Secondary accession number(s): Q5JSA5
, Q5JSA6, Q5JSA7, Q9NVJ1, Q9NXR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.