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Q6PH81

- CP087_HUMAN

UniProt

Q6PH81 - CP087_HUMAN

Protein

UPF0547 protein C16orf87

Gene

C16orf87

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UPF0547 protein C16orf87
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:33754. C16orf87.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162378458.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 154154UPF0547 protein C16orf87PRO_0000326521Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei91 – 911Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ6PH81.
    PaxDbiQ6PH81.
    PRIDEiQ6PH81.

    PTM databases

    PhosphoSiteiQ6PH81.

    Expressioni

    Gene expression databases

    BgeeiQ6PH81.
    CleanExiHS_C16orf87.
    GenevestigatoriQ6PH81.

    Organism-specific databases

    HPAiHPA041179.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HDAC1Q135473EBI-6598617,EBI-301834

    Protein-protein interaction databases

    BioGridi132622. 5 interactions.
    IntActiQ6PH81. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PH81.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili104 – 13229Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the UPF0547 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG26271.
    HOGENOMiHOG000060343.
    HOVERGENiHBG059456.
    InParanoidiQ6PH81.
    OMAiSDMENRR.
    OrthoDBiEOG7NKKN7.
    PhylomeDBiQ6PH81.
    TreeFamiTF331719.

    Family and domain databases

    InterProiIPR018886. UPF0547.
    [Graphical view]
    PfamiPF10571. UPF0547. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6PH81-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSATRAKKVK MATKSCPECD QQVPVACKSC PCGYIFISRK LLNAKHSEKS    50
    PPSTENKHEA KRRRTERVRR EKINSTVNKD LENRKRSRSN SHSDHIRRGR 100
    GRPKSASAKK HEEEREKQEK EIDIYANLSD EKAFVFSVAL AEINRKIINQ 150
    RLIL 154
    Length:154
    Mass (Da):17,799
    Last modified:July 5, 2004 - v1
    Checksum:i016A2E075FF60223
    GO
    Isoform 2 (identifier: Q6PH81-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         55-115: Missing.

    Show »
    Length:93
    Mass (Da):10,431
    Checksum:i30DB292DF93014E8
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei55 – 11561Missing in isoform 2. 1 PublicationVSP_032670Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX647945 mRNA. Translation: CAH56192.1.
    CH471092 Genomic DNA. Translation: EAW82689.1.
    BC056676 mRNA. Translation: AAH56676.1.
    CCDSiCCDS10724.1. [Q6PH81-1]
    RefSeqiNP_001001436.1. NM_001001436.2. [Q6PH81-1]
    UniGeneiHs.406551.

    Genome annotation databases

    EnsembliENST00000285697; ENSP00000285697; ENSG00000155330. [Q6PH81-1]
    ENST00000394806; ENSP00000378285; ENSG00000155330. [Q6PH81-2]
    GeneIDi388272.
    KEGGihsa:388272.
    UCSCiuc002eek.1. human. [Q6PH81-1]

    Polymorphism databases

    DMDMi74737667.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX647945 mRNA. Translation: CAH56192.1 .
    CH471092 Genomic DNA. Translation: EAW82689.1 .
    BC056676 mRNA. Translation: AAH56676.1 .
    CCDSi CCDS10724.1. [Q6PH81-1 ]
    RefSeqi NP_001001436.1. NM_001001436.2. [Q6PH81-1 ]
    UniGenei Hs.406551.

    3D structure databases

    ProteinModelPortali Q6PH81.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 132622. 5 interactions.
    IntActi Q6PH81. 2 interactions.

    PTM databases

    PhosphoSitei Q6PH81.

    Polymorphism databases

    DMDMi 74737667.

    Proteomic databases

    MaxQBi Q6PH81.
    PaxDbi Q6PH81.
    PRIDEi Q6PH81.

    Protocols and materials databases

    DNASUi 388272.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000285697 ; ENSP00000285697 ; ENSG00000155330 . [Q6PH81-1 ]
    ENST00000394806 ; ENSP00000378285 ; ENSG00000155330 . [Q6PH81-2 ]
    GeneIDi 388272.
    KEGGi hsa:388272.
    UCSCi uc002eek.1. human. [Q6PH81-1 ]

    Organism-specific databases

    CTDi 388272.
    GeneCardsi GC16M046835.
    H-InvDB HIX0026956.
    HGNCi HGNC:33754. C16orf87.
    HPAi HPA041179.
    neXtProti NX_Q6PH81.
    PharmGKBi PA162378458.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG26271.
    HOGENOMi HOG000060343.
    HOVERGENi HBG059456.
    InParanoidi Q6PH81.
    OMAi SDMENRR.
    OrthoDBi EOG7NKKN7.
    PhylomeDBi Q6PH81.
    TreeFami TF331719.

    Miscellaneous databases

    GenomeRNAii 388272.
    NextBioi 101917.

    Gene expression databases

    Bgeei Q6PH81.
    CleanExi HS_C16orf87.
    Genevestigatori Q6PH81.

    Family and domain databases

    InterProi IPR018886. UPF0547.
    [Graphical view ]
    Pfami PF10571. UPF0547. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Endometrium.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-91, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCP087_HUMAN
    AccessioniPrimary (citable) accession number: Q6PH81
    Secondary accession number(s): Q63HN9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families
    3. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3