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Protein

UPF0547 protein C16orf87

Gene

C16orf87

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0547 protein C16orf87
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:33754. C16orf87.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162378458.

Polymorphism and mutation databases

BioMutaiC16orf87.
DMDMi74737667.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 154154UPF0547 protein C16orf87PRO_0000326521Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei91 – 911Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6PH81.
PaxDbiQ6PH81.
PRIDEiQ6PH81.

PTM databases

PhosphoSiteiQ6PH81.

Expressioni

Gene expression databases

BgeeiQ6PH81.
CleanExiHS_C16orf87.
GenevestigatoriQ6PH81.

Organism-specific databases

HPAiHPA041179.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HDAC1Q135473EBI-6598617,EBI-301834
MAGEA12Q6FHH83EBI-6598617,EBI-10178394

Protein-protein interaction databases

BioGridi132622. 7 interactions.
IntActiQ6PH81. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ6PH81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili104 – 13229Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the UPF0547 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG26271.
GeneTreeiENSGT00390000009505.
HOGENOMiHOG000060343.
HOVERGENiHBG059456.
InParanoidiQ6PH81.
OMAiSDMENRR.
OrthoDBiEOG7NKKN7.
PhylomeDBiQ6PH81.
TreeFamiTF331719.

Family and domain databases

InterProiIPR018886. UPF0547.
[Graphical view]
PfamiPF10571. UPF0547. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PH81-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSATRAKKVK MATKSCPECD QQVPVACKSC PCGYIFISRK LLNAKHSEKS
60 70 80 90 100
PPSTENKHEA KRRRTERVRR EKINSTVNKD LENRKRSRSN SHSDHIRRGR
110 120 130 140 150
GRPKSASAKK HEEEREKQEK EIDIYANLSD EKAFVFSVAL AEINRKIINQ

RLIL
Length:154
Mass (Da):17,799
Last modified:July 5, 2004 - v1
Checksum:i016A2E075FF60223
GO
Isoform 2 (identifier: Q6PH81-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-115: Missing.

Show »
Length:93
Mass (Da):10,431
Checksum:i30DB292DF93014E8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei55 – 11561Missing in isoform 2. 1 PublicationVSP_032670Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX647945 mRNA. Translation: CAH56192.1.
CH471092 Genomic DNA. Translation: EAW82689.1.
BC056676 mRNA. Translation: AAH56676.1.
CCDSiCCDS10724.1. [Q6PH81-1]
RefSeqiNP_001001436.1. NM_001001436.2. [Q6PH81-1]
UniGeneiHs.406551.

Genome annotation databases

EnsembliENST00000285697; ENSP00000285697; ENSG00000155330. [Q6PH81-1]
ENST00000394806; ENSP00000378285; ENSG00000155330. [Q6PH81-2]
GeneIDi388272.
KEGGihsa:388272.
UCSCiuc002eek.1. human. [Q6PH81-1]

Polymorphism and mutation databases

BioMutaiC16orf87.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX647945 mRNA. Translation: CAH56192.1.
CH471092 Genomic DNA. Translation: EAW82689.1.
BC056676 mRNA. Translation: AAH56676.1.
CCDSiCCDS10724.1. [Q6PH81-1]
RefSeqiNP_001001436.1. NM_001001436.2. [Q6PH81-1]
UniGeneiHs.406551.

3D structure databases

ProteinModelPortaliQ6PH81.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132622. 7 interactions.
IntActiQ6PH81. 3 interactions.

PTM databases

PhosphoSiteiQ6PH81.

Polymorphism and mutation databases

BioMutaiC16orf87.
DMDMi74737667.

Proteomic databases

MaxQBiQ6PH81.
PaxDbiQ6PH81.
PRIDEiQ6PH81.

Protocols and materials databases

DNASUi388272.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285697; ENSP00000285697; ENSG00000155330. [Q6PH81-1]
ENST00000394806; ENSP00000378285; ENSG00000155330. [Q6PH81-2]
GeneIDi388272.
KEGGihsa:388272.
UCSCiuc002eek.1. human. [Q6PH81-1]

Organism-specific databases

CTDi388272.
GeneCardsiGC16M046835.
H-InvDBHIX0026956.
HGNCiHGNC:33754. C16orf87.
HPAiHPA041179.
neXtProtiNX_Q6PH81.
PharmGKBiPA162378458.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG26271.
GeneTreeiENSGT00390000009505.
HOGENOMiHOG000060343.
HOVERGENiHBG059456.
InParanoidiQ6PH81.
OMAiSDMENRR.
OrthoDBiEOG7NKKN7.
PhylomeDBiQ6PH81.
TreeFamiTF331719.

Miscellaneous databases

GenomeRNAii388272.
NextBioi101917.
PROiQ6PH81.

Gene expression databases

BgeeiQ6PH81.
CleanExiHS_C16orf87.
GenevestigatoriQ6PH81.

Family and domain databases

InterProiIPR018886. UPF0547.
[Graphical view]
PfamiPF10571. UPF0547. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Endometrium.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-91, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCP087_HUMAN
AccessioniPrimary (citable) accession number: Q6PH81
Secondary accession number(s): Q63HN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 5, 2004
Last modified: April 29, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.