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Protein
Submitted name:

PRP4 pre-mRNA processing factor 4 homolog (Yeast)

Gene

prpf4

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • chordate embryonic development Source: ZFIN
  • embryo development ending in birth or egg hatching Source: ZFIN
  • mRNA splicing, via spliceosome Source: GO_Central
  • retina development in camera-type eye Source: ZFIN
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DRE-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Submitted name:
PRP4 pre-mRNA processing factor 4 homolog (Yeast)Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:prpf4Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 5

Organism-specific databases

ZFINiZDB-GENE-030131-5143. prpf4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000103157.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini212 – 507296WD_REPEATS_REGIONInterPro annotationAdd
BLAST

Keywords - Domaini

RepeatUniRule annotation

Phylogenomic databases

eggNOGiKOG0272. Eukaryota.
ENOG410XNP8. LUCA.
GeneTreeiENSGT00840000129797.
HOGENOMiHOG000157615.
HOVERGENiHBG030892.
KOiK12662.
OMAiCWDVRKV.
OrthoDBiEOG7P5T0Z.
TreeFamiTF314922.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR027106. Prp4.
IPR014906. PRP4-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR19846. PTHR19846. 1 hit.
PfamiPF08799. PRP4. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00500. SFM. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF158230. SSF158230. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PH45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDEDEAPVV KRSRIFYGSL EEKEKERLSR EGTSTTAKDA VKAGIEAGHI
60 70 80 90 100
NISSGESMEM EERVSERQAE VLAEFERRKR ARQITVSTDD VEVKACLRAL
110 120 130 140 150
GEPITLFGEG PAERRERLRN VLSVLGPDAL KKSKKEDEKA KRTHEEYQQT
160 170 180 190 200
WYHEGPTSLK EARLWLAKYS LPRAVKRLDA ARAQKEIPES TRTIKQQELH
210 220 230 240 250
KNLRNVNNFC SQIGDDRPIS YCQFSPNSKL LVTASWSGLC KLWKVPDCTL
260 270 280 290 300
IRTLRGHNTN VGAISFHPQA TLTLEESDVN MASCAADGSV KLWSLDSDEP
310 320 330 340 350
IADIEGHSMR VARVTWHPSG RFLGTTCYDH SWRLWDLEVQ EEILHQEGHS
360 370 380 390 400
KGVHDLHFHP DGSLAGTGGL DSFARVWDLR TGRCVMFLEG HIKEIYSINF
410 420 430 440 450
SPNGFHVATG SGDNACKVWD LRQRRCIYTI PAHQNLVSSV KFQPNDGHYL
460 470 480 490 500
LTGAYDNTAK IWTHPGWSPL KTLAGHEGKV MGVDLSPDGQ LIATCSYDRT

FKLWMSE
Length:507
Mass (Da):57,155
Last modified:July 5, 2004 - v1
Checksum:iB44B277884C56061
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX510338 Genomic DNA. No translation available.
CR925761 Genomic DNA. No translation available.
BC056720 mRNA. Translation: AAH56720.1.
BC154322 mRNA. Translation: AAI54323.1.
RefSeqiNP_956049.1. NM_199755.1.
UniGeneiDr.76045.

Genome annotation databases

EnsembliENSDART00000097395; ENSDARP00000088166; ENSDARG00000067639.
GeneIDi326944.
KEGGidre:326944.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX510338 Genomic DNA. No translation available.
CR925761 Genomic DNA. No translation available.
BC056720 mRNA. Translation: AAH56720.1.
BC154322 mRNA. Translation: AAI54323.1.
RefSeqiNP_956049.1. NM_199755.1.
UniGeneiDr.76045.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000103157.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000097395; ENSDARP00000088166; ENSDARG00000067639.
GeneIDi326944.
KEGGidre:326944.

Organism-specific databases

CTDi9128.
ZFINiZDB-GENE-030131-5143. prpf4.

Phylogenomic databases

eggNOGiKOG0272. Eukaryota.
ENOG410XNP8. LUCA.
GeneTreeiENSGT00840000129797.
HOGENOMiHOG000157615.
HOVERGENiHBG030892.
KOiK12662.
OMAiCWDVRKV.
OrthoDBiEOG7P5T0Z.
TreeFamiTF314922.

Enzyme and pathway databases

ReactomeiR-DRE-72163. mRNA Splicing - Major Pathway.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR027106. Prp4.
IPR014906. PRP4-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR19846. PTHR19846. 1 hit.
PfamiPF08799. PRP4. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00500. SFM. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF158230. SSF158230. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."
    Mammalian Gene Collection Program Team
    Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., Hopkins R.F., Jordan H., Moore T., Max S.I.
    , Wang J., Hsieh F., Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Krzywinski M.I., Skalska U., Smailus D.E., Schnerch A., Schein J.E., Jones S.J., Marra M.A.
    Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Embryo cell lineImported.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: KidneyImported.
  3. NIH MGC Project
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Embryo cell lineImported.
  4. Ensembl
    Submitted (NOV-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  5. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ6PH45_DANRE
AccessioniPrimary (citable) accession number: Q6PH45
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.