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Protein
Submitted name:

F-box and WD-40 domain protein 11a

Gene

fbxw11b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: GO_Central
  • sprouting angiogenesis Source: ZFIN
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DRE-1169091. Activation of NF-kappaB in B cells.
R-DRE-202424. Downstream TCR signaling.
R-DRE-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-DRE-2871837. FCERI mediated NF-kB activation.
R-DRE-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-DRE-5607764. CLEC7A (Dectin-1) signaling.
R-DRE-5676590. NIK-->noncanonical NF-kB signaling.
R-DRE-5684264. MAP3K8 (TPL2)-dependent MAPK1/3 activation.
R-DRE-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Submitted name:
F-box and WD-40 domain protein 11aImported
Gene namesi
Name:fbxw11bImported
Synonyms:fbxw11aImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-040426-2903. fbxw11b.

PTM / Processingi

Proteomic databases

PRIDEiQ6PGW4.

Expressioni

Gene expression databases

BgeeiENSDARG00000017230.
ExpressionAtlasiQ6PGW4. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000017497.

Structurei

3D structure databases

ProteinModelPortaliQ6PGW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 F-box domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG0281. Eukaryota.
ENOG410XTA8. LUCA.
HOGENOMiHOG000006638.
HOVERGENiHBG002521.
KOiK03362.
OrthoDBiEOG091G0437.
PhylomeDBiQ6PGW4.
TreeFamiTF105679.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR021977. Beta-TrCP_D.
IPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12125. Beta-TrCP_D. 1 hit.
PF12937. F-box-like. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM01028. Beta-TrCP_D. 1 hit.
SM00256. FBOX. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 5 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PGW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDKTLEQMN TSVMDPQTAD RSPKITLIKS TFICPQVSNG PLTGSRKRPS
60 70 80 90 100
EGNYEKEKDV CIQLFDQWSE ADQVEFVEHL ISRMCHYQHG HINSYLKPML
110 120 130 140 150
QRDFITALPA QGLDHIAENI LSFLDARSLC SAELVCKEWQ RVISEGMLWK
160 170 180 190 200
KLIERMVRTD PLWKGLSERH QWEKYLFKNR TTEVPPNSYY RSLYPKIIQD
210 220 230 240 250
IETIEANWRC GRHNLQRIQC RSENSKGVYC LQYDDEKIIS GLRDNSIKIW
260 270 280 290 300
DKQTLECLKI LTGHTGSVLC LQYDERVIVT GSSDSTVRVW DVNSGEVLNT
310 320 330 340 350
LIHHNEAVLH LRFCNGLMVT CSKDRSIAVW DMASPTDISL RRVLVGHRAA
360 370 380 390 400
VNVVDFDDKY IVSASGDRTI KVWSTSTCEF VRTLNGHKRG IACLQYRDRL
410 420 430 440 450
VVSGSSDNTI RLWDIECGAC LRVLEGHEEL VRCIRFDNKR IVSGAYDGKI
460 470 480 490 500
KVWDLQAALD PRAPASTLCL RTLVEHSGRV FRLQFDEFQI ISSSHDDTIL
510 520
IWDFLNVSTN GQTEGRSPSR TYTYISR
Length:527
Mass (Da):60,547
Last modified:July 5, 2004 - v1
Checksum:i563F3C014CA099C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC056809 mRNA. Translation: AAH56809.1.
RefSeqiNP_998669.2. NM_213504.2.
UniGeneiDr.75211.

Genome annotation databases

GeneIDi406825.
KEGGidre:406825.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC056809 mRNA. Translation: AAH56809.1.
RefSeqiNP_998669.2. NM_213504.2.
UniGeneiDr.75211.

3D structure databases

ProteinModelPortaliQ6PGW4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000017497.

Proteomic databases

PRIDEiQ6PGW4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi406825.
KEGGidre:406825.

Organism-specific databases

CTDi406825.
ZFINiZDB-GENE-040426-2903. fbxw11b.

Phylogenomic databases

eggNOGiKOG0281. Eukaryota.
ENOG410XTA8. LUCA.
HOGENOMiHOG000006638.
HOVERGENiHBG002521.
KOiK03362.
OrthoDBiEOG091G0437.
PhylomeDBiQ6PGW4.
TreeFamiTF105679.

Enzyme and pathway databases

ReactomeiR-DRE-1169091. Activation of NF-kappaB in B cells.
R-DRE-202424. Downstream TCR signaling.
R-DRE-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-DRE-2871837. FCERI mediated NF-kB activation.
R-DRE-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-DRE-5607764. CLEC7A (Dectin-1) signaling.
R-DRE-5676590. NIK-->noncanonical NF-kB signaling.
R-DRE-5684264. MAP3K8 (TPL2)-dependent MAPK1/3 activation.
R-DRE-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Gene expression databases

BgeeiENSDARG00000017230.
ExpressionAtlasiQ6PGW4. baseline and differential.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR021977. Beta-TrCP_D.
IPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12125. Beta-TrCP_D. 1 hit.
PF12937. F-box-like. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM01028. Beta-TrCP_D. 1 hit.
SM00256. FBOX. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 5 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6PGW4_DANRE
AccessioniPrimary (citable) accession number: Q6PGW4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.