BORA

Functionⁱ

Required for the activation of AURKA at the onset of mitosis.1 Publication

GO - Molecular functionⁱ

protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 18521620
- 18615013

Complete GO annotation...

GO - Biological processⁱ

cell division Source: UniProtKB-KW
G2/M transition of mitotic cell cycle Source: Reactome
regulation of mitotic nuclear division
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18521620
regulation of mitotic spindle organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18521620
regulation of protein localization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18521620

Complete GO annotation...

Keywordsⁱ

Biological process	Cell cycle, Cell division, Mitosis

Biological process

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
SIGNORⁱ	Q6PGQ7.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein aurora borealis Short name: HsBora
Gene namesⁱ	Name:BORA Synonyms:C13orf34
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24724. BORA.

HGNCⁱ

HGNC:24724. BORA.

Subcellular locationⁱ

GO - Cellular componentⁱ

cytosol Source: Reactome

Complete GO annotation...

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000136122.
PharmGKBⁱ	PA162378045.

Polymorphism and mutation databases

DMDMⁱ	74737659.

DMDMⁱ

74737659.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000273205	1 – 559	Protein aurora borealisAdd BLAST		559

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	183	PhosphoserineCombined sources	1
Modified residueⁱ	191	PhosphoserineCombined sources	1
Modified residueⁱ	270	PhosphoserineCombined sources	1
Modified residueⁱ	325	PhosphoserineBy similarity	1
Modified residueⁱ	331	PhosphoserineBy similarity	1
Modified residueⁱ	354	PhosphothreonineBy similarity	1

Post-translational modificationⁱ

Phosphorylated by AURKA.1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q6PGQ7.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6PGQ7.
PaxDbⁱ	Q6PGQ7.
PeptideAtlas More...PeptideAtlasⁱ	Q6PGQ7.
PRIDEⁱ	Q6PGQ7.

PTM databases

iPTMnetⁱ	Q6PGQ7.
PhosphoSitePlusⁱ	Q6PGQ7.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000136122.
CleanExⁱ	HS_C13orf34.
ExpressionAtlasⁱ	Q6PGQ7. baseline and differential.
Genevisibleⁱ	Q6PGQ7. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA040866.

HPAⁱ

HPA040866.

Interactionⁱ

Subunit structureⁱ

Interacts with AURKA.1 Publication

GO - Molecular functionⁱ

protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 18521620
- 18615013

Complete GO annotation...

Protein-protein interaction databases

BioGridⁱ	122954. 26 interactors.
Database of interacting proteins More...DIPⁱ	DIP-53424N.
IntActⁱ	Q6PGQ7. 11 interactors.
STRINGⁱ	9606.ENSP00000375082.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6PGQ7.
SMRⁱ	Q6PGQ7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	188 – 278	Ser-richAdd BLAST		91

Sequence similaritiesⁱ

Belongs to the BORA family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IHF2. Eukaryota. ENOG410ZQ9X. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013790.
HOGENOMⁱ	HOG000074046.
HOVERGENⁱ	HBG080904.
InParanoidⁱ	Q6PGQ7.
KEGG Orthology (KO) More...KOⁱ	K16831.
PhylomeDBⁱ	Q6PGQ7.
TreeFamⁱ	TF329674.

Family and domain databases

InterProⁱ	View protein in InterPro IPR023252. Aurora_borealis_protein.
PANTHERⁱ	PTHR14728. PTHR14728. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15280. BORA_N. 1 hit.
PRINTSⁱ	PR02038. AURORABORA.

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q6PGQ7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDVKESKMQ ITPETPGRIP VLNPFESPSD YSNLHEQTLA SPSVFKSTKL 
        60         70         80         90        100
PTPGKFRWSI DQLAVINPVE IDPEDIHRQA LYLSHSRIDK DVEDKRQKAI 
       110        120        130        140        150
EEFFTKDVIV PSPWTDHEGK QLSQCHSSKC TNINSDSPVG KKLTIHSEKS 
       160        170        180        190        200
DAACQTLLSL PVDFNLENIL GDYFRADEFA DQSPGNLSSS SLRRKLFLDG 
       210        220        230        240        250
NGSISDSLPS ASPGSPHSGV QTSLEMFYSI DLSPVKCRSP LQTPSSGQFS 
       260        270        280        290        300
SSPIQASAKK YSLGSITSPS PISSPTFSPI EFQIGETPLS EQRKFTVHSP 
       310        320        330        340        350
DASSGTNSNG ITNPCIRSPY IDGCSPIKNW SPMRLQMYSG GTQYRTSVIQ 
       360        370        380        390        400
IPFTLETQGE DEEDKENIPS TDVSSPAMDA AGIHLRQFSN EASTHGTHLV 
       410        420        430        440        450
VTAMSVTQNQ SSASEKELAL LQDVEREKDN NTVDMVDPIE IADETTWIKE 
       460        470        480        490        500
PVDNGSLPMT DFVSGIAFSI ENSHMCMSPL AESSVIPCES SNIQMDSGYN 
       510        520        530        540        550
TQNCGSNIMD TVGAESYCKE SDAQTCEVES KSQAFNMKQD HTTQRCWMKT 

ASPFQCSSP

Length:559

Mass (Da):61,203

Last modified:December 21, 2004 - v2

Checksum:ⁱF817E6DC2C7600DB

GO

Isoform 2 (identifier: Q6PGQ7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-87: MGDVKESKMQ...RQALYLSHSR → MNKLSPVLLFLNQQNYQ

« Hide

        10         20         30         40         50
MNKLSPVLLF LNQQNYQIDK DVEDKRQKAI EEFFTKDVIV PSPWTDHEGK 
        60         70         80         90        100
QLSQCHSSKC TNINSDSPVG KKLTIHSEKS DAACQTLLSL PVDFNLENIL 
       110        120        130        140        150
GDYFRADEFA DQSPGNLSSS SLRRKLFLDG NGSISDSLPS ASPGSPHSGV 
       160        170        180        190        200
QTSLEMFYSI DLSPVKCRSP LQTPSSGQFS SSPIQASAKK YSLGSITSPS 
       210        220        230        240        250
PISSPTFSPI EFQIGETPLS EQRKFTVHSP DASSGTNSNG ITNPCIRSPY 
       260        270        280        290        300
IDGCSPIKNW SPMRLQMYSG GTQYRTSVIQ IPFTLETQGE DEEDKENIPS 
       310        320        330        340        350
TDVSSPAMDA AGIHLRQFSN EASTHGTHLV VTAMSVTQNQ SSASEKELAL 
       360        370        380        390        400
LQDVEREKDN NTVDMVDPIE IADETTWIKE PVDNGSLPMT DFVSGIAFSI 
       410        420        430        440        450
ENSHMCMSPL AESSVIPCES SNIQMDSGYN TQNCGSNIMD TVGAESYCKE 
       460        470        480 
SDAQTCEVES KSQAFNMKQD HTTQRCWMKT ASPFQCSSP

Note: No experimental confirmation available.

Show »

Length:489

Mass (Da):53,438

Checksum:ⁱCBD976AE2BA1E52E

GO

Sequence cautionⁱ

The sequence BAB15426 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	545	R → K in AAH07119 (PubMed:15489334).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_030110	210	S → L. Corresponds to variant dbSNP:rs9543107Ensembl.		1
Natural variantⁱVAR_030111	308	S → F. Corresponds to variant dbSNP:rs1146858Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_055543	1 – 87	MGDVK…LSHSR → MNKLSPVLLFLNQQNYQ in isoform 2. 1 PublicationAdd BLAST		87

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK026277 mRNA. Translation: BAB15426.1. Different initiation. AK298608 mRNA. Translation: BAG60792.1. AL138695 Genomic DNA. No translation available. CH471093 Genomic DNA. Translation: EAW80515.1. BC007119 mRNA. Translation: AAH07119.1. BC025367 mRNA. Translation: AAH25367.2. BC044213 mRNA. Translation: AAH44213.1. BC056876 mRNA. Translation: AAH56876.2.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS66560.1. [Q6PGQ7-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001273675.1. NM_001286746.1. NP_001273676.1. NM_001286747.1. [Q6PGQ7-2] NP_079084.3. NM_024808.3.
UniGeneⁱ	Hs.643464.

Genome annotation databases

Ensemblⁱ	ENST00000377815; ENSP00000367046; ENSG00000136122. [Q6PGQ7-2]
GeneIDⁱ	79866.
KEGGⁱ	hsa:79866.
UCSC genome browser More...UCSCⁱ	uc010thr.3. human. [Q6PGQ7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK026277 mRNA. Translation: BAB15426.1. Different initiation. AK298608 mRNA. Translation: BAG60792.1. AL138695 Genomic DNA. No translation available. CH471093 Genomic DNA. Translation: EAW80515.1. BC007119 mRNA. Translation: AAH07119.1. BC025367 mRNA. Translation: AAH25367.2. BC044213 mRNA. Translation: AAH44213.1. BC056876 mRNA. Translation: AAH56876.2.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS66560.1. [Q6PGQ7-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001273675.1. NM_001286746.1. NP_001273676.1. NM_001286747.1. [Q6PGQ7-2] NP_079084.3. NM_024808.3.
UniGeneⁱ	Hs.643464.

3D structure databases

ProteinModelPortalⁱ	Q6PGQ7.
SMRⁱ	Q6PGQ7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122954. 26 interactors.
Database of interacting proteins More...DIPⁱ	DIP-53424N.
IntActⁱ	Q6PGQ7. 11 interactors.
STRINGⁱ	9606.ENSP00000375082.

PTM databases

iPTMnetⁱ	Q6PGQ7.
PhosphoSitePlusⁱ	Q6PGQ7.

Polymorphism and mutation databases

DMDMⁱ	74737659.

DMDMⁱ

74737659.

Proteomic databases

EPDⁱ	Q6PGQ7.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6PGQ7.
PaxDbⁱ	Q6PGQ7.
PeptideAtlas More...PeptideAtlasⁱ	Q6PGQ7.
PRIDEⁱ	Q6PGQ7.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	79866.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000377815; ENSP00000367046; ENSG00000136122. [Q6PGQ7-2]
GeneIDⁱ	79866.
KEGGⁱ	hsa:79866.
UCSC genome browser More...UCSCⁱ	uc010thr.3. human. [Q6PGQ7-1]

Organism-specific databases

CTDⁱ	79866.
GeneCardsⁱ	BORA.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24724. BORA.
Human Protein Atlas More...HPAⁱ	HPA040866.
MIMⁱ	610510. gene.
neXtProtⁱ	NX_Q6PGQ7.
Open Targets More...OpenTargetsⁱ	ENSG00000136122.
PharmGKBⁱ	PA162378045.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IHF2. Eukaryota. ENOG410ZQ9X. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013790.
HOGENOMⁱ	HOG000074046.
HOVERGENⁱ	HBG080904.
InParanoidⁱ	Q6PGQ7.
KEGG Orthology (KO) More...KOⁱ	K16831.
PhylomeDBⁱ	Q6PGQ7.
TreeFamⁱ	TF329674.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
SIGNORⁱ	Q6PGQ7.

Miscellaneous databases

ChiTaRSⁱ	BORA. human.
GenomeRNAiⁱ	79866.
Protein Ontology More...PROⁱ	PR:Q6PGQ7.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000136122.
CleanExⁱ	HS_C13orf34.
ExpressionAtlasⁱ	Q6PGQ7. baseline and differential.
Genevisibleⁱ	Q6PGQ7. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR023252. Aurora_borealis_protein.
PANTHERⁱ	PTHR14728. PTHR14728. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15280. BORA_N. 1 hit.
PRINTSⁱ	PR02038. AURORABORA.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BORA_HUMAN
Accessionⁱ	Q6PGQ7Primary (citable) accession number: Q6PGQ7 Secondary accession number(s): B4DQ30 , Q5W0P3, Q5W0P4, Q86YC6, Q96IW9, Q9H640
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
	Last sequence update:	December 21, 2004
	Last modified:	June 7, 2017
	This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6PGQ7 (BORA_HUMAN)

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Protein aurora borealis

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (2)ⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ