UniProtKB - Q6PGQ7 (BORA_HUMAN)
(max 400 entries)x
Your basket is currently empty. i
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
Protein aurora borealis
Gene
BORA
Organism
Homo sapiens (Human)
Status
Functioni
Required for the activation of AURKA at the onset of mitosis.1 Publication
GO - Molecular functioni
- protein kinase binding Source: UniProtKB
GO - Biological processi
- cell division Source: UniProtKB-KW
- G2/M transition of mitotic cell cycle Source: Reactome
- regulation of mitotic nuclear division Source: UniProtKB
- regulation of mitotic spindle organization Source: UniProtKB
- regulation of protein localization Source: UniProtKB
Keywordsi
Biological process | Cell cycle, Cell division, Mitosis |
Enzyme and pathway databases
Reactomei | R-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition. |
SIGNORi | Q6PGQ7. |
Names & Taxonomyi
Protein namesi | Recommended name: Protein aurora borealisShort name: HsBora |
Gene namesi | Name:BORA Synonyms:C13orf34 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000136122.15. |
HGNCi | HGNC:24724. BORA. |
MIMi | 610510. gene. |
neXtProti | NX_Q6PGQ7. |
Subcellular locationi
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000136122. |
PharmGKBi | PA162378045. |
Polymorphism and mutation databases
DMDMi | 74737659. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000273205 | 1 – 559 | Protein aurora borealisAdd BLAST | 559 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 183 | PhosphoserineCombined sources | 1 | |
Modified residuei | 191 | PhosphoserineCombined sources | 1 | |
Modified residuei | 270 | PhosphoserineCombined sources | 1 | |
Modified residuei | 325 | PhosphoserineBy similarity | 1 | |
Modified residuei | 331 | PhosphoserineBy similarity | 1 | |
Modified residuei | 354 | PhosphothreonineBy similarity | 1 |
Post-translational modificationi
Phosphorylated by AURKA.1 Publication
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | Q6PGQ7. |
PaxDbi | Q6PGQ7. |
PeptideAtlasi | Q6PGQ7. |
PRIDEi | Q6PGQ7. |
PTM databases
iPTMneti | Q6PGQ7. |
PhosphoSitePlusi | Q6PGQ7. |
Expressioni
Gene expression databases
Bgeei | ENSG00000136122. |
CleanExi | HS_C13orf34. |
ExpressionAtlasi | Q6PGQ7. baseline and differential. |
Genevisiblei | Q6PGQ7. HS. |
Organism-specific databases
HPAi | HPA040866. |
Interactioni
Subunit structurei
Interacts with AURKA.1 Publication
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
PLK1 | P53350 | 3 | EBI-719836,EBI-476768 |
GO - Molecular functioni
- protein kinase binding Source: UniProtKB
Protein-protein interaction databases
BioGridi | 122954. 36 interactors. |
DIPi | DIP-53424N. |
ELMi | Q6PGQ7. |
IntActi | Q6PGQ7. 12 interactors. |
STRINGi | 9606.ENSP00000375082. |
Structurei
3D structure databases
ProteinModelPortali | Q6PGQ7. |
SMRi | Q6PGQ7. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 188 – 278 | Ser-richAdd BLAST | 91 |
Sequence similaritiesi
Belongs to the BORA family.Curated
Phylogenomic databases
eggNOGi | ENOG410IHF2. Eukaryota. ENOG410ZQ9X. LUCA. |
GeneTreei | ENSGT00390000013790. |
HOGENOMi | HOG000074046. |
HOVERGENi | HBG080904. |
InParanoidi | Q6PGQ7. |
KOi | K16831. |
PhylomeDBi | Q6PGQ7. |
TreeFami | TF329674. |
Family and domain databases
InterProi | View protein in InterPro IPR023252. Aurora_borealis_protein. |
PANTHERi | PTHR14728. PTHR14728. 1 hit. |
Pfami | View protein in Pfam PF15280. BORA_N. 1 hit. |
PRINTSi | PR02038. AURORABORA. |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6PGQ7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MGDVKESKMQ ITPETPGRIP VLNPFESPSD YSNLHEQTLA SPSVFKSTKL
60 70 80 90 100
PTPGKFRWSI DQLAVINPVE IDPEDIHRQA LYLSHSRIDK DVEDKRQKAI
110 120 130 140 150
EEFFTKDVIV PSPWTDHEGK QLSQCHSSKC TNINSDSPVG KKLTIHSEKS
160 170 180 190 200
DAACQTLLSL PVDFNLENIL GDYFRADEFA DQSPGNLSSS SLRRKLFLDG
210 220 230 240 250
NGSISDSLPS ASPGSPHSGV QTSLEMFYSI DLSPVKCRSP LQTPSSGQFS
260 270 280 290 300
SSPIQASAKK YSLGSITSPS PISSPTFSPI EFQIGETPLS EQRKFTVHSP
310 320 330 340 350
DASSGTNSNG ITNPCIRSPY IDGCSPIKNW SPMRLQMYSG GTQYRTSVIQ
360 370 380 390 400
IPFTLETQGE DEEDKENIPS TDVSSPAMDA AGIHLRQFSN EASTHGTHLV
410 420 430 440 450
VTAMSVTQNQ SSASEKELAL LQDVEREKDN NTVDMVDPIE IADETTWIKE
460 470 480 490 500
PVDNGSLPMT DFVSGIAFSI ENSHMCMSPL AESSVIPCES SNIQMDSGYN
510 520 530 540 550
TQNCGSNIMD TVGAESYCKE SDAQTCEVES KSQAFNMKQD HTTQRCWMKT
ASPFQCSSP
Sequence cautioni
The sequence BAB15426 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 545 | R → K in AAH07119 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_030110 | 210 | S → L. Corresponds to variant dbSNP:rs9543107Ensembl. | 1 | |
Natural variantiVAR_030111 | 308 | S → F. Corresponds to variant dbSNP:rs1146858Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055543 | 1 – 87 | MGDVK…LSHSR → MNKLSPVLLFLNQQNYQ in isoform 2. 1 PublicationAdd BLAST | 87 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK026277 mRNA. Translation: BAB15426.1. Different initiation. AK298608 mRNA. Translation: BAG60792.1. AL138695 Genomic DNA. No translation available. CH471093 Genomic DNA. Translation: EAW80515.1. BC007119 mRNA. Translation: AAH07119.1. BC025367 mRNA. Translation: AAH25367.2. BC044213 mRNA. Translation: AAH44213.1. BC056876 mRNA. Translation: AAH56876.2. |
CCDSi | CCDS66560.1. [Q6PGQ7-2] |
RefSeqi | NP_001273675.1. NM_001286746.1. NP_001273676.1. NM_001286747.1. [Q6PGQ7-2] NP_079084.3. NM_024808.3. |
UniGenei | Hs.643464. |
Genome annotation databases
Ensembli | ENST00000377815; ENSP00000367046; ENSG00000136122. [Q6PGQ7-2] |
GeneIDi | 79866. |
KEGGi | hsa:79866. |
UCSCi | uc010thr.3. human. [Q6PGQ7-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | BORA_HUMAN | |
Accessioni | Q6PGQ7Primary (citable) accession number: Q6PGQ7 Secondary accession number(s): B4DQ30 Q9H640 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 23, 2007 |
Last sequence update: | December 21, 2004 | |
Last modified: | January 31, 2018 | |
This is version 115 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |