Reviewed, UniProtKB/Swiss-Prot Q6PGQ7 (BORA_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein aurora borealis
      Short name=HsBora

Gene names

Name:	BORA
Synonyms:	C13orf34

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	559 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Required for the activation of Aurora-A (AURKA/STK6) at the onset of mitosis. Ref.4
Subunit structure	Interacts with AURKA/STK6. Ref.4
Post-translational modification	Phosphorylated by AURKA/STK6. Ref.4 Ref.5
Sequence similarities	Belongs to the BORA family.
Sequence caution	The sequence CAH72713.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Coding sequence diversity	Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell division Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 559	559	Protein aurora borealis		PRO_0000273205
Regions
	Compositional bias	188 – 278	91	Ser-rich
Amino acid modifications
	Modified residue	137	1	Phosphoserine
	Modified residue	183	1	Phosphoserine Ref.5
	Modified residue	189	1	Phosphoserine Ref.5
	Modified residue	191	1	Phosphoserine Ref.5
	Modified residue	270	1	Phosphoserine
	Modified residue	552	1	Phosphoserine
	Modified residue	558	1	Phosphoserine
Natural variations
	Natural variant	210	1	S → L: dbSNP rs9543107.		VAR_030110
	Natural variant	308	1	S → F: dbSNP rs1146858.		VAR_030111
Experimental info
	Sequence conflict	545	1	R → K in AAH07119. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q6PGQ7-1 [UniParc]. Last modified December 21, 2004. Version 2. Checksum: F817E6DC2C7600DB	FASTA	559	61,203
	10 20 30 40 50 60 MGDVKESKMQ ITPETPGRIP VLNPFESPSD YSNLHEQTLA SPSVFKSTKL PTPGKFRWSI 70 80 90 100 110 120 DQLAVINPVE IDPEDIHRQA LYLSHSRIDK DVEDKRQKAI EEFFTKDVIV PSPWTDHEGK 130 140 150 160 170 180 QLSQCHSSKC TNINSDSPVG KKLTIHSEKS DAACQTLLSL PVDFNLENIL GDYFRADEFA 190 200 210 220 230 240 DQSPGNLSSS SLRRKLFLDG NGSISDSLPS ASPGSPHSGV QTSLEMFYSI DLSPVKCRSP 250 260 270 280 290 300 LQTPSSGQFS SSPIQASAKK YSLGSITSPS PISSPTFSPI EFQIGETPLS EQRKFTVHSP 310 320 330 340 350 360 DASSGTNSNG ITNPCIRSPY IDGCSPIKNW SPMRLQMYSG GTQYRTSVIQ IPFTLETQGE 370 380 390 400 410 420 DEEDKENIPS TDVSSPAMDA AGIHLRQFSN EASTHGTHLV VTAMSVTQNQ SSASEKELAL 430 440 450 460 470 480 LQDVEREKDN NTVDMVDPIE IADETTWIKE PVDNGSLPMT DFVSGIAFSI ENSHMCMSPL 490 500 510 520 530 540 AESSVIPCES SNIQMDSGYN TQNCGSNIMD TVGAESYCKE SDAQTCEVES KSQAFNMKQD 550 HTTQRCWMKT ASPFQCSSP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow, Leiomyosarcoma, Rhabdomyosarcoma and Testis carcinoma.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 135-559. Tissue: Small intestine.
[4]	"Mitotic activation of the kinase Aurora-A requires its binding partner Bora." Hutterer A., Berdnik D., Wirtz-Peitz F., Zigman M., Schleiffer A., Knoblich J.A. Dev. Cell 11:147-157(2006) [PubMed: 16890155] [Abstract] Cited for: FUNCTION, PHOSPHORYLATION, INTERACTION WITH AURKA.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-183; SER-189 AND SER-191, MASS SPECTROMETRY.
[6]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137; SER-552 AND SER-558, MASS SPECTROMETRY.
[7]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-270, MASS SPECTROMETRY. Tissue: T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL138695 Genomic DNA. Translation: CAH72712.2. AL138695 Genomic DNA. Translation: CAH72713.1. Sequence problems. BC007119 mRNA. Translation: AAH07119.1. BC025367 mRNA. Translation: AAH25367.2. BC044213 mRNA. Translation: AAH44213.1. BC056876 mRNA. Translation: AAH56876.2. AK026277 mRNA. Translation: BAB15426.1. Different initiation.
IPI	IPI00937172.
RefSeq	NP_079084.2.
UniGene	Hs.714340
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6PGQ7. 3 interactions.
STRING	Q6PGQ7.
PTM databases
PhosphoSite	Q6PGQ7.
Proteomic databases
PRIDE	Q6PGQ7.
Genome annotation databases
Ensembl	ENST00000377815; ENSP00000367046; ENSG00000136122; Homo sapiens. [Genome view] ENST00000390667; ENSP00000375082; ENSG00000136122; Homo sapiens. [Genome view]
GeneID	79866.
KEGG	hsa:79866.
UCSC	uc001viv.1. human.
Organism-specific databases
CTD	79866.
GeneCards	GC13P072199.
HGNC	HGNC:24724. C13orf34.
MIM	610510. gene.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q6PGQ7.
Gene expression databases
ArrayExpress	Q6PGQ7.
Bgee	Q6PGQ7.
CleanEx	HS_C13orf34.
Genevestigator	Q6PGQ7.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	69614.
SOURCE	Search...

Entry information

Entry name

BORA_HUMAN

Accession

Primary (citable) accession number: Q6PGQ7
Secondary accession number(s): Q5W0P3 , Q5W0P4, Q86YC6, Q96IW9, Q9H640

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	December 21, 2004
Last modified:	November 24, 2009
This is version 43 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.