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UniProtKB - Q6PGQ7 (BORA_HUMAN)

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Protein

Protein aurora borealis

Gene

BORA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for the activation of AURKA at the onset of mitosis.1 Publication

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • G2/M transition of mitotic cell cycle Source: Reactome
  • regulation of mitotic nuclear division Source: UniProtKB
  • regulation of mitotic spindle organization Source: UniProtKB
  • regulation of protein localization Source: UniProtKB
Complete GO annotation...

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
SIGNORiQ6PGQ7.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein aurora borealis
Short name:
HsBora
Gene namesi
Name:BORA
Synonyms:C13orf34
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:24724. BORA.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136122.
PharmGKBiPA162378045.

Polymorphism and mutation databases

DMDMi74737659.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002732051 – 559Protein aurora borealisAdd BLAST559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei183PhosphoserineCombined sources1
Modified residuei191PhosphoserineCombined sources1
Modified residuei270PhosphoserineCombined sources1
Modified residuei325PhosphoserineBy similarity1
Modified residuei331PhosphoserineBy similarity1
Modified residuei354PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylated by AURKA.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PGQ7.
MaxQBiQ6PGQ7.
PaxDbiQ6PGQ7.
PeptideAtlasiQ6PGQ7.
PRIDEiQ6PGQ7.

PTM databases

iPTMnetiQ6PGQ7.
PhosphoSitePlusiQ6PGQ7.

Expressioni

Gene expression databases

BgeeiENSG00000136122.
CleanExiHS_C13orf34.
ExpressionAtlasiQ6PGQ7. baseline and differential.
GenevisibleiQ6PGQ7. HS.

Organism-specific databases

HPAiHPA040866.

Interactioni

Subunit structurei

Interacts with AURKA.1 Publication

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB
Complete GO annotation...

Protein-protein interaction databases

BioGridi122954. 26 interactors.
DIPiDIP-53424N.
IntActiQ6PGQ7. 11 interactors.
STRINGi9606.ENSP00000375082.

Structurei

3D structure databases

ProteinModelPortaliQ6PGQ7.
SMRiQ6PGQ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi188 – 278Ser-richAdd BLAST91

Sequence similaritiesi

Belongs to the BORA family.Curated

Phylogenomic databases

eggNOGiENOG410IHF2. Eukaryota.
ENOG410ZQ9X. LUCA.
GeneTreeiENSGT00390000013790.
HOGENOMiHOG000074046.
HOVERGENiHBG080904.
InParanoidiQ6PGQ7.
KOiK16831.
PhylomeDBiQ6PGQ7.
TreeFamiTF329674.

Family and domain databases

InterProiView protein in InterPro
IPR023252. Aurora_borealis_protein.
PANTHERiPTHR14728. PTHR14728. 1 hit.
PfamiView protein in Pfam
PF15280. BORA_N. 1 hit.
PRINTSiPR02038. AURORABORA.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PGQ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDVKESKMQ ITPETPGRIP VLNPFESPSD YSNLHEQTLA SPSVFKSTKL 
        60         70         80         90        100
PTPGKFRWSI DQLAVINPVE IDPEDIHRQA LYLSHSRIDK DVEDKRQKAI 
       110        120        130        140        150
EEFFTKDVIV PSPWTDHEGK QLSQCHSSKC TNINSDSPVG KKLTIHSEKS 
       160        170        180        190        200
DAACQTLLSL PVDFNLENIL GDYFRADEFA DQSPGNLSSS SLRRKLFLDG 
       210        220        230        240        250
NGSISDSLPS ASPGSPHSGV QTSLEMFYSI DLSPVKCRSP LQTPSSGQFS 
       260        270        280        290        300
SSPIQASAKK YSLGSITSPS PISSPTFSPI EFQIGETPLS EQRKFTVHSP 
       310        320        330        340        350
DASSGTNSNG ITNPCIRSPY IDGCSPIKNW SPMRLQMYSG GTQYRTSVIQ 
       360        370        380        390        400
IPFTLETQGE DEEDKENIPS TDVSSPAMDA AGIHLRQFSN EASTHGTHLV 
       410        420        430        440        450
VTAMSVTQNQ SSASEKELAL LQDVEREKDN NTVDMVDPIE IADETTWIKE 
       460        470        480        490        500
PVDNGSLPMT DFVSGIAFSI ENSHMCMSPL AESSVIPCES SNIQMDSGYN 
       510        520        530        540        550
TQNCGSNIMD TVGAESYCKE SDAQTCEVES KSQAFNMKQD HTTQRCWMKT 

ASPFQCSSP
Length:559
Mass (Da):61,203
Last modified:December 21, 2004 - v2
Checksum:iF817E6DC2C7600DB
GO
Isoform 2 (identifier: Q6PGQ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: MGDVKESKMQ...RQALYLSHSR → MNKLSPVLLFLNQQNYQ

Note: No experimental confirmation available.
Show »
Length:489
Mass (Da):53,438
Checksum:iCBD976AE2BA1E52E
GO

Sequence cautioni

The sequence BAB15426 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti545R → K in AAH07119 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030110210S → L. Corresponds to variant dbSNP:rs9543107Ensembl.1
Natural variantiVAR_030111308S → F. Corresponds to variant dbSNP:rs1146858Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0555431 – 87MGDVK…LSHSR → MNKLSPVLLFLNQQNYQ in isoform 2. 1 PublicationAdd BLAST87

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026277 mRNA. Translation: BAB15426.1. Different initiation.
AK298608 mRNA. Translation: BAG60792.1.
AL138695 Genomic DNA. No translation available.
CH471093 Genomic DNA. Translation: EAW80515.1.
BC007119 mRNA. Translation: AAH07119.1.
BC025367 mRNA. Translation: AAH25367.2.
BC044213 mRNA. Translation: AAH44213.1.
BC056876 mRNA. Translation: AAH56876.2.
CCDSiCCDS66560.1. [Q6PGQ7-2]
RefSeqiNP_001273675.1. NM_001286746.1.
NP_001273676.1. NM_001286747.1. [Q6PGQ7-2]
NP_079084.3. NM_024808.3.
UniGeneiHs.643464.

Genome annotation databases

EnsembliENST00000377815; ENSP00000367046; ENSG00000136122. [Q6PGQ7-2]
GeneIDi79866.
KEGGihsa:79866.
UCSCiuc010thr.3. human. [Q6PGQ7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026277 mRNA. Translation: BAB15426.1. Different initiation.
AK298608 mRNA. Translation: BAG60792.1.
AL138695 Genomic DNA. No translation available.
CH471093 Genomic DNA. Translation: EAW80515.1.
BC007119 mRNA. Translation: AAH07119.1.
BC025367 mRNA. Translation: AAH25367.2.
BC044213 mRNA. Translation: AAH44213.1.
BC056876 mRNA. Translation: AAH56876.2.
CCDSiCCDS66560.1. [Q6PGQ7-2]
RefSeqiNP_001273675.1. NM_001286746.1.
NP_001273676.1. NM_001286747.1. [Q6PGQ7-2]
NP_079084.3. NM_024808.3.
UniGeneiHs.643464.

3D structure databases

ProteinModelPortaliQ6PGQ7.
SMRiQ6PGQ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122954. 26 interactors.
DIPiDIP-53424N.
IntActiQ6PGQ7. 11 interactors.
STRINGi9606.ENSP00000375082.

PTM databases

iPTMnetiQ6PGQ7.
PhosphoSitePlusiQ6PGQ7.

Polymorphism and mutation databases

DMDMi74737659.

Proteomic databases

EPDiQ6PGQ7.
MaxQBiQ6PGQ7.
PaxDbiQ6PGQ7.
PeptideAtlasiQ6PGQ7.
PRIDEiQ6PGQ7.

Protocols and materials databases

DNASUi79866.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377815; ENSP00000367046; ENSG00000136122. [Q6PGQ7-2]
GeneIDi79866.
KEGGihsa:79866.
UCSCiuc010thr.3. human. [Q6PGQ7-1]

Organism-specific databases

CTDi79866.
GeneCardsiBORA.
HGNCiHGNC:24724. BORA.
HPAiHPA040866.
MIMi610510. gene.
neXtProtiNX_Q6PGQ7.
OpenTargetsiENSG00000136122.
PharmGKBiPA162378045.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHF2. Eukaryota.
ENOG410ZQ9X. LUCA.
GeneTreeiENSGT00390000013790.
HOGENOMiHOG000074046.
HOVERGENiHBG080904.
InParanoidiQ6PGQ7.
KOiK16831.
PhylomeDBiQ6PGQ7.
TreeFamiTF329674.

Enzyme and pathway databases

ReactomeiR-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
SIGNORiQ6PGQ7.

Miscellaneous databases

ChiTaRSiBORA. human.
GenomeRNAii79866.
PROiPR:Q6PGQ7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136122.
CleanExiHS_C13orf34.
ExpressionAtlasiQ6PGQ7. baseline and differential.
GenevisibleiQ6PGQ7. HS.

Family and domain databases

InterProiView protein in InterPro
IPR023252. Aurora_borealis_protein.
PANTHERiPTHR14728. PTHR14728. 1 hit.
PfamiView protein in Pfam
PF15280. BORA_N. 1 hit.
PRINTSiPR02038. AURORABORA.
ProtoNetiSearch...

Entry informationi

Entry nameiBORA_HUMAN
AccessioniPrimary (citable) accession number: Q6PGQ7
Secondary accession number(s): B4DQ30
, Q5W0P3, Q5W0P4, Q86YC6, Q96IW9, Q9H640
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: December 21, 2004
Last modified: June 7, 2017
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.